Science in the Arts Rationalism, Science, and Freedom of Speech: Voltaire Marek H. Dominiczak* The 18th century Enlightenment thinkers began to regard observation as a primary means of gaining knowledge. Crucial to this were the discoveries of Isaac Newton and the philosophy of John Locke (1632–1704). Isaac Newton was previously mentioned in this series (1 ). Locke maintained that the only source of our knowledge was our senses, and that there was no innate knowledge that a human possessed. This view implied that knowledge had its limits because things that were unavailable to sensory perception would be unknowable. Locke also addressed the process of scientific induction, acknowledging that inductive knowledge may yield errors; therefore, knowledge at any point was not unchangeable and might need to be corrected in the future. He extrapolated some of his epistemological comments to thinking of politics and government. His lasting contribution was the view that, because there was no absolute knowledge, political tolerance was essential (2, 3 ). France at that time was ruled by Louis XV, after the death of Louis XIV in 1715. Elsewhere in Europe this was the time of the so-called enlightened despots: Frederick II in Prussia and Catherine II in Russia. In France, intellectuals developing the Enlightenment ideas became known as the philosophes. Prominent among them was François Marie Arouet (1694 –1778), who changed his name to Voltaire (4, 5 ). He was a playwright and a historian. For much of his life he was associated with the leading Parisian theater, Comédie Française, and very quickly became a celebrated writer (6 ). He had an extraordinary wit and a clear, concise, to-the-point writing style. Early in his career, after an altercation with a nobleman, he was arrested and sent into exile to England. He became fascinated with England’s liberties and its drive to rationalism. In Letters on England (known in France as Lettres philosophiques), he became a champion of Newton’s and Locke’s ideas (7 ). Voltaire admired the emerging science and later went as far as building himself a laboratory for personal experimentation—with no signif- College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. * Address correspondence to the author at: Gartnavel General Hospital, 1053 Great Western Rd., Glasgow G12 0YN, Scotland, UK. Fax +44-141-211-3452; e-mail [email protected]. Received February 15, 2016; accepted February 19, 2016. © 2016 American Association for Clinical Chemistry icant results. Science was for him a subject of leisurely study for intellectual pleasure. Voltaire had a longstanding relationship with Émile de Châtelet, an intellectually accomplished woman who translated Newton’s Principia Mathematica. Interestingly, she also wrote an essay on happiness (5 ). Later he spent 3 years at the court of Frederick II, who was keen to establish Potsdam as an intellectual center. Unfortunately, he eventually contradicted Frederick in a scientific dispute and decided to leave Prussia, settling outside Geneva. He then bought an estate in Ferney (today Ferney-Voltaire) on the French–Swiss border. At the very end of his life he triumphantly returned to Paris. Voltaire’s rational point of view was grounded in literature and history, and he backed his arguments by characteristically careful analyses. His Philosophical dictionary defined his views in a series of short articles (8 ). He also collaborated with Denis Diderot and Jean d’Alembert, the editors of the seminal Enlightenment publication, the Encyclopedia. He was an irrepressible advocate of freedom of speech. His willingness to express his opinions without any restraint meant that a substantial part of his writing was being censored and banned, and it had to be initially published outside France. Fig. 1 provides a glimpse into the artistic style of the times, the Rococo. It shows the work from the workshop of a leading French painter, Francois Boucher (1727– 1765) (9, 10 ). Boucher was a pupil of François Lemoyne, and he was influenced by Jean-Antoine Watteau. He also visited Rome and admired the work of Baroque artists. Boucher was also involved in the tapestry design for the famous Beauvais and Gobelin workshops. In 1765 he became the First Painter to the King. His patron was Madame du Pompadour, the mistress of Louis XV, who incidentally was also a supporter of Voltaire. The panel shown in Fig. 1 was painted in 1770 –1772 and belongs to a series entitled The Arts and Sciences. It shows a characteristically playful allegory of architecture and chemistry. Boucher trained as a theatrical set designer and one can detect a theatrical slant to his work. The very playfulness of this picture demonstrates how concepts of science started to permeate wider society. This style would soon be superseded by the much more stern Neoclassicism. Voltaire remains a role model for independent thinkers, people who are loath to unthinkingly submit to Clinical Chemistry 62:5 (2016) 789 Science in the Arts either religious or state authority. Toward the end of his life he achieved a truly iconic status in France but, interestingly, this was due not only to his literary achievements. He became engaged in a long fight to make the French judicial system more transparent, and organized appeals against several death sentences, which he perceived to be unjust (4 ). Thus, Voltaire was both a champion of emerging science and an early advocate of human rights. Author Contributions: All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article. Authors’ Disclosures or Potential Conflicts of Interest: No authors declared any potential conflicts of interest. Acknowledgments: My thanks to Jacky Gardiner for her excellent secretarial assistance. References Fig. 1. François Boucher (1703–1770). Workshop of François Boucher. The Arts and Sciences: Architecture and Chemistry, 1750 –1752 Oil on canvas, 85 1/2 ×30 1/2 in. The Frick Collection, New York. Photo: Michael Bodycomb. ©2016 Artists Rights Society (ARS), New York/SOFAM, Brussels. Reproduced with permission. 790 Clinical Chemistry 62:5 (2016) 1. Dominiczak MH. 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