=^opn]_p
Pdeo l]lan lnaoajpo ] ?'' eilhaiajp]pekj kb pda ldn]oa o_knejc opal ej ldn]oa)^]oa` ouo)
paio pd]p dahlo pk atlhkep pda ]r]eh]^ha _kilqpejc naokqn_ao ikna a{e_eajphu ]j` pn]ejo ranu
h]nca ouopaio ej na]okj]^ha peia sepdkqp o]_ne|_ejc pda ouopai̢o lanbkni]j_a ej panio kb >haq
o_kna*
Pdnaa l]n]hhahevejc pkkho ]na i]`a bnaahu ]r]eh]^ha* Pda |nop atlhkepo od]na` iaiknu l]n]h)
haheoi ]j` iqhpelha `eogo bkn l]n]hhah EKo sdeha pda psk kpdano nqj ej ] `eopne^qpa` ajrenkjiajp*
Sa `aikjopn]pa pda a{e_eaj_u ]j` _kjoeopaj_u kb kqn pkkho( ej pda bn]iaskng kb pda Bn)Aj
ouopaio sa `arahkla` bkn pda SIP ]j` ESOHP ar]hq]pekj _]il]ecjo( ej sde_d sa sana ]^ha
pk cajan]pa pda ldn]oa p]^ha ej kja pden` ql pk kja oarajpd kb pda peia p]gaj ^u Ikoao ej pda
o]ia p]ogo*
-* Ejpnk`q_pekj
Ldn]oa o_knejc eo kja kb pda ikop eilknp]jp ]j` uap ranu atlajoera opalo ej ldn]oa)
^]oa` pn]joh]pekj ouopai pn]ejejc* Pule_]hhu( ep _kjoeopo kb aopei]pejc pda _knnaolkj`)
ejc o_knao bkn a]_d qjemqa ldn]oa l]en atpn]_pa` bnki ]j ]hecja` l]n]hhah _knlqo* Qoq)
]hhu( pda o_knao ]na aopei]pa` ^]oa` kj psk `ena_pekjo $bnki okqn_a pk p]ncap ]j` re_a
rano]%* Pdanabkna( pda lnk_aoo eo ]__kilheoda` ej psk nqjo* Ej pda |nop nqj( _kqjpo ]na
_khha_pa` ]j` pdaj pda o_knao ]na aopei]pa` ^]oa` kj pda okqn_a ldn]oao sdeha ej pda
oa_kj` nqj ] oeieh]n p]og eo lanbknia` ^]oa` kj pda p]ncap ldn]oao*
Pdeo lnk_aoo eo iaiknu cnaa`u* Dksaran( bkn jkj h]nca _knlkn] ep _kqh` ^a lan)
bknia` a{e_eajphu ej pda lduoe_]h iaiknu ^u okia eilhaiajp]pekjo* Bkn ejop]j_a(
iaio_kna $D]n`iaean( .,-,% qoao ] hkkgql d]od p]^ha ^]oa` kj OPH- i]lo pk ej`at
- ?''
Op]j`]n` Pailh]pa He^n]nu
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
pda ldn]oao* Pdaj pda d]od e`ajpe|ano ]na qoa` pk `ena_phu ]__aoo pda _knnaolkj`ejc
ldn]oao ej kn`an pk ql`]pa pda i]ncej]h ]j` fkejp _kqjpo* Qjbknpqj]pahu( pdeo `kao jkp
o_]ha ranu sahh bkn _knlkn] kb h]nca oevao* =o ] i]ppan kb b]_p( ] iaiknu namqenaiajp kb
ikna pd]j 2,Ce> s]o nalknpa` bkn ] _knlqo kb 0*3I oajpaj_a l]eno $D]n`iaean( .,-,%*
Kj pda kpdan d]j`( ikop ouopaio oq_d ]o pda se`ahu qoa` ldn]oa)^]oa` ouopai
Ikoao $Gkadj ap ]h*( .,,3%( d]j`ha pda iaiknu heiep]pekj ^u opna]iejc pda h]nca `]p]
oapo( gaalejc kjhu ] heiepa` ]ikqjp kb `]p] ejpk iaiknu( ]j` o]rejc pailkn]nu na)
oqhpo ejpk `eog* Ej b]_p( ]hh pda l]eno sde_d _knnaolkj` pk ] ceraj ldn]oa odkqh` ^a galp
ejpk iaiknu sdeha c]pdanejc pda i]ncej]h ]j` fkejp _kqjpo bkn pdeo ldn]oa* ?kjoa)
mqajphu( pda opna]ia` `]p] iqop ^a oknpa` `alaj`ejc kj sdapdan pda _kilqp]pekj
eo ^aejc dah` ^]oa` kj okqn_a ldn]oao kn p]ncap ldn]oao * Ej Ikoao( pdeo eo ]_deara`
^u lanbkniejc psk oknpejc klan]pekjo qoejc pda op]j`]n` Qjet oknp _kii]j`*. Araj
pdkqcd( ^aejc ] ckk` atpanj]h iaiknu oknpejc pkkh( pda Qjet oknp _kii]j` eo jkp
klpei]h sdaj pda _knlqo eo ranu h]nca* Bkn ejop]j_a( pda nqjo ]na bknia` ]j` oknpa`
oane]hhu( ep h]_go oqllknp bkn iqhpelha `eogo( ]j` pda EK _kqh` jkp ^a kranh]lla` sepd
pda _kilqp]pekjo*
C]k ]j` Rkcah $.,-,% `arahkla` ] lh]pbkni bkn `eopne^qpa` pn]ejejc kb ldn]oa)
^]oa` ouopaio op]npejc bnki skn` ]hecjiajp qjpeh ldn]oa o_knejc* Araj pdkqcd at)
_ahhajp olaa` c]ejo sana nalknpa`( pdeo ouopai nqjo kj pkl kb pda D]`kkl bn]iaskng(
]j` pdanabkna jaa`o pda _hqopan pk |p pdeo ola_e]h ejbn]opnq_pqna*
Qjhega ]llhe_]pekjo sde_d klan]pa at_hqoerahu kj `]p] opkna` ej i]ej iaiknu(
]llhe_]pekjo sde_d ejrkhra atpanj]h iaikneao oq_d ]o d]n` `eogo b]_a ]j ]``epekj]h
_d]hhajca sepd pda decd `]p] pn]joban h]paj_u ^apsaaj pda atpanj]h ]j` i]ej iai)
knu* Bkn pdeo lqnlkoa( `]p] opnq_pqnao ]j` ]hcknepdio d]ra ^aaj `arahkla` ej kn`an
pk iejeieva pda EK kranda]` ]j` pk atlhkep pda ]r]eh]^ha naokqn_ao oq_d ]o l]n]hhah
`eogo ]j` iqhpelha lnk_aookno ikna a{e_eajphu $Reppan( .,,4%* Hq_gehu( `e{anajp atpan)
j]h iaiknu =LEo d]ra ^aaj _na]pa` ej kn`an pk i]ga pda qj`anhuejc `eog ]__aoo ]j`
hks harah klan]pekjo pn]jol]najp pk lnkcn]iiano* Oq_d lh]pbknio ej_hq`a( ^qp ]na jkp
heiepa` pk( HA@=)OI $?n]qoan ]j` Iadhdknj( -555%( PLEA $=nca ap ]h*( .,,.%( >angahau
@> $Khokj ap ]h*( -555%( ]j` OPTTH $@aiajpear ]j` Gappjan( .,,1%*
Pda i]ej ck]ho kb kqn pkkho bkn ldn]oa o_knejc ]na pk atlhkep ?LQ ]j` `eog l]n)
]hhaheoi ej ]j atpanj]h iaiknu ajrenkjiajp( ok pd]p pda ldn]oa oknpejc ]j` o_kna
_kilqp]pekj ]na lanbknia` ikna a{e_eajphu* Pda ?LQ l]n]hhaheoi eo ajoqna` ^u pda
KlajIL he^n]nu $?d]li]j ap ]h*( .,,3% $arajpq]hhu _kqlha` sepd ]j ILE eilhaiajp])
pekj $L]_da_k( -552%%( sdeha pda `eog l]n]hhaheoi ]j` kpdan atpanj]h iaiknu bqj_pekj)
]hpeao ]na ajoqna` ^u pda OPTTH he^n]nu* OPTTH eo lnabanna` kran kpdan ajrenkjiajpo
`qa pk epo oqlanekn lanbkni]j_a( a]oa kb qoa $OPH)_kil]pe^ha ejpanb]_a%( ]j` atlhe_ep
oqllknp bkn l]n]hhah `eogo $@aiajpear ap ]h*( .,,4%*
Ikop kb kqn pkkho ]na sneppaj ej ?''* Pda qj`anhuejc ?LQ l]n]hhaheoi _kiao ej
pdnaa }]rkqno6 iqhpepdna]`a`( du^ne`( ]j` `eopne^qpa`* Pda iqhpepdna]`a` ranoekj
.
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
qoao od]na` iaiknu l]n]hhaheoi ]j` pdanabkna nqjo kj ] oejcha jk`a* Ej pda du^ne`
oappejc( iqhpelha jk`ao _]j ^a qoa`* Kj a]_d kb pdaoa jk`ao pda od]na` iaiknu l]n)
]hhaheoi eo atlhkepa`* Pda `eopne^qpa` pkkh lnk_aa`o ej ] I]lNa`q_a opn]pacu $@a]j
]j` Cdai]s]p( .,,4%6 Op]npejc bnki Cev] ]hecjiajpo( pda h]nca _knlqo eo olhep ejpk
l]npepekjo ]j` pn]ejejc eo lanbknia` ej`alaj`ajphu kj pda l]npepekjo* Bkn a]_d l]np(
op]j`]n` Ikoao pkkho ]na qoa` bkn ]hecjiajp _ki^ej]pekj( hate_]h o_knejc( ]j` ldn]oa
atpn]_pekj* Bkn ldn]oa o_knejc( sa qoa ] ohecdphu ik`e|a` ranoekj kb pda iqhpepdna]`a`
pkkh* Ep ]hhkso ]hh pda l]npe]h _kqjpo pk ^a o]ra` ]o sahh* Pda l]npe]h ldn]oa p]^hao ]na
pdaj ianca` ]j` pda lnk^]^ehepeao ]na naaopei]pa` qoejc pda jas ql`]pa` _kqjpo*
Ej pda jatp oa_pekj( pda atpanj]h iaiknu oknpejc eo ^nea}u lnaoajpa` ej pda bn]ia)
skng kb pda OPTTH eilhaiajp]pekj* =bpans]n`o( pda ]n_depa_pqna ]j` qj`anhuejc ]h)
cknepdio kb kqn `e{anajp okbps]na }]rkqno ]na `eooa_pa` ]j` epo qo]ca eo atlh]eja`*
Pdaj okia atlaneiajp]h naoqhpo ]na lnaoajpa` ]j` `eo_qooa`* Bej]hhu( ] _kj_hqoekj
]^kqp pda i]ej |j`ejco ]j` arajpq]h atpajoekjo aj`o pda l]lan*
.* Atpanj]h iaiknu oknpejc ej OPTTH
@qa pk epo atpnaia eilknp]j_a( pda atpanj]h iaiknu oknpejc d]o na_aera` _kjpejq)
kqo eilnkraiajpo kran pda ua]no* Pda `e{anajp pa_djemqao _]j ^a _]packneva` ej psk
_h]ooao6 `eopne^qpekj oknpo ]j` iancejc oknpo* = `ap]eha` oqnrau kb ^kpd ]llnk]_dao
_]j ^a bkqj` ej Reppan $.,,4%*
@ap]eho ]^kqp OPTTH oknp eilhaiajp]pekj ]na ceraj ej O]j`ano ]j` @aiajpear
$.,,/%* Ej pda bkhhksejc( sa ^nea}u nareas epo eilknp]jp ]ola_po*
OPTTH eilhaiajpo ] iqhpes]u)ianca oknp* Ep ]ooqiao pd]p pda `]p] na_kn`o ]na kb
|ta` oeva* Pda lnk_aooejc pdaj _kqh` ^a dah` kj |ta` oeva `]p] ^hk_go* Pda OPTTH
he^n]nu bknio pda ^]_g^kja kb i]ju oknpejc ^aj_di]ng/ sejjano ej pda l]op ua]no
$=j`na]o ap ]h*( .,--7 N]dj ap ]h*( .,,57 >a_gi]jj ap ]h*( .,-.%* Pda psk gau opalo kb
OPTTH oknpejc ]na ]o bkhhkso6
Nqj bkni]pekj Ej ] `kq^ha ^q{anejc opn]pacu( psk pdna]`o _kklan]pa pk na]`+oknp
pda `e{anajp nqjo* Pda |nop pdna]` oknpo pda nqj sde_d k__qleao d]hb kb pda oknpejc
iaiknu( sdeha pda oa_kj` pdna]` eo aepdan na]`ejc pda jatp nqj kn snepejc pda oknpa`
nqj* Pda oknpan pdna]` _na]pao hecdpan `]p] opnq_pqna _kjoeopejc kb kjhu pda gauo ]j`
lkejpano pk pda ]_pq]h ahaiajpo* =bpan pd]p( ep oknpo pda gauo ej pda jas `]p] opnq_pqna
sdana pda oknpejc iapdk` `alaj`o kj pdaen jqi^an $opn]ecdp heja _k`a eb ep `kaoj̢p
at_aa` 0( ejoanpekj oknp eb ep eo ^apsaaj 1 ]j` -2( kpdanseoa ep qoao mqe_goknp%*
Iqhpes]u iancejc Ej kn`an pk `a|ja pda kn`an ej sde_d ^hk_go sehh ^a opna]ia` ejpk
pda iancan( pda oi]hhaop ahaiajpo ej a]_d ^hk_g ]na na_kn`a` ej ] oknpa` heop `qnejc nqj
/
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
bkni]pekj* Pda lkoepekj kb ]j ahaiajp ej pdeo heop `a|jao sdaj epo _kjp]ejejc ^hk_g sehh
ajpan pda iancejc ^q{ano* Pda iancan gaalo ] jqi^an kb ^hk_go amq]h pk pda jqi^an
kb pda oknpa` nqjo ej iancejc ^q{ano* Ej kn`an pk iejeieva pda peia kb oaha_pejc pda
_qnnajp oi]hhaop ahaiajp( pda gauo kb pda oi]hhaop ahaiajpo kb ]hh ^hk_go ej iancejc
^q{ano ]na galp ej ] pnaa o_pnq_pqna*
OPTTH qoao ]j kranh]l ^q{an bkn na]`ejc ]j` ] snepa ^q{an bkn snepejc ej kn`an pk
kranh]l EKo ]j` iancejc* Pda oeva kb pda kranh]l ^q{an `alaj`o ^kpd kj pda jqi^an
kb nqjo ]j` pda jqi^an kb l]n]hhah `eogo sdeha pda oeva kb pda snepa ^q{an `alaj`o kj
pda jqi^an kb `eogo kjhu* Eb pda snepa ^q{an d]o ] jqi^an kb ^hk_go sde_d at_aa`o
pda jqi^an kb `eogo( ] l]n]hhah kqplqp eo oq^ieppa`* Oeieh]nhu( eb pda kranh]l ^q{an
d]o ] jqi^an kb bnaa ^hk_go sde_d at_aa`o pda jqi^an kb `eogo( ] l]n]hhah na]` eo
lanbknia`*
@eopne^qpa` Atpanj]h Iaiknu oknpejc $@AIOknp% eo ]j atpajoekj kb pda OPTTH oknp)
ejc ok pd]p ep |po pda `eopne^qpa` _]oa sdana pda oknpejc eo n]pdan lanbknia` kj iqh)
pelha i]_dejao $N]dj ap ]h*( .,-,%* Pda gau `e{anaj_a dana eo pda ejpnk`q_pekj kb ]j
]``epekj]h ejpania`e]pa ld]oa ^apsaaj nqj bkni]pekj ]j` iqhpes]u iancejc6 pda ok)
_]hha` Iqhpes]u oaha_pekj*
Hega pda `eopne^qpekj oknpo( pda iqhpes]u oaha_pekj paj`o pk |j` chk^]h olheppejc
lkejpo kran ]hh pda oknpa` nqjo* >u pda aj` kb pdeo klan]pekj( a]_d jk`a gjkso epo at)
_hqoera n]jca kb `]p]* =bpans]n`o( pda `]p] ]na na`eopne^qpa` chk^]hhu kran pda jk`ao
qoejc ]j ]hh)pk)]hh klan]pekj pk o]peobu pda n]jca _kjopn]ejpo* Ej pdeo _]oa( pda ILE ej)
panb]_a eo qoa` bkn pda ejpan)jk`a _kiiqje_]pekj* Bej]hhu( pda iancejc eo `kja hk_]hhu
]o atlh]eja` ^abkna*
/* Okbps]na ]n_depa_pqna ]j` ]hcknepdio
Hega Ikoao o_knejc pkkh( kqn ldn]oa o_knejc pkkho p]ga pdnaa |hao ]o ejlqp ]j` lnk)
`q_a ] ldn]oa p]^ha ]o kqplqp* Pda |nop ejlqp |ha _kjp]ejo pda atpn]_pa` ldn]oao $_]hha`
̢
̢ ej Ikoao _kjrajpekj% ]j` pda kpdan |hao ]na psk ^ehejcq]h `e_pekj]n)
eao sde_d ik`ah Ln(s | t) ]j` Ln(t | s) bkn aranu okqn_a ]j` p]ncap skn`o s ]j` t eb pdau
]na ]hecja` ]p ha]op kj_a $̢
̢ ]j` ̢
̢ ej Ikoao _kjrajpekj%*
Pule_]hhu( pda ldn]oa p]^ha na_kn`o 0 o_knao bkn aranu atpn]_pa` ldn]oa l]en* Nah])
pera bnamqaj_u ]j` hate_]h o_kna bkn a]_d `ena_pekj $okqn_a pk p]ncap ]j` re_a rano]%*
Kqn hate_]h o_kna eo e`ajpe_]h pk pda kja lnk`q_a` ^u Ikoao O_knejc pkkh( sdana]o kqn
nah]pera bnamqaj_u eo oikkpda` qoejc ik`e|a` Gjaoan)Jau oikkpdejc ]o `ao_ne^a`
ej Bkopan ap ]h* $.,,2%*
Pda `arahkliajp kb kqn pkkho ha` pk pdnaa `e{anajp haraho kb l]n]hhaheoi6 iqhpe)
pdna]`a`( du^ne`( ]j` `eopne^qpa`* Pda iqhpepdna]`a` ranoekj bknio pda _kna kb pda
kpdan psk ranoekjo* Pda iqhpepdna]`a` ]j` du^ne` ranoekjo l]n]hhaheva kjhu pda ldn]oa
o_knejc sdana]o pda `eopne^qpa` ranoekj l]n]hhahevao pda bknian opalo pkk* Ej pda bkh)
hksejc( sa atlh]ej a]_d kb pdaoa ranoekjo*
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
*Hk]`
*Behao
*T*0
*Oknp ^u p]ncap
*T1
* **
*
*Tn
*Ianca
*Ianca
*Oknp ^u okqn_a
*Ianca
*Ianca
*Kqplqp
/*-* Iqhpepdna]`a` ldn]oa o_knejc
Pda ^]oe_ `]p] opnq_pqna qoa` ej pdeo okbps]na eo OPTTH ra_pkn sdkoa ejpanb]_a eo
oeieh]n pk OPH ra_pkn ^qp ep n]pdan opknao `]p] sde_d `kao jkp ]hh naoe`a ej iaiknu*
OPTTH ra_pkn ahaiajpo ]na opkna` ej pda bkni kb gau( r]hqa* Pda gauo kb pdeo ra_pkn
]na pda ldn]oa l]eno $okqn_a ]j` p]ncap ldn]oao _kj_]paj]pa`% ]j` pda r]hqao ]na pda
`e{anajp _kqjpo* Ej kn`an pk o]peobu pda |ta` oeva na_kn` kb OPTTH ra_pkno( pda gauo
]na nalnaoajpa` ^u ] |ta`)hajcpd opnejc*
=o `ale_pa` ej Becqna -( pda lnk_aoo _kjoeopo kb oaran]h pdna]`o( a]_d kb sde_d p]gao
_]na kb kja h]nca OPTTH ra_pkn kb `]p]* Pda ldn]oa p]^ha eo pda naoqhp kb |ra _kjoa_qpera
opalo* @ap]eho ]^kqp a]_d kb pdaoa opalo ]na lnaoajpa` ej sd]p bkhhkso*
Hk]`ejc pda `]p] Benop kb ]hh( pda hate_]h `e_pekj]neao ]na hk]`a` ejpk psk OPH i]lo
$kja bkn a]_d `ena_pekj%* =bpans]n`o( a]_d pdna]` na]`o kja ldn]oa l]en ]p ] peia(
_kilqpao epo hate_]h o_kna( ]j` pdaj hk]`o ep ejpk epo _knnaolkj`ejc OPTTH ra_pkn* Pdeo
iqhpepdna]`a` s]u ]hhkso bkn _kilqp]pekjo ]j` EKo pk ^a kranh]lla`*
Pdana ]na psk s]uo pk na]` l]eno bnki pda |ha ejpk iaiknu* Pda b]op s]u6 sdana
]hh pda pdna]`o na]` pda o]ia |ha _kj_qnnajphu kja heja ]p ] peia* Ej pdeo _]oa( pda ejlqp
|ha odkqh` jkp ^a vella`* Pda ]hpanj]pera s]u ]hhkso pk na]` `ena_phu bnki pda vella`
|ha( pda i]opan na]`o bnki pda |ha ]j` lqodao pda hejao ejpk ] BEBK mqaqa* Pda kpdan
pdna]`o lkl hejao bnki pda mqaqa ]j` lnk_aoo pdai*
=o okkj ]o pda hk]`ejc eo _kilhapa( pda hate_]h i]lo ]na `eolkoa` oej_a pdau sehh
jkp ^a jaa`a` ]juikna*
Oknpejc ^u p]ncap ldn]oao Aranu pdna]` oknpo epo ra_pkn ^u oeilhu _]hhejc pda OPTTH
oknp bqj_pekj sde_d lanbknio ] iqhpes]u iancejc oknp kj pda _knnaolkj`ejc ra_pkn*
Iancejc ]j` _kilqpejc pda p]ncap)^]oa` o_knao Pda iancejc bkhhkso pda o]ia ]l)
lnk]_d ]o pda iqhpes]u iancejc* Pda |nop ahaiajpo bnki ]hh ra_pkno ]na knc]jeva` ej ]
pnaa opnq_pqna* Sdajaran ]j ahaiajp eo p]gaj kqp( ep eo nalh]_a` sepd pda jatp ahaiajp
bnki pda o]ia ra_pkn*
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
L]n]hhah pdna]`o ]_mqena ] hk_g kj pda pnaa ]j` cap ]hh pda l]eno sepd pda o]ia p]ncap
ldn]oa ej ] hk_]h ra_pkn( pdaj naha]oa pda hk_g bkn pda jatp pdna]`* =bpan _khha_pejc pda
l]eno( aranu pdna]` ql`]pao pda _knnaolkj`ejc _kqjp |ah`o ]j` snepao pda ql`]pa`
na_kn`o pk ] jas OPTTH ra_pkn* Oej_a pda e`ajpe_]h l]eno d]ra pk ^a qjemqe|a` ej pdeo
opal( kqn eilhaiajp]pekj ]hhkso _dkoejc kja hate_]h o_kna ]j` kja ]hecjiajp ^]oa`
kj i]tei]h hate_]h o_kna kn pda ikop k__qnnejc kja*
Oknpejc ^u okqn_a ldn]oao
=c]ej( pdeo eo `kja ej l]n]hhah ^u pda OPTTH oknp*
Iancejc ]j` _kilqpejc pda okqn_a)^]oa` o_knao
ianca ^]oa` kj p]ncap ldn]oao*
Pdeo klan]pekj eo e`ajpe_]h pk pda
Snepejc kqp pda ldn]oa p]^ha Hega pda hk]`ejc ld]oa( psk snepejc s]uo ]na lkooe^ha*
Pda s]u sde_d oqllknpo snepejc vella` ldn]oa p]^ha eo lanbknia` ^u ] oejcha pdna]`
sdeha pda iqhpepdna]`a` s]u snepao kjhu qjvella` |hao*
Klpekj]hhu( ]hh pda _kqjpo _]j ^a na_kn`a` bkn bqnpdan qoa $]o ej pda `eopne^qpa` ran)
oekj%* Ep eo ]o sahh lkooe^ha pk snepa kqp ]j klpekj]h ]^ne`ca` ldn]oa p]^ha _kjp]ejejc
kjhu ldn]oao sde_d i]p_d ] heop kb ceraj j)cn]io*
/*.* Du^ne` l]n]hhah ldn]oa o_knejc
Pda atpajoekj @AIOknp ]hhkso qo pk a{ea_eajphu oknp ]j OPTTH ra_pkn olna]` kran
iqhpelha ejpan_kjja_pa` i]_dejao* Pdana ]na kjhu bas _d]jcao ej pda ]n_depa_pqna
_kil]na` pk pda lnarekqo ranoekj* Sa oqllkoa pd]p pda jk`ao `eolkoa kb ] od]na`
`eog ol]_a* Benop kb ]hh( ]hh pda jk`ao ^qeh` pda hate_]h i]lo ej pda o]ia s]u* =bpan)
s]n`o( aranu jk`a na]`o ] mqkp] kb pda ejlqp |ha kb ldn]oa l]eno ejpk ]j OPTTH ra_pkn*
Nqjjejc pda @AIOknp _kqh` n]eoa pda bkhhksejc eooqa6 pda ldn]oa l]eno sde_d _knna)
olkj` pk ] ceraj ldn]oa _kqh` ^a olna]` ^apsaaj psk ]`f]_ajp jk`ao `qa pk pda na`eo)
pne^qpekj ]o atlh]eja` ej Oa_pekj .* Pk |t pdeo( aranu jk`a oaj`o ]hh pda ldn]oa l]eno
_knnaolkj`ejc pk pda |nop ldn]oa pk epo eiia`e]pa lna`a_aookn* =o ] _kjoamqaj_a kb
pdeo oknpejc ]llnk]_d( jk bqnpdan `]p] at_d]jca ^apsaaj pda jk`ao eo jaa`a`*
Aranu jk`a lanbknio pda hk_]h iancejc ]j` o_knejc opne_phu e`ajpe_]h pk pda iqh)
pepdna]`a` ranoekj* Ej kqn `arahkliajp lnk_aoo( pdeo naoqhpa` ej ]j qj^]h]j_a` hk]`
^apsaaj pda jk`ao* ?kjoamqajphu( sa atpaj`a` pda iancejc sepd ] `uj]ie_ hk]`
^]h]j_ejc opn]pacu* Pda |j]h iancejc lnk_a`qna ata_qpa` kj aranu jk`a hkkgo ]o
bkhhkso6
-* Ata_qpa ] iqhpepdna]`a` iancejc ]j` heopaj pk oecj]ho bnki kpdan jk`ao
.* Eb namqaop bkn od]nejc eo na_aera` bnki ]jkpdan jk`a( pdaj oaj` d]hb kb pda na)
i]ejejc l]eno pk pd]p jk`a
/* Sdaj |jeoda`( oecj]h ]hh kpdan jk`ao
0* Eb ]hh jk`ao d]ra jk nai]ejejc l]eno( pdaj atep
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
*
*?ki^*=hecj
*Cev]
*
*?ki^*=hecj
*Ldn*Atpn]_p
*Iqhpepdn*O_kna
*L]np*hat*?kqjp*
*
*
*Hat*?ki^*
*L]np*hat*?kqjp
*Chk^]h*Ianca
*Iqhpepdn*O_kna
*Ldn*Atpn]_p
1* Na_aera d]hb kb pda nai]ejejc l]eno bnki pda jk`a sepd pda h]ncaop nai]ejejc
jqi^an kb l]eno
2* Ck pk Pda kqplqp eo `kja ej ] oeieh]n i]jjan pk pda lnarekqo ouopai sdana ]hh pda jk`ao
snepa pk pda o]ia |ha _kj_qnnajphu* Pda lkoepekj bnki sde_d ] jk`a op]npo snepejc ej
pda _kiikj kqplqp |ha eo aopei]pa` ^]oa` kj pda jqi^an kb ajpaneao ej pdeo jk`a̢o
ra_pkn*
/*/* @eopne^qpa` pn]joh]pekj ik`ah _kjopnq_pekj
Pdeo ranoekj eo ^]oa` kj psk _kilhaiajp]nu lea_ao6 pda ]bknaiajpekja` iqhpe)
pdna]`a` o_knan ]j` ] iqhpepdna]`a` iancan* Pda k^fa_pera kb pda h]ppan eo pk ianca
opna]ia` l]npe]h ldn]oa p]^hao lnk`q_a` ^u pda o_knan*
Ej b]_p( op]npejc bnki l]npepekja` Cev] ]hecjaiajp |hao ]hh pda oq^oamqajp opalo ]na
nqj ej`alaj`ajphu $pule_]hhu kj ] _hqopan kb i]_dejao%* Dksaran( ] ohecdp ik`e|_])
pekj eo ejpnk`q_a` ej pdeo lelaheja ej kn`an pk lnk`q_a _knna_p hate_]h `e_pekj]neao*Pda
_kqjpo bkn ]hecja` skn`o ]na _khha_pa` bnki a]_d l]np ej`alaj`ajphu ]j` pdaj chk^)
]hhu _ki^eja` ej ]j ]``epekj]h opal bnki ]hh pda _khha_pa` _kqjpo* Pda oamqaj_ejc
]j` `alaj`aj_a ^apsaaj pda `e{anajp opalo kb pdeo ranoekj eo odksj ej Becqna . $bkn
] jqi^an kb l]npepekjo amq]ho pk .%*
Pda chk^]h iancan eo ranu oeieh]n ej `aoecj pk pda iqhpepdna]`a` o_knan* Pda kjhu
`e{anaj_a eo pd]p pda _kqjpo ]na jkp ejepe]heva` pk ,( ^qp n]pdan ^]oa` kj pda o]ra`
_kqjpo ej pda l]npe]h ldn]oa p]^hao* =bpans]n`o( ep lnk_aa`o ej pda o]ia opalo ]o pda
iqhpepdna]`a` o_knan*
/*0* Qo]ca
=hh kqn pkkho odks `e{anajp klpekjo ^u ola_ebuejc
kn
}]c*
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
Iqhpepdna]`a` ldn]oa o_knan Pda jqi^an kb pdna]`o _]j ^a ola_e|a` ^u oappejc pda
ajrenkjiajp r]ne]^ha* Eb pdeo r]ne]^ha eo jkp oap( ep sehh ^a oap pk pda
jqi^an kb lduoe_]h _knao ]r]eh]^ha kj pda i]_deja* Pda ikop eilknp]jp klpekjo ]j`
}]co bkn pdeo okbps]na ]na $]hh klpekjo _]j ^a lnejpa` qoejc pda
}]c%6
]na qoa` pk lnkre`a pda atpn]_p( hate_]h `e_pekj]nu okqn_a pk p]ncap( hate_]h
`e_pekj]nu p]ncap pk okqn_a |hao naola_perahu*
sepd pdeo klpekj( pda oknpejc ejpanj]h iaiknu lan pdna]` _]j ^a ola_e|a` ej Iac]
^upao*
eo qoa` pk ola_ebu pda `e{anajp `eogo $l]pdo% sde_d sehh oanra ]o l]n]hhah `eogo bkn
OPTTH oknp* Ep eo ] _kii])oal]n]pa` heop*
Du^ne` ldn]oa o_knan Pda ^ej]nu ej pdeo _]oa eo _]hha`
* Ep ]__alpo pda o]ia
]ncqiajpo ]o pda lnarekqo kja* Pdkqcd( ep jaa`o pk ^a op]npa` sepd
*
Nqjjejc pda `eopne^qpa` ranoekj kj ] _hqopan Pda o_nelp sde_d ]qpki]pao pda l]npe)
pekjejc pda Cev] ]hecjiajp |hao ]j` ajoqnao pda _knna_p `alaj`aj_u ^apsaaj pda fk^o
$]o odksj ej Becqna .% eo sneppaj ej Lupdkj ]j` qoao ola_e|_ _kii]j`o bkn pda Ohqni0
mqaqa i]j]can* Sa ^aheara dksaran pd]p ep _]j ^a a]oehu ]`]lpa` pk kpdan o_da`qhano*
0* Atlaneiajp]h naoqhpo
Ej pdeo oa_pekj( sa odks okia lanbkni]j_a _kil]neokjo ^apsaaj pda `e{anajp ran)
oekjo kb kqn o_knejc pkkho* Sa _kil]na pdai ]o sahh pk Ikoao* Pda d]n`s]na ajre)
nkjiajp sdana pdaoa atlaneiajpo pkkg lh]_a eo ] _hqopan _kjoeopejc kb 4 _kna i]_dejao
sepd /.Ce> kb iaiknu ]j` -2 _kna i]_dejao sepd 20Ce> iaiknu*
=hh pda i]_dejao d]ra ]__aoo pk ] N=E@ JBO od]na` ol]_a ]j` `eolkoa kb ] hk_]h
`eog kb -*3Pe>* Ej ]hh atlaneiajpo pda l]n]hhah o_knano qoa psk `eogo bkn pda OPTTH
ra_pkno $pda hk_]h `eog ]j` JBO%* Pda |nop oap kb atlaneiajpo $ej SIP.,--% s]o dah`
kj pda 4 _kna i]_dejao( sdeha pda kpdano sana dah` kj pda -2 _kna i]_dejao*
Atlaneiajpo ej pda SIP.,-- Ej pdeo oap kb atlaneiajpo( pda Iqhpepdna]`a` ran)
oekj s]o nqj kj ] -2)_kna i]_deja( sdana]o pda du^ne` s]o nqj kj bkqn `e{anajp
i]_dejao $qoejc 0 _knao kqp kb 4 kj a]_d kja%* P]^ha - _kil]nao pda olaa` kb `e{anajp
pkkho qoa` ej pdeo atlaneiajp( sdana]o P]^ha . odkso pda >haq o_knao naoqhpejc bnki
] ouopai ^]oa` kj Ikoao ldn]oa p]^ha ]j` pda du^ne` ^]h]j_a` ouopai $sa galp kjhu
kja ldn]oa p]^ha oej_a ]hh pda p]^hao lnk`q_a` ^u kqn pkkho ]na e`ajpe_]h%* Pdaoa ldn]oa
p]^hao ]na pn]eja` ^]oa` kj pdnaa l]n]hhah _knlkn] $ianca` ejpk ] oejcha h]nca _knlqo%6
ALLO( J?( ]j` QJ* Pda pkp]h jqi^an kb l]n]hhah oajpaj_ao eo -/*4 iehhekjo* ?ha]nhu(
pda ^aop _dke_a dana eo pda du^ne` ^]h]j_a` ranoekj* Ep eo 3*1 peiao b]opan pd]j Ikoao
0
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
o_knan* Dksaran( atlhe_ephu d]j`hejc pda _kiiqje_]pekj $bkn ^kpd ranoekjo% ]j` pda
hk]` ^]h]j_ejc $bkn pda ^]h]j_a` ranoekj% bnki sdepdej pda o_knejc nkqpejao `acn]`ao
na]`]^ehepu( ]j` pdqo i]ejp]ejejc pdeo _k`a ^a_]ia atlajoera* Pdeo s]o pda na]okj
sdu sa jatp _na]pa` pda bqhhu `eopne^qpa` ranoekj ]j` sa `e`j̢p nalknp bqnpdan paopo
sepd pda du^ne` ranoekj*
Ouopai
Peia ol]j
Ikoao
Iqhpepdna]`a`
Du^* qj^]h]j_a`
Du^* ^]h]j_a`
Ouopai
Ikoao
Iqhpepdn*
1/d /0i
.4d 05i
4d 01i
3d ,4i
ALLO'J?
'QJ
--d ./i+.3*.5d /0i+.3*1
05d /0i+.5*-/
.3d 00i+.5*,.
Ouopai
aj)bn
bn)aj
Ikoao
L]n]hhah o_knejc
./*-2
./*.0
.0*-2
.0*.-
Ouopai
Ikoao
@eopne^qpa`
Peia
>haq
5.d 02i
05d .,i
.5*33
/,*,,
Atlaneiajpo ej pda ESOHP.,-- Atlaneiajpo ej pdeo _kjpatp ]na odksj bkn Ikoao ro*
pda iqhpepdna]`a` ranoekj bkn pda o]ia _knlkn] ]o pda lnarekqo* Bkn aranu _knlqo ]j`
ouopai( P]^ha / cerao pda _knnaolkj`ejc peia ol]j ]j` >haq o_kna* =o ej pda lnarekqo
atlaneiajp( pda ]ikqjp kb olaa` ql ^a_kiao ikna ]j` ikna ]lla]najp ]o pda _knlqo
oeva ]qciajpo( sdeha pda pn]joh]pekj ik`ah̢o lanbkni]j_a ej panio kb >haq o_knao eo
]hikop ejr]ne]jp* Dksaran( pda ohecdp `e{anaj_a $P]^ha /( _khqij 'QJ _kil]na` pk
P]^ha -% eo i]ejhu `qa pk ] `e{anajp oap kb `eogo*
Atlaneiajpo ej pda SIP.,-. Pdeo oap kb atlaneiajpo eo dah` ^apsaaj Ikoao ]j`
pda `eopne^qpa` ranoekj* Ej ]``epekj pk pda ALLO( J?( ]j` QJ _knlkn]( pda pn]ejejc
`]p] dana ej_hq`a pda Cec] _knlqo ]o sahh $naoqhpejc ej .5*0 iehhekjo l]n]hhah oaj)
paj_ao%* Pda jqi^an kb l]npepekjo dana s]o -. ]j` pda fk^o sana oq^ieppa` ej`alaj)
`ajphu pk pda _hqopan $okia kb pdai aj` ql kj pda o]ia jk`a( sde_d eo jkp klpei]h%*
P]^ha 0 na_kn`o pda peia namqena` bkn ldn]oa o_knejc* Ep eo odksj dana pd]p pda `eo)
pne^qpa` ranoekj eo ]hikop . peiao b]opan pd]j Ikoao*
Ep eo jkpasknpdu pd]p nah]pera bnamqaj_u ej Ikoao ranoekj dana s]o ]hok ik`e|a`
]o ej Bkopan ap ]h* $.,,2%* Pdaoa atlaneiajpo odks pd]p jkp kjhu kqn pkkho ]na b]opan
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
pd]j Ikoao( ^qp pdau ]hok lnk`q_a ej ikop _]oao ohecdphu ^appan naoqhpo* Sa pdejg pda
na]okj bkn pd]p eo `qa pk pda hate_]h o_kna oaha_pekj atlh]eja` ej Oa_pekj /*-( qjhega
Ikoao sdana pda |nop k__qnnejc o_kna eo oaha_pa`*
Oqnlneoejchu( pda `eopne^qpa` ranoekj s]o jkp ]o b]op ]o pda du^ne` ranoekj* Pdeo
_kqh` ^a fqope|a` ^u pda n]_a _kj`epekj sde_d k__qno `qnejc _kj_qnnajp ]__aoo pk pda
pda JBO ol]_a ^u ok i]ju lnk_aooao*
1* ?kj_hqoekj
Ej pdeo l]lan( sa lnaoajpa` pdnaa ranoekjo kb ] pkkh sde_d i]gao pda ldn]oa o_knejc
i]j]ca]^ha bkn atpn] h]nca _knlkn]* Pdeo s]o ]_deara` ^u atlhkepejc iqhpelha lnk_aoo)
ejc qjepo ]j` l]n]hhah `eog EKo qoejc pda OPTTH he^n]nu bkn atpanj]h iaikneao* Pda
|nop eilhaiajp]pekj _]j ^a nqj kj ] oejcha i]_deja* Sdana]o pda kpdan psk _]j ^a
ata_qpa` ej ] iqhpejk`a ajrenkjiajp $pule_]hhu kj ] _hqopan kb jk`ao%* Pda pdnaa ei)
lhaiajp]pekjo ]na bnaahu ]r]eh]^ha qj`an pda HCLH he_ajoa ]j` _]j ^a `ksjhk]`a`
bnki
* =hh pdaoa pkkho `alaj` kj
pda OPTTH ]j` KlajIL he^n]neao* Ej ]``epekj pk pd]p( pda du^ne` ranoekj ]ooqiao
pda ateopaj_a kb ]j ILE eilhaiajp]pekj ]j` pda @AIOknp atpajoekj bkn pda OPTTH
he^n]nu*
Ceraj pd]p pda ^kpphaja_g ej pdeo lnk_aoo eo pda ohks `eog olaa`o _kil]na` pk ejpan)
j]h iaiknu( pda ]ikqjp kb eilnkraiajp opnkjchu `alaj`o kj pda jqi^an kb l]n]hhah
`eogo* Pdeo _kqh` ^a odksj ^u pda atlaneiajp ej Oa_pekj 0( sdana pda du^ne` ranoekj
lanbknia` ^appan pd]j kpdan ranoekjo oej_a ep qoao iqhpelha jk`ao a]_d kb sde_d qoao
epo hk_]h `eog ]o sahh ]o pda JBO ol]_a* Pda `eopne^qpa` ranoekj eo opehh ^aejc paopa` ]j`
klpeieva`( pdanabkna pda olaa`ql ep ^nejco eo opehh hks _kil]na` pk pda du^ne` ranoekj
araj pdkqcd pdau ]na okiadks oeieh]n ej olenep*
Oej_a pda k^fa_pera kb pda atlaneiajpo odksj ej pdeo l]lan s]o pk l]npe_el]pa ej
pda IP ar]hq]pekj _]il]ecj( pdau sana nqj kj nah]perahu lksanbqh d]n`s]na* Dks)
aran( pdaoa pkkho skqh` ]hok skng bkn haoo lksanbqh ]n_depa_pqnao( oej_a pda iaiknu
_kjoqilpekj eo ^kqj`a` ^u `aoecj*
Pda i]ej heiep]pekj kb kqn pkkho eo pda `eog ol]_a _kjoqilpekj* Pdeo eo aooajpe]hhu
`qa pk pda b]_p pd]p kqn ^]oe_ `]p] opnq_pqna qoao ] |ta` oeva _d]n]_pan opnejc bkn pda
gauo kb kqn OPTTH ra_pkno* =o ] naoqhp( okia ranu hkjc l]eno _]jjkp ^a p]gaj ejpk
]__kqjp ]j` odknpan kjao d]ra pk ^a |hha` sepd ^h]jg _d]n]_pano* Pdeo eilheao pd]p ]
_kjoe`an]^ha ]ikqjp kb pda ol]_a ]hhk_]pa` bkn gauo eo jkp qoabqh* = lkooe^ha okhqpekj
pk pdeo skqh` ^a pk qoa oq{et ]nn]uo pk ej`at pda ldn]oao ]j` qoa kjhu pda E@̢o ej pda
OPTTH ra_pkn gauo*
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
=_gjksha`caiajpo
Pdeo skng s]o na]heva` ]o l]np kb pda Mq]ank Lnkcn]iia( bqj`a` ^u KOAK( Bnaj_d
Op]pa ]caj_u bkn ejjkr]pekj* Pda ]qpdkno ]na ]hok ch]` pk Uqme Vd]jc bkn dan _kiiajpo
]j` oqccaopekjo kj pdeo l]lan*
>e^hekcn]ldu
=j`na]o( >a_gi]jj( Iauan Qhne_d( O]j`ano Lapan( ]j` Oejchan Fkd]jjao* Ajancu)a{e_eajp oknp)
ejc qoejc okhe` op]pa `eogo* Oqop]ej]^ha ?kilqpejc6 Ejbkni]pe_o ]j` Ouopaio( -$.%6-1-̞-2/(
.,--*
=nca( H]no( K_p]re]j Lnk_kleq_( ]j` Fa{nau O_kpp Reppan* Eilhaiajpejc E+K)a{e_eajp `]p] opnq_)
pqnao qoejc PLEA* Ej Ej Lnk_* Aqnkla]j Ouilkoeqi kj =hcknepdio( l]cao 44̞-,,* Olnejcan(
.,,.*
>a_gi]jj( =j`na]o( Qhne_d Iauan( Lapan O]j`ano Fkd]jjao Oejchan( ]j` Lapan O]j`ano Fk)
d]jjao Oejchan* Ajancu)a{e_eajp b]op oknpejc .,--( .,-.* QNH
*
?d]li]j( >]n^]n]( C]^neaha Fkop( ]j` Nqq` r]j `an L]o* Qoejc KlajIL6 Lknp]^ha Od]na` Iaiknu
L]n]hhah Lnkcn]iiejc $O_eajpe|_ ]j` Ajcejaanejc ?kilqp]pekj%* Pda IEP Lnaoo( .,,3*
?n]qoan( =j`na]o ]j` Gqnp Iadhdknj* HA@=)OI atpaj`ejc HA@= pk oa_kj`]nu iaiknu*
Ej Lnk_aa`ejco kb pda /n` Ejpanj]pekj]h Skngodkl kj =hcknepdi Ajcejaanejc( S=A ̢55( l]cao
..4̞.0.( Hkj`kj( QG( QG( -555* Olnejcan)Ranh]c* EO>J /)10,)220.3),*
@a]j( Fa{nau ]j` O]jf]u Cdai]s]p* I]lNa`q_a6 oeilhe|a` `]p] lnk_aooejc kj h]nca _hqopano*
?kiiqj* =?I( 1-$-%6-,3̞--/( F]j* .,,4* EOOJ ,,,-),34.*
@aiajpear( N* ]j` H* Gappjan* OPTTH6 Op]j`]n` pailh]pa he^n]nu bkn TTH `]p] oapo* Ej Ej6 Lnk_*
kb AO= .,,1* Rkhqia /225 kb HJ?O( l]cao 20,̞21-* Olnejcan( .,,1*
@aiajpear( N*( H* Gappjan( ]j` L* O]j`ano* OPTTH6 op]j`]n` pailh]pa he^n]nu bkn TTH `]p] oapo*
Okbps* Ln]_p* Atlan*( /4$2%6145̞2/3( I]u .,,4* EOOJ ,,/4),200*
Bkopan( Caknca B*( Nkh]j` Gqdj( ]j` Dks]n` Fkdjokj* Ldn]oap]^ha oikkpdejc bkn op]peope_]h
i]_deja pn]joh]pekj* Ej AIJHL( l]cao 1/̞2-( .,,2*
C]k( Mej ]j` Opald]j Rkcah* Pn]ejejc ldn]oa)^]oa` i]_deja pn]joh]pekj ik`aho kj pda
_hkq`klaj okqn_a i]_deja pn]joh]pekj pkkhgep _d]oge* Ln]cqa >qhh* I]pd* Hejcqeope_o( 5/6
/3̞02( .,-,*
D]n`iaean( ?dneope]j* B]op ]j` atpajoe^ha ldn]oa o_knejc bkn op]peope_]h i]_deja pn]joh]pekj*
Ln]cqa >qhh* I]pd* Hejcqeope_o( 5/643̞52( .,-,*
Gkadj( Ldehell( Deaq Dk]jc( =hat]j`n] >en_d( ?dneo ?]hheokj)>qn_d( I]n_ahhk Ba`ane_k( Je_kh]
>anpkh`e( >nkkga ?ks]j( S]`a Odaj( ?dneopeja Ikn]j( Ne_d]n` Vajo( ?dneo @uan( Kj`ķaf
>kf]n( =hat]j`n] ?kjop]jpej( ]j` Ar]j Dan^op* Ikoao6 klaj okqn_a pkkhgep bkn op]peope_]h
i]_deja pn]joh]pekj* Ej Lnk_aa`ejco kb pda 01pd =jjq]h Iaapejc kb pda =?H kj Ejpan]_pera Lkopan
]j` @aikjopn]pekj Oaooekjo( =?H ̢,3( l]cao -33̞-4,( Opnkq`o^qnc( L=( QO=( .,,3* =ook_e])
pekj bkn ?kilqp]pekj]h Hejcqeope_o*
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25
Khokj( Ie_d]ah =*( Gaepd >kope_( ]j` I]nck Oahpvan* >angahau @>* Ej Lnk_aa`ejco kb pda ]jjq]h
_kjbanaj_a kj QOAJET =jjq]h Pa_dje_]h ?kjbanaj_a( =PA? ̢55( l]cao 0/̞0/( >angahau( ?=(
QO=( -555* QOAJET =ook_e]pekj*
L]_da_k( Lapan O* L]n]hhah lnkcn]iiejc sepd ILE* Iknc]j G]qbi]jj Lq^heodano Ej_*( O]j Bn]j)
_eo_k( ?=( QO=( -552* EO>J -)1142,)//5)1*
N]dj( Iengk( Lapan O( Fkd]jjao Oejchan( ]j` Pei Geanepv* @AIOknp)`eopne^qpa` atpanj]h iaiknu
oknp( .,,5* QNH
*
N]dj( Iengk( Lapan O]j`ano( ]j` Fkd]jjao Oejchan* O_]h]^ha `eopne^qpa`)iaiknu atpanj]h oknp)
ejc* Ej kj @]p] Ajcejaanejc $E?@A%( Ejpanj]pekj]h ?kjbanaj_a( a`epkn( .2pd EAAA Ejpanj]pekj]h
?kjbanaj_a kj @]p] Ajcejaanejc( I]n_d -)2( .,-,( Hkjc >a]_d( ?]hebknje]( QO=( l]cao 241̞244*
EAAA ?kilqpan Ok_eapu( IÄnv .,-,*
O]j`ano( Lapan ]j` Nki]j @aiajpear* =ouj_dnkjkqo l]n]hhah `eog oknpejc* Naoa]n_d Nalknp
ILE)E).,,/)-),,-( I]t)Lh]j_g)Ejopepqp bÜn Ejbkni]peg( Opqdho]pvajd]qosac 41( 22-./ O]]n)
^nÜ_gaj( Cani]ju( Ba^nq]nu .,,/*
Reppan( Fa{nau O_kpp* =hcknepdio ]j` @]p] Opnq_pqnao bkn Atpanj]h Iaiknu* Jks Lq^heodano Ej_*(
D]jkran( I=( QO=( .,,4* EO>J -2,-54-,22( 534-2,-54-,22*
=``naoo bkn _knnaolkj`aj_a6
Ikd]iia` Ia`e]je
G]nhonqda Ejopepqpa bÜn Pa_djkhkcu
=`aj]qannejc .(
G]nhonqda 32-/-( Cani]ju
Bereitgestellt von | knowledge inside novo nordisk library
Angemeldet | 152.81.64.19
Heruntergeladen am | 16.10.12 17:25