Evaluating the effects of genetic engineering through popular fiction Kristin Cook, Donna Keller, and Alyce Myers S tudents are immensely interested in the acclaimed science fiction trilogy, The Hunger Games (Collins 2008), which was made into a popular movie in 2012. In the story, Panem, a post-apocalyptic version of North America, uses genetically engineered organisms, such as jabberjays and tracker jackers, to frighten citizens to keep them in line. Students often wonder about our real-life abilities to create hybrid species. In fact, cross-species gene splicing is becoming increasingly common. Recent examples include the Enviropig that incorporates mouse DNA to improve digestion of phosphorus, jellyfish genes being used to make pigs glow, and experimental mice being given a “humanized” version of a gene linked to speech. January 2014 31 So, if hybrids are possible in real life, what are the implications for society? Are there bioethical issues to consider regarding the possible effects of these new technologies on people as well as on the organisms themselves? Investigating questions like these through popular fiction allows students to achieve many of the literacy goals outlined in the Common Core State Standards (NGAC and CCSSO 2010) and the Next Generation Science Standards (NGSS Lead States 2013). (Note: While this activity centers on the The Hunger Games, it could easily be adapted for other books or films. For example, the classic 1997 film Gattaca explores similar issues involving genetic modification in humans.) FI G U R E 1 Scaffolded assessment prompts according to Bloom’s Taxonomy (1956). Remembering Define genetic engineering, natural and artificial selection, and transgenic species. List current ways we use genetically engineered organisms in society. Understanding Describe the pros and cons of genetic engineering. Describe why bioethical issues need to be considered when engaging in genetic engineering. Applying Interpret how bioethics is considered or not considered in both The Hunger Games and in contemporary society. Analyzing Compare and contrast Panem to the United States in terms of bioethics and genetic engineering. Evaluating Consider how responsible Panem was in genetically engineering the “jabberjays” and “tracker jackers,” as well as how responsible real-life scientists have been in engineering organisms. Defend and argue your position on genetic engineering with regard to bioethics. Creating Formulate a plan the United States should have in place to make sure the genetic engineering being done or contemplated is ethical. 32 The Science Teacher Literary connection In the first book of The Hunger Games trilogy, mockingjays are described as descendants of engineered jabberjays who were manipulated so they could recall and repeat what they heard people say, similarly to parrots. Mockingjays developed unintentionally: The officials at Panem high command created genetically modified male jabberjays that could eavesdrop on rebel conversations and repeat them to the authorities. The rebels caught on and started feeding the jabberjays false information. That led authorities to abandon the jabberjays in the wild, hoping they would die off. Instead, the jabberjays mated with female mockingbirds, spawning mockingjays that could learn and repeat musical notes but not memorize words. The inability of the government to control these animals made them a symbol for the rebellion. Panem’s Capitol city commanders used the tracker jackers—genetically engineered wasps—to attack anything that disturbed their nests, serving as cruel reminders of the commanders’ power over the inhabitants. The Hunger Games by Suzanne Collins Bioethics in The Hunger Games FI G U R E 2 Connections to the NGSS and Common Core State Standards. NEXT GENERATION SCIENCE STANDARDS (NGSS Lead States 2013) HS-LS4 Biological Evolution: Unity and Diversity Performance Expectations HS-LS4-2. Construct an explanation based on evidence that the process of evolution primarily results from four factors: (1) the potential for a species to increase in number, (2) the heritable genetic variation of individuals in a species due to mutation and sexual reproduction, (3) competition for limited resources, and (4) the proliferation of those organisms that are better able to survive and reproduce in the environment. HS-LS4-5. Evaluate the evidence supporting claims that changes in environmental conditions may result in: (1) increases in the number of individuals of some species, (2) the emergence of new species over time, and (3) the extinction of other species. Scientific and Engineering Practice Constructing Explanations and Designing Solutions Constructing explanations and designing solutions in 9–12 builds on K–8 experiences and progresses to explanations and designs that are supported by multiple and independent student-generated sources of evidence consistent with scientific ideas, principles, and theories. Construct an explanation based on valid and reliable evidence obtained from a variety of sources (including students’ own investigations, models, theories, simulations, peer review) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future. (HS-LS4-2) u Disciplinary Core Ideas LS4.B: Natural Selection Natural selection occurs only if there is both (1) variation in the genetic information between organisms in a population and (2) variation in the expression of that genetic information—that is, trait variation—that leads to differences in performance among individuals. (HS-LS4-2) u LS4.C: Adaptation Evolution is a consequence of the interaction of four factors: (1) the potential for a species to increase in number, (2) the genetic variation of individuals in a species due to mutation and sexual reproduction, (3) competition for an environment’s limited supply of the resources that individuals need in order to survive and reproduce, and (4) the ensuing proliferation of those organisms that are better able to survive and reproduce in that environment. (HS-LS 4-2) u Changes in the physical environment, whether naturally occurring or human induced, have thus contributed to the expansion of some species, the emergence of new distinct species as populations diverge under different conditions, and the decline—and sometimes the extinction—of some species. (HS-LS4-5) u COMMON CORE STATE STANDARDS (NGAC and CCSSO 2010) ELA/Literacy: WHST.9-12.9: Draw evidence from informational texts to support analysis, reflection, and research. (HS-LS4-2) SL.11-12.4: Present claims and findings, emphasizing salient points in a focused, coherent manner with relevant evidence, sound valid reasoning, and well-chosen details; use appropriate eye contact, adequate volume, and clear pronunciation. (HS-LS4-2) January 2014 33 FI G U R E 3 Roundtable presentation instructions and rubric. One way that scientists communicate—an essential part of scientific inquiry—is by holding roundtable sessions. Scientists present their findings, then other scientists ask questions and offer suggestions for future research. Our class roundtable discussion will cover the theme: “Bioethics in The Hunger Games: Evaluating the Effects of Genetic Engineering Through Popular Fiction.” Guidelines: 1. Divide into groups of three. 2. Individuals take turns giving five-minute presentations of their topic, addressing scaffolded assessment prompts (Figure 1, p. 32), discussing sources, describing connections to data-driven research, and offering a clear conclusion or recommendation. You may use one index card with bulleted points, but you may not read the presentation from printed text. 3. Next, the presenter answers questions from other students at the table for about five minutes. The other students should also make suggestions and provide feedback. Note: This should be done in a critical but collegial way. The focus should be on helping people to see connections in a different way, not attacking what they think. 4. The instructor moves from group to group asking questions as well. In this way, each student is assessed individually on the ability to present, discuss, and answer questions about the topic. RUBRIC Name of student:____________________________________________________________________________ Discussion of issue (addressing prompts, discussion of sources, connections to data-driven research, and clear conclusion/recommendation): 0 5 10 15 20 15 20 Ability to answer related questions posed by peers: 0 5 10 Contribution to overall discussion/asking others questions, offering suggestions/feedback: 0 5 10 15 20 Overall professionalism (clarity, enunciation, eye contact, listening to others) 0 5 Comments: 34 The Science Teacher 10 15 20 Bioethics in The Hunger Games This part of the story raises questions about real life: Should hybrid species be regulated? What are the possible effects of hybrids mating with native species? In this vein, students can research the effects of real-life cases of hybrid species affecting native populations. Then they can form guidelines for determining the ethical treatment and humane protection of both native and hybrid populations. A striking example of this issue is the Glofish, considered the first genetically modified pet and often used in science classrooms as a bio indicator to test for pollution and other chemicals. Glofish released into the wild are thought to be threatening native fish populations (Mueller and Zeidler 2010). F IGUR E 4 Determining the credibility of a source. Authorship Who is the author(s)? Note: If the author is not known, is it clearly issued by a respected university, government program or department, or well-known non-governmental organization? u Do the authors cite their sources? u Project description In this guided inquiry, students investigate advantages and disadvantages of genetic engineering by integrating popular fiction into their study of bioethics. What are the effects of artificially created hybrid creatures on characters in The Hunger Games and in our society? What are the effects on and basic rights of the organisms themselves given their unnatural entry into the world? What impact might these hybrids have on native species? To consider the consequences of genetically engineered organisms in our own society, students must research current practices and policies, as well as contemporary case studies of genetically engineered organisms. Centered on a cognitively scaffolded set of guiding assessment prompts (Figure 1, p. 32), the curriculum presented here frames the exploration of bioethics in genetic engineering through collective exploration and articulation of varying viewpoints based on evidence. Connections to cross-curricular standards are shown in Figure 2 (p. 33). This project would fit well in a biology curriculum, perhaps to conclude a unit on genetic engineering. The driving question is, “If hybrids like those we see in The Hunger Games are possible, what are the bioethical implications of such endeavors in our society?” The project culminates in roundtable presentations addressing all aspects of the scaffolded assessment prompts. The project should take about one week (five 45-minute class periods). How recent is the source (and the sources referenced in it)? u Purpose What is the author’s purpose? u Is more than one view presented? Note: A source written from a particular point of view may be credible; however, you need to be careful that your sources don’t limit your coverage of a topic to one side of a debate. u Who is funding this source? u Audience For whom is this article being written? u What type of sources does this author value (e.g., peer-reviewed, popular media, etc.)? u What type of readership would one expect for this source? u January 2014 35 Activities On the first day, students read an excerpt from The Hunger Games about mockingjays: “They’re funny birds and something of a slap in the face to the Capitol. The jabberjays mated with female mockingbirds, creating a whole new species that could replicate both bird whistles and human melodies” (Collins 2008, pp. 42–43). Teachers may include a short video clip from the movie as well. The teacher invokes students’ prior knowledge by posing the following questions that students should answer in their science notebooks: ◆◆ ◆◆ ◆◆ ◆◆ What is genetic engineering (GE)? How does the biology in this book relate to our lives in America? Why did the leaders in Panem create only male jabberjays? How did this plan backfire? Do you see any parallels with actual genetically modified organisms? In what fields and for what purposes do you think GE is used today? The teacher moves around the room, briefly discussing ideas with students individually to informally assess how well students understand the process and contemporary applications of GE. After students have had time to answer the questions, the teacher forms groups of three students to discuss their answers. Groups’ ideas will be shared on whiteboards and discussed as a class. Students should record group discussion points in their science notebooks to help them with subsequent research. Note: For other activities and terms relevant to genetic engineering, see Genetically Modified Crops: Resources for Environmental Literacy (NSTA 2007). In the next phase of the project (taking about two days), students conduct internet-based research to address the next subset of questions (see assessment prompts in Figure 1, p. 32): ◆◆ ◆◆ ◆◆ 36 Describe the pros and cons of genetic engineering. Describe why bioethical issues need to be considered when engaging in genetic engineering. (Assessment prompt: Understanding) Interpret how bioethics is considered or not considered in The Hunger Games.(Assessment prompt: Applying) Compare and contrast Panem to the United States in terms of bioethics and genetic engineering. (Assessment prompt: Analyzing) The Science Teacher Recommended websites (see “On the web”) will help students address the scaffolded assessment prompts for which they need to collect data. Teachers should encourage students to use outside resources as well, such as library resources or other media referencing similar topics (e.g., Brave New World [Huxley 2006], Gattaca). While students view the recommended resources, the teacher should assist them in defining what constitutes ethical or unethical GE, using the guidelines on the Presidential Commission for the Study of Bioethical Issues (see “On the web”). Students often find engaging viewpoints by perusing environmental websites and corporate food distributor websites that present one-sided arguments for or against genetic engineering. To critically evaluate these sites, teachers should direct students to answer questions about source credibility (Figure 4, p. 35). This will help students think critically about the multiple viewpoints represented in the GE debate. Students should record the data from their research in their science notebooks for reference during the activity’s culminating event: roundtable discussions. Roundtable discussions In the final phase of the project (estimated two days), students present their final arguments in a roundtable format addressing the following prompts (Figure 1, p. 32): ◆◆ ◆◆ Consider how responsible Panem was in genetically engineering the jabberjays and tracker jackers. Defend and argue your position on genetic engineering with regard to bioethics. Formulate a plan the United States should have in place to make sure the genetic engineering done here is ethical. During the roundtable, students will present their research in groups of three (see student instructions in Figure 3, p. 34). This small-group format allows students to readily share and critically dissect ideas and requires students to succinctly synthesize the information they’ve gathered during the week. Students often report they enjoy the personalized feedback of roundtable presentations. At the end of the presentations, the teacher can lead a whole-class discussion of the various approaches to bioethics in genetic engineering that arose from the roundtable presentations. Bioethics in The Hunger Games Conclusion Educators trying to develop a scientifically literate citizenry should pay attention to the intersection of science and literature. The project presented in this article engages students in learning to articulate wellinformed decisions about complex socio-scientific issues. This addresses multiple components of scientific literacy (Sadler, Barab, and Scott 2007) and allows learners to explore the most meaningful connections of science to their lives through topics that require dialogue, discussion, and deliberation. This inquirybased unit engages high school students in considering the role of bioethics in America’s increasing fascination with genetic modification. Illuminating content standards of both biological science and Common Core literacy standards, students will be engaged with developing arguments from evidence and important 21st-century skills such as gathering and assessing information, thinking critically, and communicating among multiple perspectives. n Kristin Cook ([email protected]) is an assistant professor at Bellarmine University in Louisville, Kentucky. Donna Keller (dok [email protected]) is a biology teacher at North Judson-San Pierre High in North Judson, Indiana, and Alyce Myers ([email protected]) is a life science teacher at North Montgomery High School in Crawfordsville, Indiana. On the web Exploring bioethics. Presidential Commission for the Study of Bioethical Issues: www.bioethics.gov Exploring policy. U.S. Food and Drug Administration: http://1.usa.gov/5BWpG; http://1.usa.gov/ovdqm Exploring positions and current applications. Iowa Public Television (students should click on all side tabs to explore different perspectives on genetically engineered organisms): http://bit.ly/1e3YUJI Genetic Engineering and Farm Animals: http://bit.ly/ GDI20z Genetic Engineering in Crops: http://bit.ly/19vqudy Glofish: http://bit.ly/1hwIQjB Transgenic pigs: http://bit.ly/GIBGNd References Aken, J., and E. Hammond. 2003. Genetic engineering and biological weapons. Science and Society 4 (1): S57– S60. Bloom, B., and D. Krathwohl. 1956. Taxonomy of educational objectives: The classification of educational goals, by a committee of college and university examiners. Handbook 1: Cognitive domain. New York: Longmans. Collins, S. 2008. The hunger games. New York: Scholastic Press. Collins, S. 2009. Catching fire. New York: Scholastic Press. Collins, S. 2010. Mockingjay. New York: Scholastic Press. Huxley, A. 2006. Brave new world. New York: Harper Perennial Modern Classics. Mueller, M., and D. Zeidler. 2010. Moral-ethical character and science education: EcoJustice ethics through socioscientific issues (SSI). Cultural Studies of Science Education 3: 105–128. National Governors Association Center for Best Practices and Council of Chief State School Officers (NGAC and CCSSO). 2010. Common core state standards. Washington, DC: NGAC and CCSSO. National Science Teachers Association (NSTA). 2007. Genetically modified crops: Resources for environmental literacy. www.enviroliteracy.org/nsfmod/GM-Crops.pdf NGSS Lead States. 2013. Next Generation Science Standards: For states, by states. Washington, DC: National Academies Press. Sadler, T., S. Barab, and B. Scott. 2007. What do students gain by engaging in socioscientific inquiry? Research in Science Education 37: 371–391. January 2014 37
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