What is the difference between LGL leukemia and chronic
lymphocytic leukemia (CLL)?
Copyright 2017 by the Rector and Visitors of the University of Virginia
What is the difference between LGL leukemia
and chronic lymphocytic leukemia (CLL)?
A.
Types of Blood Cells
Non-White Blood Cells
Red blood cell Platelet
White Blood Cells
Neutrophil
Eosinophil
 This diagram shows all the different types of
blood cells, and groups them as either nonwhite blood cells or white blood cells.
 We are going to focus on the lymphocytes.
There are three types: T-cell, NK-cell, and
B-cell.
Basophil
Lymphocyte
T-cells
Monocyte
B-cells
NK-cells
Copyright 2017 by the Rector and Visitors of the University of Virginia
What is the difference between LGL leukemia
and chronic lymphocytic leukemia (CLL)?
B.
Types of Lymphocytes
T-LGL or NK-LGL Leukemia
B-cell CLL
CD19
CD3
CD8 CD57
T-cells
TCR
CD16 CD56CD94
NK-cells
 In LGL leukemia, T- or NK-cells become clonal (make
copies of themselves). The different markers
indicate which cell is clonal.
 Previous content described how a diagnosis is made
for either case, but briefly, it is based on the cell
markers (CD proteins) and for T-LGLL the TCR gene
rearrangement test establishes clonality.
CD5
CD23
B-cells
 B-cells, another type of lymphocyte,
become clonal. This cell has different
markers.
 In the case of CLL, this is a cancer of the
B-cells, which are also lymphocytes. In
this case, there are different CD markers
which are used in identifying that this cell
type has expanded and made many
copies of itself.
Copyright 2017 by the Rector and Visitors of the University of Virginia