The History of Biomedical Engineering at Tulane University Jennifer S. Stearns-Drake 1995 Contents FORWARD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . III ACKNOWLEDGEMENTS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V CHAPTER 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 LOUISIANA NEEDS A MEDICAL SCHOOL .............................................................................................. 1 CHAPTER 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 DR. WARREN STONE......................................................................................................................... 4 CHAPTER 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 DR. JOHN L. RIDDELL ....................................................................................................................... 8 CHAPTER 4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 3 DR. RUDOLPH MATAS..................................................................................................................... 13 CHAPTER 5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 8 DR. GEORGE BURCH AND PROFESSOR JAMES CRONVICH ..................................................................... 18 CHAPTER 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3 DR. L. MATTHEW M. BACH AND PROFESSOR CLAUDE J. SPERRY, JR.................................................... 23 CHAPTER 7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 DR. JACK WICKSTROM AND PROFESSOR JOHN MARTINEZ.................................................................... 29 CHAPTER 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3 DRS. RAYMOND BAILEY, DUANE BRULEY, BOB CHAMBERS, AND BOB WEAVER ..................................... 33 CHAPTER 9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 9 DRS. SAM HULBERT, STEVE COWIN, JERRY KLAWITTER, AND ALLAN WEINSTEIN .................................. 39 CHAPTER 10 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 9 THE BIOMEDICAL ENGINEERING PROGRAM BECOMES THE DEPARTMENT OF BIOMEDICAL ENGINEERING .... 49 CHAPTER 11 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4 DRS. WILLIAM VAN BUSKIRK, CEDRIC F. WALKER AND A LOOK INTO THE FUTURE ................................. 54 CHAPTER 11 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2 OTHER CONTRIBUTIONS .................................................................................................................. 62 REFERENCES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 5 ii Fo rwa r d This is a story of the physicians and engineers who have made a difference. They have made a difference at Tulane, they've made a difference in the world of science, and they've made a difference in the world. Most were biomedical engineers before such an illustrious term existed, some were the founding fathers of that term, but all made a difference, and all were part of Tulane University's rich history. If you are concerned with how the biomedical engineering department at Tulane was developed, how much money it cost to develop, or who designed the labs, this isn't the literature you are looking for. If, however, you want to meet the men of Tulane who devoted their time and energy into bettering the physical human condition through their innovations and research, then keep reading. This history is of biomedical engineers at Tulane University. It covers not only what they did, but more importantly, who they are. After all, it is who they are that has shaped who we are, and what we do. The Medical College of Louisiana is mentioned throughout this piece. Tulane University is simply the Medical College of Louisiana with a new name. Paul Tulane, a philanthropist who had made a fortune in New Orleans, made a substantial donation to the school. In 1884 the Medical College of Louisiana became the Tulane University of Louisiana. This history starts in the 1830's, and ends in the future. I would like to apologize for not including every biomedical engineer that has been a part of Tulane. I suppose that is the beauty and wonder of a powerful institute of learning, like Tulane: there are just too many names worth iii mentioning, and not enough time to mention them. So, for each story told, remember that there are at least a hundred that were not. One last thing: enjoy! iv Ack n owledgements In order to have a history there must first be history makers... my greatest respect and gratitude goes to those people who dedicated their time and innovation to Tulane making its history worth writing about. In order to write about history, there must be a wealth of documentation. I am greatly indebted to all who enthusiastically searched for the right pieces of hay in the haystacks, in particular: the staff of the Rare Books and Documents in the Howard Tilton Memorial Library who never seemed to run out of ideas or patience. Sixteen of the people featured in The History of Biomedical Engineering at Tulane took time out of their busy lives to grant me an interview. That made all the difference in the world. I greatly appreciate all of the people who gave me confidence and reassurance. A special thanks goes to Cedric Walker for ideas, guidance, and E-mail lessons. Thanks to Loretta the pig, Sushi the cat, and of course, I could not have done it without my love of Whit. v C h a pter 1 Louisiana Needs A Medical School Thus the world has progressed from age to age, imparting discoveries and exchanging benefits until the wise man's abstruse idea, in modern times, soon becomes the obvious heritage of the whole human family. -Dr. Thomas Hunt April 2, 1866 In 1832, at the ripe old age of 23, Dr. Warren Stone left New York and set sail for New Orleans upon the brig Amelia. Unfortunately for him, but instrumental to the founding of the Medical College of Louisiana, the boat encountered great storms and was beached on Folly Island off Charleston, South Carolina. While on Folly Island, the passengers and crew were stricken by a Cholera outbreak. Dr. Stone was attending to the sick until he, too, caught the dreaded illness. A young Charleston doctor by the name of Thomas Hunt was called to the island to care for the sick passengers and it is there that he met and befriended Dr. Stone. After fully recovering from Cholera, Stone continued his journey to New Orleans to practice medicine at Charity hospital. The following year Hunt moved to New Orleans and was appointed house surgeon of Charity Hospital. It was in New Orleans where Hunt met the third of the founding triumvirate, Dr. John H. 1 Harrison. Seeing a clear need for a college of medicine in the Southwest, Hunt began to formulate a plan. He realized the necessity of a working relationship with Charity for the use of clinical facilities and dissection subjects, so when he resigned he saw to it that Harrison was his successor and that Stone was promoted to assistant house surgeon (Duffy, 7). After his resignation from Charity, Hunt devoted his time to gaining support from local physicians and the other proper authorities. When he felt sure of acceptance Hunt issued a prospectus for the new college by emphasizing that New Orleans was the largest town in the Southwest and was therefore the logical choice for a medical college. He pointed out that it had the best clinical facilities and it offered unrivaled facilities for the study of anatomy. He predicted the hospital would be busy because of the large population and the high number of accidents among seamen. Room and board could be obtained for only $25.00 per year, which would serve as incentive for prospective students (Duffy, 8). The prospectus was published in the New Orleans Bee newspaper on September 29, 1834 and was generally welcomed. There was some opposition from the Creole physicians, but most criticism was of the constructive kind. There were a few changes, a few changes in both prospectus and its professors, and on Monday, January 5, 1835, the school opened. Dr. Hunt delivered the first lecture, and the rest, as we shall see, is history... 2 On a personal note: As reported in the Times Picayune, on July 15, 1851, Dr. Thomas Hunt was under indictment for the slaying of John W. Frost, with a double barrel shot gun loaded with a ball, in a duel at 40 paces. The event took place during a Whig Ward convention and it "agitated and divided the city." However, no conviction could be had where there was no charge of unfairness at the meeting. 3 Chapter 2 Dr. Warren Stone "Soon after I got your letter I called on Dr. Stone, who I had only known by sight before, his manners are anything but prepossessing, and if as you say your grandson is timid I doubt if he would profit much by Dr. Stone's tuition." -in response to a woman's inquiry about having her grandson work under Dr. Stone 4 Dr. Warren Stone was born at St. Albans, Vermont, February 3, 1801. He grew up on a typical New England farm where his education was extremely limited. He began to study medicine at Keene, New Hampshire and he received his medical degree at the Berkshire Medical Institute in Pittsfield, Massachusetts. His classical education, however, left much to be desired; yet despite his lack of culture, he had a natural aptitude for medicine, particularly in the field of surgery. His stature was gigantic, his head was massive, and his heart was of similar proportions. His language was pithy and his students revered him. He was called "Old Stone" by his contemporaries, who worshipped him for his skill and respected him as a humanitarian. Stone was a pioneer in the field of vascular surgery. In 1836 he performed the first ligation of the external iliac artery in Louisiana. The most significant ligation of the common iliac artery performed by Dr. Stone occurred in 1859 when he used a silver wire to ligate instead of the standard septic ligature. This breakthrough changed the state of the art in surgery. The antibiotic properties of silver when implanted in the body helped prevent infection that was so frequently was the cause for morbidity in those times of preantiseptic and pre-anesthesia. Although anesthesia was absent for the first fourteen years of Dr. Stone's career, he is known as one of the pioneers in the use of chloroform. Performing surgery with the patient under etherization was neither commonplace nor fully accepted in the mid eighteen hundreds, but Stone amputated a man's thigh under etherization as early as 1841 (Rand, 1942). On September 25, 1849, the Times Picayune reported that, "The city 5 had surgical practitioners who compared favorably with any in the world for boldness and success of execution. An example of the performance of one of the most difficult operations was the removal by Dr. Warren Stone, at his Infirmary on Canal, of a bony tumor of about ten ounces from the lower jaw of a slave girl. The girl was put under the influence of chloroform and walked away from the eightminute operation ignorant of what had been done. The hospital was under the most admirable and competent management and as a surgical infirmary was believed to have no superior in the nation." In those times before surgical precision, Dr. Warren Stone, carved his place in history with his inherent understanding of medicine, and his assiduous studies. Fortunately for the Medical College of Louisiana (later Tulane University), Dr. Stone gifted several classes of aspiring doctors with his knowledge, innovation, and love of medical practice. 6 On a personal note: Dr. Warren Stone died in New Orleans of diabetes in 1872. So revered, was he, that New Orleans was in mourning; the courts adjourned, stores closed and flags were at half-mast (Rand, 1942). 7 C h a pter 3 Dr. John L. Riddell "It gives the observer perfectly correct views, in length, breadth and depth, whatever power he may employ; objects are seen holding their true relative positions, and wearing their real shapes; In looking at solid bodies, however, depressions sometimes appear as elevations, and vice versa, forming a curious illusion." -John L. Riddell 1852 Securing his medical degree in 1836 from Cincinnati Medical College, Dr. John L. Riddell moved to New Orleans to become a professor of chemistry in the Medical College of Louisiana. The school had only recently been founded, and Riddell maintained his professorship there until his death in 1865. Riddell was interested in many areas of science including chemistry, botany, microscopy as well as other civic interests. He headed the School of Pharmacy at the University of Louisiana and he was involved in a scientific exploration of Texas in 1838. Riddell was the melter and refiner in the branch United States Mint until 1849. In 1844 he became a member of the commission appointed by the Louisiana legislature and the governor to devise protection against the Mississippi river floods. Riddell had a broad understanding of the sciences, but an 8 infamous rapport with his colleagues. He was frequently absent from faculty meetings, he would decline to vote on faculty resolutions, and he would blatantly ignore regulations from time to time. In 1851, a bitter dispute resulted in a request for his resignation, but Riddell refused and went on to bring the Medical College of Louisiana international fame with his development of the first workable system for a binocular microscope in 1852. Riddell claims to have completed his original design for the binocular microscope in 1851, but it was not until October 2, 1852 that he exhibited the completed instrument (Woodward, 1881). In the New Orleans Monthly Register of October 1852 he wrote: "Behind the objective, and as near thereto as practicable, the light is equally divided, and bent at right angles, and made to travel in opposite directions, by means of two rectangular prisms which are in contact by their edges, that are somewhat ground away. The reflected rays are received at a proper distance for binocular vision upon two other rectangular prisms and again bent at right angles, being thus either completely inverted, for an inverted microscope, or restored to their original direction. These outer prisms may be cemented to the inner, by means of Canadian balsam, or left free to admit of adjustment to suit different observers. Prisms of other forms, with due arrangements, may be submitted." He emphasized the microscope's ability to present a true stereoscopic effect. Riddell was quick to point out that his microscope gave a psuedoscopic effect that impaired its performance, and acting upon his own suggestion, he tried "prisms of other forms." A description of his new design was published in the New Orleans Monthly Medical 9 Register's April 1853 publication. In this design, he explained that only two prisms were used: "They must be of such form, that the faces, at which the light is immergent and emergent, shall form equal angles with the face on which the internal reflection occurs." He continued to explain that with this new arrangement, in order "to produce orthoscopic binocular vision, simple, not erecting eyepieces are required." Riddell Binocular Microscope } objective } objective improved design original design Although it was his microscope that gained recognition for both him, and the college, Dr. Riddell was also instrumental in discovering the microscopic characteristics of the blood, and black vomit in yellow fever. His microscopy work continued, and in 1846 10 he "predicted the existence of the constituent particles of the atom and the existence of internal forces between these particles" (Times Picayune, 1955). Dr. Riddell religiously kept a journal. He wrote, not only about events of the days, but about ideas, dreams, inventions, and his controversial lectures, such as the one about the possibility that there was conservation of momentum just as there was conservation of mass (Riddell, 1838). He had several notes and sketches about his various science projects in his journal that clearly describe his eclectic interests. For all of his talent and work with chemistry, botany, and pharmacy, it is his innovation in the world of microscopy that brought him, and the Medical College of Louisiana, international attention. 11 On a personal note: During the Civil War, New Orleans was in need of a postmaster to do an unbiased job, despite the hostilities across the Mason- Dixon line. John L Riddell, being from Massachusetts, but living in Louisiana, volunteered for the job. He remained head post master until the end of the war. So agitated was he by the end of the war, that his mind had shown signs of failure. His death in October of 1865, at 59 years old, came as a surprise to no one. 12 C h a pter 4 Dr. Rudolph Matas His world wide reputation as a surgeon was universally described in superlatives such as, "greatest," "most learned," "most illustrious," "best;" his valuable contributions to medical science as, "first in the South," "first in America," "first in the world;" and his writing as "brilliant," "masterful," "exhaustive," "most attention holding." -from In Memorium about Dr. R. Matas 13 For more than seventy of his ninety-seven years, Dr. Rudolph Matas was involved and dedicated to Tulane University. Matas was born on September 12, 1860 in Bonnet Carre, Louisiana, where his father was a plantation physician. He graduated from St. Johns College at Matamoros, attended Soule College, and began medical school at Tulane School of Medicine (Medical College of Louisiana). As an 1880 graduate of medical school, the nineteen-year-old Dr. Matas began a two-year internship at Charity hospital and was appointed clerk and microscopist of the Federal Havana Yellow Fever Commission. While in Cuba, Matas conducted more than 100 microscopic studies of living yellow fever samples. These samples helped lead to the discovery that the mosquito was the carrier of the dreaded fever. He began his career at Tulane as demonstrator of anatomy in 1886, and was promoted to professor of surgery in 1894. Dr. Matas was recognized almost immediately as a talented physician, and a brilliant surgeon. In 1888, only eight years after graduating from medical school, he made medical history, which was hailed at the time as the greatest advance in vascular surgery in 200 years. The procedure of treating aneurysms was developed by Matas while treating a patient at Charity Hospital. Although the standard procedure was to ligate, Matas boldly cut into the bulging aneurysm and sutured the weakened tissues and orifices. This procedure, later called an endoaneurysmorraphy, was named after the innovative young doctor, and is still commonly referred to as the "Matas operation." 14 During his lengthy career, Matas pioneered many medical advances. He was the first in Louisiana to perform thyroid surgery, he was the first to use catgut rings for suturing intestines, the first to utilize intravenous drip, the introduction of fluids into a vein drop by drop, the first to perform surgery using spinal anesthesia, the first to use a simple siphoning process to avert post-operative discomfort, and among the first to advocate the use of movies in medical education, and he was the co-inventor of the Matas-Symthe pump for artificial respiration. Dr. Matas received worldwide attention for his brilliance, but was always quick to link his accomplishments and honors with Tulane University and his faculty status. He took enormous pride in his affiliation with the University, and it was his work, which led to Tulane's status as a vascular surgery center. Matas was a professor at Tulane for 42 years, and it was his title as "professor", and later a "professor emeritus", that he cherished more than any of his other titles. In addition to teaching medicine at Tulane, he kept a rigorous surgical schedule at Charity Hospital, and later, at Touro Infirmary. He practiced surgery until the age of 87, despite the loss of sight in one of his eyes in 1908. He was extremely enthusiastic about his practice, and was active in several medical societies. He was president of the International Surgical Society, and the American College of Surgeons, in addition to donating time to student and professional groups. He was heavily involved in the fundraising for the University, and he willed $1,000,000 to the Tulane Medical Library, and willed the rest of his estate to the University. In 1937, the Tulane Medical Library was named after its honored benefactor. 15 Matas has been called Tulane's most illustrious alumnus. His friend and colleague, Dr. Alton Ochsner, said it well: "there has been no other person who has brought so much renown and distinction to his beloved Alma Mater... Tulane is proud of her most distinguished son and will always be grateful to have been able to share with the world the accomplishments of the great benefactor, Rudolph Matas." In a December 17, 1931 award acceptance speech, Matas said, "Personally, I am happy to say that I have crossed the danger line without fear and without regret, and that my interest and enthusiasm for my profession and all that concerns its health-giving and humanitarian mission, has never abated. This I attribute to my good fortune in inheriting good health and preserving my enthusiasm. Please remember that enthusiasm is the salt of life. It seasons our lives with a flavor that makes living palatable, giving zest to our existence. Without it, life becomes vapid and tasteless and we no longer care to sit at the table. "As long as enthusiasm remains we need not worry. We can still indulge in the spirit if not in the substance of our dreams even though we may be well aware, like the venturesome Alpine climber treading on the thin ice that bridges over a bottomless pit, that the next step may be his last." The world of medicine and early biomedical engineering were touched by that enthusiasm and brilliance that was so much a part of this great man. 16 On a personal note: In 1949, at the age of 89, Dr. Matas was present to welcome the International Surgical Society at its New Orleans Convention. He made the welcoming address in English, Spanish, French, and Italian. This, he did, without notes or manuscripts. Dr. Matas was a schoolboy when Lincoln was assassinated, and Dwight D. Eisenhower was president when Matas died in 1957. 17 C h a pter 5 Dr. George Burch and Professor James Cronvich Dr. George Burch Professor James Cronvich "Doctors could not practice modern medicine without electronics, their dependence on it has grown so. We all must remember, however, that the equipment is our slave, we are not slaves to the equipment." -Dr. George Burch Medical World News May 17, 1968 Actual biomedical engineering at Tulane, as we know it today, started in the mid 1900's when the faculty from the School of 18 Engineering joined forces with the faculty from the School of Medicine. With the physicians' knowledge of the human body, and the engineers' understanding of mechanics and electronics, new challenges could be faced in the pursuit of medical technologies. From 1944 until the early 1970's, Jim Cronvich of the School of Engineering, and George Burch from the School of Medicine worked together in the study of biomedical engineering. Dr. Burch received his undergraduate and medical degrees from Tulane University. He worked at Charity for a year, and was hired as an assistant professor at Tulane in 1934. He became a full professor in 1947, and was considered a leading authority on cardiovascular disease. He studied the effects of room climate control on the heart, and he was a great aficionado of clinical observation, rather than computers, charts, or graphs for patient diagnosis. In the June 4, 1965 edition of Medical World News , he noted, "As long as clinical observation continues to be dismissed as unscientific and unobjective, and even unreliable, students and young physicians will become more and more dependent upon the laboratory for diagnosis. The physician who presents charts, graphs, and computations to support his diagnosis will be considered modern and scientific, whereas the physician who supports his diagnosis by data collected at the bedside, no matter how accurate, objective, and critical, will be considered old-fashioned and nonscientific." Despite this attitude, Dr. Burch did not deny the importance of the laboratory in medicine. He, after all, worked with Jim Cronvich on many diagnostic tools. 19 Jim Cronvich received his B.S. at Tulane University in 1935, his M.S. at Tulane University in 1937, and his S.M. at the Massachusetts Institute of Technology in 1938. He went on to become assistant to full professor at Tulane in 1942 where was responsible for the instruction and laboratories in electronics, communications, and microwaves. A doctor from Charity Hospital who was in charge of the electroencephalographic laboratory called the Department of Electrical Engineering at Tulane for help when some of his equipment was causing problems. Cronvich solved the problem for the hospital and continued to help with the maintenance of this doctor's equipment for years to come. This was Cronvich's first contact with biomedical engineering. In 1944 Dr. Burch ran into some difficulties with the control system he was using in his research. He brought the apparatus to Cronvich who was able to show him what was causing the trouble. Not long after that, Burch was getting odd results from his basal metabolism apparatus. He called Cronvich, described the problem over the phone and Cronvich told him how to fix it even though he had never seen the device. In late 1945, or early 1946, Dr. Burch found great interest in some electrocardiology work that had been reported by Dr. Frank Wilson of the University of Michigan. He thought of Cronvich and decided to ask him if they could try to reproduce Dr. Wilson's work. So one evening, Cronvich took some equipment from the electrical engineering lab down to Burch's laboratory at Charity hospital. He and Burch were able to recreate vectorcardiograms like those of Dr. Wilson's. Because of this success they decided to pursue the 20 research further. Doctor Burch was able to get enough funding for the research equipment needed and to hire Cronvich full-time during the summer and part-time during the school year. In June of 1946, Cronvich and Burch began what would be 40 years of steady association which each other. Together they tackled projects relating to electrocardiology, radioactivity's affect on humans, and digital plethysmography to study blood flow into the fingers and toes and the effect of the environment on this flow. Even after Burch's retirement at age 65, he and Cronvich continued to work together on research projects. Their funding came from donations made by Burch's grateful patients and Cronvich worked with Burch even though he no longer received monetary compensation. In addition to employing Cronvich personally, Dr. Burch also had him appointed to the faculty of the School of Medicine in the same title positions he held in the School of Engineering... assistant professor, associate professor, and professor of Biomedical Engineering in the Department of Medicine. For forty years Burch and Cronvich worked together tackling biomedical engineering challenges. Together they witnessed the invention of ultrasound, pacemakers, electron microscopes, the polio vaccine, CAT scans, MRI's, radioactive tracers, and heart transplants, among others. As Cronvich recalls, "My 40 years of association with Dr. Burch, until his death in 1986, were most enjoyable. We respected each other's abilities, and I cannot recall a single disagreement that was not easily resolved. We had essentially the same political and social outlooks," (Cronvich, 1995). 21 On a personal note: Late in his career, Burch returned from some medical meetings and told Cronvich that some of his former associates did not look well. Within six months they all died. Watching a Sugar Bowl game, he saw a well known former Tulane star appear on the television screen in a halftime interview. Burch told his wife that the man looked sick and should not be out. Two weeks later the Tulane star died. During a visit to New York for an athletic conference, Cronvich told Burch, "NEVER tell me I don't look well." -As told by James Cronvich, 1995 Cronvich's family was from the New Orleans area and his brother was sheriff of Jefferson Parish for several years. 22 C h a pter 6 Dr. L. Matthew M. Bach and Professor Claude J. Sperry, Jr. 400 HUMAN ENGINEERING (1) Dr. Bach. Human Engineering seeks to match human beings with modern machines so that their combined output will be comfortable, safe, and more efficient. Electronic applications in medicine, acoustics and hearing, space medicine, heating and ventilation, aerodynamics, illuminations and dial design, feedback theory in nervous system function, recording problems, prosthetic design for amputees, and man-machine relationships. Technical terminology will be minimized. The importance of this rapidly expanding field to the engineering profession will be emphasized. -from Tulane University Bulletin, a listing of classes for the College of Engineering. December 15, 1952. 23 "Human Engineering," taught by Dr. Matthew Bach, is perhaps the first class offered at Tulane that centered around Biomedical Engineering. Bach was a professor in the Department of Physiology, and his "Human Engineering" course discussed the engineering analogies of certain physiological functions. Matthew Bach's research interests, for a great part of his career, revolved around Biomedical Engineering. In 1949, Dr. Bach contacted Professor Claude J. Sperry of the Department of Electrical Engineering. Bach needed help in designing and building a blood-flow metering device for a research project. This project was only the first of many in Bach and Sperry's long and productive collaboration and friendship (Sperry, 1995). Together, Bach and Sperry tackled several projects ranging from cats to weapons. Their first joint research project occurred during 1951 and 1953 for the United States Army Research and Development Laboratory. It was named "Artificial Moonlight." The Korean War was underway, and the troops were in danger during the very dark nights. "Artificial Moonlight" was based on the theory that atmospherically scattered light from powerful searchlight beams would allow the troops to see the approaching enemy soldiers. The "Artificial Moonlight" research consisted of laboratory work and field work. The field work was done along the western levee of the Bonnet Carre spillway away from the city lights. Insect repellent was purchased by the gallon! The project entailed setting a searchlight beam at various altitudes and azimuths under varying climatic conditions and then measuring both the illumination on the 24 ground and the visual acuity of personnel in a field situation using artificial moonlight. Based on the data Bach, Sperry and the other researchers found, the army constructed a slide rule which field commanders used to set searchlight elevations and azimuths for optimum illumination under various weather conditions. They were told that the "Artificial Moonlight" greatly improved morale on pitch-black nights (Sperry, 1995). The Army Research and Development Laboratories turned to Bach and Sperry again in 1954. They wanted to know how flickering lights affected the human mind. Bach and Sperry found that "unpleasant and hypnotic subjective effects consistently were reported when exposed to diffuse flickering light (Sperry, 1995)." However, it was not proven that the cognitive processes were affected by the flickering light used in the investigation. This project, which was conducted from 1954-1956, was classified due to its potential use as a weapon. In April of 1957, the results were published. Mr. Phil Johnson, a reporter for the New Orleans Item Newspaper, published an article on April 7, 1957 in which he quoted Dr. Bach out of context in order to sensationalize the project results. The title of the article was, " 'War Winning' Weapon Unveiled Here By Army." He gave the impression that the army intended to use flickering lights to distract enemy soldiers, when in fact, that was not the case. As Sperry recalls, "The fact was that the process was essentially useless as a weapon and the Army declassified the results." For the next eleven years, Bach and Sperry's joint research involved trying to understand and quantify the relationship between 25 the electrical activity of the brain, and defensive behavior in cats. Initially, the experiment took place in an isolation chamber. The cat was prepared with implanted cortex electrodes, and placed in the chamber. The electrodes were connected to an electroencephalogram (EEG), with flexible wires through a connector in the wall of the chamber. The cat would then be subjected to various controlled stimuli while the brainwaves and behaviors were recorded. Unfortunately, the results of the experiment were criticized due to the behavior of the cat being severely limited by the wire leads and the artificial environment. Sperry decided to attempt to devise a radio transmitter, which was small enough to be implanted subcutaneously, and which would broadcast brainwaves to a remote receiver. This would allow the cat to function naturally, in an unrestrained environment, while the scientists recorded the behavior and the brainwaves. With the help of engineering colleagues, Sperry accomplished his goal towards the end of 1961. This invention, published in SCIENCE, received a great deal of attention. Bach and Sperry received correspondence from all over the world, including iron-curtain countries. They were also interviewed and featured in the September 1961 issue of TULANIAN. By 1968, the telemetering transmitter had been drastically improved, and a completely implantable stimulator had been devised. Bach and Sperry were able to analyze the differences in the evoked potentials between a resting, isolated state and the defensive state in the cat. The analysis was performed on an early main-frame computer. The experiment was then ready to be moved to the Hebert Research Center, near Belle Chasse, which would serve as a 26 natural habitat. However, before significant results could be obtained, Dr. Bach was asked to help start a new medical school at the University of Nevada in Reno. The experiment was terminated when Bach left. Sperry did very little Biomedical Engineering independently of Bach. He participated with some colleagues from the Tulane Biophysics program in the study of sonic signaling, taking into account the frequency response of the human ear. Sperry also served as an expert witness concerning visual acuity at night, and noise induced hearing loss. Claude J. Sperry, Jr. retired as Professor Emeritus and is currently living in New Orleans. 27 On a personal note: When asked to describe Dr. L. Matthew M. Bach, Sperry replied: "He was one of the three most intelligent colleagues of my acquaintance. Matt's quick wit allowed for instant and sometimes sharp retorts. It was amusing to observe him using that ability on slower antagonists who sometimes were not immediately aware that he had made a devastating point. He had a highly developed sense of humor and was extraordinarily cooperative and pleasant to work with. Matt was a large man: about 6'3" and over 300 pounds. He was a compulsive eater and avoided exercise. He jokingly told me that whenever he felt like exercising, he would lie down until the feeling passed. He also told me that he knew he would die young, probably of a heart attack. Indeed, that happened." 28 C h a pter 7 Dr. Jack Wickstrom and Professor John Martinez Professor John L. Martinez Dr. Jack Wickstrom "Once, our whiplash [experiment] was covered by a German magazine which photographed Donald Garcia, our engineering graduate student at the time, together with a test monkey in the test vehicle. This magazine turned out to be the equivalent of the National Enquirer and the picture caption showed 'The smiling executioner and test animal’ when it was published." - John Martinez 29 Another great Tulane physician/engineer pair was that of Dr. Wickstrom of Orthopedics, and Professor Martinez of Mechanical Engineering. Together, these men explored the causes and effects of whiplash using laboratory animals, and equipment which simulated the rear-end collision in automobiles. The animals were tested during impacts with headrests, and impacts without headrests. Because this work took place in the early 1960's, headrests were not yet a required safety feature, and the effects of whiplash were not well understood. In addition to whiplash, brain injuries were inflicted with no impact to the head, just rotational acceleration. The test animals were examined by Orthopedics, Psychiatry/Neurology, and finally, by Pathology for signs of injury. This highly technical work was accompanied by highly technical equipment such as high-speed motion pictures that ran at 3000 frames per second, and "flash" X-rays taken of the head and neck positions during the acceleration. So well received was their work, that Professor Martinez was hired as a deputy policeman for a year in the investigation of car accidents that occurred with cars made in 1968 which had installed various safety devices. In addition to working on projects together, they were partners in education. Doctor Wickstrom would ask Martinez to lecture to his medical students about strength of materials or mechanics. Many medical students had taken only one course in physics, and had only a minimum education in mathematics. Wickstrom and Martinez both saw the importance of physics in orthopedics, and Martinez would provide them with that kind of information. 30 Doctor Wickstrom was always munificent both to Martinez and the Tulane School of Engineering. Martinez describes Wickstrom as a man who was, "very smart [and] tough but admired by his students and residents who referred to him as 'Cactus Jack.' He was nationally known and the source of most of our grants. He was very generous professionally -- always listing me as co-principal investigator, something not usually done." In addition to sharing credit for the work they had done, he once gave nine out of ten slots of a three-year training grant to the School of Engineering. This generosity was a vital step toward starting the Biomedical Engineering Department. Doctor Wickstrom spent the last 24 years of his life at Tulane University, and was Chairman of Orthopedics for the majority of that time. He died in 1979 leaving behind a legacy of work and slew of orthopedists. John Martinez still lives in New Orleans, and works every morning as a consultant to Tulane Medical School's Development Office. If Martinez were still a researcher at Tulane, he thinks he would "probably still work in Orthopedics using physics and math -- improving joints such as knees, elbows, shoulders, and fingers." 31 On a personal note: Known as "Cactus Jack" for his 'prickly' personality, Dr. Jack Wickstrom was given a six-foot cactus one year from his interns. He was so proud of this sharp gift, that he planted it right in his front yard. 32 C h a pter 8 Drs. Raymond Bailey, Duane Bruley, Bob Chambers, and Bob Weaver "My prediction is that Bioengineering will be the fifth traditional engineering discipline. Napoleon started military engineering in the 18th century. His soldiers came home and built roads and bridges, which led to civil engineering, which progressed into mechanical and electrical engineering. Those disciplines are based on physics and math. Then, in World War I, the Germans' work led to chemical engineering. The only science left is biology which leads to the fifth traditional discipline... bioengineering." - Dr. Duane Bruley on the progression of engineering disciplines. April, 1995 The Chemical Engineering Department had several engineers on its faculty whose research interests crossed over into the biomedical discipline. The Chemical Engineering Department Head from 1951 until 1967, Dr. Raymond Bailey, was a great proponent of biomedical engineering. Bailey earned his B.S. in Chemical Engineering from Louisiana Polytechnic Institute in 1944, his M.S. and his Ph.D. in Chemical Engineering from Louisiana State 33 University in 1948, and 1949 respectively. He was an associate professor at the University of Mississippi from 1948 until 1951, and came to Tulane as Chemical Engineering Department Head in 1951. In 1967, Bailey was appointed to Assistant Dean of Engineering, and in 1973 he was appointed Associate Dean of Engineering. While at Tulane, Bailey developed the first accredited chemical engineering program for Tulane and he initiated one of the first programs for pre-medical students in engineering. From 1970 to 1972, Bailey chaired an engineering task force to start the five-year engineering masters program. It is this task force that recommended the establishment of a biomedical engineering program staffed by mechanical engineering faculty. In 1960 Dr. Bailey hired Dr. Robert E. C. Weaver. Weaver grew up in New Orleans and attended Warren Easton High School. When Weaver earned his high school diploma in 1949, he also earned the distinction of attaining the highest-grade average in the history of Warren Easton High School -- a 98.5%. His performance in high school earned him a scholarship to Tulane University in 1949. His first year of college Weaver's major was pre-law, but as a sophomore he transferred into chemical engineering. On June 2, 1953 Weaver graduated from Tulane University as the first student to achieve a straight "A" average in the history of Tulane's School of Engineering. In 1955 Weaver earned his M.S. in Chemical Engineering from Tulane and then continued his studies at Princeton where he earned his M.S. in Economics and his Ph. D. Weaver joined the Chemical Engineering faculty in 1960 and was involved in research dealing with complex automated control 34 systems. This work eventually prompted Weaver to look at the body's nervous system. The complexity and the interdependency of bodily systems led Weaver's research towards the integrated functions of the circulatory system, the respiratory system, and eventually, kidney function. Weaver and his research team were the first to publish material describing, in detail, a single neuron and the effects of stress and fatigue on neural function. Weaver taught physiology to engineering students, was a consultant for the vascular department of the V.A. Hospital, and was the first to simulate physiological processes from an engineering standpoint. In 1973 Dr. Samuel F. Hulbert, the new Dean of the School of Engineering, hired Dr. Duane Bruley as the Chemical Engineering Department Head. Bruley received his B.S. in Mechanical Engineering from the University of Wisconsin in 1956, his M.S. in Nuclear Engineering from the School of Reactor Technology in 1957, another M.S. in Mechanical Engineering from Stanford in 1959, and a Ph.D. in Chemical Engineering from the University of Tennessee in 1962. In addition to excelling in engineering, Duane Bruley had a talent for the game of tennis. While a graduate student at the University of Tennessee, Bruley was also head tennis coach. From 1962 until 1973 Bruley was a professor and the head tennis coach for Clemson University in South Carolina. When Dean Hulbert was trying to recruit Bruley to come to Tulane, he offered him a choice of being Associate Dean, head of the new Biomedical program, or head of Chemical Engineering. Hulbert also arranged for Bruley to 35 be head tennis coach. In 1973 Bruley came to Tulane as the head tennis coach and the department head of Chemical Engineering. Bruley's research in biomedical engineering began long before he came to Tulane. His primary research was in oxygen transport to the brain. In 1962, he received funding through NIH to research oxygen transport, and in 1973 he formed the International Society on Oxygen Transport to Tissue. They are a group that is still active and that meets annually around the world. Bruley considers his major contributions in biomedical engineering to be in areas relating to human tissues (particularly the brain), blood coagulation and glutenation, and pathologic states for the viability of neurons. In 1977 Dean Hulbert became president of Rose Hulman Institute of Technology, and Bruley left Tulane to be the Vice President of Academic Affairs at Rose Hulman. In 1983 Bruley became head of Biomedical Engineering at Louisiana Tech, and he is currently Dean of Engineering at University of Maryland - Baltimore County. Bruley's main research interest now is in the search for anti-coagulants that can be used clinically to prevent thrombosis and coagulation. He is doing research on Protein-C, which, if it can be manufactured inexpensively enough, can replace more dangerous anti-coagulant drugs that are now on the market. After Dr. Duane Bruley left Tulane Dr. Weaver was appointed Chairman of Chemical Engineering. Weaver remained chairman until 1980 when he went to the University of Tennessee as the Dean of Engineering. He stayed at University of Tennessee until 1984 when he moved into private industry. He is now the Vice President of International Matex Tank Terminals (IMTT) in New Orleans. IMTT is 36 a Dutch-American partnership company that specializes in the storage of liquid products. Another Tulane Chemical Engineering Professor involved in biomedical research was Dr. Robert C. Chambers. Chambers earned his B.S. and M.S. degrees at Cal Tech and his Ph.D. at University of California at Berkeley in 1965. After receiving his Ph.D. Chambers joined the Tulane University Chemical Engineering faculty where he stayed until 1976. In 1973 Chambers was a principal investigator for research on an enzyme reactor. The blood of a patient afflicted with an enzyme disorder would be circulated and filtered through Chamber's enzyme reactor. Through this process, necessary enzymes could be added to the body, or excess enzymes could be removed. In 1975 Chambers studied the methods to convert whey, a waste byproduct of cheese, into useful sugar and protein nutrients. He predicted that he could reclaim 70 million tons of sugar syrup each year for the whey produced in American dairies. In addition to working with enzymes Chambers researched inherited genetic diseases, liver assist devices, and cancer chemotherapy. Chambers is now the Chairman of Chemical Engineering at Auburn where he continues his work in two main areas of enzyme research. The first is in the use of multi-enzyme systems to lower alcohol levels, and the second is in environmental biotechnology using fungi to remove harmful materials produced by industrial pollution. 37 On a personal note: One of Dr. Bruley's students built a random number generator. This machine was a box about six inches long by eight inches wide. On its face it had about 30 little lights that would randomly flash on and off. One evening it was left, turned on, in Bruley's office. His secretary went in to his dark office and the flashing lights startled her. The next day she asked Bruley what it was and he told her he was intercepting signals from the planet Mars. His secretary was scared to death and went around telling everybody that Dr. Bruley was talking to Mars. Bruley allowed her to go on believing this for quite a while until he gave in and told her the truth. In the 1970's in Louisiana, it was not required to change license plates when a car was sold from one person to another. Well, one of the professors in this chapter sold his car. Unbeknownst to this professor, people started seeing what they thought was his car parked in front of the freshman girls dorm at Tulane. One afternoon he received a phone call from someone who was demanding to know why this professor's car was always by the girls dorm. So embarrassed was this professor, that he still wishes to remain unnamed. 38 C h a pter 9 Drs. Sam Hulbert, Steve Cowin, Jerry Klawitter, and Allan Weinstein Dr. Samuel F. Hulbert "It is my hope and objective that the Tulane School of Engineering will become greatly involved in areas which are of prime importance today -- bioengineering, energy conversion engineering, and ocean and coastal engineering. Tulane is particularly well suited to become a national leader in bioengineering because it has a medical school of outstanding status and an engineering school, whose faculty is largely concerned with the application of engineering to medicine and the biological sciences." - Dr. Samuel Hulbert, 1974 39 By 1970, Tulane had a track record and a reputation for research combining engineering and medicine, thus placing itself on the path towards the development of a biomedical engineering curriculum. William Van Buskirk was hired in 1970 as the first faculty member to have specific training in biomedical engineering, and by the mid 1970’s; most of the mechanical engineering graduate students chose research in biomechanics as the topic of their dissertations. The climate for developing a biomedical engineering program became more favorable when Dr. Lee H. Johnson, after serving as Dean of Engineering for 22 years, retired in 1973 and was replaced by Dr. Samuel F. Hulbert. Hulbert attended Alfred University in New York where he earned his B.S. in ceramic engineering in 1958 and his Ph.D. in Ceramic Science in 1964. That year, he joined the faculty of Clemson University in South Carolina, and in 1970 he became associate dean interdisciplinary studies. for engineering research and While at Clemson, Dr. Hulbert was instrumental in developing one of the largest and most well equipped biomedical engineering programs in the country. It was also at Clemson where he began his association with Drs. Allan Weinstein, and Duane Bruley, who would follow him to Tulane in the mid 1970's. Sam Hulbert began his work at Tulane in 1973. He had a strong background in biomedical engineering and saw that Tulane had many of the resources it needed to establish a biomedical engineering department. He sat down with every staff member and 40 asked him or her about their personal interests and their visions for the school's future. Like him, a great many of his faculty had an interest in biomedical engineering. The first year he was at Tulane, Hulbert recruited and hired Duane Bruley as head of chemical engineering, and Dave Wieting as head of mechanical engineering. Both men had strong research interests in biomedical engineering. Hulbert's emphasis on hiring department heads with biomedical backgrounds was not a popular move with many of the faculty in the School of Engineering. In retrospect, Hulbert attributes that lack of support to jealousy among departments due to the attention biomedical engineering was receiving. Also that first year, Hulbert developed three programs within the School of Engineering: Engineering Management, Biomedical Engineering, and Computer & Information Systems. He appointed Dr. William Van Buskirk, an aerospace engineer whose initial Tulane appointment had been in the Department of Orthopedic Surgery, as director of the Biomedical Engineering Program. Dr. Robert Weaver was appointed as director of the Engineering Management Program, and Dr. Victor Law, a chemical engineer, was appointed as director of the Computer and Information Systems Program. When Hulbert was an Alfred University graduate student, Jerry Klawitter was an Alfred University undergraduate student. They were in the same small, local fraternity and Hulbert recalls always seeing Klawitter on his back under an automobile tinkering with and/or fixing something. Hulbert was in need of someone with good mechanical skills to help him with his research and he knew 41 Klawitter was the man for the job. They worked together until 1964 when they both graduated... Hulbert received his Ph.D. in ceramic science and Klawitter received his B.S. in ceramic engineering. Hulbert joined the faculty of Clemson in 1964, persuaded Graduate the and he Clemson School to admit Klawitter as a graduate student. Unfortunately, Klawitter did not have an outstanding undergraduate academic record and Clemson would only accept him with a provision that he would make up required courses his first semester. well Klawitter did very that semester and Dr. Allan Weinstein (left) & Dr. Jerry Klawitter continued on to get his M.S. in Ceramic Engineering, and his Ph.D. in Bioengineering under Hulbert's direction. Clemson had a strict rule against hiring their own graduates as part faculty members. Again, Hulbert put his persuasive talents to work and convinced Clemson that they would be losing an incredible teacher if they did not hire Klawitter. Hulbert was then, and still is, of the strong opinion that "Jerry has an incredible mechanical skill, 42 but his greatest quality is being an outstanding teacher; he can inspire, encourage and demonstrate difficult concepts." Hulbert's passion for Klawitter's ability prevailed, and Clemson hired Klawitter as the first Clemson graduate in many years to be on the faculty. Shortly thereafter, Klawitter received a Clemson Award for being an outstanding teacher. Another of Hulbert's recruits at Clemson was Dr. Allan Weinstein. Weinstein earned his Ph.D. in physical metallurgy in 1971 from the Polytechnic Institute of Brooklyn. He then spent a year doing post doctorate work at the University of Pennsylvania. It was at the University of Pennsylvania that Hulbert and Weinstein first met. Hulbert was attending a meeting at Penn when he heard Weinstein speak. Hulbert was "immediately impressed by his work, his self-confidence, and his oral communication." He invited Weinstein to interview at Clemson, and he hired him on to the Clemson faculty. When Hulbert took the position as Dean of Engineering at Tulane, he had every intention of bringing Klawitter and Weinstein along. Hulbert knew he had two talented engineers in Klawitter and Weinstein, and because of their similar research interests in biomaterials he knew that they were a team that should stay together. It wasn't until 1975 that the Tulane positions opened, but when they did Klawitter and Weinstein moved again to be with their mentor, Sam Hulbert, and joined the faculty in Mechanical Engineering at Tulane. Klawitter never enjoyed the theoretical side of engineering-- he stayed on the practical side. He also enjoyed the 43 clinical side of biomedical engineering. When he left Clemson to come to Tulane, he did so partially because of the strong relationship between Tulane's Department of Orthopedics and the School of Engineering. He knew Dr. Jack Wickstrom, the Chairman of Orthopedic surgery, worked with engineers therefore providing clinical research possibilities. Klawitter and Weinstein's research interests while at Tulane revolved around biomaterials and their applications in the human body. They worked primarily on the use of porous material implants, dental implants and the development of hip replacement. Together they developed a biomaterials lab, which was the most rewarding project for Klawitter. They enjoyed working with patients in a clinical environment and were both Clinical Associate Professors of Orthopedic Surgery at Tulane School of Medicine. Hulbert's main research interests while at Clemson and Tulane were in biomechanics and the engineering aspects of developing artificial body parts. He also was involved in research, using his ceramics background, to develop materials for a glass-packaging container, which could be easily processed, to dissolve in water after use, thus reducing solid waste pollution. While at Tulane Hulbert, Klawitter, and Weinstein had a very good relationship both professionally and personally. According to Weinstein, he and Klawitter operated like one individual. "We were the best of friends and professional partners. It is rare to find a professional relationship that existed as ours did. families together, we did everything together." We moved our Every couple of months Hulbert, Klawitter, Weinstein, Bruley, and their respective 44 wives would buy a bag of oysters and have an oyster party at the Hulbert's home. The men would shuck the oysters and the women would each make their "specialty" oyster platter. Another member of the Tulane's faculty in Mechanical Engineering was Dr. Stephen Cowin. Cowin earned his B.S. and M.S. degrees from Johns Hopkins, his Ph.D. from Pennsylvania State, and he spent a year doing postdoctoral work at the University of Nottingham. Dr. Cowin's principal research interest early in his career was in the mechanics of materials. He began teaching at Tulane in 1969 and he was consistently rated by students as one of the most effective professors until he left Tulane in 1988. When Hulbert, Klawitter Dr. Stephen C. Cowin and Weinstein came to Tulane, Cowin's research interests moved into bone remodeling. Cowin's strengths in theoretical engineering and applied mathematics were a natural complement to the practical abilities of his colleagues Klawitter and Weinstein. With Sam Hulbert as dean, William Van Buskirk as head of the biomedical engineering program and Cowin, Klawitter, and Weinstein as biomedical engineers, Tulane had the most of the 45 faculty it needed to form a separate department of biomedical engineering. Within the School of Engineering, there was a great deal of debate surrounding establishing a biomedical engineering as an undergraduate major. Dr. Dave Wieting, for example, was adamantly opposed to offering an undergraduate degree in biomedical engineering at Tulane. Wieting was hired by Hulbert as the Head of Mechanical Engineering in July of 1974. While at Tulane, Wieting furthered his research that involved artificial heart valves. Wieting thought students should have a traditional engineering background and then add biomedical engineering at the graduate level. concerned that there would be no jobs for Wieting was undergraduate biomedical engineers. Since his undergraduate studies, Wieting has been involved in heart valve research. Dr. Wieting is currently working for PfizerShiley Heart Valve Research Center, and he still holds the opinion that biomedical engineering at the undergraduate level does not provide enough preparation for work in the industry. Wieting was always impressed by Tulane University. One thing that attracted Wieting to Tulane was the close proximity of the Engineering and Medical Schools. Unfortunately, he felt a real reservation on the part of the administration to allow faculty to do consulting work. Wieting saw this as a loss of opportunity for the students to have 'hands-on' experience. In general, he feels that the education system in the United States is hurting its students by not providing enough practical application. 46 In 1976 Dr. Hulbert was offered the position of President at Rose Hulman Institute in Terre Haute, Indiana. Although he was hesitant to leave Tulane after such a short time, he couldn't pass up the opportunity to move on to a university presidency. He attempted to bring Klawitter and Weinstein with him to Rose Hulman, but eventually they both declined. Bruley, however, did move with Hulbert, and became the Vice President of Academic Affairs at Rose Hulman in 1978. Samuel Hulbert is still the President of Rose Hulman, and is currently working with his graduate students on research areas of biomedical engineering such as: reducing the loosening of orthopedic appliances due to wear, improving wear resistance of polyethylene, making better bearings for hip and knee replacements and improving bone cement by adding hydroxyapatite. 47 On a personal note: While growing up, Jerry Klawit father was a shop instructor for a high school near where they lived. Jerry spent a great deal of time at the shop, and it is there that he developed his great ability to work with his hands. Now, he spends his free time building road racer motorcycles. He has built three motorcycles and his "tinkering hobby" has won him two national championships. One of the early Biomedical Engineering Department offices was physically housed on the top floor of Stanley Thomas Hall. Because little was understood about their work, people thought 'Frankenstein' type experiments went on up there. One night, in the office, Klawitter and Weinstein set up a skeleton in Klawitter's chair wearing Klawitter's jacket and hat. Early the next morning, Dorothy, the maid came into the room, saw the skeleton upright in the desk, and went running out screaming in fright. She vowed she would NEVER set foot in that office again! 48 C h a pter 10 The Biomedical Engineering Program Becomes The Department of Biomedical Engineering "It seemed like a real good gamble at the time" - Dean Hugh Thompson on why he turned the Biomedical Program into the Biomedical Department Following Dean Hulbert's resignation in 1976, Dr. Hugh Allison Thompson became the Dean of Tulane's School of Engineering. Thompson earned his B.S. at Auburn University in 1956. He completed his graduate work at Tulane, earning his M.S. in 1962 and his Ph.D. in 1964. Thompson taught at Tulane in the Mechanical Engineering Department and conducted research in mechanical vibrations and dynamics at the interface between mechanical and electrical engineering. Much of Thompson's research was sponsored by various power companies. When Hulbert left Tulane in 1967, he had already implemented three new programs: Biomedical Engineering, Computer and 49 Information Systems, and Engineering Management. Each of these programs had exhibited great success so Thompson moved to create departments out of the programs. The reason Thompson was so supportive of creating the Department of Biomedical Engineering was because Tulane's history and principle attraction was medicine. The most popular of majors in the Tulane School of Arts and Sciences was pre-medical, and it stood to reason that there should be a strong pre-medical program in the School of Engineering. Dr. William Van Buskirk had been the Biomedical Engineering Program Chair, and because the program was successful, Dean Thompson appointed Van Buskirk as Department Chair. In 1977 it was official -- Biomedical Engineering was finally a department of Tulane's School of Engineering. Van Buskirk was Chairman, Dr. Klawitter, Dr. Weinstein and Dr. Cowin were on the faculty, and their office was "under the leaky skylights on the fourth floor of Stanley Thomas Hall" (Walker, 1994). Klawitter and Weinstein were the department's biomaterials experts and Cowin and Van Buskirk were the biomechanics experts. In order to be complete, they needed someone who was an expert in bioelectronics. Enter Dr. Cedric F. Walker as the fifth Biomedical Engineering faculty member and their expert in bioelectronics and medical instrumentation. One of the first graduates of Tulane's Department of Biomedical Engineering was Mr. Steven Greenstein, a native of New York. Greenstein graduated from Tulane in 1978 with a B.S. in Biomedical Engineering. Greenstein remembers the department's early days as being disorganized and difficult. There was no air conditioning and very little ventilation in the classrooms and the 50 curriculum had not been well planned. In his Senior year, Greenstein and the entire graduating class had to take a Freshmen English course because the requirements for engineers had changed. Although Greenstein's memories of Tulane are not all positive, he was involved in some fascinating research projects regarding spinal injury due to Air Force Jet ejector seats, electrical stimulus in blood serum, and intraventricular pressure gradients. Greenstein was a disc jockey for the Tulane radio station, WTUL, where he was known as the "Doctor of Soul and Jazz." Greenstein is now living in Kenner and is the owner of three companies: Advanced Medical Systems, Laserfile International, and House of Cards. Greenstein says he was the smartest one in his graduating class. Most of his classmates went on to medical school; Greenstein relied on luck. In 1990 he won a 27 million dollar Florida Lottery. Fransisco Arabia Jr. was one of the people who graduated with a B.S. in Biomedical Engineering in 1979. Arabia then went to University of Pennsylvania Medical School where he graduated from in 1983. Currently, Fransisco Arabia Jr. is a surgeon at the University of Arizona Medical Center where he specializes in cardiothorasic implantations. Arabia's work involves heart and lung transplants and artificial heart implants. Arabia has nothing but fond memories of his years at Tulane University. He enjoyed studying engineering and he still uses biomedical engineering in his work. His knowledge of biomedical instrumentation is a great help to him when implanting artificial hearts. There are several patients of his who are awaiting heart 51 transplants. While waiting for a donor heart, these patients rely on artificial hearts. Arabia is also involved in engineering education. He is trying to develop an Aerospace and Mechanical Engineering department at the University of Arizona. By 1980 the Biomedical Engineering Department at Tulane was a booming success. Unfortunately, 1980 is the year that Dr. Jerry Klawitter left Tulane. Klawitter's research had led him to discover a way to dramatically reduce the turbulence in the flow of blood through artificial heart valves. Klawitter designed his artificial heart valve but his responsibilities as a professor prevented him from commercially marketing his invention. He figured he had been in college, in some capacity, for twenty years and it was time for him to move on. Move on he did... Klawitter developed a company called Hemex, which he sold to Baxter International in 1987. Klawitter then started his second company, Ascension Biomedical, which manufactures hand and foot joint replacement parts. Klawitter is the president and only employee of Ascension Biomedical. In 1981, Dr. Jerry Weinstein left Tulane to be the director of an orthopedic company called Intermedics Orthopedics. Weinstein is now the "president, CEO and chairman of the board" for a company called Orthologic. Orthologic specializes in external fixation devices and bone growth simulators. 52 On a personal note: In the fall of 1978, Fransisco Arabia attended a school-wide party out on the Newcomb Quad. One of the attractions at this party was the whipped cream pie-throwing booth. For only one dollar you could have a pie thrown at the person of your choice. Arabia paid his dollar and pointed out Dr. Cedric F. Walker. The pie thrower chased Walker clear across the quad until he finally had a good shot. Walker was struck by a whipped cream pie. To this day, Arabia can only describe Walker's reaction in one way: "Ooooh, he was SO pissed off." 53 C h a pter 11 Drs. William Van Buskirk, Cedric F. Walker and a Look Into the Future "If my only legacy when I am gone is having developed Tulane Biomedical Engineering into what it is, than that is a legacy I will be proud of. It is the accomplishment I am most proud of." -Dr. William Van Buskirk 54 William Van Buskirk came to Tulane in 1970 as a postdoctorate working with the Head of Biomechanics and Orthopedics at the Tulane Medical Center on a nine-month research grant. Van Buskirk started teaching Statics and dynamics as an adjunct instructor for the Department of Mechanical Engineering. The reason Van Buskirk stayed at Tulane was because there was an opening in the Mechanical Engineering Faculty. He took the position as Assistant Professor and also took over advising the pre-medical students. Van Buskirk was the first faculty member hired at Tulane who had actual training in biomedical engineering. He earned his B.S. from United States Military Academy, West Point, New York in 1964. He then went to Stanford University where he earned his M.S. (1966) and his Ph.D. (1970) in Aeronautical and Astronautical Engineering. While at Stanford, Van Buskirk's graduate research centered around developing a mathematical model of the semicircular canals in the human ear. His model was the best model available at that time, and his dissertation research has been picked up by several other institutions including MIT and University of Utah. While Hulbert was Dean (1973-1976) the School of Engineering took a turn towards Biomedical Engineering and decided to develop a program that would allow students to major in Biomedical Engineering even though there was no department. Van Buskirk was appointed Head of the Biomedical Engineering Program in 1974. The interest in a Biomedical Engineering major grew and grew, and by the time the Department was founded (1977) Van 55 Buskirk knew it was destined for success. Van Buskirk was appointed to Head of the Department of Biomedical Engineering where he would remain until he was promoted to Dean of the Tulane School of Engineering in 1991. Van Buskirk remembers his feeling of gratification when the new Biomedical Department had its first evaluation and was praised as being very good. Right away, the Department was the most successful and the Biomedical major was the most popular. He had made a commitment to the Department of Biomedical Engineering and was determined to make it great. Biomedical Engineering at Tulane has grown and evolved the way Van Buskirk hoped it would. He attributes much of the success to the emphasis put on teaching and the democratic way in which departmental decisions were made. Biomedical Engineering's approach to hiring was, and still is, to never rush the hiring process -- to always wait for the right person to come along. Van Buskirk wanted his faculty to be a part of the decisions made. He didn't considered it to be his department, it was everyone's department and Van Buskirk wanted everyone involved. The first faculty member hired for the Department of Biomedical Engineering was Dr. Cedric F. Walker. Walker earned both his B.S. and his M.S. from Stanford University in 1972 on a special five-year plan. Walker went to Duke after graduating from Stanford. In 1978, Walker earned his Ph.D. in Biomedical Engineering from Duke University. Van Buskirk saw Walker giving a speech at Duke on the feedback of an electrical prosthetic hand. After Walker was done 56 speaking the students surrounded him and asked him questions for about half an hour. Van Buskirk needed a faculty member who specialized in bioelectronics and he knew Walker was his man. In October of 1976 Walker came to New Orleans to be interviewed. Van Buskirk picked him from his Hotel to take him to campus. They recognized each other from a biomechanics class they had taken together at Stanford. Walker remembers feeling sure he had the job before the interview even started. He was correct... the job was his. Walker taught two classes to the Biomedical Engineering students. The first was medical instrumentation and the second was physiology. When the Biomedical Department was developed, they had to find a place for offices. For the first semester, which was in the fall of 1977, the Biomedical Faculty was given tiny offices on the first floor of Stanley Thomas Hall. The offices were no larger than 8 feet by 11 feet, and no more than two people could comfortably meet in the offices. Luckily, in November of 1977, the faculty got to move up into the fourth floor of Stanley Thomas Hall. There were several offices, and Walker got last choice. His office was very different from the others. It had stark white walls, small white tile flooring and expensive, bright and hot track lighting. It was the largest office, but both Van Buskirk and Walker agree that it looked exactly like a men's bathroom -- without the urinal. There was only one laboratory available to the Biomedical Engineers, and it was under the leaky skylights. Klawitter and Weinstein developed their biomaterials laboratory in this space, and all other experiments took place in corners of the room. 57 It was difficult, however, to find a place in the lab that would not be under one of the leaks in the roof. When Dr. David Wieting, who also had a lab on the fourth floor, left Tulane, Walker took over his lab space and created the electronics lab. Walker remembers it being nice up on the top floor where no one would bother them and they could do any modifications that suited them. Of all of Walker's research, the project he finds most rewarding is a cerebellar stimulator project. He and Dr. Robert Heath, a physician specializing in brain function and psychoanalysis, studied a group of 42 people who were severely emotionally disturbed. Walker and Heath implanted electrodes over the patient's cerebellum that fed stimulants 24 hours per day. effects were fascinating. The The first patient they used was a man who was completely unmanageable. He was institutionalized and spent a great deal of time in a straight jacket so he would not hurt himself or others. He was very strong, and he was slightly retarded. Four weeks after the electrodes were implanted he was able to move back in with his parents. He was home for about three years, and then over Thanksgiving dinner he became very violent and overturned the dining room table. His parents called the police and the patient ended up hurting one of the officers before they could get him under control. When they took an X-ray of this patient's head, they saw that one of the wires from one of the electrodes had come loose. The problem was fixed and he is now working as a busboy in a fast-food restaurant. 58 More than any of his research, Walker is proud of his involvement in developing the Engineering into what it is today. Department of Biomedical He watched it grow from five faculty members and one laboratory into one of the greatest programs in the country. In 1991 when Van Buskirk became Dean of Engineering, Walker took over as Chairman of the Department of Biomedical Engineering. Walker knows the importance of being in line with technological advancements. All of the students, beginning with the class of 1996, own Macintosh laptop computers and the curriculum have been renovated to make full use of that resource. The laptop computers are used in an electronic classroom environment, in the teaching laboratories, and for a broad range of course-related assignments. (Walker, 1994). Biomedical engineering is moving to a cellular level. Biomedical Engineers are trying to figure out ways to re-engineer cells so they'll take on desirable characteristics. For example, if biomedical engineers figure out a way to re-engineering cells to adhere better, they could improve implantation fixation. Walker knows this is the future of biomedical engineering, and he is prepared to make the changes in his curriculum when the time comes. William Van Buskirk feels he has a contribution to make as Dean of the School of Engineering. His goal is to increase the amount of research going on in all of the departments while maintaining the commitment to teaching. He believes that there is no better job in the world than being a professor of Biomedical Engineering at Tulane University. When he feels his work is done as 59 Dean, he would be very pleased to be on the faculty of the department he created. 60 On a personal note: Dr. Walker’s wife, Julie Walker, also works for Tulane. She is the Vice President of Development of Institutional Advancement. They both plan to stay at Tulane until they retire from education. One year, Dr. William Van Buskirk received an endowed chair position. His students all got together and gifted him with furniture polish that they felt sure he would need for his new "chair." Van Buskirk didn't think it was all that humorous, but Reader's Digest did. They published the story in a section about humorous events that happen at college. A man named Max Anliker has played an important part in the development of Tulane Biomedical Engineering's faculty. Anliker was Dr. Cedric Walker's undergraduate adviser at Stanford until 1971. He was William Van Buskirk's dissertation advisor at Stanford until 1970. In 1971, Anliker left Stanford and began teaching at the Swiss Federal Institute of Technology (SFIT). One of the Biomedical Engineering faculty members at Tulane, Dr. Kirk Bundy, attended the SFIT, and Anliker was his dissertation advisor until 1975. Since then, Anliker has sent two of his students to teach at Tulane's Department of Biomedical Engineering. 61 C h a pter 11 Other Contributions There are many, many scientists that have contributed to Tulane's history of Biomedical Engineering. Unfortunately, much of their work and their lives were not recorded. The people featured in this chapter have done great research for Tulane and for Biomedical Engineering; however, the information available about them is limited. Dr. Robert G. Heath and Hal C. Becker worked together at Tulane in the mid 1900's. Heath was a psychiatry and neurology specialist at Tulane Medical Center, and Becker was a Tulane Electrical Engineering graduate. They worked together on a number of projects using various recording methods. Heath did work on electrode recordings relating the brain function to emotion and mapping out centers for the brain's pleasure system, and other emotions like rage and fear. He also explored the pathology behind schizophrenia. Edward Harris was Head of Mechanical Engineering at Tulane from 1977 until 1981. Harris did research on blood cell deformability, craneospinal fluid pressures, shoulder mechanics, head impact models, and kinesiology. Harris died in 1982 at the age of 66. 62 One of Tulane's graduates, Dr. Steve Cook, earned his Ph.D. in 1978 under Dr. Jerry Klawitter's advisement. He stayed on the faculty of Biomedical Engineering for four years, but then he began to work at the Tulane Medical Center. Cook developed a hip implant called the Long-term Stable Fixation hip, or LSF hip. He is still doing research at Tulane Medical Center. 63 On a personal note: Dr. Jerry Klawitter directed Dr. Steve Cook's Ph.D. in 1978. One of Steve Cook's first LSF hip implants went into Klawitter's father. 64 References Arabia, Fransisco: personal communication, April 17, 1995 The Raymond Bailey Collection, Archives Department, HowardTilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Bailey, Raymond: personal communication, April 5, 1995. The Duane Bruley Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Bruley, Duane: personal communication, April 10, 1995. The George Burch Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. The Bob Chambers Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Chambers, Robert: personal communication, April 19, 1995 The Steve Cowin Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Cowin, Steve: personal communication, 1995 The James Cronvich Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Cronvich, James: personal communication, January 16, 1995 65 Deutsch, Hermann, The Tulanian. December 1957. "A great Man's Life" re. Rudolph Matas Dictionary of American Biography. "Matas, Rudolph." Dumas Malone, editor. Charles Soribner's Sons, NY. 1935. ibid. "Riddell, John L." ibid. "Stone, Warren." Duffy, John. The Tulane University Medical Center. Louisiana State University Press, Baton Rouge, 1984. Dyer, John P. Tulane -- The biography of a University 1834-1965. Field, Beatrice M. "Potpourri." August 1983. Greenstein, Steven: personal communication, April 18, 1995 The Robert G. Heath Collection, Archives Department, HowardTilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Heath, Robert: personal communication, March, 1995. The Edward Hooper Harris Collection, Archives Department, HowardTilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. The Samuel Hulbert Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Hulbert, Samuel F.: personal communication, April 10, 1995 Hunt, Thomas, April 2, 1866. "Address on the Utility of Science." The Thomas Hunt Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. 66 The Jerry Klawitter Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Klawitter, Jerry: personal communication, March 9, 1995 The John Martinez Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Martinez, John L.: personal communication, December 9, 1994. Matas, Rudolph. History of Medicine in Louisiana. Volume II. The Rudolph Matas Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. The Rudolph Matas Collection, Manuscripts Department, HowardTilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. The Rudolph Matas Collection, Special Collections Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. New Orleans Times. March 15, 1873. re. Newspaper reprint of the eulogy of Dr. Warren Stone. New Orleans, Louisiana. Rand, Clayton. "They Built Louisiana." 1942. re. Warren Stone. Riddell, John L. New Orleans Monthly Medical Registry. "Binocular Microscope" October, 1852 The John L. Riddell Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. The John L. Riddell Collection, Manuscripts Department, HowardTilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. ibid. "Simplification of the Binocular Microscope" April, 1853. 67 Stone, Warren., New Orleans Medical and Surgical Journal. September, 1859 "Ligature of Common Iliac Artery for Aneurysm." The Warren Stone Collection, Archives Department, Howard-Tilton Memorial Library, Tulane University, New Orleans, Louisiana 70118. Thompson, Hugh Allison: personal communication, April 10, 1995. Times Picayune. December 31, 1955. re. Riddell's prediction on existence of constituent particles of the atom in 1846. Times Picayune. August 22, 1976. "Spare Human Parts to 'Grow' May One Day Be Commonplace." re. Allan Weinstein. New Orleans, Louisiana. Times Picayune. September 25, 1849. re. Stone's use of chloroform. New Orleans, Louisiana. Times Picayune. July 15, 1851. re. Hunt's slaying of John w. Frost Tulane University Bulletin. College of Engineering. "400 Human Engineering." December 15, 1952. Series 53, No. 17. Tulane University of Louisiana. 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"Riddell's Binocular Microscopes: An Historical Notice." 69 Jennifer S. Stearns-Drake has attended Tulane University School of Biomedical Engineering since August of 1991. Born August 7, 1973, she grew up in Boise, Idaho and has attended Miami Dade College in Israel, Boston College, and now, Tulane University. 70
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