glycolate
FIS1
gi-12836616
Isocitrate
urate
PMP22
2-oxoglutarate
URIC
PMP24
5-hydroxyirourate
phytanoyl-CoA
gi-13385290298
palmitoyl-CoA
AMACR
RHO1
squalene
EMP24
zymosterol
cystathionine
STR3
carboxylate
AAT2
glyoxylate
acetyl-CoA
FAT2
fatty-acid
PXA1
PXA2
CoA
FAA2
ATP
(n-2)
acyl(n)-CoA
FAA1
ANT1
FOX3
TES1
fecosterol
CIT2
PMP34
citrate
L-aspartate
NADH
NPY1
NAD
DCI1
FOX2
ECI1
2-trans-(n)enoyl-CoA
FOX1
NADPH
2-oxoglutarate
IDP3
NAD
DCI/EC1
ECHP
cis-enoyl-CoA
3-trans-(n)enoyl-CoA
choloyl-CoA
glycine
BAAT
CTA1
2H2O + O2
glycocolate
PEX14 PEX13
PEX1
PEX10 PEX19 PEX3 PEX26
PEX16
PEX11
Minimal Rat peroxisome
NMNH + AMP
cis-enoyl-CoA
3-trans-(n)enoyl-CoA
SPS19
NADP+
AMP
PEX2
nicotinamite
PNC1
nicotinamide
gi-6679507
GTK1
NADH
2-trans-(n)enoyl-CoA
CAO3
2-oxoglutarate
2H2O2
PEX12
sn-glycerol-3P
GPD1
gi-12002203
PEX7
PEX6
homoisocitrate
LYS4
gi-13929028
AMP
PEX5
L-Lysine
LYS1
homocitrate
O-acetyl-carnitine
beta-ketoacyl-CoA
ATP
OXRTA
FOX2
1-acyl-glycerone-3P
1-alkyl-glycerone-3P
gi-6912418
beta-ketoacyl-CoA
(n-2)
DAPT
gi-13384998
formyl-CoA
acyl(n)-CoA
YGR154C
glycerone-P
CAT2
PTE1
LACS
LCF2
ALDP
L-homocysteine + pyruvate
PCD1
oxidized-CoA
PMP70
squalene-2,3-epoxide
L- saccharopine
(s)-malate
MLS1 MLS2
ERG6
oxaloacetate
MDH3
YMR204C
3',5'-ADP
ERG1
VPS1
fatty-acid
glycerone-P
2-hydroxy-phytanoyl-CoA
pristanal
PTE2B
acetyl-CoA
palmitate
carboxylate
CoA
FOX3
VLACS
pyruvate
succinate
PAHX
sterol
AGT
NADPH
NADP+
IDP3
SCP2
L-alanine
gi-14091775
gi-6754156
glyoxylate
Isocitrate 2-trans-4-trans/cis-(n)enoyl-CoA
2H2O2
CTA1 2H2O + O2
PEX18
PEX5 PEX7
PEX25
YOR084W
PEX15
PEX17
PEX21
PEX11
PEX6 PEX12
PEX30
PEX22
PEX14 PEX4 PEX28
PEX32 PEX19 PEX3
PEX2
PEX8 PEX13
PEX1
PEX10 PEX29 PEX31
PEX27
Minimal Yeast peroxisome
MLS1 MLS2
oxaloacetate
MDH3
(s)-malate
glycolate
glyoxylate
urate
gi-14091775
5-hydroxyirourate
acetyl-CoA
carboxylate
VLACS
CoA
fatty-acid
PXA1
FOX3
TES1
ATP
ANT1
AMP
PEX6
NADH
ECHP
DCI1 cis-enoyl-CoA
ECI1
2-trans-(n)enoyl-CoA
FOX1
3-trans-(n)enoyl-CoA
2-oxoglutarate
IDP3 NADPH
FOX2
(n-2)
NAD
Isocitrate
PEX5 PEX7
Minimal ancestral opisthokont peroxisome
beta-ketoacyl-CoA
acyl(n)-CoA
FAA2
PXA2
URIC
2H2O2
CTA1
NADP+
2H2O + O2
PEX4
PEX14
PEX13
PEX12
PEX1 PEX10 PEX19 PEX3 PEX11
PEX2
glycosomes
PXA1
PXA2
beta-ketoacyl-CoA
FOX2
fatty-acid
ATP
FOX1
acyl(n)-CoA
FAA2
Plant peroxisomes
NADH
NAD
2-trans-(n)enoyl-CoA
AMP
2H2O2
CTA1
2H2O + O2
PEX5
PEX2
PEX1
PEX4 PEX14
PEX10
Minimal ancestral eukaryotic peroxisome
Figure 5