FLUTIANIL
Fungicide
Product name: GATTEN®
－Tokyo, Japan－
IR-4 Food Use Workshop, September 22, 2016
Flutianil, Characteristics
 New chemical group : cyano-methylene
thiazolidine
 Effective in controlling powdery mildew
 Novel Mode of Action against powdery mildew
(FRAC Code U13)
 No Cross-Resistance with other chemical classes
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Regulatory Information
 US
 Reduced risk status granted for all of the proposed crops.
 Anticipated approval: 2017
 Proposed crops: Apple, Cantaloupe, Cherry, Cucumber, Grape, Squash,
and Strawberry
 Japan
 Registered on Eggplant, Cucumber, Pumpkin and Squash,
Watermelon, Melons, Strawberry, and Flowers and Ornamental plants
 Korea
 Registered on Green & Red pepper (Fresh), Strawberry, Watermelon,
Cucumber, Korean melon, and Sweet pepper
 EU
 Under evaluation
 Anticipated registration in 2017
 Proposed crops: Grapes and Flowers and Ornamental plants
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US Label (proposed)
 Type: Fungicide
 Product Name: GATTEN®
 Active ingredient: Flutianil
 Formulation: 5% EC
 Use rate: 0.04 lb ai/acre (0.01-0.05 lb ai/acre global)
 Application: 4-5 times per season, 7 day interval
 PHI: 0-14 days
 Proposed crops: Apple, Cantaloupe, Cherry, Cucumber,
Grape, Squash, and Strawberry
 All granted reduced risk status
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Novel Mode of Action
untreated
Inhibition of
haustorial
formation, and
sporulation
10 mg/L
Flutianil
Conidiophores
The 1.2-leaf stages of cucumber plants that were inoculated
with Podosphaera xanthii 7 d before a flutianil application were
observed in a low-temperature cryofixation electron
microscope
Haustorium
The 1.2-leaf stages of barley that were inoculated with Blumeria
grainis f.sp. hordei 7 days before a flutainil application and
stained with lactophenol trypan blue, at 3 d after fungicide
application and observed under a microscope. Bars=50 µm
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Novel Mode of Action
untreated
Actin disruption
and abnormal
nuclei were
observed
10 mg/L
Flutianil
conidiophores
Nuclei
distribution
conidiophores
Hyphae
Actin organization
The 1.2-leaf stages of barley that were inoculated with B. grainis f.sp. hordei 7
days before a flutainil application and stained with DAPI or rhodaine phalloidin,
at 3 d after fungicide application and observed under a microscope.
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Erysiphe necator on Chardonnay Grape
Control Value
100
Effective at Low Dose
80
Leaves
60
Bunches
Leaves
40
Bunches
20
0
Flutianil
(0.01 lb
ai/acre)
•
•
•
•
Flutianil
(0.02 lb
ai/acre)
Flutianil
(0.04 lb
ai/acre)
A fungicide
(0.06 lb
ai/acre)
B fungicide
(0.11 lb
ai/acre)
Location: Italy
Four applications, targeted for every 10 days until color change
Assessment was determined at 11 (leaves) and 10 (bunches) days after the last application
Application: 1 – 6/28/11, 2 – 7/9/11, 3 – 7/20/11, 4 – 7/31/11
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Erysiphe necator on Tempranillo Grape
Control value
100
Effective at Low Dose
80
Leaves
60
Bunches
Leaves
40
Bunches
20
0
Flutianil
(0.01 lb
ai/acre)
•
•
•
•
Flutianil
(0.02 lb
ai/acre)
Flutianil
(0.04 lb
ai/acre)
A fungicide
(0.06 lb
ai/acre)
B fungicide
(0.11 lb
ai/acre)
Location: Spain
Four applications made every 7-10 days. Applications were started late in the season when bunches
were already formed.
Assessment was determined at 12 (leaves) and 8 (bunches) days after the last application
Application: 1 – 7/7/11, 2 – 7/15/11, 3 – 7/27/11 and 4 – 8/4/11
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Podosphaera xanthii on Leaves of Yellow Squash
100
Effective at Low Dose
Control value
80
60
40
20
0
Flutianil
Flutianil
Flutianil
A fungicide
C fungicide
(0.01 lb ai/acre) (0.02 lb ai/acre) (0.04 lb ai/acre) (0.10 lb ai/acre) (0.25 lb ai/acre)
•
•
•
•
Location: Raleigh, NC
Five applications targeted at 7 days intervals
Assessment was determined at 7 days after the last application
Application: 1 - 7/27/2011, 2 - 8/3/2011, 3 - 8/10/2011, 4 - 8/17/2011, 5 - 8/24/2011
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Sphaerotheca fuliginea on Squash
0.03 lb ai/acre Flutianil
•
•
•
untreated
Location: Tokushima, Japan, OAT AGRIO
One application targeted, Assessment was determined at 25 days after application
Application: 1 - 6/18/2012
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Thank you
－Tokyo, Japan－
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