Biology 3/10/17
Do Now
Do in Class
Please pick up the
DNA to Disease
handout. Take out
your Mutations
handout
Mutations handout – class Use your Mutations
assignment to add notes to
discussion/review
8:15-9:28- 1st Period
9:35- 10:48- 2nd Period
10:55-12:08- 3rd Period
12:08-12:38 Lunch
12:45- 1:58- 4th Period
1:58-2:10 Walk to rally
2:10-3:00- Rally
DNA to Disease
3/15/17 – last day
to turn in missing
assignments from
quarter 3
Do at Home
your lab notebook. Be sure
to include types of
mutations and potential
outcomes
Complete any of your DNA to
Disease assignment that is
not finished
Test: 3/16/17
Topic: DNA
structure/replication; Protein
synthesis; Mutations
VAL
stop
GLU
Sickle cell anemia
• Hemoglobin protein in red blood cells
• strikes 1 out of 400 African Americans
• limits activity, painful & may die young
Normal
round cells
Misshapen
sickle cells
Only 1 out of
146 amino acids
Old codon
New codon
New codon
Old codon
Salt channel
Effect on Lungs
normal lungs
airway
salt channel
salt
normal mucus
H 2O
cells lining
lungs
cystic fibrosis
salt
H 2O
transports salt through protein
channel out of cell
Osmosis problems!

thick mucus
mucus & bacteria build up
= lung infections & damage
mRNA Codon Charts