Brigham Young University
BYU ScholarsArchive
All Theses and Dissertations
2013-03-15
Evidences for Protein-Protein Interactions Between
PstB and PhoU in the Phosphate Signaling
Complex of Escherichia coli
Kristine Dawn Johns
Brigham Young University - Provo
Follow this and additional works at: http://scholarsarchive.byu.edu/etd
Part of the Microbiology Commons
BYU ScholarsArchive Citation
Johns, Kristine Dawn, "Evidences for Protein-Protein Interactions Between PstB and PhoU in the Phosphate Signaling Complex of
Escherichia coli" (2013). All Theses and Dissertations. Paper 3932.
This Thesis is brought to you for free and open access by BYU ScholarsArchive. It has been accepted for inclusion in All Theses and Dissertations by an
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TABLE OF CONTENTS
TITLE PAGE««««««««««««««««««««««««««««««««««««««««««««««««««i
ABSTRACT«««««««««««««««««««««««««««««««««««««««««««««««.««««ii
TABLE OF CONTENTS ............................................................................................................................................ iii
LIST OF TABLES......................................................................................................................................................... v
LIST OF FIGURES ......................................................................................................................................................vi
INTRODUCTION ......................................................................................................................................................... 1
Two-component signaling .........................................................................................................................................2
Histidine Kinases ....................................................................................................................................................... 2
Extracellular domain ..............................................................................................................................................3
Cytoplasmic domain ..............................................................................................................................................4
Response Regulators ..................................................................................................................................................5
REC domain .......................................................................................................................................................... 5
Effector domain ..................................................................................................................................................... 6
ABC Transporters ...................................................................................................................................................... 7
Transmembrane domain ........................................................................................................................................8
Nucleotide-binding domain ...................................................................................................................................8
Conformational changes ........................................................................................................................................9
The Pho Regulon ....................................................................................................................................................... 9
The two-component system, PhoR-PhoB ................................................................................................................ 10
PhoB ± Response Regulator (RR) ....................................................................................................................... 10
PhoR ± Sensory Histidine Kinase (HK)............................................................................................................... 11
The ABC transporter, PstSCAB2 ............................................................................................................................. 12
TMD- PstA and PstC ........................................................................................................................................... 12
NBD- PstB dimer................................................................................................................................................. 13
PhoU involvement in signal transduction ................................................................................................................ 13
MATERIALS AND METHODS ................................................................................................................................ 16
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