Alkyl-lipids: biomolecules as a source of
inspiration to design modulators of ion
channels involved in metastatic processes.
Chemists
C. Sevrain, H. Couthon-Gourvès, J.P. Haelters, M. Berchel, P.A. Jaffrès
Biologists M. Gueguinou, A. Chantôme, M. Potier-Cartereau, C. Vandier
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Alkyl-lipids: biomolecules as a source of
inspiration to design modulators of ion
channels involved in metastatic processes.
Chemists
C. Sevrain, H. Couthon-Gourvès, J.P. Haelters, M. Berchel, P.A. Jaffrès
Phosphorus Chemistry
Lipid chemistry
Gene delivery
Bactericides
Ion channel inhibitors
SK3 channel
Brest – Orléans – Rennes
Nantes - Paris
Platform
Vectorization
http://www.univ-brest.fr/synnanovect
Tours - Brest
New drugs inspired
from marine molecules
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Alkyl-lipids: biomolecules as a source of
inspiration to design modulators of ion
channels involved in metastatic processes.
Alkyl-lipids (or Ether lipids)
Discovery in 1922 (Tsujimoto & Toyama) [1]
Compounds present in Chondrichthyes class of fishes (shark liver oil),
Characterized by an ether linkage at the sn-1 position of the glycerol.
Ohmline : an original alkyl-lipid
synthesized in 9 steps.
Ohmline : Action on SK3 ion channels that are implicated in cell migration and metastasis formation.
Reduction of ion current (Patch clamp measurements)
Reduction of cell migration
In vivo-model : reduction of the occurrence of metastases
SK3 ion channel
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