Downloaded from http://bmjopen.bmj.com/ on June 16, 2017 - Published by group.bmj.com PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf) and are provided with free text boxes to elaborate on their assessment. These free text comments are reproduced below. ARTICLE DETAILS TITLE (PROVISIONAL) AUTHORS Differences in predictors of permanent work disability between immigrants and natives – a cohort study of adults with sick leave due to common mental disorders Werlen, Laura; Helgesson, Magnus; Mittendorfer-Rutz, Ellenor VERSION 1 - REVIEW REVIEWER REVIEW RETURNED Blanca Reneses Institute of Psychiatry and Mental Health. Institute of Research (IdISSC). San Carlos University Hospital. Complutense University. Madrid. Spain 02-Dec-2016 GENERAL COMMENTS The manuscript is well written, the objectives are clear and the methodology correct. The results are adequately discussed and the conclusions are accurate. REVIEWER Billy Gazard King's College London, Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, 10 Cutcombe Road, London, UK 03-Jan-2017 REVIEW RETURNED GENERAL COMMENTS This paper makes use of rich data from a complex data linkage in order to investigate differences in the predictors of permanent work disability in migrant and non-migrant groups who have had sick leave due to common mental disorder. Overall, the paper is well written and the paper‟s use of appropriate data sources to address its aims make a novel and important contribution to the literature. However, the study has been designed to investigate differences between what the authors describe as „western‟ and non-western‟ immigrant groups which presents a number of problems that are not fully addressed in the paper. My main concern is that there is no justification for grouping migrants in such a way and that this division may mask the real reason for differences such as „reason for migration‟. As the authors states, the „non-Western‟ group consists mainly of refugees and relatives seeking reunification. This sentence also suggests that they have data on „reason for migration‟ that could be incorporated into the analysis. The rest of the analysis is sound, however, I would like to see this main concern addressed before publication as well as some other specific suggestions as outlined below: 1. Introduction Downloaded from http://bmjopen.bmj.com/ on June 16, 2017 - Published by group.bmj.com Page4Line25-26; references 9-11 refer to studies in Sweden only. Please make this clear or include international references (which are more mixed in terms of the findings on this association). Page4Line 52; the author states that pathways to permanent disability may vary in migrant groups by country of birth/reason for migration. Could you add a sentence on this giving more detail e.g. which country of birth/reasons for migration and how? When expanding on this I would like to see a justification for grouping migrants as „Western‟ and „non-Western‟. 2. Methods Page7Line14-16; The author states that „non-Western‟ migrants consist mainly of refugees and relatives seeking reunification. Does this mean that you have data on reason for migration? If so, why has this not been incorporated into the analysis and presented in tables? Given the higher risk of CMD symptoms in refugees I would like to see this incorporated into the study design if possible. 3. Discussion Page16Line41-43; You state that the differences in morbidity measures could be interpreted as differences in symptom severity but do not discuss why. What role does „reason for migration‟ play here? Surely, one explanation could be due to the proportion of refugees in this grouping? Page17Line30-34; the sentence suggests that differences in the culture of migrants as an explanation for differences in access to labour markets etc. Another possible explanation in the research literature is that migrants experience more discrimination in the labour market (See Hatch, S. L., et al. "Discrimination and common mental disorder among migrant and ethnic groups: findings from a South East London Community sample." Social psychiatry and psychiatric epidemiology 51.5 (2016): 689-701). What role does discrimination based on ethnicity and first language add to this relationship given the differences for „non-Western‟ migrants? Page18Line23; Again, what about the role of discrimination and responses to discrimination in this process (e.g. avoidance of health services) Page18Line32-34; Too little attention given to this limitation. You have acknowledged the limitation but could this not be addressed by using reason for migration as a variable in the analysis? VERSION 1 – AUTHOR RESPONSE 1. Introduction Page4Line25-26; references 9-11 refer to studies in Sweden only. Please make this clear or include international references (which are more mixed in terms of the findings on this association). A: We have clarified that the stated relationship refers to conditions in Sweden and Denmark (Page 4, Line 25). Page4 Line 52; the author states that pathways to permanent disability may vary in migrant groups by country of birth/reason for migration. Could you add a sentence on this giving more detail e.g. which country of birth/reasons for migration and how? When expanding on this I would like to see a justification for grouping migrants as „Western‟ and „non-Western‟. Downloaded from http://bmjopen.bmj.com/ on June 16, 2017 - Published by group.bmj.com A: Thank you for this comment. We have removed “reason for migration” to be more consistent with the study aim (Page 4, Line 52). We have also added a sentence on differences between countries of birth and subsequent pathways to disability pension (Page 4, Lines 52-57). The reason for dividing immigrants in Western and non-Western immigrants was to highlight differences in the reasons for migration. Western migrants mostly consist of voluntary immigrants, i.e. labour migrants while nonwestern immigrants are more likely to be refugees or kin to refugees who more or less have been forced to leave their birth country due to war and conflicts. 2. Methods Page7Line14-16; The author states that „non-Western‟ migrants consist mainly of refugees and relatives seeking reunification. Does this mean that you have data on reason for migration? If so, why has this not been incorporated into the analysis and presented in tables? Given the higher risk of CMD symptoms in refugees I would like to see this incorporated into the study design if possible. A: As the reviewer points out, there are a number of reasons to divide migrants regarding ground for settlement. As we in our dataset unfortunately do not have data on ground for settlement, our reasoning for dividing immigrants into Western and non-Western immigrants was to find a proxy for ground for settlement. Based on statistics from Statistics Sweden one can see that refugees and relatives seeking reunification build the outmost largest share of immigrants to Sweden from outside the Western World. From Asia, 21,890 refugees, (mostly Syrian, 17,601 persons), 22,823 relatives seeking reunification (much more divided into several countries) and 10,870 labour migrants (India (3,443), Thailand (3,033), China (1,337) Syria (780), Iran (446), Pakistan (237) etc.) immigrated to Sweden in 2014 according to Swedish Migration Agency. Labour migrants came mostly from. From Africa, 8,811 refugees, 7,515 relatives seeking reunification and 516 labour migrants immigrated to Sweden in 2014 (https://www.migrationsverket.se/English/About-the-Migration-Agency/Facts-andstatistics-/Statistics/Overview-and-time-series.html). We have now more clearly stated the reason for dividing migrants into Western and Non-Western countries in the manuscript (Page 4, Lines 47-57, Page 5, Lines 3-10). We have also stated more clearly that the division into Western and nonWestern immigrants might be prone to some limitations (Page 19, Lines 34-41). In the methods part, this information was taken out in order to limit misunderstanding (Page 7, Lines 18-25). 3. Discussion Page16Line41-43; You state that the differences in morbidity measures could be interpreted as differences in symptom severity but do not discuss why. What role does „reason for migration‟ play here? Surely, one explanation could be due to the proportion of refugees in this grouping? A: We agree that one explanation could be the proportion of refugees in this group. Therefore, we have added a sentence regarding refugees in this section (Page 17, Lines 41-43). Page17Line30-34; the sentence suggests that differences in the culture of migrants as an explanation for differences in access to labour markets etc. Another possible explanation in the research literature is that migrants experience more discrimination in the labour market (See Hatch, S. L., et al. "Discrimination and common mental disorder among migrant and ethnic groups: findings from a South East London Community sample." Social psychiatry and psychiatric epidemiology 51.5 (2016): 689701). What role does discrimination based on ethnicity and first language add to this relationship given the differences for „non-Western‟ migrants? A: As the reviewer points out, discrimination might be an underlying reason for difficulties among immigrants to enter the labour market. Studies report that problems on the labour market are greater among migrants from countries where the cultural distance to the host country is wide and discrimination may be a factor leading to these problems. We have added a sentence regarding the Downloaded from http://bmjopen.bmj.com/ on June 16, 2017 - Published by group.bmj.com role of discrimination in the manuscript and added additional references – including the one suggested (Page 18, Lines 34-36). Page18Line23; Again, what about the role of discrimination and responses to discrimination in this process (e.g. avoidance of health services) A: We have added a sentence regarding discrimination also here, avoidance of health care may be multifactorial and discrimination of different kinds might play a role (Page 19, Lines 25-27). Page18Line32-34; Too little attention given to this limitation. You have acknowledged the limitation but could this not be addressed by using reason for migration as a variable in the analysis? A: We have now clarified as a limitation in the manuscript that we do not have data on ground for settlement (Page 19, Lines 34-41). Please revise your title so that it includes your study design. This is the preferred format for the journal. A: We have, in the title, stated that the study is a cohort-study (Page 1, Lines 3-5). VERSION 2 – REVIEW REVIEWER REVIEW RETURNED GENERAL COMMENTS Billy Gazard King's College London, UK 15-Feb-2017 The authors have addressed my concerns regarding the categorization of migrant groups and have modified the manuscript accordingly. Their additions to the paper have made the justification for grouping migrants in the way that they did clear while also addressing this as a limitation of the study. Downloaded from http://bmjopen.bmj.com/ on June 16, 2017 - Published by group.bmj.com Differences in predictors of permanent work disability between immigrants and natives: a cohort study of adults with sick leave due to common mental disorders Laura Werlen, Magnus Helgesson and Ellenor Mittendorfer-Rutz BMJ Open 2017 7: doi: 10.1136/bmjopen-2016-014431 Updated information and services can be found at: http://bmjopen.bmj.com/content/7/3/e014431 These include: References This article cites 22 articles, 4 of which you can access for free at: http://bmjopen.bmj.com/content/7/3/e014431#BIBL Open Access This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. 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