第 25 回仙台シンポジウム Poster 発表要旨
Monodispersed PEG:
building block for functional amphiphilic molecules
Adam Wawro, Takahiro Muraoka, Kazushi Kinbara
（IMRAM, Tohoku Univeristy）
Poly(ethylene glycol)s (PEGs) are hydrophilic polymers that have been extensively studied for
the last several decades. Due to their solubility in both water and organic solvents, chain
flexibility and low toxicity, PEGs have found numerous applications in material science,
chemical biology and chemistry, including medical, surface and supramolecular chemistry.
PEGs are widely available in a polydispersed form, i.e. as mixture of molecules of various
lengths with average molecular weight given. However, in many cases, especially in structural
studies and in syntheses of well-defined, tailored compounds, monodispersed oligomeric PEGs
are indispensable.
One of the fields in which PEGs attracted serious attention is chemistry of biological
macromolecules. Although PEGs interaction with proteins are widely utilized, e.g. for protein
precipitation, thermal stabilization, protein refolding and as suppressors of non-specific
protein adsorption, the interaction at the molecular level has not been fully understood yet.
Our interest is focused on well-defined amphiphilic derivatives of PEG, consisting of
hydrophilic polymer chain and relatively small hydrophobic moiety, such as phenyl group. This
kind of bifunctional PEG may interact with proteins in a more efficient way than conventional
hydrophilic PEGs.
＜参考文献＞
1）Muraoka, T., Kinbara, K. et al., Angew. Chem., Int. Ed. 2013, 52, 2430-2434 (VIP)
2）Sadhukhan, N. et al., Chem. Lett., in press, DOI: 10.1246/cl.140241
3）Muraoka, T. et al., Biochem. Eng. J. 2014, 86C, 41-48
発表者紹介
氏名
Adam Wawro （アダム
所属
東北大学
学年
D1
研究室
金原研究室
ヴァヴロ）
多元物質科学研究所