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**
**
V.cholerae VC0512
V.cholerae VCA1034
V.cholerae VCA0974
V.cholerae VCA0068
**
V.cholerae VC0825
*
V.cholerae VC0282
V.cholerae VCA0906
V.cholerae VCA0979
V.cholerae VCA1056
V.cholerae VC1643
V.cholerae VC2161
V.cholerae VCA0923
**
V.cholerae VC0514
**
V.cholerae VC1868
V.cholerae VCA0773
V.cholerae VC1313
V.cholerae VC1859
V.cholerae VC1413
V.cholerae VCA0268
V.cholerae VCA0658
**
V.cholerae VC1405
V.cholerae VC1298
*
V.cholerae VC1248
V.cholerae VCA0864
V.cholerae VCA0176
V.cholerae VCA0220
**
V.cholerae VC1289
V.cholerae A1069
**
V.cholerae VC2439
V.cholerae 1967
V.cholerae A0031
V.cholerae VC1898
V.cholerae VCA0663
V.cholerae VCA0988
V.cholerae VC0216
V.cholerae VC0449
*
V.cholerae VCA0008
V.cholerae VC1406
V.cholerae VC1535
V.cholerae VC0840
B.subtilis gi2633766
Synechocystis sp. gi1001299
Synechocystis sp. gi1001300
*
Synechocystis sp. gi1652276
*
Synechocystis sp. gi1652103
*
H.pylori gi2313716
** H.pylori 99 gi4155097
**
C.jejuni Cj1190c
C.jejuni Cj1110c
A.fulgidus gi2649560
** A.fulgidus gi2649548
B.subtilis gi2634254
B.subtilis gi2632630
B.subtilis gi2635607
B.subtilis gi2635608
B.subtilis gi2635609
** **
**
B.subtilis gi2635610
B.subtilis gi2635882
E.coli gi1788195
E.coli gi2367378
**
E.coli gi1788194
*
E.coli gi1787690
V.cholerae VCA1092
V.cholerae VC0098
E.coli gi1789453
H.pylori gi2313186
99 gi4154603
** H.pylori
C.jejuni Cj0144
C.jejuni Cj1564
** C.jejuni Cj0262c
**
C.jejuni Cj1506c
H.pylori gi2313163
*
** H.pylori 99 gi4154575
H.pylori gi2313179
**
** H.pylori 99 gi4154599
C.jejuni Cj0019c
C.jejuni Cj0951c
C.jejuni Cj0246c
B.subtilis gi2633374
T.maritima TM0014
V.cholerae VC1403
V.cholerae VCA1088
T.pallidum gi3322777
T.pallidum gi3322939
T.pallidum gi3322938
** **
B.burgdorferi gi2688522
T.pallidum gi3322296
B.burgdorferi gi2688521
*
** T.maritima TM0429
T.maritima TM0918
** T.maritima TM0023
T.maritima TM1428
*
T.maritima TM1143
T.maritima TM1146
P.abyssi PAB1308
P.horikoshii gi3256846
**
P.abyssi PAB1336
**
** P.horikoshii gi3256896
**
P.abyssi PAB2066
P.horikoshii gi3258290
**
*
P.abyssi PAB1026
P.horikoshii gi3256884
**
D.radiodurans DRA00354
D.radiodurans DRA0353
**
**
D.radiodurans DRA0352
V.cholerae VC1394
P.abyssi PAB1189
P.horikoshii gi3258414
**
B.burgdorferigi 2688621
M.tuberculosis gi1666149
V.cholerae VC0622
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© 2000 Macmillan Magazines Ltd
!+0
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© 2000 Macmillan Magazines Ltd
91
1049
5
281
448
2
757
451
954
955
459
572
574
12
8
964
1063
863
772
12
575
5
965
679
468
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576
470
773
680
300
106
14
2742
969
1067
Amino acid biosynthesis
774
472
681
16
474
1068
971
865
776
578
972
777
1069
10
9
581
778
202
2175
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481
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310
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208
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5s rRNA
16s rRNA
687
1073
781
872
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23s rRNA
9
587
977
588
8
873
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3
978
22
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12
590
979
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876
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328
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Repeat region
Three tRNAs
1075
980
875
24
117
9
Membrane protein
1077
982
496
1078
983
786
593
12
119
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877
692
213
25
4
2278
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564
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384
563
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288
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467
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2141
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1853
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80
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1486
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1852
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174
1309
1214
1401
13
5
1023
830
737
648
558
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284
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1123 1124 1125
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1039
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654
79
172
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376
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557
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283
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1122
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828
556
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374
1580
1939
1658
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270
425
1038
937
11
744
78
2714
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1485
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1754
1938
460
282
927
92
186
1121
1850
1579
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1937
827
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423 424
936
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269
2233
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1936
2713
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373
91
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11
185
372
90
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1118 1119
1935
2337
652
843
740
420
169
549
419
268
168
825
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1575
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10
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455
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184
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10
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923
552
730
2031
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2131
13
280
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13
1934
1845
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922
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728
551
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1933
9
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737
648
416
74
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415
266
165
545
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265
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544
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16Sf
410
2708
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261 262
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RNasePRNA
2127
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1746
1652
1391
1301
14
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2
822
1014
920
640
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725
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634
2222
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729
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537
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544
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2604
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536
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253
396
155
9
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2019
1923
1833
1562
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175
354
1105
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818
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633
543
353
269
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4
1002
542
445
73
632
268
720
350
173
6
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444
267
2116
2491
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2602
2402
2018
1921
1831
1735
1645
1560
1463
1379
719
631
1001
1102
9
911
815
2115
825
727
635
532
395
250
154
2601
1114
634
152
726
915
823
725
63
249
391
151
2600
2489
2401
2113
2016
2017
1732
1644
1377
1101
349
540
5
72
172
6
266
443
1198
718
1000
814
630
539
5
442
265
348
1828
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2320
2700
2111
2215
2400
1827
1460
1376
71
171
441
70
910
999
1291
9
1558
2015
632 633
248
822
724
631
5
6
2488
10
2110
2014
1730
538
717
813
1197
1099
1643
1290
1196
909
715
439
440
69
264
12
346
170
537
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1826
150
913
630
247
61
5
438
1375
1098
2487
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10
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1641
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812
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2012
2108
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260
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242
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2695 2696
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342
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2009
2483
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240
1821
64
166
258
624
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1287
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146
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63
532
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165
807
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432
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10
2008
2210
2590
239
17
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2481
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2100 2101
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1911
1820
1722
1549
1286
1371
62
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5
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901
806
530
431
341
254
1635
1186
1092
6
1548
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2692
2308
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61
164
1285
1370
1721
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2007
1909
2307
2774
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812
712
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371
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2773
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803
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528
252
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710
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523
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2004
1632
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10
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9
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801
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621
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339
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7
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13
251
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141
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799
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337
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2000
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363
616
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229
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361
136
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2469
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2205 2206 2207
228
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360
1093 1094
358
227
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2295
2089
1180
16Sa
23Sb
704
618
13
894
247
335
796
423
518
988
617
5
246
1277 1278
1808
1998
1902
1628
1362
1714
1807
795
1
58
334
12
57
703
893
1085
987
616
422
333
245
56
16Sb
1276
1539
11
8
1179
1997
1627
1901
2568
135
2467
8
2203
11
2681
2762
1361
1806
12
2088
1995
1805
2567
2466
2384
2566
8
1450
8
794
892
702
517
332
421
1084
1178
55
244
986
701
615
1
793
1275
13
54
159
1536 1537 1538
2294
2202
1092
225
133
6
8
2565
2465
2383
2293
2087
1994
1083
890
331
243
1177
1360
1274
1713
1900
1803
1712
5
1359
1273
1625
356
517
132
355
39
2761
12
1081
985
9
700
52
158
516
614
330
51
792
420
242
889
1174
1448
7
2201
2464
2382
6
5
1899
2292
2564
2678
2760
2563
2463
2198
2086
1993
1800
1711
1534
1358
1272
1173
1079
2291
1533
1447
1624
791
698
613
157
50
515
984
49
241
888
983
329
48
1271
1172
981
1270
2380
8
790
697
1077
1898
1799
2759
351
514
802
703
8
606
350
36
2677
5
1532
1269
156
514
419
886
612
240
47
1354
1076
1171
2197
2562
129
8
2461
696
788
980
2085
2289
2378
2676
2758
702
2675
2561
2460
2377
2196
2084
1992
1623
1446
418
884
1075
1710
1798
1991
1896
2287
2195
34
1622
1529
1268
1170
8
787
695
5
513
46
154
417
239
979
416
611
1353
1797
2083
8
221
346
604
127
2757
345
11
2674
2560
2459
2286
2194
2082
1990
1621
45
153
1074
881
786
1169
977
1445
1267
1527
11
1894
2458
33
8
220
124
2756
2673
2559
2193
2081
1989
1893
1794
1709
1526
5
1266
1168
880
5
152
238
415
9
44
694
610
512
328
237
151
12
1073
976
1350
1444
2285
693
43
784
236
975
1525
1987
2755
602
1167
1892
2456
32
11
876
2376
2558
341
123
2671
2557
11
1084
601
699
2670
16Sh
2454
12
1986
7
11
150
692
974
1265
1524
1791
2283
2080
2191
1985
1890
1523
1442
12
973
783
1708
1166
1349
1264
1071
1706
8
875
608
414
327
235
42
509 510
326
149
691
234
41
508
325
148
972
690
607
1789
2555
3
8
1889
2282
793
30
1083
792
600
337
29
697
1082
2554
2668
5
2374
2281
2190
1788
324
413
506
1441
1522
1263
1165
7
40
233
781
1070
873
606
1620
1439
1984
508
218
599
28
2553
2453
2280
8
1888
1786
1704
1438
1348
1521
7
1069
780
689
605
505
412
323
147
39
232
322
411
1164
971
870
779
1261
12
2666
23Sh
334
217
688
12
503
410
146
37
231
321
6
409
1163
2188
2552
2279
596
11
882
789
27
120
1347
2077
8
144
SRPRNA
13
604
408
4
778
9
1983
1887
1784
1703
1437
1346
1260
1162
36
230
970
687
1067
7
505
694
504
880 881
788
12
331
595
214
1079
693
501
330
2664
5Sh
2550
2452
2187
2373
2549
12
2075
1701
1520
1259
5
869
969
407
502
320
229
142
777
9
406
1980 1981
2662
16Sg
2451
16
2074
2548
2661
1783
1886
1979
2277
1782
1435
6
1345
1066
5
1161
685
35
140
501
319
228
139
34
776
8
968
1619
1519
1434
1344
1698
1618
11
1697
592
118
2660
13
2276
2073
2450
2371
2185
Rho-ind. terminator
784
325
690
6
493
23
9
2657
2547
2448
23Sg
2184
2274
2370
2183
1433
1258
1160
1064
1517 1518
1978
1781
1885
1977
5
1779
1884
6
1343
1617
1432
1695
1615
1431
1516
1257
1159
775
684
603
500
405
318
227
33
137
683
499
317
225
1063
866
498
965
5
136
32
404
774
1062
682
602
315
224
135
496
403
1158
1061
964
864
773
495
223
5Sc
1
134
1342
2072
1976
1778
1614
1515
1430
211
689
491
322
116
1157
1060
2656
5Sg
1
1074
783
589
688
782
210
318
21
494
402
7
31
222
963
863
1883
1777
2273
2447
2751
490
2369
2272
2182
2070
681
1341
1693
1429
1256
1882
1975
2181
7
1776
2545
2655
2446
115
317
2750
485 486 487
Other RNA
1072
975
871
686
2544
2654
316
114
2653
2368
2271
2180
2069
1974
1880
12
601
772
221
23Sc
1156
1612
1340
1513
1611
1692
10
1775
1610
6
30
132
493
1059
962
1155
1058
1428
1154
400
861 862
771
29
220
680
131
11
492
399
1255
1427
1339
2270
1973
2445
207
586
113
5
313
11
585
483
16
780
584
311
205
112
19
2749
2542
2651
2444
2541
2649
2443
2365 2366
2269
6
1879
1774
2179
1690
1972
5
2068
2178
2267 2268
2067
1773
1689
1878
1512
1609
7
6
1426
1253
1153
1056
961
770
6
600
491
2
860
28
217
678
859
16Sc
130
960
858
1152
959
857
769
677
597
490
1511
1425
1608
6
1338
1252
8
216
398
27
1054
7
9
596
1151
856
958
1971
1772
685
583
870
1607
1509
1424
1250
2748
309
204
111
1053
312
129
676
595
397
215
1150
2176
2647
18
779
582
479
2747
12
2442
11
2364
26
128
768
1688
2266
2066
1970
12
2265
684
308
2538
110
867
580
476
2064
2441
17
2746
307
201
683
475
8
2537
2646
2174
2363
109
2440
2262
2536
200
108
1 Kb
303
2744
2645
2362
2172
2063
1968
1877
9
1508
1423
1337
675
396
957
594
1249
1606
1687
309
489
855
1149
1507
1050
767
674
6
395
213
127
214
23 24
126
593
1875
1771
1686
10
1336
1506
1422
1685
1874
1967
1148
956
1248
854
6
22
673
7
308
592
488
212
125
1049
21
1335
1505
1605
1684
1504
1421
1246
766
853
672
591
394
307
211
1048
1147
954
682
1683
1604
1503
2535
15
107
199
864
301
2743
Conserved hypothetical
1062
963
862
769
678
465
299
198
2741
2644
2534
2171
2439
No database match
962
768
676 677
197
13
2740
2643
2360
2261
12
2062
1966
Protein fate/protein synthesis
1060
767
294
196
463 464
195
104
2532
2642
5
2260
2168
2061
11
1770
1682
5
1603
1419
1334
1873
1245
6
487
590
306
210
20
1420
953
852
764
671
589
12
122
1047
1333
11
486
Other categories
1059
961
860
766
675
573
460
293
194
103
2739
2531
2359
2438
2358
2259
2166 2167
1681
1872
1965
1502
12
1244
1602
7
1418
2060
1769
1964
2058 2059
2258
1601
1242
9
1145
951
305
209
393
851
763
668
208
1332
849
587
1046
950
848
1680
1871
13
667
304
485
392
19
Transport and binding proteins
1058
765
674
193
291
9
12
9
2641
2529
6
1501
1962 1963
2257
2164
2057
2437
2356
2256
7
1679
1869
1768
1330
1417
1600
1870
1329
1599
5
1144
1239 1240
1044
9
762
tmRNA
586
1045
761
949
847
585
483
207
120
Regulatory functions
1057
859
764
960
458
571
673
290
11
102
2528
7
2
2056
1960
1678
1500
5
1238
948
760
665
583
391
11
18
Transcription
457
288
192
101
2738
2638
6
7
2255
2162
2055
1959
2436
2524 2525 2527
2637
1767
9
1416
1598
1868
2355
14
1328
7
1237
1043
303
482
206
119
16
Nucleotides
958
856
763
671
191
9 10
2254
15
2053
1675
2353
2434 2435
2736
1499
1597
1956
5
1327
1236
1141
1042
846
759
5
204
118
Fatty acid and phospholipid metabolism
1056
855
568
455
287
100
2636
2523
2433
2352
9
2161
2052
2253
1955
1867
1766
1498
1674
10
1415
1325
1235
1041
481
582
947
664
480
14
203
15
117
DNA metabolism
854
957
669
762
12
567
454
190
99
8
2734
2522
10
2432
2159 2160
2051
9
1866
11
1596
1497
1414
1140
1040
581
390
302
758
9
19
116
14
Energy metabolism
1055
853
1
14
189
98
7
2733
2520
2350
2252
2635
2157
2431
2349
286
2519
285
956
6
566
284
186
97
2634
2156
2251
2049
1953
1765
1673
1595
1323
1139
944
663
478
202
115
580
943
757
579
845
662
942
756
11
12
477
13
114
201
300
113
578
389
1234
1496
1138
1039
941
661
576
577
299
1
12
Central intermediary metabolism
1054
2348
2250
1865
1413
1594
1321
1495
2048
1137
1232
1038
1136
112
200
476
755
5Sd
111
Cellular processes
1053
5
453
667
4
2047
1952
12
1672
2517 2518
2732
760
565
852
283
96
3
1231
1593
1411
2153
2430
1135
940
5
575
660
298
844
753
939
574
475
5
10
Biosynthesis of cofactors, prosthetic groups, and carriers
1052
851
8
666
758
564
450
183
759
2731
95
2347
2249
2631 2632 2633
2514
2346
2248
843
9
1037
9
1764
1671
2046
2152
2045
1494
12
1229
1592
1864
1410
1951
1863
1763
1670
1591
1320
199
9
Cell envelope
1051
9
449
282
94
952
850
1050
951
756
13
665
182
92
563
447
5
949
663
181
1
2428
2729 2730
2630
2727
2513
2427
2510 2511
2426
2345
1036
8
23Sd
938
752
659
573
842
474
296 297
198
108
5 6 7
1134
841
937
1228
1319
1133
2247
1862
1762
1409
1226
936
2
5
570 571
295
4
749 750 751
658
473
840
568
2628 2629
2425
6
2344
2246
2146
2043
1950
196
16Sd
106
1590
1318
1132
1035
748
293
9
1861
1761
1669
1492
1408
1224
935
839
2145
2245
2042
1860
1760
567
195
7
747
1317
1589
3
105
656 657
1034
1407
12
934
838
746
655
386
472
566
385
194
291
1 2
103
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