Principles of
ANATOMY &
PHYSIOLOGY
13th Edition
Gerard J. Tortora
Bergen Community College
Bryan Derrickson
Valencia Community College
John Wiley & Sons, Inc.
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ISBN 13 978-0470-56510-0
ISBN 13 978-0470-91777-0
Printed in the United States of America.
10 9 8 7 6 5 4 3 2 1
HELPING TEACHERS
AND STUDENTS
SUCCEED TOGETHER
An anatomy and physiology course can be the gateway to a gratifying career in a whole host of health-related professions. It can
also be an incredible challenge. Through years of collaboration
with students and instructors alike, we have come to intimately
understand not only the material but also the evolving dynamics of teaching and learning A&P. So
with every new edition, it’s our goal to find new ways to help instructors teach more easily and
effectively and students to learn in a way that sticks.
We believe we bring together experience and innovation like no one else, offering a unique solution
for A&P designed to help instructors and students succeed together. From constantly evolving animations and visualizations to design based on optimal learning to lessons firmly grounded in learning
outcomes, everything is designed with the goal of helping instructors like you teach in a way that
inspires confidence and resilience in students and better learning outcomes.
The thirteenth edition of Principles of Anatomy and Physiology, integrated with WileyPLUS,
builds students’ confidence; it takes the guesswork out of studying by providing students with a clear
roadmap (one that tells them what to do, how to do it, and if they did it right). Students will take
more initiative, so instructors can have greater impact.
Principles of Anatomy and Physiology 13e continues to offer a balanced presentation of content
under the umbrella of our primary and unifying theme of homeostasis, supported by relevant discussions of disruptions to homeostasis. In addition, years of student feedback have convinced us that
readers learn anatomy and physiology more readily when they remain mindful of the relationship
between structure and function. As a writing team—an anatomist and a physiologist—our very
different specializations offer practical advantages in fine-tuning the balance between anatomy
and physiology.
On the following pages students will discover the tips and tools needed to make the most of their
study time using the integrated text and media. Instructors will gain an overview of the changes to
this edition and of the resources available to create dynamic classroom experiences as well as build
meaningful assessment opportunities. Both students and instructors will be interested in the
outstanding resources available to seamlessly link laboratory activity with lecture presentation and
study time.
iii
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TO
The challenges of learning anatomy and physiology
can be complex and time-consuming. This textbook
and WileyPLUS for Anatomy and Physiology have been
carefully designed to maximize your study time by
simplifying the choices you make in deciding what to
study and how to study it, and in assessing your understanding of the content.
S T U D E N T S
Anatomy and Physiology
Is a Visual Science
Studying the figures in this book is as important as reading the narrative. The tools described here will help you
understand the concepts being presented in any figure
and ensure that you get the most out of the visuals.
LEGEND. Read this first. It explains what
the figure is about.
Figure 24.11 External and internal anatomy of the stomach.
KEY CONCEPT STATEMENT. Indicated
The four regions of the stomach are the cardia, fundus, body, and pyloric part.
by a “key” icon, this reveals a basic idea
portrayed in the figure.
Esophagus
BODY
Longitudinal layer
ORIENTATION DIAGRAM. Added to many
figures, this small diagram helps you understand the perspective from which you are
viewing a particular piece of anatomical art.
Lesser
curvature
Circular layer
FIGURE QUESTION. Found at the bottom of
FUNDUS
Lower
esophageal
sphincter
Serosa
Muscularis:
CARDIA
each figure and accompanied by a “question
mark” icon, this serves as a self-check to help
you understand the material as you go along.
PYLORUS
Oblique layer
Greater curvature
FUNCTIONS BOX. Included with selected
figures, these provide a brief summary of the
functions of the anatomical structure or system
depicted.
Duodenum
Pyloric
sphincter
PYLORIC
CANAL
Rugae of mucosa
FUNCTIONS OF THE STOMACH
PYLORIC ANTRUM
1. Mixes saliva, food, and gastric juice to form chyme.
(a) Anterior view of regions of stomach
2. Serves as reservoir for food before release into
small intestine.
3. Secretes gastric juice, which contains HCl (kills
bacteria and denatures protein), pepsin (begins
the digestion of proteins), intrinsic factor (aids
absorption of vitamin B12), and gastric lipase (aids
digestion of triglycerides).
Figure 23.17 Changes in partial pressures of oxygen and carbon dioxide (in mmHg) during external and internal
4. Secretes gastrin into blood.
respiration.
Esophagus
Gases diffuse from areas of higher partial pressure to areas of lower partial pressure.
Duodenum
Atmospheric air:
PO2 = 159 mmHg
PCO = 0.3 mmHg
2
CO2 exhaled
O2 inhaled
PYLORUS
Pyloric sphincter
PYLORIC CANAL
Lesser
curvature
FUNDUS
CARDIA
Alveoli
BODY
CO2 O
2
Alveolar air:
PO2 = 105 mmHg
PCO = 40 mmHg
2
PYLORIC ANTRUM
Rugae of mucosa
Pulmonary capillaries
(a) External respiration:
pulmonary gas
exchange
Greater curvature
To left atrium
To lungs
(b) Anterior view of internal anatomy
After a very large meal, does your stomach still have rugae?
Deoxygenated blood:
PO2 = 40 mmHg
PCO = 45 mmHg
Oxygenated blood:
PO = 100 mmHg
2
PCO = 40 mmHg
2
2
To right atrium
To tissue cells
MP3 DOWNLOADS. In each chapter you will find that several
illustrations are marked with an icon that looks like an iPod.
This indicates that an audio file that narrates and discusses the
important elements of that particular illustration is available.
You can access these downloads on the student companion website or within WileyPLUS.
(b) Internal respiration:
systemic gas
exchange
Systemic capillaries
CO2
O2
Systemic tissue cells:
PO2 = 40 mmHg
PCO = 45 mmHg
2
What causes oxygen to enter pulmonary capillaries from alveoli and to enter tissue cells from systemic capillaries?
iv
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Physiology of Hearing
The following events are involved in hearing (Figure 17.22):
1
●
2
●
Studying physiology
requires an understanding of the sequence of
processes. Correlation of
sequential processes in
text and art is achieved
through the use of special
numbered lists in the narrative that correspond to
numbered segments in
the accompanying figure.
This approach is used
extensively throughout
the book to lend clarity
to the flow of complex
processes.
3
●
4
●
The auricle directs sound waves into the external auditory canal.
When sound waves strike the tympanic membrane, the alternating waves of high and low pressure in the air cause the
tympanic membrane to vibrate back and forth. The tympanic
membrane vibrates slowly in response to low-frequency
(low-pitched) sounds and rapidly in response to highfrequency (high-pitched) sounds.
The central area of the tympanic membrane connects to the
malleus, which vibrates along with the tympanic membrane.
This vibration is transmitted from the malleus to the incus
and then to the stapes.
As the stapes moves back and forth, its oval-shaped footplate,
which is attached via a ligament to the circumference of the
oval window, vibrates in the oval window. The vibrations at the
oval window are about 20 times more vigorous than the tympanic membrane because the auditory ossicles efficiently
transmit small vibrations spread over a large surface area (the
5
●
6
●
7
●
8
●
9
●
tympanic membrane) into larger vibrations at a smaller surface
(the oval window).
The movement of the stapes at the oval window sets up fluid
pressure waves in the perilymph of the cochlea. As the oval
window bulges inward, it pushes on the perilymph of the
scala vestibuli.
Pressure waves are transmitted from the scala vestibuli to the
scala tympani and eventually to the round window, causing it
9 in the figure.)
to bulge outward into the middle ear. (See ●
The pressure waves travel through the perilymph of the scala
vestibuli, then the vestibular membrane, and then move into
the endolymph inside the cochlear duct.
The pressure waves in the endolymph cause the basilar membrane to vibrate, which moves the hair cells of the spiral
organ against the tectorial membrane. This leads to bending
of the stereocilia and ultimately to the generation of nerve
impulses in first-order neurons in cochlear nerve fibers.
Sound waves of various frequencies cause certain regions of
the basilar membrane to vibrate more intensely than other
regions. Each segment of the basilar membrane is “tuned” for
Figure 17.22 Events in the stimulation of auditory receptors in the right ear.
The numbers correspond to the events listed in
the text. The cochlea has been uncoiled to more easily visualize the transmission of sound waves and their distortion
of the vestibular and basilar membranes of the cochlear duct.
Hair cells of the spiral organ (organ of Corti) convert a mechanical vibration (stimulus) into an electrical signal (receptor
potential).
Incus
Malleus
Helicotrema
Stapes vibrating
in oval window
Cochlea
Sound waves
Perilymph
8
3
4
Scala
tympani
Scala
vestibuli
7
5
1
2
Basilar
membrane
6
9
External auditory
canal
8
Spiral organ
(organ of Corti)
Tectorial membrane
Vestibular membrane
Cochlear duct
(contains endolymph)
Tympanic
membrane
Secondary tympanic
membrane vibrating
in round window
Middle ear
Auditory tube
Which part of the basilar membrane vibrates most vigorously in response to high-frequency (high-pitched) sounds?
There are many visual resources within
WileyPLUS, in addition to the art from your text. These
visual aids can help you master the topic you are studying. Examples closely integrated with the reading
material include animations, cadaver video clips, and
Real Anatomy Views. Anatomy Drill and Practice lets
you test your knowledge of structures with simple-to-use
drag-and-drop labeling exercises or fill-in-the-blank
labeling. You can drill and practice on these activities
using illustrations from the text, cadaver photographs,
histology micrographs, or lab models.
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Exhibits Organize Complex Anatomy
into Manageable Modules
Many topics in this text have been organized into
Exhibits that bring together all of the information
and elements that you need to learn the complex
terminology, anatomy, and the relevance of the
anatomy into a simple-to-navigate content module.
You will find Exhibits for tissues, bones, joints,
skeletal muscles, nerves, and blood vessels. Most
exhibits include the following:
EXHIBIT 11.B
Objective to focus your study.
Overview narrative of the structure(s).
Table summarizing key features of the structure(s).
Illustrations and photographs.
Checkpoint Question to assess your understanding.
Clinical Connection to provide relevance for learning
the details.
Muscles of the Head That Move the Eyeballs
(Extrinsic Eye Muscles) and Upper Eyelids (Figure 11.5)
OBJECTIVE
• Describe the origin, insertion, action, and innervation of
the extrinsic eye muscles that move the eyeballs and upper
eyelids.
Muscles that move the eyeballs are called extrinsic eye muscles because
they originate outside the eyeballs (in the orbit) and insert on the outer
surface of the sclera (“white of the eye”) (Figure 11.5). The extrinsic eye
muscles are some of the fastest contracting and most precisely controlled
skeletal muscles in the body.
Three pairs of extrinsic eye muscles control movements of the eyeballs: (1) superior and inferior recti, (2) lateral and medial recti, and
(3) superior and inferior obliques. The four recti muscles (superior, inferior, lateral, and medial) arise from a tendinous ring in the orbit and
insert into the sclera of the eye. As their names imply, the superior and
inferior recti move the eyeballs superiorly and inferiorly; the lateral
and medial recti move the eyeballs laterally and medially, respectively.
The actions of the oblique muscles cannot be deduced from their
names. The superior oblique muscle originates posteriorly near the
tendinous ring, then passes anteriorly superior to the medial rectus muscle, and ends in a round tendon. The tendon extends through a pulleylike
loop of fibrocartilaginous tissue called the trochlea (⫽ pulley) on the anterior and medial part of the roof of the orbit. Finally, the tendon turns and
inserts on the posterolateral aspect of the eyeball. Accordingly, the superior oblique muscle moves the eyeballs inferiorly and laterally. The inferior oblique muscle originates on the maxilla at the anteromedial aspect
of the floor of the orbit. It then passes posteriorly and laterally and inserts
on the posterolateral aspect of the eyeball. Because of this arrangement,
the inferior oblique muscle moves the eyeballs superiorly and laterally.
Unlike the recti and oblique muscles, the levator palpebrae superioris does not move the eyeballs, since its tendon passes the eyeball and
inserts into the upper eyelid. Rather, it raises the upper eyelids, that is,
opens the eyes. It is therefore an antagonist to the orbicularis oculi,
EXHIBIT
which closes the eyes.
CLINICAL CONNECTION | Strabismus
11.B
Muscles of the Head That Move the Eyeballs
(Extrinsic Eye Muscles) and Upper Eyelids (Figure 11.5)
RELATING MUSCLES TO MOVEMENTS
CONTINUED
CHECKPOINT
Strabismus (stra-BIZ-mus; strabismos ⫽ squinting) is a condiWhich muscles that move the eyeballs contract and relax as
Arrange
tion in which the two eyeballs are not properly aligned. This can
be the muscles in this exhibit according to their actions on the eyeyou look to your left without moving your head?
balls:
hereditary or it can be due to birth injuries, poor attachments of
the (1) elevation, (2) depression, (3) abduction, (4) adduction, (5) medial rotation, and (6) lateral rotation. The same muscle may be menmuscles, problems with the brain’s control center, or localized disease.
tioned
more
than
once.
Strabismus can be constant or intermittent. In strabismus, each eye
sends an image to a different area of the brain and because the brain
usually ignores the messages sent by one of the eyes, the ignored eye
becomes weaker; hence “lazy eye,” or amblyopia, develops. External
strabismus results when a lesion in the oculomotor (III) nerve causes
Figure 11.5 Muscles of the head that move the eyeballs (extrinsic eye muscles) and upper eyelid.
the eyeball to move laterally when at rest, and results in an inability
to move the eyeball medially and inferiorly. A lesion in the abducens
The extrinsic muscles of the eyeball are among the fastest contracting and most precisely controlled skeletal muscles in the
(VI) nerve results in internal strabismus, a condition in which the eyebody.
ball moves medially when at rest and cannot move laterally.
Treatment options for strabismus depend on the specific type of
Trochlea
problem and include surgery, visual therapy (retraining the brain’s control
INFERIOR OBLIQUE
SUPERIOR RECTUS
center), and orthoptics (eye muscle training to straighten the eyes).
•
SUPERIOR
OBLIQUE
Frontal
bone
LEVATOR PALPEBRAE
SUPERIORIS (cut)
Trochlea
SUPERIOR RECTUS
MUSCLE
ORIGIN
INSERTION
ACTION
INNERVATION MEDIAL RECTUS
Superior rectus
(rectus ⫽ fascicles
parallel to midline)
Common tendinous ring
(attached to orbit around
optic foramen).
Superior and central part of
eyeballs.
Moves eyeballs superiorly (elevation)
and medially (adduction), and rotates
them medially.
Optic (II) nerve
Oculomotor (III) nerve.
Inferior rectus
Same as above.
Inferior and central part of
eyeballs.
Moves eyeballs inferiorly (depression)
and medially (adduction), and rotates
them medially.
LATERAL RECTUS
Oculomotor (III) nerve.
Abducens (VI) nerve.
LATERAL
RECTUS
Cornea
Common tendinous
ring
SUPERIOR INFERIOR
OBLIQUE
RECTUS
Sphenoid bone
INFERIOR RECTUS
Lateral rectus
Same as above.
Lateral side of eyeballs.
Moves eyeballs laterally (abduction).
Medial rectus
Same as above.
Medial side of eyeballs.
Moves eyeballs medially (adduction).
INFERIOR OBLIQUE
Oculomotor (III) nerve.
Superior oblique
(oblique ⫽ fascicles
diagonal to midline)
Sphenoid bone, superior
and medial to common
tendinous ring in orbit.
Eyeball between superior and
lateral recti. Muscle inserts
into superior and lateral
surfaces of eyeball via tendon
that passes through trochlea.
Moves eyeballs inferiorly (depression)
and laterally (abduction), and rotates
them medially.
Trochlear (IV) nerve.
Inferior oblique
Maxilla in floor of orbit.
Eyeballs between inferior and
lateral recti.
Moves eyeballs superiorly (elevation)
and laterally (abduction), and rotates
them laterally.
Oculomotor (III) nerve. Frontal bone (cut)
Levator palpebrae
superioris
(le-VĀ-tor PAL-pe-brē
soo-per⬘-ē -OR-is;
palpebrae ⫽ eyelids)
Roof of orbit (lesser
wing of sphenoid bone).
Skin and tarsal plate of upper
eyelids. (opens eyes).
Elevates upper eyelids
Oculomotor (III) nerve. SUPERIOR RECTUS
Maxilla
(a) Right lateral view of right eyeball
(b) Movements of right eyeball in response to
contraction of extrinsic muscles
SUPERIOR OBLIQUE
LEVATOR PALPEBRAE
SUPERIORIS
MEDIAL RECTUS
LATERAL RECTUS
E X H I B I T 11.B
INFERIOR RECTUS
CONTINUES
INFERIOR OBLIQUE
Zygomatic bone (cut)
(c) Right lateral view of right eyeball
How does the inferior oblique muscle move the eyeball superiorly and laterally?
380
vi
MEDIAL
RECTUS
Eyeball
EXHIBIT 11.B
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Clinical Discussions Make Your Study Relevant
The relevance of the anatomy and physiology that you are studying is best understood when you make the connection between normal structure and function and what happens when the body doesn’t work the way it should.
Throughout the chapters of the text you will find Clinical Connections that introduce you to interesting clinical
perspectives related to
the text discussion. In
CLINICAL CONNECTION | Arthroplasty
addition, at the end of
Joints that have been severely damaged by diseases such as
tic such as polyethylene, and the femoral component is composed of
arthritis, or by injury, may be replaced surgically with artificial joints
a metal such as cobalt-chrome, titanium alloys, or stainless steel.
each body system chapThese materials are designed to withstand a high degree of stress and
in a procedure referred to as arthroplasty (AR-thrō-plas’-tē; arthr-⫽
to prevent a response by the immune system. Once the appropriate
joint; plasty⫽plastic repair of). Although most joints in the body can
ter you will find the
acetabular and femoral components are selected, they are attached
be repaired by arthroplasty, the ones most commonly replaced are
to the healthy portion of bone with acrylic cement, which forms an
the hips, knees, and shoulders. About 400,000 hip replacements and
Disorders: Homeostatic
interlocking mechanical bond.
300,000 knee replacements are performed annually in the United
Knee replacements are actually a resurfacing of cartilage and,
States. During the procedure, the ends of the damaged bones are reImbalances section,
like hip replacements, may be partial or total. In a partial knee removed and metal, ceramic, or plastic components are fixed in place.
placement (PKR), also called a unicompartmental knee replaceThe goals of arthroplasty are to relieve pain and increase range of
which includes concise
ment, only one side of the knee joint is replaced. Once the damaged
motion.
discussions of major discartilage is removed from the distal end of the femur, the femur is rePartial hip replacements involve only the femur. Total hip reshaped and a metal femoral component is cemented in place. Then
placements involve both the acetabulum and head of the femur
eases and disorders.
the damaged cartilage from the proximal end of the tibia is removed,
(Figures A–C). The damaged portions of the acetabulum and the head
along with the meniscus. The tibia is reshaped and fitted with a plasof the femur are replaced by prefabricated prostheses (artificial deThese provide answers
tic tibial component that is cemented into place. If the posterior survices). The acetabulum is shaped to accept the new socket, the head
face of the patella is badly damaged, the patella is replaced with a
of the femur is removed, and the center of the femur is shaped to fit
to many of your quesplastic patellar component.
the femoral component. The acetabular component consists of a plastions about medical
problems. The Medical
Hip bone
Terminology section
Hip bone
Artificial
that follows includes
acetabulum
Reshaped
Artificial
Artificial
acetabulum
selected terms dealing
femoral
acetabulum
head
Head of femur
with both normal and
Artificial
removed
femoral
pathological conditions.
head
Artificial
metal shaft
Artificial
metal shaft
Shaft of femur
Shaft of
femur
(A) Preparation for total hip replacement
(B) Components of an artificial hip joint
prior to implantation
(C) Radiograph of an artificial hip joint
WileyPLUS offers
you opportunities for even further
Clinical Connections with animated
and interactive case studies that
relate specifically to one body system.
Look for these under additional
chapter resources as an interesting
and engaging break from traditional
study routines.
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Chapter Resources Help You Focus and Review
Your book has a variety of special features that will make your time studying
anatomy and physiology a more rewarding experience. These have been developed based on
feedback from students—like you—who have used previous editions of the text. Their effectiveness is even further
enhanced within WileyPLUS for Anatomy and Physiology.
Chapter Introductions set the stage for the content to
come. Each chapter starts with a succinct overview of the
particular system’s role in maintaining homeostasis in your
body, followed by an introduction to the chapter content.
This opening page concludes with a question that always
begins with “Did you ever wonder…?” These questions
will capture your interest and encourage you to find the
answer in the chapter material to come.
Objectives at the start of each section help you focus on
what is important as you read. All of the content within
WileyPLUS is tagged to these specific learning objectives
so that you can organize your study or review what is still
not clear in simple, more meaningful ways.
Checkpoint Questions at the end of each section help
you assess if you have absorbed what you have read.
Take time to review these questions or answer them within the Practice section of each WileyPLUS concept module,
where your answers will automatically be graded to let
you know where you stand.
Mnemonics are a memory aid that can be particularly
helpful when learning specific anatomical features.
Mnemonics are included throughout the text—some displayed in figures, tables, or Exhibits, and some included
within the text discussion. We encourage you not only to
use the mnemonics provided, but also to create your own
to help you learn the multitude of terms involved in your
study of human anatomy.
Chapter Review and Resource Summary is a helpful
table at the end of chapters that offers you a concise summary of the important concepts from the chapter and
links each section to the media resources available in
WileyPLUS for Anatomy and Physiology.
Self-Quiz Questions give you an opportunity to evaluate
your understanding of the chapter as a whole. Within
WileyPLUS, use Progress Check to quiz yourself on
individual or multiple chapters in preparation for exams
or quizzes.
Critical Thinking Questions are word problems that
allow you to apply the concepts you have studied in the
chapter to specific situations.
Mastering the Language of Anatomy and Physiology
Throughout the text we have included Pronunciations
and, sometimes, Word Roots for many terms that may
be new to you. These appear in parentheses immediately
following the new words. The pronunciations are repeated
in the Glossary at the back of the book. Look at the
words carefully and say them out loud several times.
Learning to pronounce a new word will help you remember it and make it a useful part of your medical vocabulary. Take a few minutes to read the Pronunciation Key,
found at the beginning of the Glossary at the end of this
text, so it will be familiar as you encounter new words.
To provide more assistance in learning the language of
anatomy, a full Glossary of terms with phonetic pronunciations appears at the end of the book. The basic building
blocks of medical terminology—Combining Forms, Word
viii
Roots, Prefixes, and Suffixes—are listed inside the back
cover, accompanied by Eponyms, traditional terms that
include reference to a person’s name, along with the
current terminology.
WileyPLUS houses help for you in building your new language skills as well. The
Audio Glossary, which is always available to you, lets you hear all these new,
unfamiliar terms pronounced. Throughout the e-text,
these terms can be clicked on and heard pronounced as
you read. In addition, you can use the helpful
Mastering Vocabulary program, which creates electronic flashcards for you of the key terms within each chapter
for practice, as well as take a self-quiz specifically on the
terms introduced in each chapter.
NOTES TO INSTRUCTORS
As active teachers of the course, we recognize both the rewards and challenges in providing a strong foundation for
understanding the complexities of the human body. We believe that teaching goes beyond just sharing information.
How we share information makes all the difference—especially, if as we do, you have an increasingly diverse population of students with varying learning abilities. As we revised this text we focused on those areas that we knew we
could enhance to provide greater impact in terms of better learning outcomes. Feedback from many of you, as well
as from the students we interact with in our own classrooms, guided us in ensuring that the revisions to the text,
along with the powerful new WileyPLUS for Anatomy and Physiology, support the needs and challenges you face
day to day in your own classrooms.
We focused on several key areas for revision: enhancing the all-important visuals, both drawings and photographs;
increasing the use of Exhibits that provide a focused and functional organization of detailed content; adding some
new and revising many of the tables to increase their effectiveness; updating and adding clinical material that helps
students relate what they are learning to their desired career goals and the world around them; and making narrative
changes aimed at increasing student engagement with—and comprehension of—the material. For a detailed list of
revisions for each chapter please visit our website at www.wiley.com/college/sc/aandp and click on the text cover.
The Art of Anatomy and Physiology
Illustrations throughout the text have been refined. The color palette for
the skulls in Chapter 7, and for the brain and spinal cord throughout the
text, has been adjusted for greater impact. Illustrations in each chapter
have been revised and updated to provide
greater clarity and more saturated colors.
Particular emphasis was placed on revised
drawings of joints, muscles, and blood vessels.
ix
NOTES TO INSTRUCTORS
Cadaver photographs are included throughout the text to help
students relate the content to real-life images. These are often
paired with diagrams to help make the connections. Most of the
meticulous dissections and outstanding photography come from
Mark Nielsen’s lab at the University of Utah.
Most tissue Photomicrographs have
been replaced with exceptionally clear
photomicrographs with high-magnification
blowups.
LM 630x
LM 400x
LM
x
240x
LM 630x
NOTES TO INSTRUCTORS
Exhibits and Tables
The use of the pedagogically designed Exhibits has
been expanded to include the axial and appendicular
skeletons, as well as cranial nerves, providing students
with simplified presentations of complex content.
EXHIBIT 14.H
New Tables, including Skin Glands, Common Bone
Fractures, Summary of the Levels of Organization
within a Skeletal Muscle, and Summary of the
Respiratory System, have been added, in addition
to refinement of many of the existing tables with
either new illustrations or rewritten text.
Vagus (X) Nerve (Figure 14.24)
OBJECTIVE
• Identify the origin of the vagus nerve in the brain, the
foramen through which it exits the skull, and its function.
The vagus (X) nerve (VĀ-gus ⫽ vagrant or wandering) is a mixed cranial nerve that is distributed from the head and neck into the thorax and
abdomen (Figure 14.24). The nerve derives its name from its wide distribution. In the neck, it lies medial and posterior to the internal jugular
vein and common carotid artery.
Sensory axons in the vagus nerve arise from the skin of the external
ear for touch, pain, and thermal sensations; a few taste buds in the
epiglottis and pharynx; and proprioceptors in muscles of the neck and
throat. Also, sensory axons come from baroreceptors in the carotid sinus
and chemoreceptors in the carotid and aortic bodies. The majority of
sensory neurons come from visceral sensory receptors in most organs of
the thoracic and abdominal cavities that convey sensations (such as
hunger, fullness, and discomfort) from these organs. The sensory neu-
rons have cell bodies in the superior and inferior ganglia and then pass
through the jugular foramen to end in the medulla and pons.
The branchial motor neurons, which run briefly with the accessory
nerve, arise from nuclei in the medulla oblongata and supply muscles of the
pharynx, larynx, and soft palate that are used in swallowing, vocalization,
and coughing. Historically these motor neurons have been called the cranial
accessory nerve, but these fibers actually belong to the vagus (X) nerve.
Axons of autonomic motor neurons in the vagus nerve originate in
nuclei of the medulla and supply the lungs, heart, glands of the gastrointestinal (GI) tract, and smooth muscle of the respiratory passageways,TABLE 6.1
esophagus, stomach, gallbladder, small intestine, and most of the large
intestine (see Figure 15.3). Autonomic motor axons initiate smooth mus-Some Common
cle contractions in the gastrointestinal tract to aid motility and stimulate
secretion by digestive glands; activate smooth muscle to constrict respi-FRACTURE
ratory passageways; and decrease heart rate.
Fractures
Open (Compound)
CHECKPOINT
On what basis is the vagus nerve named?
Figure 14.24 Vagus (X) nerve.
DESCRIPTION
ILLUSTRATION
The broken ends of the bone
protrude through the skin.
Conversely, a closed (simple)
fracture does not break
the skin.
RADIOGRAPH
Humerus
The vagus nerve is widely distributed in the head, neck, thorax, and abdomen.
Carotid
sinus
Radius
Ulna
Carotid
body
Aortic
bodies
CLINICAL CONNECTION |
Vagal Paralysis,
Dysphagia, and
Tachycardia
Larynx
GLOSSOPHARYNGEAL (IX)
NERVE
Heart
Anterior
Lungs
Inferior
ganglion
Medulla
oblongata
Injury to the vagus (X) nerve due to
conditions such as trauma or lesions
causes vagal paralysis, or interruptions of sensations from many organs
in the thoracic and abdominal cavities; dysphagia (dis-FĀ-gē-a), or difficulty in swallowing; and tachycardia
(tak’-i-KAR-dē-a), or increased heart
rate. •
Comminuted
(KOM-i-noo-ted;
com- ⫽ together;
-minuted ⫽ crumbled)
Humerus
Greenstick
Liver and
gallbladder
Superior
ganglion
Stomach
VAGUS (X)
NERVE
Posterior
Pancreas
(behind
stomach)
Pancreas
Vagus (X)
nerve
Inferior surface of brain
Impacted
Small
intestine
Colon
The bone is splintered,
crushed, or broken into
pieces at the site of impact,
and smaller bone fragments
lie between the two main
fragments.
A partial fracture in which one
side of the bone is broken and
the other side bends; similar
to the way a green twig breaks
on one side while the other
side stays whole, but bends;
occurs only in children,
whose bones are not fully
ossified and contain more
organic material than
inorganic material.
Ulna
Radius
Wrist
bones
One end of the fractured bone is
forcefully driven into the
interior of the other.
Where is the vagus nerve located in the neck region?
Humerus
Clinical Connections
Your students are fascinated by the Clinical Connections to the normal anatomy and physiology
that they are learning. You’ll find that the text is liberally peppered with engaging discussions
of a wide variety of clinical scenarios from disease coverage to tests and procedures. As always,
we have updated all of the Clinical Connections and Disorders: Homeostatic Imbalances sections
to reflect the most current information. We have added several new Clinical Connections, such
as a feature on fibromyalgia, to the text. A complete reference list of the Clinical Connections
within each chapter follows the Table of Contents.
xi
NOTES TO INSTRUCTORS
WileyPLUS and You
WileyPLUS for Anatomy and Physiology is an innovative, research-based
online environment designed for both effective teaching and learning.
Utilizing WileyPLUS in your course provides your students with an accessible,
affordable, and active learning platform and gives you tools and resources to
efficiently build presentations for a dynamic classroom experience and to create
and manage effective assessment strategies. The underlying principles of design, engagement, and measurable
outcomes provide the foundation for this powerful, new release of WileyPLUS.
DESIGN
• New research-based design helps students manage their time better and develop better study skills.
• Course Calendars help track assignments for both students and teachers.
• New Course Plan makes it easier to assign reading, activities, and assessment. Simple drag-and-drop tools
make it easy to assign the course plan as-is or in any way that best reflects your course syllabus.
The new design makes it easy for students to know what it is they need to do, boosting their confidence and
preparing them for greater engagement in class and lab.
ENGAGEMENT
• Complete online version of the textbook allows for seamless integration of all content.
• Relevant student study tools and learning resources ensure positive learning outcomes.
• Immediate feedback boosts confidence and helps students see a return on investment for each study session.
• Precreated activities encourage learning outside of the classroom.
• Course materials, including PowerPoint stacks with animations and Wiley’s Visual Library for Anatomy and
Physiology, help you personalize lessons and optimize your time.
Concept mastery in this discipline is directly related to students keeping up with the work and not falling behind.
The new Concept Modules, Animations and Activities, Self Study, and Progress Checks in WileyPLUS will ensure that
students know how to study effectively so they will remain engaged and stay on task.
MEASURABLE OUTCOMES
• Progress Check enables students to hone in on areas of weakness for increased success.
• Self-assessment and remediation for all Learning Objectives let students know exactly how their efforts have
paid off.
• Instant reports monitor trends in class performance, use of course materials, and student progress toward
learning objectives.
With new detailed reporting capabilities, students will know that they are doing it right. With increased confidence, motivation is sustained so students stay on task—success will follow.
Please contact your Wiley representative for details about these and other resources or visit our website at
www.wiley.com/college/sc/aandp and click on the text cover to explore the assets more fully.
xii
RESOURCES FOR INTEGRATING LABORATORY
EXPERIENCES
Laboratory Manual for Anatomy
and Physiology, 4e
Connie Allen and Valerie Harper
Newly revised, Laboratory Manual for Anatomy and Physiology with
WileyPLUS 5.0 engages your students in active learning and focuses on the most
important concepts in A&P. Exercises reflect the multiple ways in which students
learn and provide guidance for anatomical exploration and application of critical
thinking to analyzing physiological processes. A concise narrative, self-contained
exercises that include a wide variety of activities and question types, and two types of lab reports for each exercise
keep students focused on the task at hand. Depending on your needs, a Cat Dissection Manual or Fetal Pig
Dissection Manual accompanies the main text. Rich media within WileyPLUS further enhance the student experience
and include dissection videos, animations, and illustrated drill and practice exercises with illustrations, micrographs,
cadaver photos, and popular lab models. Each lab text comes with access to PowerPhys 2.0.
Atlas of Human Anatomy, 1e
Mark Nielsen and Shawn Miller
This new atlas filled with outstanding photographs of meticulously executed
dissections of the human body has been developed to be a strong teaching
and learning solution, not just a catalog of photographs. Organized around
body systems, each chapter includes a narrative overview of the body system
and is then followed with detailed photographs that accurately and realistically represent the anatomical structures. Histology is included. Atlas of
Human Anatomy will work well in your laboratories, as a study companion to
your textbook, and as a print companion to the Real Anatomy DVD.
Photographic Atlas of
the Human Body, 2e
Gerard J. Tortora
Like the new atlas from Nielsen and Miller, this popular atlas is also systemic
in its approach to the photographic review of the human body. In addition to
the excellent cadaver photographs and micrographs, this atlas also contains
selected cat and sheep heart dissections. The high-quality imagery can be used
in the classroom, in the laboratory, or for study and review.
xiii
RESOURCES FOR INTEGRATING LABORATORY
EXPERIENCES
Real Anatomy
Mark Nielsen and Shawn Miller
Real Anatomy is 3-D imaging software that allows you to dissect
through multiple layers of a three-dimensional real human body to
study and learn the anatomical structures of all body systems.
• Dissect through up to 40 layers of the body
and discover the relationships of the structures
to the whole.
• Rotate the body, as well as major organs, to
view the image from multiple perspectives.
• Use a built-in zoom feature to get a closer look
at detail.
• A unique approach to highlighting and labeling
structures does not obscure the real anatomy in view.
xiv
RESOURCES FOR INTEGRATING LABORATORY
EXPERIENCES
• Related images provide multiple views of
structures being studied.
• Snapshots of any image
can be saved for use in
PowerPoints, quizzes, or
handouts.
• View histology micrographs at varied levels
of magnification with
the virtual microscope.
• Audio pronunciation of all
labeled structures is readily
available.
Virtual Dissection—100% Real
xv
RESOURCES FOR INTEGRATING LABORATORY
EXPERIENCES
PowerPhys 2.0
Connie Allen, Valerie Harper, Thomas Lancraft, and Yuri Ivlev
PowerPhys 2.0 provides a simulated laboratory experience for students, giving them the opportunity to
review their knowledge of core physiological concepts,
predict outcomes of an experiment, collect data, analyze it, and report on their findings. This revised edition
features a new activity on Homeostatic Imbalance of
Thyroid Function and revised lab report questions
throughout. An easy-to-use and intuitive interface
guides students through the experiments from basic
review to laboratory reports. All experiments contain
randomly generated data, allowing students to experiment
multiple times but still arrive at the same conclusions. A
perfect addition to distant learning or hybrid courses,
PowerPhys 2.0 is a stand-alone web-based program and is
fully integrated with Allen and Harper’s laboratory manual.
Interactions: Exploring the Functions
of the Human Body 3.0
Thomas Lancraft and Frances Frierson
Interactions 3.0 is the most complete program of interactive animations and activities available for anatomy and physiology. A series of modules encompassing all body systems focuses on a review of anatomy, the
examination of physiological processes using animations and interactive exercises, and clinical correlations to
enhance student understanding. At the heart
of Interactions is a focus on core principles—
homeostasis, communication, energy flow,
fluid flow, and boundaries—that underscore
the key relationships between structure and
function as well as interrelationships between
systems. It is the reinforcement of these fundamental organizing principles that sets this series
apart from others. Interactions is available on
DVD, web-based, or fully integrated within
WileyPLUS.
xvi
ACKNOWLEDGMENTS
We wish to especially thank several academic colleagues for their helpful contributions to this edition. Creating and
implementing the integration of this text
with WileyPLUS for Anatomy and
Physiology was only possible because of
the expertise and fine work of the following group of people. We are so very
grateful to you:
Sarah Bales
Moraine Valley Community College
Celina Bellanceau
University of South Florida
Curtis DeFriez
Weber State University
Alan Erickson
South Dakota State University
Gibril Fadika
Hampton University
Pamela Fouche
Walters State Community College
Sophia Garcia
Tarrant County College–Trinity River
Clare Hays
Metropolitan State College of Denver
Jason Hunt
Brigham Young University–Idaho
Judy Learn
North Seattle Community College
Jerri K. Lindsey
Tarrant County College
Todd Miller
Hunter College
Erin Morrey
Georgia Perimeter College
Gus Pita
Hunter College
Susan Puglisi
Norwalk Community College
Christine Ross Earls
Fairfield University
Saeed Rahmanian
Roane State Community College
Angela Edwards
University of South Carolina Allendale
Lori A. Smith
American River College
Sharon Ellerton
Queensborough Community College
Randall Tracy
Worcester State College
David Evans
Pennsylvania College of Technology
Jay Zimmer
South Florida Community College
Gibril Fadika
Hampton University
We are also very grateful to our colleagues who have reviewed the manuscript or participated in focus groups
and offered numerous suggestions for
improvement:
Sandy Garrett
Texas Woman’s University
Charles J. Biggers
University of Memphis
Jane Horlings
Saddleback College
Gladys Bolding
Georgia Perimeter College
Barbara Hunnicutt
Seminole State College
Lois Borek
Georgia State University
Jason Hunt
Brigham Young University–Idaho
Betsy Brantley
Lansing Community College
Alexander T. Imholtz
Prince George’s Community College
Arthur R. Buckley
University of Cincinnati
Amy E. Jetton
Middle Tennessee State University
Alex Cheroske
Mesa Community College
Becky Keck
Clemson University
Robert Comegys
Old Dominion University
Marc LaBella
Ocean County College
Curtis DeFriez
Weber State University
Ellen Lathrop-Davis
Community College of Baltimore County
William Dunscombe
Union County College
Billy Bob Long
Del Mar College
Heather Dy
Long Beach Community College
Wayne M. Mason
Western Kentucky University
Michael Harman
Lone Star College
xvii
xviii
ACKNOWLEDGMENTS
Karen McLellan
Indiana Purdue University Fort Wayne
Philip D. Reynolds
Troy University
Peter Susan
Trident Technical College
Marie McMahon
Miramar College
John Roufaiel
SUNY Rockland Community College
Jared Taglialatela
Clayton State College
Erin Morrey
Georgia Perimeter College
Kelly Sexton
North Lake College
Bonnie J. Tarricone
Ivy Tech Community College
Maria Oehler
Florida State College at Jacksonville
Colleen Sinclair
Towson University
Heather Walker
Clemson University
Betsy Ott
Tyler Junior College
Lori A. Smith
American River College
Janice Webster
Ivy Tech Community College
Gilbert Pitts
Austin Peay State University
Nora Stevens
Portland Community College
Delores Wenzel
University of Georgia
Saeed Rahmanian
Roane State Community College
Leo B. Stouder
Broward College
Matthew A. Williamson
Georgia Southern University
Terrence J. Ravine
University of South Alabama
Dennis Strete
McLennan Community College
Finally, our hats are off to everyone at Wiley. We enjoy collaborating with this enthusiastic, dedicated, and talented team of publishing professionals. Our thanks to the entire team: Bonnie Roesch, Executive Editor; Mary Berry and Karen Trost, Developmental
Editors; Lorraina Raccuia, Project Editor; Lauren Morris, Program Assistant; Suzanne Ingrao, Outside Production Editor; Hilary
Newman, Photo Manager; Claudia Volano, Illustration Coordinator; Anna Melhorn, Senior Illustration Editor; Madelyn Lesure,
Senior Designer; Laura Ierardi, LCI Design; Linda Muriello, Senior Media Editor; and Clay Stone, Executive Marketing Manager.
Gerard J. Tortora
Department of Science and Health, S229
Bergen Community College
400 Paramus Road
Paramus, NJ 07652
Bryan Derrickson
Science Department
Valencia Community College
1800 S. Kirkman Rd.
Orlando, FL 32811
ABOUT THE AUTHORS
Gerard J. Tortora is Professor of Biology and
former Biology Coordinator at Bergen
Community College in Paramus, New Jersey,
where he teaches human anatomy and physiology as well as microbiology. He received his
bachelor’s degree in biology from Fairleigh
Dickinson University and his master’s degree
in science education from Montclair State
College. He is a member of many professional
organizations, including the Human Anatomy
and Physiology Society (HAPS), American
Society of Microbiology (ASM), American
Courtesy of Heidi Chung.
Association for the Advancement of Science
(AAAS), National Education Association (NEA), and Metropolitan
Association of College and University Biologists (MACUB).
Above all, Jerry is devoted to his students and their aspirations. In recognition of this commitment, Jerry was the recipient
of MACUB’s 1992 President’s Memorial Award. In 1996, he
received a National Institute for Staff and Organizational
Development (NISOD) excellence award from the University of
Texas and was selected to represent Bergen Community College
in a campaign to increase awareness of the contributions of community colleges to higher education.
Jerry is the author of several best-selling science textbooks and
laboratory manuals, a calling that often requires an additional
40 hours per week beyond his teaching responsibilities.
Nevertheless, he still makes time for four or five weekly aerobic
workouts that include biking and running. He also enjoys attending college basketball and professional hockey games and performances at the Metropolitan Opera House.
To my mother, Angelina M. Tortora.
(August 20, 1913–August 14, 2010).
Her love, guidance, faith, support, and example continue to be
the cornerstone of my personal and professional life. G.J.T.
Bryan Derrickson is Professor of Biology
at Valencia Community College in Orlando,
Florida, where he teaches human anatomy
and physiology as well as general biology
and human sexuality. He received his bachelor’s degree in biology from Morehouse
College and his doctorate in cell biology
from Duke University. Bryan’s study at
Duke was in the Physiology Division within
the Department of Cell Biology, so while
his degree is in cell biology, his training focused on physiology.
At Valencia, he frequently serves on faculty hiring committees.
He has served as a member of the Faculty Senate, which is the
governing body of the college, and as a member of the Teaching
and Learning Academy, which sets the standards for the acquisition of tenure by faculty members. Nationally, he is a member of
the Human Anatomy and Physiology Society (HAPS) and the
National Association of Biology Teachers (NABT).
Bryan has always wanted to teach. Inspired by several biology
professors while in college, he decided to pursue physiology with
an eye to teaching at the college level. He is completely dedicated
to the success of his students. He particularly enjoys the challenges of his diverse student population, in terms of their age,
ethnicity, and academic ability, and he finds being able to reach
all of them, despite their differences, a rewarding experience. His
students continually recognize Bryan’s efforts and care by nominating him for a campus award known as the “Valencia Professor
Who Makes Valencia a Better Place to Start.” Bryan has received
this award three times.
To my family: Rosalind, Hurley, Cherie, and Robb.
Your support and motivation have been invaluable. B.H.D.
xix
BRIEF CONTENTS
1 AN INTRODUCTION TO THE HUMAN BODY
2 THE CHEMICAL LEVEL OF ORGANIZATION
3 THE CELLULAR LEVEL OF ORGANIZATION
4 THE TISSUE LEVEL OF ORGANIZATION
5 THE INTEGUMENTARY SYSTEM
6 THE SKELETAL SYSTEM: BONE TISSUE
7 THE SKELETAL SYSTEM: THE AXIAL SKELETON
8 THE SKELETAL SYSTEM: THE APPENDICULAR SKELETON
9 JOINTS
10 MUSCULAR TISSUE
11 THE MUSCULAR SYSTEM
12 NERVOUS TISSUE
13 THE SPINAL CORD AND SPINAL NERVES
14 THE BRAIN AND CRANIAL NERVES
15 THE AUTONOMIC NERVOUS SYSTEM
16 SENSORY, MOTOR, AND INTEGRATIVE SYSTEMS
17 THE SPECIAL SENSES
18 THE ENDOCRINE SYSTEM
19 THE CARDIOVASCULAR SYSTEM: THE BLOOD
20 THE CARDIOVASCULAR SYSTEM: THE HEART
21 THE CARDIOVASCULAR SYSTEM: BLOOD VESSELS AND HEMODYNAMICS
22 THE LYMPHATIC SYSTEM AND IMMUNITY
23 THE RESPIRATORY SYSTEM
24 THE DIGESTIVE SYSTEM
25 METABOLISM AND NUTRITION
26 THE URINARY SYSTEM
27 FLUID, ELECTROLYTE, AND ACID–BASE HOMEOSTASIS
28 THE REPRODUCTIVE SYSTEMS
29 DEVELOPMENT AND INHERITANCE
APPENDIX A: MEASUREMENTS A-1
1
29
63
113
153
182
208
255
289
327
366
447
492
527
581
606
635
680
728
757
802
875
918
967
1024
1065
1110
1129
1181
APPENDIX B: PERIODIC TABLE B-3
APPENDIX C: NORMAL VALUES FOR SELECTED BLOOD TESTS C-4
APPENDIX D: NORMAL VALUES FOR SELECTED URINE TESTS D-6
GLOSSARY G-1
CREDITS C-1
INDEX I-1
APPENDIX E: ANSWERS E-8
xxi
CONTENTS
1
AN INTRODUCTION TO THE
HUMAN BODY 1
1.1 Anatomy and Physiology Defined 2
1.2 Levels of Structural Organization and Body
Systems 2
1.3 Characteristics of the Living Human Organism 5
Basic Life Processes 5
1.4 Homeostasis 8
Homeostasis and Body Fluids 8
Control of Homeostasis 9
Homeostatic Imbalances 11
1.5 Basic Anatomical Terminology 12
Body Positions 12
Regional Names 12
Directional Terms 13
Planes and Sections 16
Body Cavities 17
Abdominopelvic Regions and Quadrants 19
1.6 Medical Imaging 21
Chapter Review and Resource Summary 25 / Self-Quiz
Questions 27 / Critical Thinking Questions 28 / Answers to
Figure Questions 28
2 THE CHEMICAL LEVEL OF
ORGANIZATION 29
2.1 How Matter Is Organized 30
2.5 Organic Compounds 44
Carbon and Its Functional Groups 44
Carbohydrates 45
Lipids 47
Proteins 51
Nucleic Acids: Deoxyribonucleic Acid (DNA) and Ribonucleic
Acid (RNA) 56
Adenosine Triphosphate 56
Chapter Review and Resource Summary 58 / Self-Quiz
Questions 60 / Critical Thinking Questions 61 / Answers to
Figure Questions 61
3 THE CELLULAR LEVEL OF
ORGANIZATION 63
3.1 Parts of a Cell 64
3.2 The Plasma Membrane 65
Structure of the Plasma Membrane 65
Functions of Membrane Proteins 66
Membrane Fluidity 66
Membrane Permeability 67
Gradients across the Plasma Membrane 68
3.3 Transport across the Plasma Membrane 68
Passive Processes 68
Active Processes 73
3.4 Cytoplasm 78
Cytosol 78
Organelles 81
Chemical Elements 30
Structure of Atoms 31
Atomic Number and Mass Number 31
Atomic Mass 32
Ions, Molecules, and Compounds 32
3.5 Nucleus 88
3.6 Protein Synthesis 92
2.2 Chemical Bonds 33
Somatic Cell Division 96
Control of Cell Destiny 99
Reproductive Cell Division 100
Ionic Bonds 33
Covalent Bonds 35
Hydrogen Bonds 36
2.3 Chemical Reactions 37
Forms of Energy and Chemical Reactions 37
Energy Transfer in Chemical Reactions 37
Types of Chemical Reactions 38
2.4 Inorganic Compounds and Solutions 40
Water 40
Solutions, Colloids, and Suspensions 41
Inorganic Acids, Bases, and Salts 42
Acid–Base Balance: The Concept of pH 42
Maintaining pH: Buffer Systems 42
xxii
Transcription 92
Translation 94
3.7 Cell Division 94
3.8 Cellular Diversity 103
3.9 Aging and Cells 103
Medical Terminology 106 / Chapter Review and Resource
Summary 106 / Self-Quiz Questions 110 / Critical Thinking
Questions 112 / Answers to Figure Questions 112
4 THE TISSUE LEVEL OF
ORGANIZATION 113
4.1 Types of Tissues 114