Scientific Group on Methodologies for
the Safety Evaluation of Chemicals
N. P. B«ko¥. Director. Ins,itute of Medl"3t Genel~S_ and S<:ienlilk Secr.tal)
Generat. Academy of Medical Scie"""s of 'he USSR. Kalirtkoe lo.se 60.
Moscow 11547S, USSR
Philippe Bourd.... Di,,-"tor. Dir~torate-Gen.ral for SciellCe. R.search ond
De"elopmenl. Commi..ion of'he European Communities. Ruede la loi 200.
B·Ifl49. Bru....ls. BelgIUm
'Gordo~ C. 8<I'ler. Divis;on of BIological Scl'~' t-;auona1 Research Council
of Canada. Ona"'-o. Ontario KIA OR6. Caoada (Viu Cha"man)
• Milr.! GOIO. Profess<>r. Department of Chemistr)' and Dircclor. In'ttlute of
EcOlo.icolollY. Gaku,hu;n University. 1·5-1 M.jiro, T o,h'lt\ll.ku. T ok) 0 171.
Japan
• A. G. Jolu.els. Prcs>dent. The Royal S...edi,h Academ)' of Sciences.
Naturhimi,h rikimu...t. S·Ifl4 05 Stockholm. S".den
C. R. Krl,h..a ,\lurr.!, Pnnclpal Coordlna'or. In,.grated En"ironmental
Programm. on He",)' Metal.. Go,'.mm.n' of India. Centr. for
En'lronmen,al StudIes. Anna Un;,'ersi')'. GUlDd). Madras·60002S. India
\'. L.n<la. Director. IM,i'ute of En'omolos). Czech.,.lo'·ak Acad.my' of
S<:ie~_ \'inl~:i. 7. 12S00 Prahlt 2, Czechoslo,..k,a
"'-I)" M• ........". Professor and Chairman. Departmenl of Commun;')'. Industrial
and En,-ironmenla1 Health. Atn Shams Un,,'e..i',. PO 80, 38. Abba..ia.
Cairo. Eg) pi
• NOrlo" N.I...... Profes...r, N.... York Univ.r,it) Medi..1Center, InStitute of
En'ironmental Medicllle. 550 Fir-o' Avenur. Ne'" York. New York 10016,
I,;SA (Cha",""n)
T....m•• R. O<Iblalllbo_ Dlreclor. Intem'''on.1 C.n're ro, lnsrct Ph) ,"otogy .nd
Ecotoil'. P,O, 80. 30772. l'airobi. Kenya
• Blanca R.q~l OrdOlln. En,·ironm.ntal Ad,·i ..r 10 'he Und.rsccrctol) of
Health. lope2. COlina 739. Colomia del Vall. 03100. OF MeSlco
J. Pari..k. Scientist. Intcr!lalional Programme on Chem"'al Saret),. D,Y,s,on or
En,',ronmen'al He.lth. World Health Organiza'ion. 1211 Ge.....'. 27.
Sw;'zerl.nd (Su....",}')
rkggis V. Pub. Head of Depanmem and Profeoo! of BlochemIStT).
Ikpanment of BiochemiSl!). Uni'ersil~ of Surre) Guildford. Su,re~ Gl;"
5XH. England. United Kinidom
D.,'ld B. Put-II. Head. W,ldlif. Tox;colog; SecllOn, Wildlif. To.",olog) and
Pathology Dj,·;s,on. :>'atlonal Wildlife R.soar<h Centre, Canadian W;ldlife
Sc""co, Env;ronm.nt Canada. Ollawa. On,ano KIA OE7. Canadll
J ....,. K. PIo.ro ..skl. Ch,ef. Dtpartmont ofTox;coloR",al ChemiSI!). In,l;lUI. of
En"tonmen,.1 R..oar<h and Bioanal~'..s. Med>eal Acadom) ,n KOdi,
~arutowicza I2QA. 9O-1~5 Kooi. Poland
P."l<k J. S.... han. D"',,;on of B;olog;cal S,,,.n«s. Nat'Dnal Rosear<h CDuncil
of Canada. Onawa KIA OR6. Canada (AwS/ant $«""a')')
ElIIlllu...1 SOm..... Director General. En";ronmental H.alth Directorate.
H.allh PrD'e<tion Bran<h. Hoahh .nd Wolfar. C.nad•. Eo"rDnm.n,.1
H.alth Centr•. TunnO) " Pa"u",. Otta"'a. On'ano K \ A Qll. C.nada
R.n~ Truhau•. Prof..""r and Director. Llborato;,. d. Tox,rologi. el d'H) gu'n.
[ndumi.II•. f""ulte d., Sci.n«> Phanm.<xuti'l"" .1 B,ologi'lu, d. Pari.
lu:tembourl. Un"'...,,. Rene Dos<.rtO'$.~. A'on"" d. rObw"'a'o,re. Pans
7S006. france
V.limi, B. V.... k, V",tlna Sci.nt..,. Nalionalln,nl"" of En,,,ronmen,al H.ahh
Sci.n«s. P.Q Box 12H3, Rose.reh Tnangl. Park. North Carolina 27709,
U"
Participants oj the Workshop on
Methods Jor Estimating Risk oj
Chemical Injury: Human and Non·
human Biota and Ecosystems, Rome,
Italy, /2-/6 July, /982
Roy E. AIMr!. Prof=r IlJId Deputy Direclor. In,mute of En';ronmen~1
Medic,ne. "'.,., York Un,w""y Medical Cente,. ~50 Fi"t A,·enlle. N.,.
York. New York 10016. USA
EIi.aMth Andersoa, Oir""toc. Offie< of Health and En' .ronmentat A.....ment.
Offie< of R"""arch and !)e"etopment. En~ironmental Prot«;tion Agency.
401 M Street. S W.. Wuh,nglon. DC 20-160. USA
Br".. K. Arm..."",. Prof"'$Or. Department of Medic,ne. QU«1I Elizabeth II
Medicat Cen're. The Un",.",,,) of Western Australia. Nedland. 6009.
WeSlcrn A....tr.1ia
oN. V. B.lenko. A. N, Ma.-.ee. Research In"itute of General and Community
H)grene. Popudrenko SO. K,ev .S2 160. USSR
J. C.rl Balun. Laboratof} of Pulmonaf}' FUl>Ction and Toxicoloi)'.
In,ramural R=arch Proir.1m. Nanonal [ns"tute of En"lfonmental Health
Sciencn, P,O. Bo, 12233. Re..arch Triangle Park. :-;C 27709, USA
Rolf B.... lnstilut ru, A.-.neimittel d.. Bunde.ge.undheit..mt"'.
S~ulfenbtrptrasse 30. Postf.ch 330013 0·1()()() Berhn (W..t) 30
J. A. R. B.t... Pesticide Spe<:ialiSt. Plant Production and P,ot«;tion Oi.'i.ion.
Food and Agriculture Orpnization oftl>e Un,ted Nauons. V~ <klle Tenne di
Caroealla. 00100 Rome. 1Ial)
Burt"" C. Bennen. Mon'tonnll and A$.5e$smcn, Rese.rch Centre (MARC).
Chelsea College. Uni"ersll) of London. TbeOc~gon Buildin&- 4~9A Fulham
Road. London SwlO OQX. Unned Kinldom
A. Berlin. Heallh and Safety Dire<torate. Comm"'ion of the European
Communitie•. 3ean Monnet Bu,ldmll. Luxembourg (G.O.)
'Ccrd Bochert, lnstitut liir Tox,l:ololle uod Emb')onalpharmakologie der
Fm<n l.)nwe",iu;t Berlin. Ga')'strasse 9. D·I()()() Berlin (W..t) 33
""viii
.~.
Pa'li~ipan1J
of 1M WlJrluht>p
IJII
Mrrht><b flJr E>1im<lling RiJt
r. !'OCtOl'. Director, Institute of Medical Genetics. Academy of Medical
Sci,n<:e$ IJf thr USSR. Kdi"ko<; los$( 6A, ).1050:0" 115478. USSR
Pbilip~ Bou'd.... Directo,. Dim;torate-G.n.ral fo' Science, R=a"'h and
o.,'e!opm.m.Commiulonoftl\c: European Communi lies.. Rued. b loi 200,
B-l049. D,uslel,. Belgium
Go,d"" C. Butl.r. Oi'i"on of Biolopeal Scien~es. NallOnal Relea",h Council of
Canada. Otta"a KIA OR6. Canada
DI"idr C.I.IlI.rl, [.tilulO di Rice",a ,uU. Acqu•. ConSIglio Naziona[. delle
RI~",he. 20047 Brugh.rio. MIlano. h.[)
K.nMlh P. CUllH'. En,ironm.ntal Epidemio[olY Branch. Nationa[ Cancer
In.tilut•. 3C08 Lando" aui[dini> Bethesda. Mary[and 20205, USA
'L A. CrnUhlko. A N Ma=ev R=a"'h lnSl1tul( of Gene,al and
Community Hygl.ne. Po!'udrenko SO. Kie' 252 [60. USSR
'C. C. Chang. o.panmenl ofPediatri<:> and Human o.'.[opm.nL Coll.g. of
Human Medicin•. MichIgan Slat. Un"""'l). EaSl lanSIng. MIChIgan 48824
'G. Chiaudui. In,"'uto dl Ri~rca ,u[!e Acq .... Consillio Nazional. deU.
Rice"'be. 20047 Brollh.no. Milano. Lt.[)
M••slmo Cr"pl. Prof......r. C.otro Diagno., Pre<:~. Ospedale R.gina EI.na.
Rom., haly
H..... y Cro... United !'oalion, Environm.n, Pro,ramm. (UNEP). PO. aox
30552. NalfQb" Ken)a {Rq'....nring UFEP)
Leanall Dani.!sotI. [n,'ironm.nlal Directoral•. Orpnization for EconomIC
CooperahOo and o.,'e!opmcn, (DECO) (Rrp'....nrllfg GEeD). 2. rue Andre
Pascal. 75775 Pari, Ced., 16, France
Nith<>[., O.y. Programme of a,OSlalistlcs. Di,i.ion of Epid.miolol\l and
aioSlalislics. Internalional Agency for R...arch on Cancer, 1SO COUl, AlbenThomas. 69372 l)'on Cedu 2. Funce
'Mlklo hjill. Radiation Effects R...,a",h Foundation. ,·2 HIJiyama. Park.
Hlfosh,ma 130. Japan
'Ka.uki Corlkl. Radialion Effect. Re5Ca"'h Foundalion. 5-2 Hlji)lma Park.
H,rosh,ma 730. Japan
Miki Golo. Professor. Departm.nt of Chemi5lry and Director. In'titule of
EcOlOAlColoi)'. Gaku'huin Un",,",ty. 1-5_1 Mej"o. Toshima-ku. Tok)'o 171.
Japan
Da,'ld G. Hoel. D"ector. Blome,') and Ri'k Assessment Pr0llram, Nalional
In'tltul' of En~ironmental H~a\lh Scl=. P.O. BoA 12233, R...a",h
TrianJle Park. NC 27709. USA
Jobn W. Huck.bu. Electric Pow~r R...a",h In'li'ut•. 3412 Hill"iew A".nue.
Palo Alto, California 94303. USA
Jan Hni.IIlI.... Director. Inlornational Relll""' of Pot.ntially TOAIC Cbemical•.
Uniled Nalion' En,'ironment ProgJ"amme {UNEPj. (lUpr~uming vAEp).
Pab" drs NIIlOns. 1211 Ge=... 10. S"'lUrland
N. J •. JUl''''''', Profes"". A. N. Maw:e" R~..afch In'tilute of Gen.ral and
Communll~ H}llene. Popudrenko SO. KlCV 2'2 160. L;SSR
L "_ro. Scienust. Eo"ronrnm\.l.l Hazards aDd Food. PrOl<CUOn.
of E..a'~ron"..o\.l.l H~allh. .... orId HWlb OrpOlZ.llJ01l. 1211 Gcne-'1l H.
S..,lJrfbnd
T. T. Ko
ski O>RCtor ofllw 8101f'OC1 and A J RJ.1<..- Professor of forestf) ,
t:DJ,· ,~ of WtV'1M!UII \bd_ 211' ~alOf) Drw~. Maduoor..
.... lJCOMUl '3~ L;SA
C. K............ .'>In. O>rcctOl". IlldOSlNI T~ Il~ Cmue,
M:ahJ.lm3 G3Ddtu Ma.... POst 80s 1'00 10. L""kDoo. 216001 UP. IlldA
J .. I. "-'in. Director. KX' R.etca..:h I,,",,'u~ of Laboar Hl~ and
Occup;al>ODlll o...wes.. L'I. Cblo>lI :U. K.... L:SSR
\. LaM•. o.rcctor. l""--,,u~ of EDl<IIDOIot:l. CU<:bO<!mU Aademl of
0>,,_
Scieoces-. ''-u'!b\a. 7. U800 f'ra&w 2. Czu:boolo>-ak.a
Couu .\tllllOlli.. O>rcctor, ]Sltln,O dl Olll:olop 'F Ad<bni'. Ce<t,ro Tumon.
''-Iak EroiaDJ. 4 2. 4O13ll 8olopta.I\.l.ly
ProfOS$Ot and Chl,lmII.n. Do-p.rtmetI, of CotnnlllDltl. lodllSU"lll1
and En onmenUlI MedJa"". Em Stwns Un,,~n,,~. P.O 80s 38. Abbasta.
C.. ro. E~iPt
'1""" ,'\..,~Iet. Mana~•• Intcmauo""l P'0Jf3= on Ch~ntJcal Slfel)
(IPCS). D1'ision of En"lronmentll H,alth, World H~"',b OrpnlUUOtt
(WHO). (R,prrM~11ng WHO JPCS/. 1211 Gene.a 27. S...m~.laod
D. R. Miller. Division of 8101o~.1 Sc.. ncn. Nallonal Research Conncll of
Canada. Ona"a KIA OR~. C.""d.
L.n. Moo",d•. 1J\t~...slonal Research Unit. Int.mational Pros.amm. on
Chem,cal Saf~ty. National InituUl, of Envlronm,nlal H.alth Sci.nul. P ,0,
Be, 12233. R.search Tr;anil~ Park. NC 27709. L:SA
J ...... V. roo«l. P.of....... (Xpartmenl of Human G.n.t"'l. Uni .... "il) of
MlChipn Medical School. lIn E C.thonn. StIttL Ann A.bo•. M"'hlpn
481O'J. USA
l'>orIOlll'>,IsOII. Prof",,,,,•. 1'0.... York Unl....... l) Medical Center. IOSlItUW of
En".onmenUlI Mo<I"',~. SSO fIrst AvctI~. N.... York. N~1Il' Yo.k 10016.
All \I
USA
• {);Od,er :-.",,1Ioert. h'SUlUt fljr TOllkolot>e ut>d Embr)onalplw-makolopc lkr
FreIC1l l:Dl'et'Sltl.t ilerlln. G.')'st...... 9. 0-1000. Berlin (West) 11
"dlo :-;~to. Socond Dc-panmelU ollnlCftl.ll Mo<IlCIfle. H"m.IwDa
LDl..... ~ Scbool of MedJane. H'............ 7J.t. hpaD
l'>_M<-&. ProfC$loOf and CllIlnnall. Depanmc:nt of En"........... w
H)pet>e. Scbool or Medlant. 1]..... U"""""). 5-90187 U...... S.."eden
81...". R""'P<I ~... Coonl'OItOf olllw En,-U-OItttlCtlW HwLh Research
Protn-mme. Utliwenicbd AIII_ MctropoIru.na.. Boale>'Md \la.llud
A,,.. Oomacho 90. SallCl.lpan. MCSJO, z.p 10. A~ posulllS. MC'DI:O
e-
J.Df
J. P.fu:d;. SaenltSl-. Inlmlll>ODlll Prosnm- "'" Cbett>nI Sirf'!) (IPCS),
xu
Parti(lp<ml. of I~~
Worh~op on M~rlwdJ
for &limaU"" RiJk
Dh'i>ion of Em'ironmental Health. World Health Organization. 1211 Gene-I
H, S",uerland
DI.'id B. PU~III. Head. Wildlife ToxicolollY Section. Wildlife Toxicology and
Pathololl}' Oi'-"'On. Nauonal Wildlife Research Centre, Canada Wildlife
Service. Environment Canada. Ona...·a. Ontario KIA OE7 Canada
Joli.. Pelo. Divi.ion of EP>demlolozy. In.mute of Cancer Research. aifton
A'·enue. Sulton. Surre; 5M2 5PX. Enlliand. United Kingdom
Jouy Piolro •.-.Jd, In'tnute of Environmental R......rch and B"".naly....
Medical Academ; in KOdi. Naruto... icza 120 A, 90-145 KOdi. Poland
Sir EA",.r1I Pochio. I'ational RadioloJICIl Protection Board. Chillon. DidcOl.
Oxford'hire. aXil ORQ. England. Unned Kingdom
I. F. H. Porch..... D,rector. Central ToxlCololll Laboratory.lmperill Chemic.1
lndumi.. PLC, Alderle,. Park. l'r Macclesfield. Cheshire SKIO 4TJ.
Enllland, Unittd K,ngdom
Muffed Rljo".ky. Prof.....r. In.titut fUr Zellbiolo&le (Tumorforsehuna).
Uni"ersllit E...n (GH). Hufeland,tra<$e 55. 0-4)00 Essen 1. Federal
Republic of German;
U..be,to Sillionl, Chief. Laboratnry of Experimenul Pathololll_ National
Canc« In.utute. f redend Cancer Research Faeiht;. Bldg s.6O. Room 32·60.
Frederick. Maryland 21701, USA
Chelliab S.thnuuth.n. I, Unity PIaa':. Colnmbo 3, Sn Lanka
'Chiyoko Satob, Radiation Elfeet' Research Foundation. 5·2 Hijl;~m. Puk.
Hiroshima 730. Japan
Pur;ck Slt«hu. Dt'iSlon of B,oloaieal S<:1enee<. l'auonal Researcb Council of
C.nada. Ottawa KIA OR6. Canada
Gio.-anni Silini. Secreta!)'. United Nation' S<:ientific Committee on the Elf"'t. of
Atmoic Radiation. V,enna International Centre. P,O Box 500. A·I400
Vienna. Austria
E..."'.....I SOm...~_ Doreetor--Gencra1. En,-oronmental Health Directorate.
Health Proteetion Branch. Heallh &: Welfare Canada, Tunne,,'. Pallur~.
Otuwa KIA OLl. Canada
"""r~" ~. Deputy DIr«1nr. Mnnnonna and Ass«.mcnt Research Centre
(MARC). Chel..... Collelle, University of London. The Octallon Build,nll.
459A Fulham ROlld_ london SWIO OQX. United K\nadom
'Harry St~lur_ C. H, Bo<hrinaet lnaell>elm. Abtellung fur (xpenmrnteUe
Pathol<Jiie und Toalkologie, ~507.lngelhe,m Rbein. Federal Republic of
Germany
• Per SI,an2~f1. MInIStry of lndu'try. Fa~k. S·103 33. Stockholm. Sweden
Rnberf G. Tardiff. Eaeeuti,.. Direetor. Board ofToxicolog" and En"ironmcntal
H~a1th H....rds. A...mbly nf Life Sciel\C($. National Research CounciL
I'ational Academy of SC,.n.... 2101 Cnnstltut,nn A,·enue. Wa,hlngton. DC
20418. USA
• D..-id G. Thomasson, Em'oronmental Carc,nogene.is Group. Llborato!)' of
P'''';C;panIS of liIL Worhhop on Mtlhods for £Si;mt1lin{} RisJ<
~XXI
Pulmonar~
Function ana To,icologj. Inlramural Research Program.
I'at,onal In'IItUle of En' ",on menIal Heallh Sc;.,,,,,.., Research Triangk Park.
l'iC 2:709. USA
l.o.~nl" T"mali•. DireclOr. Int.rnational Ag.ncj for R''''arch on Cancer
(lARC). 150. coun Allxn:Thomas. 69372 Lyon Ccdex 2. France
'R. K. T,.d.". 5911 Lo\Ojo} COUrl. Springfi.ld. VirgInia 12152. USA
J...... E. Trosko. Prof..",r and A5SOCiat. Director.,f O;yillon. D<panmcnl of
Pcd,alflCS and Human o.'Clopm.nl. MIchigan Slat. Uni... nuy. Ea,t
Lan,mi!. Michlgan 4gS:l4. USA
':\1. VI~hi. In,nluto dl RlCCrca ,ulle Aeque. Con"gl;o :"uionak dell. R,cerch•.
2(10.17 Brui!MnO. Milan.,. Italy
Velimir B, Vouk. Visiting Sc,enti.l. Office of Hullh Hazard A....'m.nl.
:"allonal In'tltUle of En'",onmental Health Scien...... P,O II<>x 12233.
Re<earch Triangle Park. l"C r'09. USA
:\1. "".ldlcbuk. Fi.hene. and (keanl Ca!\llda. W.,t Vaneou,'er Laooralor~.
4160 Marine Dri"" Wesl Vancouver, B.C. V7V 11'6. Canada
'I. Ikrnard "" oin"oln. Di""on of EnY'imnmenlal Sc;en<:cl. Cancer C.nt.r.
[n,nlute .,f Cancer Rel<arrh. C.,n'le of Ph) lieianl and Surge<>nl. Columb,a
VniY'erlit). X."" York. l'e'" York lOO32. USA
Allen J. ""ikox. Ep,d.miololY Branch. B;ornel!"; and R"k A....'ment
Program. National In,l;tut. of EnY'ironrnental He.lth Scien...... PO, 11<>,
12233. Re<earrh Tnangle Park, /,;C 27709. USA
Hi,...bi Yamasaki, Unit .,f \I«hani,rn of Ca""n.,~.nc"s. D"',,,on of
EnY'Lfonrnental Carrlnol.ne",. International A~.nC} f.,r R.... rch on
C.ncer. 150. cOurl Allxn·Tl\.,rnas. 69372 Ly.,n Ccde' 2. Fran«
·Y. Yoshimoto. Radi.lion EfT«t' R.... rrh Found.lion. 5·2 HiJiy.rn. Park.
H"",h,ma 730. Jap.on