ISWC '14 ADJUNCT, SEPTEMBER 13 - 17, 2014, SEATTLE, WA, USA A Smart Scarf for Pulse Signal Monitoring Using a Flexible Pressure Nanosensor Dongzhan Chen Ting Zhang Abstract Mobile Computing Center, iLab, Suzhou Institute of Nano- University of Science and Tech and Nano-Bionics, Technology of China. Chinese Academy of Sciences Chengdu,China Suzhou, [email protected] Jiangsu China Real-time, long-term pulse signal monitoring plays a significant role in monitoring chronic diseases for elder people, pregnant women etc. For users with weak pulse, a carotid pulse signal monitoring system can be appropriate. However, till today no unobtrusive solution is available. Therefore, we suggest a novel flexible and planar pressure nanosensor weaved in a smart scarf system for pulse signal monitoring with better user experience called Smart-SP (smart scarf for pulse signal monitoring system). To our knowledge, this is the first time applying a flexible pressure nanosensor on a wearable carotid pulse monitoring system. To meet the needs of the application, a method is proposed to design the size of the sensor. An interface allows third-party analysis software and provides raw data. A database of pulse signal for diagnostic purposes is set-up. Digital low-pass filter improves the signal accuracy. [email protected] Michael Lawo TZI – Center for Computing and Yang Gu Communication Technologies, iLab, Suzhou Institute of Nano- Universität Bremen, Tech and Nano-Bionics, Bremen, German Chinese Academy of Sciences [email protected] Suzhou, Jiangsu China Yu Zhang [email protected] Mobile Computing Center, University of Science and Dongyi Chen Technology of China. (Corresponding author) Chengdu,China Mobile Computing Center, [email protected] University of Science and Technology of China. Author Keywords Chengdu,China wearable, carotid pulse monitoring, pressure nanosensor, interface design [email protected] Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the owner/author(s). Copyright is held by the owner/author(s). ISWC '14 Adjunct, September 13-17, 2014, Seattle, WA, USA ACM 978-1-4503-3047-3/14/09. 237 Introduction In recent years due to the ageing population [1] and increasing healthcare costs wearable long-term healthcare monitoring plays a more and more significant role for disease prevention in daily life. ISWC '14 ADJUNCT, SEPTEMBER 13 - 17, 2014, SEATTLE, WA, USA Monitoring and diagnosis of some chronic disease like cardiac disease, hypertensive disease and chronic obstructive pulmonary disease (COPD) require artery pulse signals [2]-[5]. Contour, duration and amplitude of the pulse signal provide important information [6]. Users suffering diseases like cold syndrome or bad blood circulation have pulse signals hard to detect, including radial artery, ulnar artery but except carotid artery signal. The carotid is an aorta easily detected and signals there make sure that the patient is alive. However, as the neck is sensitive and flexible a carotid pulse monitoring system is difficult to design. Figure 1. Detection of carotid pulse. Several methods of measuring carotid pulse signals have been proposed. The most common way is using some photoelectric principle [7]. Light emitted by LED is reflected and transmitted by tissue, muscles, skin and blood vessels before received by the photodiode. To avoid the photodiode influenced by other illuminant the sensor must be pressed onto the users’ body. For the sensitive neck it is obviously an uncomfortable method. Paper [8] presents a method to detect the carotid pulse signal based on electromagnetic induction. The carotid pulse is in [9] detected using the principle of the Bragg probe. Yu-Pin Hsu and Darrin J. Young used a MEMS pressure sensor [10] to detect the blood pressure waveform by skin surface coupling. The papers propose new but infeasible methods for wearable systems, as the sensors used are hard, rigid, bulky and heavy, which make them unfeasible to be applied at the flexible and sensitive neck, as any sudden movement may hurt the user. Thus, all the above systems are inappropriate for any long-term wearing. But without long-term data system is required for diagnostic purposes. For elder, weak, bad blood circulated, cold syndrome users, monitoring regions 238 such as the wrist and finger do not deliver reliable data. In conclusion, building a long-term carotid pulse monitoring wearable system is desirable. This paper proposes a carotid pulse signal monitoring system -- SmartSP, which is based on a new-type of soft pressure nanosensor[11][12]. SmartSP can provide the users the feeling of unrestrained and relaxed to do indoor or outdoor activities while constantly monitoring the carotid pulse. A user centered design approach is proposed for the size of the sensor meeting the needs of comfort and measurability. Beyond this, SmartSP is designed as a common scarf, users are wearing SmartSP will not feel weird or even stigmatized. SmartSP cannot only suit for critical patient, but might become fashionable. The flexible, light-weight, comfortable and non-irritant sensor is adhered on the skin-surface to get the carotid pulse, and the PCB is weaved on the other side of the scarf, so that users will not directly contact with hard components. Because of the ultra-high sensitivity of the sensor, the carotid pulse signal can be measured without constraint. The data is collected in a general file system integrated in SmartSP can be checked on mainstream operating system platforms. This interfaces third-party analysis software. The data can be merged with other physical data for improved diagnosis. This paper explores and implements the new-type nanosensor in the application of wearable carotid pulse signal monitoring significant also for other applications of soft sensors. System design Characters of the sensor and the detecting principle The flexible pressure nanosensor was fabricated with the method published in the previous work[11], which WORKSHOP: WOSG is constructed as a sandwich structure containing two single-walled carbon nanotubes(SWCNTs) conductive layers on micro-patterned polydimethylsiloxane(PDMS) substrates, where the SWCNTs layers contact with each other. Microstructured PDMS film is the most popular flexible substrate to integrate sensitive nanomaterials for the sensing applications due to its excellent elasticity and biocompatibility, and SWCNTs networks can be stretched and bended without large changes in conductivity. Because of these advantages, the sensor is soft with little effect on the users’ daily life when applied. The pattern on the PDMS substrate will deform when applied tiny pressure, so the contact resistance between two SWCNTs conductive layers will change, which allows to detectable pressure as low as 0.6 Pa Carotid Artery and have a 1.8 kPa (a) Side view of carotid artery A B D E sensitivity under 300 Pa . Besides, the size of the sensor can be defined as we need. Through testing, these characters make the sensor perfect to detect carotid pulse signal. C Carotid Artery 1 Figure 1 shows the principle of detecting carotid pulse by using the sensor. Carotid pulse causes shockwaves. When a pulse wave is spreading to the skin-surface through the muscle and tissue and then received by the sensor, the resistance of the sensor will change depending on the strength of the wave. The resistance is converted into a voltage signal. With an electronic amplifier and a low-pass filter the signal-to-noise ratio is improved. (b) Cross section of neck Figure 2. Demonstration of carotid artery position. The design of sensor size The sensor will be directly adhered onto the skin of the neck. To identify the right position one might recall that the carotid pulse signal should be detected on the side of the neck as indicated in figure 2. A proper size of the sensor should ensure covering the activity area. Figure 239 2(a) shows that the carotid artery is vertical distribution in the neck. So, whether the sensor could capture the signal just depends on the horizontal rather than vertical position. Though there are different neck perimeters, the persons’ carotid artery position is individual with more or less similar proportion. Actually, as the carotid pulse signal will spread, the section A-B is affected as figure 2(b) shows. Although the sensor can detect a wider section, for simplicity, this segment AB is used as target section for putting the sensor on the skin of the neck. In the figure 2(b), the points C, D and E divide the perimeter of the neck into 3 parts. The cylindrical projection is shown in figure 3. Point C as the center of the front side of the neck is easy to be located. Although it is hard to locate the accurate point D, every position of segment DE should doubtless belong to the back of the neck. The sensor has to be in segment CD rather than segment DE . Two extreme conditions should be considered for an appropriate position. If the sensor is placed like M or N in figure 3, the length of the sensor should be longer than Max( BD, AC ) . If so, the sensor can certainly cover the segment AB and detect the carotid pulse. Assuming that : CD and CD : (with as the perimeter of neck), the length of the sensor can be designed as follows: (1) The proportion of each segment of this model is AC : AB : BD : DE 1:1:1: 3 . That is 1 . 3 ISWC '14 ADJUNCT, SEPTEMBER 13 - 17, 2014, SEATTLE, WA, USA Figure 3. Analysis model of dimension of sensor. Normal persons’ perimeter of neck is less than 400mm. Substitute into the formula results to 45mm . After consumption and the poor reliability of wireless communication. adding necessary package, the length of the sensor should be 15 60mm . Figure 5(a) shows the hardware of the system. Modules of SmartSP are weaved in a common scarf and the wire is weaved as well. Figure 5(b) left shows the on-body appearance. As right of figure 5(b) shows a smart phone or watch can be used to check the data in realtime. Users could adjust the system by themselves according to the data. Unless the users’ perimeter of the neck is less than 180mm , the sensor will be usable. In this way the sensor is suitable for most of users. In this case, users who have wider neck perimeter can still locate the active section accurately after simple practices. (a) Hardware block diagram. Carotid pulse signal Digital Low-pass filter Data storage Data translate (b)Digital signal processing stage. Figure 4. Overview of the SmartSP. System architecture SmartSP meets the primary needs of wearable mobile monitoring. Figure 4 shows the overview of the whole system including hardware block diagram (a) and digital signal processing stage (b). Signals acquired by the sensor will be pre-processed by an AC coupling circuit to obtain high noise-signal ratio outputs. And then, signal is acquired with a frequency of 500Hz by the 12-bit ADC which is integrated in the STM32F103C8T6 microprocessor. Li-battery and its management unit, Mini-USB (for charging battery) and T-Flash Card interfaces are also designed in the MCU module. The collected data will be processed by a digital low-pass filter first. The preprocessed data is sent via circumscribed ultra-low power consumption Bluetooth module (HC-05) and stored onto a Micro SD card through the SPI interface. The SmartSP integrated with a FAT File System (FATFS) also store the data into “.txt” files. Thus third-party developers and the users can obtain the data easily. Storing data into Micro SD card directly ensures the reliability and integrity of the data and due to the band width of Bluetooth, power 240 Evaluation and Discussion 100 participants were invited to evaluate the SmartSP (53 males and 47 females). The ages of the participants arranged from 18 to 65 (average age is about 39.6 and the standard deviation is about 12.4) and education background arranged from junior high to Ph.D degree. The distribution of age is that 23 participants in the 18-27 year old, 16 participants in the 28-37 year old, 25 participants in the 38-47 year old, 21 participants in the 48-57 year old, 15 participants in the 58-67 year old. The distribution of education background is that 16 participants in junior high degree, 25 participants in senior high degree, 29 participants in bachelor degree, 20 participants in master degree, 10 participants in Ph.D degree. The evaluation had two parts to check whether the SmartSP was easy to use and the user experience. To analyze if the SmartSP could capture carotid signal with fuzzy location, the users were first instructed to use the SmartSP by a direction-handbook of SmartSP. The handbook explained what SmartSP was, how to use it, its functions, what the sensor looked like and where the correct position was to adhere to the sensor. To enlighten the users, pictures and descriptions were included in the direction-handbook. When a user was WORKSHOP: WOSG (a) (b) Modules of the system. Wearing the SmartSP and display based on Android platform. Figure 5. Wearable monitor system. At the second part, to investigate the user experience, participants were asked to wear SmartSP for an hour. Then, they were asked to describe their experiences. A 21-year-old male undergraduate said:” It just looks like a common scarf. Nobody noticed that I was wearing an electronic product. Even for me, I occasionally forgot that it’s not just a scarf.” A 20-year-old female participant said:” It’s amazing that I can see my heart beat whenever I want to.” For a 41-year woman, she thought her father would love it. “It’s a wonderful wearable device. It's comfortable to wear.”, a 34-yearold teacher said. A 59-year-old worker asked where he could buy a scarf like this. As mentioned above, a low-pass filter is used to obtain the signal with higher signal to noise ratio. Figure 6(a) shows the raw data and figure 6(b) shows the signal processed by the low-pass filter. As a result, low-pass filter successfully restrain the noise signal. To following analysis and research, a signal with better features is necessary. 241 1 .9 Raw Carotid Pulse Waveform 1 .8 5 A m p litu d e (V ) 1 .8 1 .7 5 1 .7 1 .6 5 1 .6 1 .5 5 1 .5 0 500 1000 1500 2000 2500 S a m p le 3000 3500 4000 4500 5000 1 .9 Filtered Carotid Pulse Waveform 1 .8 5 1 .8 A m p litu d e (V ) equipped with SmartSP, we consider the participant using the system correctly if pulse signal was captured by SmartSP. Participants with lower education background and elders tend to use the SmartSP in a wrong way. As a result, only 3 people could not correctly use the SmartSP at the first time (The background of the 3 persons are: 63, female, junior high; 64, male, junior high; 58, female, junior high). They could not understand the direction-handbook, neither how to used SmartSP. After explanations and training, they finally learned to use SmartSP successfully. It means that this design ensures SmartSP to be friendly to use. 1 .7 5 1 .7 1 .6 5 1 .6 1 .5 5 1 .5 0 500 1000 1500 2000 2500 s a m p le 3000 3500 4000 4500 5000 Figure 6. Carotid waveform processed by low-pass filter. A disease cannot accurately be diagnosed by merely one physical signal. Furthermore, different diseases need different interpretations of the recorded data. In case a specific algorithm is integrated into the system, the application of this system will be limited. We therefore set aside this interpretation of signals. Conclusion and further work A new method to monitor carotid pulse was presented. A flexible nanosensor is used in this wearable monitoring system called SmartSP. Users can experience this comfortable, light-weight and fashionable SmartSP. It meets the needs of real-time wearable carotid pulse monitoring. The using of digital low-pass filter produces output signal with high signal noise ratio. As a result, relatively pure carotid pulse signals were obtained. In the future, the way to eliminate the influence of neck motion, speaking and cough will be researched and added. Further more, probably, other physical signals like swallowing or breathing can be gathered ISWC '14 ADJUNCT, SEPTEMBER 13 - 17, 2014, SEATTLE, WA, USA automatically in one day for improving the accuracy in disease analysis. electromagnetic induction, Proceedings of 2012 ICME International Conference on Complex Medical Engineering”, IEEE, Japan, July 2012, pp. 441-444. Acknowledgements [9] C Leitão, L Bilro, N Alberto, et al. “Feasibility studies of Bragg probe for noninvasive carotid pulse waveform assessment”, Portugal, Journal of biomedical optics, January 2013, 18(1): 017006. We gratefully acknowledge MCC staff and volunteers, and the study participants. 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