Volume 2 Issue 2 Winter Edition Consortium of UT System MD/PhD Programs The University of Texas System has the 4 CTSA institutions in the State of Texas and 4 of the 5 largest MD/PhD Programs including one MSTP, UT-Southwestern. A Consortium of UT System MD/PhD Programs has been recently created to leverage these resources aiming to create an effective Clinician-Scientist Pipeline (from MD/ PhD student to Independent Faculty). Bi-annual meetings of the MD/PhD directors and administrators with UT System leadership have led several proposals to improve the administrative function- ing of each program. The Consortium is organizing an annual UT System MD/PhD Conference in Austin creating a larger community (~200 MD/PhD students) with thematic poster presentations for all students fostering inter-institutional collaboration, and a larger array of career development workshops. UT System MD/PhD Program Consortium ( left to right) : Randall Goldblum, MD (UTMB), Dianne Milewicz, MD, PhD (UTHSC-H), Patti Hurn, PhD (UT System), Larry Sowers, PhD (UTMB), Russell Broaddus, MD, PhD (UTHSC-H), Andrew Zinn, MD, PhD (UTSW), José E. Cavazos, MD, PhD (UTHSCSA), and Karen Browning, PhD (UT Austin). Inside this issue: Adler Endowment 2 Dr. Bruce Beutler 2 F30 & F31 Grant Recipients 3 Match Day 3 New Citizen 3 Announcements 4 Holiday Party 4 MD/PhD Awardees Katie Hinchee-Rodriguez, GS2 received the 2013 Graduate Travel Award to attend the American Society for Biochemistry and Molecular Biology ( ASBMB ) Annual Meeting. The meeting will be held April 19th24th, 2013 in Boston, MA. Katie also received a Certificate of Recognition for Best Poster at our 4th Annual MD/PhD Retreat on February 15th-16th, 2013. Raehannah Jamshidi, GS2 received an “Outstanding Poster Presentation” for her poster titled, “Long-Term Regulation of Kappa Opiod Receptor Function by a Single Administraion of the Antagonist norBNI in Peripheral Sensory Neurons”, at the Annual Behavior, Biology, and Chemistry Conference in San Antonio, March 8-10, 2013. Adler Endowment $1 million Adler Family gift provides support for scholars and research The latest program support to be announced is from the estate of Laura A. Adler in memory of her husband, Harry F. Adler, M.D., Ph.D. Half of the $1 million gift will establish the Harry F. Adler, M.D., Ph.D., Laboratory in the South Texas Research Facility. The other half will establish the Harry F. Adler, M.D., Ph.D., President's Endowment. Pioneer in translational medicine Dr. Harry Adler was an early pioneer in translational medicine who achieved the rigorous educational milestone of physician with his M.D. degree and of biomedical scientist with his Ph.D. degree. In 1950 he wrote an unpublished report on altitude decompression sickness that became a classic review used by many investigators. It was made into a book in 1964. Dr. Adler, a Chicago native, ran a family practice from 1949 to 1979 in San Antonio and was chief of staff at a Baptist hospital. He died in 1997. At a reception in November, Dallas dermatologist Max Adler, M.D., a 1976 alumnus of the School of Medicine at the UT Health Science Center, spoke on behalf of the Adler family. “Mom and Dad would be very proud of this,” he said. The event honored the memory of Dr. Adler and his wife, Laura, who met her husband when both were at Randolph Air Force Base. Although never formally trained, she developed great skill as a nurse. A group of nursing students from the Baptist Health System School of Health Professions symbolized the excellence she acquired in on-thejob training under the watchful eye of Dr. Adler. Mrs. Adler died Dr. Max Adler (center) With students from the MD/PhD Program. (Vinh Dao, Lena Wisely, David Melton, Jeff Cooney, Diana Villarreal, Katie Hinchee, and Josephine Thinwa (top row). Dr. Jose E. Cavazos, Trey Kellogg , Justin Drerup, Curtis Clark, and Daniel Barron Nobel Laureate, Dr. Bruce Beutler On March 24, the MD/PhD program hosted a roundtable discussion with Dr. Bruce Beutler, 2011 Nobel Laureate after his lunch seminar on Inflammation and Toll receptors (see your own email to students). Dr. Beutler is one of four Nobel Laureates who has lectured in our campus in the span of 12 months. Drs. Aaron Ciechanover, Stan Prusiner, and Mario Capecchi have also lectured at our institution during that span of time. Page 2 UT System Visit The MD/PhD program was featured at the annual institutional visit by the University of Texas System on February 18, 2013. The program was congratulated by the outstanding performance and productivity of our MD/PhD students with over 60% of them receiving extramural research funding during their graduate school years, an average 4.4 publications out of their PhD degree and a mean time to graduation of 7.8 years. Volume 2 Issue 2 MD/PhD Program MS4’s Match! NIH Research Service Awards Our two MS-4 MD/PhD students crisscross the country with interviews from Boston to San Francisco, and on March 17, they matched at outstanding residencies: Two more NIH National Research Service Awards were earned by our MD/PhD students. Daniel Barron: 1 F31 NS083160 - 01 entitled “Quantification of Thalamic Atrophy and Connectivity in Medial Temporal Lobe Epilepsy” Lena Wisely: 1 F30 AG043248 - 01A1 entitled “ Mechanism of Amyloid-beta mediated mTOR Dysregulation in Neurodegeneration” Angela Rodriguez Boyd – OB/GYN, UTHSCSA The MD/PhD program now has 5 F30 and 1 F31 NIH NRSA grants. In addition, two of our MD/PhD students have just received excellent F30 priority scores. We hope that we have great news later this year. With these NIH grants, our MD/PhD program ranks as top 8 out of 110 MD/PhD programs by the ratio of F30s per MD/PhD students in the program. Suzanne Thibodeaux – Pathology (Research track), University of Pennsylvania Publications Walch JD, Carreno FR, Cunninham JT. Intracerebroventricular (ICV) Losartan Infusion Modualtes Angiotensin Type 1 Receptor (ATIR) Exp ression in the Subfomicalorgan (SFO) and Drinking Behavior in bile Duct Ligated Rats. Exp Physiol. 2012 Dec 12 PMID: 23243146 Vo DT, Subramaniam D, Remke M, Burton TL, Uren PJ, Gelfond JA, de Sousa Abreu R, Burns SC, Qiao M, Suresh U, Korshunov A, Dubuc AM, Northcott PA, Smith AD, Pfister SM, Taylor MD, Janga SC, Anant S, Vogel C, Penalva LO. The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer related genes and is an indicator of poor prognosis. American Journal of Pathology. 2012 Nov; 181(5): 1762-72. Penalva LO, Vo DT, Boutz D and Smith AD. Post-transcriptional gene networks, Encyclopedia of Systems Biology, W. Dubitzky, O. Wolkenhauer, K. Cho & H. Yokota (Eds.), DOI: 10.1007/978-1-4419-9863-7, Springer. Oct 2012. Villard JW, Paranjape AS, Victor DA, Feldman MD. Applications of optical Coherenece tomography in Cardiovascular Medicine, Part 2. Advances in Non-Nuclear Imaging Technologies. Journal of Nuclear Cardiology, Vol. 16, No. 4; 620-39. Rossano A, Chouhan AK, Macleod GT. "Genetically-Encoded pH Indicators (GEpHIs) reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo." J Physiol. Accepted Dec. 14 2012, to be published early 2013 Ramirez TA, Jourdan-LeSaux C, Joy A, Zhang J, Dai Q, Mifflin S, Lindsey ML. Chronic and Intermittent Hypoxia Differentially Regulate Left Ventricular Inflammatory and Extracellular Matrix Responses. Hypertension Research, (2012). Kwek S, Dao V, Roy R, Hou Y, Alajajian D, Simko JP, Small EJ, Fong L. Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients. Journal of Immunology. 189(7): Oct 1, 2012. PMCID: PMC3448828 New Addition to the MD/PhD Program Extended Family Humberto & Diana Villarreal Lena Wisely becomes a US Citizen beauty, please visit: Lena Wisely officially be- along with Samuel welcomed http://www.brownthe newest addition to their eyedgirlphotogfamily. Sofia Rose Villarreal raphy.com/ was born on January 9th, 2013 blog/2013/01/30/babyat 11:20am at 7lbs, 8oz and 19 sofie-sneak-peeks-san- came a naturalized citizen of the good ole USA on January 31st, 2013. So now Strike a pose………. she gets to partake of all inches long. A very sweet little the duties of a citizen. Any girl that everyone loves. advice? Anyone? Family are all happy……. even her big brother. For more glamour shots of this Page 3 Congratulations! Sofia Rose taking a much needed snooze. Villarreal Family The University of Texas Health Science Center at San Antonio Announcements American Physician Scientist Association – South Region Since 2006, an annual Texas APSA conference has attendance of about 100 MD/PhD students including many of our students. The South Regional APSA conference will be hosted by our MD/PhD program in the November 2nd, 2013. For more info….. http:// www.physicianscientists.org/events/event_details.asp? id=294954&group MD/PhD Program Recruiting SACNAS 2013 will be hosted in San Antonio at the Henry B. Gonzalez Convention Center, October 3rd to 6th. For more info…….www.sacnas.org MD/PhD Holiday Party Dr. and Mrs. Cavazos hosted the 2012 MD/ PhD Holiday Party on December 9th. It was traditional white elephant where everyone enjoyed the variety of gifts, food, and just good cheer. Thanks to them for opening up their home! Best Wishes to everyone! Page 4 Publications Con’t: Cooney JD*, Hildick-Smith GJ*, Shafizadeh E*, McBride PF, Carroll KJ, Anderson H, Shaw GC, Tamplin OJ, Wong C, Gallagher PG, Dalton AJ, Shah DI, Zon LI, North TE, Paw BH. Teleost Growth Factor Independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev. Biol. 2013; 373(2):431–41. (*equal contributions) Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yvette YY, Schultz IJ, Anderson A, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish H, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metabolism 2013, in press. Boyd AR and Mortensen EM. Are Statins Beneficial for Viral Pneumonia? European Respiratory Journal. Invited Editorial. Accepted September 24 2012. Barron DS, Fox PM, Laird AR, Robinson JL, Fox PT. Thalamic medial Dorsal Nucleus Atrophy in Medial Temporal Lobe Epilepsy: A VBM Meta-analysis. NeuroImage: Clinical 2 (2013) 25-32.
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