G Model ARTICLE IN PRESS IJB-3231; No. of Pages 12 International Journal of Medical Informatics xxx (2015) xxx–xxx Contents lists available at ScienceDirect International Journal of Medical Informatics journal homepage: www.ijmijournal.com Review article Promising approaches of computer-supported dietary assessment and management—Current research status and available applications Andreas G. Arens-Volland a,∗ , Lübomira Spassova a , Torsten Bohn b a Luxembourg Institute of Science and Technology, IT for Innovative Services (ITIS) Department, 5, avenue des Hauts-Fourneaux, L-4362 Esch/Alzette, Luxembourg b Luxembourg Institute of Science and Technology, Environmental Research and Innovation (ERIN) Department, 41, rue du Brill, L-4422 Belvaux, Luxembourg a r t i c l e i n f o Article history: Received 17 November 2014 Received in revised form 11 August 2015 Accepted 14 August 2015 Available online xxx Keywords: Dietary records Food diaries Self-management Food intake Personal health records Ubiquitous and mobile devices a b s t r a c t Purpose: The aim of this review was to analyze computer-based tools for dietary management (including web-based and mobile devices) from both scientific and applied perspectives, presenting advantages and disadvantages as well as the state of validation. Methods: For this cross-sectional analysis, scientific results from 41 articles retrieved via a medline search as well as 29 applications from online markets were identified and analyzed. Results: Results show that many approaches computerize well-established existing nutritional concepts for dietary assessment, e.g., food frequency questionnaires (FFQ) or dietary recalls (DR). Both food records and barcode scanning are less prominent in research but are frequently offered by commercial applications. Integration with a personal health record (PHR) or a health care workflow is suggested in the literature but is rarely found in mobile applications. Conclusions: It is expected that employing food records for dietary assessment in research settings will be increasingly used when simpler interfaces, e.g., barcode scanning techniques, and comprehensive food databases are applied, which can also support user adherence to dietary interventions and follow-up phases of nutritional studies. © 2015 Elsevier Ireland Ltd. All rights reserved. Contents 1. 2. 3. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 2.1. Data sources and search terms employed for article and app search . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 2.2. Selection and exclusion criteria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 2.3. Data extraction and analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.1. General aspects of computer-supported dietary management and state of validation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.2. Computer-supported dietary management for overweight, obesity, and weight-loss . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.2.1. Scientific approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.2.2. Computer programs and mobile apps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.3. Computer-supported dietary management for diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.3.1. Scientific approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 3.3.2. Mobile apps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Abbreviations: 24-HDR, 24-hour dietary recall; DHQ, dietary history questionnaire; DR, dietary recall; FDA, food and drug administration; FFQ, food frequency questionnaire; FNDDS, food and nutrient database for dietary studies; FR, food records; ICT, information and communication technology; mHealth, mobile health; NCI, National Cancer Institute; NICE, National Institute for Health and Clinical Excellence; PDA, personal digital assistant; PHR, personal health record; RCT, randomized controlled trial; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; TADA, technology assisted diet assessment; USDA, United States Department of Agriculture. ∗ Corresponding author. Fax: +352 42 59 91 333. E-mail address: [email protected] (A.G. Arens-Volland). http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 1386-5056/© 2015 Elsevier Ireland Ltd. All rights reserved. Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model IJB-3231; No. of Pages 12 ARTICLE IN PRESS A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx 2 4. 5. Integrative summary and discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 4.1. Principal results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 4.2. Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Conclusions and perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Conflicts of interest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 Authors’ contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 1. Introduction Diet-related chronic health complications, such as obesity, diabetes, or food hypersensitivities are major public health burdens. According to a WHO report from 2004, diseases with major nutritional determinants make up 41% of disability-adjusted life years among all diagnosed diseases in Europe [1]. A healthy diet is a key component of a healthy lifestyle that can prevent the onset of chronic diseases or mitigate their severity. However, despite many efforts by national and international nutrition organizations to promote healthy eating behavior, the prevalence of e.g. obesity, cardiovascular diseases and diabetes is still increasing in most westernized but also in developing countries, an observation that has been related to a too high consumption of total calories [2], too many sugars [3], high sodium intake [4], and an insufficient intake of dietary fiber [2,5], among others. In general, tackling the problem of being overweight and obese is perceived as a difficult target, typically requiring complex lifestyle changes with multi-dimensional support with respect to psychological, social, and clinical aspects, including dietary support [6]. A lot of research has thus been carried out on means promoting behavioral changes, including personalized strategies such as goal setting and self-monitoring [7]. In addition to recording physical activity, self-monitoring involves the capturing of dietary intake to help individuals to become aware of their current behavior. Early computer-tailored dietary behavior interventions were introduced in the 1990s [8] and have become increasingly popular during the last decade [9]. The advent of portable technologies such as personal digital assistants and smartphones has particularly propelled research activities applying mobile health (mHealth) approaches in the field of diet management. Although evidence for the efficacy of mHealth is generally sparse [10], research has indicated that the use of hand-held devices can improve the dietary intake of healthy food groups such as whole grains and vegetables [11]. The use of mHealth technology also has the potential to reduce health care costs and to improve well-being in numerous ways, for example through continuous health monitoring, encouraging healthy patterns, and supporting self-management [10,12,13]. In their systematic review, Kroeze et al. [14] concluded that there is strong evidence in favor of computer-tailored interventions for improving dietary behavior. These findings have also been supported by Long et al. in their 2010 review on technology employed for dietary assessment [15]. In 2009, Ngo et al. systematically reviewed the literature for studies applying information and communication technology to dietary assessment [16]. The authors found that most often food frequency questionnaires (FFQ), 24-hour diet recalls (24-HDR) and diet histories have been applied in ICT. To a lesser extent, food records (FR) or taking photos of foods were used. Rusin et al. looked at logging techniques for measuring food intake, such as typing in or selecting a food type from a database [17]. They concluded that very few barcode-based solutions are available and that most systems share information via e-mail, which cannot be seen as an integrated solution. Their review, however, neglected input types other than textual, such as photo documentation, which has also been used in dietary assessment [18,19] or self-monitoring tools [20]. The majority of scientific reviews have focused on specific diseases, such as obesity [21–25] or diabetes [26–33], or on particular application areas, such as nutritional epidemiology [9,34–37]. No cross-sectional analysis of computer-based tools and applied functions for dietary management exists in the literature. In this article, we review the different fields in which computeraided dietary assessment has been employed, aiming to give an overview of the state-of-the-art possibilities of computersupported dietary management techniques from both scientific and applied perspectives. The specific questions that are addressed in this review are: (1) What current scientific evidence exists for the efficacy of computer-supported diet management approaches? (2) Which functionalities are offered by diet-related mobile apps? (3) Which similarities and differences between scientific approaches and available apps are there in terms of requirements concerning specific diseases? and (4) Which gaps exist between scientific research and commercially available applications in the respective areas? It needs to be stressed that an analysis of any psychological aspects, such as social interactions or stress, which undoubtedly play an important role in computer-supported diet management, is beyond the scope of this article. 2. Methods 2.1. Data sources and search terms employed for article and app search PubMed was searched to retrieve articles written in English and related to computer-supported dietary management approaches among adults and children (Fig. 1). There were no boundaries set for the time interval, as diet-related research involving computerbased technologies was expected to be rather novel. The search was performed between September 2013 and April 2014, and titles and abstracts of articles were evaluated. Different search terms were selected to represent information and communication technology (ICT): “mobile Health”, “PDA”, “mobile computer”, “smartphone”, “handheld”, “cell phone”, “Internet”, “computer”, “web-based”, “website”, target domains of nutrition and health: “diet”, “healthy eating”, “eating”, “nutrition”, “food”, and nutritionrelated diseases or conditions: “obesity”, “overweight”, “weight loss”, and “diabetes”. Using the PubMed advanced search interface, terms describing ICT were OR-combined and joined with OR-combined terms describing the target domains. The retrieved articles were then evaluated for additional referenced sources. In addition to PubMed, online markets for iOS and Android applications were searched, using similar terms as mentioned above for the diet-related conditions and nutrition domains. 2.2. Selection and exclusion criteria Only articles published in scientific peer reviewed journals and full papers from conference proceedings were included. Thematically, any publication related to some form of dietary management Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model ARTICLE IN PRESS IJB-3231; No. of Pages 12 A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx Research studies: - 3 Applications (commercially available): Pubmed All years until present Scientific (peer reviewed) journals + full paper proceedings - Apple iPhone apps - Android apps “Communication technology”: mobile Health, PDA, mobile computer, smartphone, handheld, cell phone, Internet, computer, web-based, web-site “Target domains”: diet, healthy eating, eating, nutrition, food “Diet-related diseases”: obesity, overweight, weight-loss, diabetes 2602 articles - with abstracts Filter on title: only individuals. No institutions, not merely educational 370 articles remaining Filter: further abstract and manuscript screening; exploration of references 41 articles remaining - 10 reviews - 31 original research 29 mobile applications Fig. 1. Selection process of studies and applications utilizing computer-aided dietary management. using ICT offered to individual end users was included. Thus, all publications irrespective of their types of study design, participant selection, and outcome measures have been considered in this review. Approaches targeted to worksite or school settings were excluded. Publications claiming to use Internet resources were also included, as recent mHealth approaches are often built upon webbased approaches. Any applications including diet management functionalities, such as diet assessment, dietary advice, diet and menu planning, social interaction and integration into health care workflow, i.e. communication with a counselor or synchronization with personal health records (PHR), were considered, while merely educational applications were left out. 2.3. Data extraction and analysis The PubMed search retrieved 2602 articles with available abstracts. After a first screening of the titles, we rejected papers that were clearly not related to diet management as described above, so that 370 articles remained for further review. Based on an evaluation of the corresponding abstracts, 36 articles finally remained for in-depth evaluation, for which full text documents were retrieved and analyzed. Through exploring their reference lists, 5 additional articles were identified, resulting in a total number of 41 articles, of which 10 were reviews and the remaining 31 were original research articles. A summary of these articles’ characteristics can be seen in Table 1. Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model ARTICLE IN PRESS IJB-3231; No. of Pages 12 A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx 4 Table 1 Overview of studies employing ICT for dietary management. Area No. of research articles reviewed Type and no. of applied diet management approach Type and no. of applied technology References General dietary assessment 10 Dietary recall: 4 Food record: 6 [11,18,19,24,38–43] Obesity, overweight, weight-loss 12 Diabetes (type 1 and 2) 3 Dietary recall: 2 Food record: 5 Self-management: 5 Food record: 2 Menu planning:1 Validation/Epidemiology 5 PDA: 2 Mobile phone: 5 Web-based: 3 PDA: 4 Mobile phone: 4 Web-based: 4 PDA: 1 Mobile phone: 1 Web-based: 1 Web-based: 4 Mobile phone: 1 Dietary recall: 3 Food record: 2 [21–23,37,44–51] [19,26,28] [35–37,52,53] Abbreviations: PDA: personal digital assistant. Table 2 Characteristics of reviewed commercially available mobile applications in the area of dietary management. Area No. Input techniques Diet recommendation/menu planning Integration with social network, HCP, or data export Major missing aspects/shortcomings Obesity, 20 Barcode scan: 6 Meal planning: 4 Social network: 11 No comprehensive underlying food databases Recipes: 1 HCP: 5 9 Picture taking: 6 Typing in/selection form a list: 14 Speech input: 2 Barcode scan: 2 Recipes: 2 Social network: 4 overweight, weight-loss Diabetes Picture taking: 2 Typing in/selection form a list: 9 HCP/data export: 8 Most apps not approved as medical applications; Diet recommendations and menu planning functionalities are missing; Integration of PHR is missing Abbreviations: PHR: personal health record; HCP: health care professional. In addition, we reviewed a total of 29 mobile applications (apps) related to diet management in the relevant fields as described above, which were available in application stores. Table 2 describes the characteristics of the evaluated apps. 3. Results 3.1. General aspects of computer-supported dietary management and state of validation In a structured review on dietary assessment technologies in nutritional epidemiology by Illner et al. [9] published in 2012, the authors identified the real-time food recording capability as the main advantage of smartphones in the context of eating events, i.e., during meals. However, the validity of dietary intake assessed with this technology remains uncertain. Predominant advantages include the cost- and time-effectiveness as well as a decreased effort in terms of data collection and a high user acceptance. According to the authors, many epidemiological studies have favored self-administered FFQs, which are poorly validated and include a high number of systematic and random measurement errors, such as no quantification or an imprecise estimation of portion sizes. However, self-administered FFQs have the advantage of being less time consuming, and they are easier to integrate into the individual lifestyle without perturbing the personal eating patterns. On the other hand, 24-HDRs are known for their high validity and good measurement properties, but they are quite expensive when used as a main instrument, and due to their short time period covered [9] they need some repetitions or a large number of participants in order to balance out possible fluctuations. As a consequence, computer- and web-based technologies have emerged to facilitate the application of 24-HDRs to large populations in a cost-saving manner. In a 2007 systematic review by Norman and Zabinski [54], in which eHealth interventions aiming at improving physical activity and/or healthy eating were reviewed, the most prominent solution to assess dietary behavior was the use of self-report FFQ or dietary recalls. This finding is supported by the 2006 work of Kroeze et al. [14], which further emphasized the fact that FR were not widely used in the mid of the last decade as compared to FFQ. Finally, Norman et al. identified an improved dietary behavior resulting in significant weight loss of subjects that were allowed to share their collected data with health professionals and were able to receive timely and personalized feedback. Unfortunately, concrete numbers were not reported. Leatherdale and Laxer performed a validation study [53] to test for the reliability and validity of the web-based FFQ eaTracker, developed by the Canadian national professional association for dietitians. For this purpose, 178 students in Ontario (Canada) used the eaTracker consumption diary [55] on a daily basis for a period of one week. The authors found that the dietary intake measures were accurate, thus supporting its potential use in research studies where other objective measures are not possible due to large-scale cohorts. In a 2009 validation study of a web-based, pictorial version of the US National Cancer Institute (NCI) paper-based diet history questionnaire (DHQ) developed by Beasley et al. [36], the authors found that the web-based version yielded similar repeatability and validity compared to the paper-based version, when used by 218 participants in randomized order. The study revealed a stable relationship between DHQ and other food intake measurement tools, such as FR or 24-HDR. As a consequence, the practical advantages of a web-based DHQ, such as remote administration, immediate nutrient analysis or a potential reduction of missing responses, may lead to its further use in research. Subar and colleagues [39,40] developed the web-based Automated Self Administered 24-HDR (ASA24) for adults. The Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model IJB-3231; No. of Pages 12 ARTICLE IN PRESS A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx respondents reported their meals through searching or browsing for foods in a hierarchical list, and afterwards, the portion sizes were estimated using digital food images. This approach has been continued in a version targeted at children [56], who are an important target group as eating behavior may be best influenced at early age, and children have difficulties articulating their eating patterns by means usually applied to adults, such as dietary records. In 2011, Arab et al. validated the web-based DietDay 24-hour recall against the established NCI DHQ, using the doubly labeled water method with 233 healthy adults aged 21–69 years and found that the web-based 24-HDR could provide cost-effective valid dietary intake reports [35]. The authors found that the validity of web-administered recalls was superior to paper-based FFQ with respect to delivering reproducible results across different ethnic groups. In the framework of the technology assisted dietary assessment (TADA) project [38] of the Purdue University, the research group around Carol Boushey developed methods for food identification and portion estimation [41,42] using pictures taken on mobile phones. The image analysis consisted of segmentation, feature extraction, classification, volume estimation of portion size, and finally, calorie and nutrient estimation using the food and nutrient database for dietary studies (FNDDS) curated by the United States Department of Agriculture. Early pilot trials [18,24] suggested good usability of this mobile phone food record, although the authors admitted that further research is needed in order to increase the accuracy of volume estimation of the approach. Unsurprisingly, it was found that mobile phone FR may be most likely adopted by adolescents, as these are the most enthusiastic users and require the least training to provide accurate diet assessment as compared to adults, who are less efficient, i.e. taking more time until reaching the same skill level. In summary, many diverse approaches for computerized diet management are being pursued: first, well established and originally paper-based research tools such as FFQ, DHQ, 24-HDR are translated into their respective electronic counterparts, whereas the application of electronic FR is still on a quite low level. Recalls and FFQs are useful in population-based studies, but in clinical studies, the preferred dietary assessment method is FR [38]. Through phone- and picture-based approaches, such as those developed in the TADA project, electronic FR might replace the currently used traditional FR methods. 3.2. Computer-supported dietary management for overweight, obesity, and weight-loss 3.2.1. Scientific approaches Applications targeting weight monitoring and a balanced diet constitute the predominant part of computer-aided diet management. Bacigalupo et al. [57] systematically reviewed randomized controlled trials (RCT) applying mobile technologies for selfmonitoring activities in overweight and obese subjects. The reviewed seven trials showed consistent evidence for short and medium-term weight-loss through the use of mobile technology as part of the intervention delivery. Hutchessen et al. observed in a 2013 small-scale pilot study [58] with nine participants that the estimated energy intake obtained by web-based FR is consistent with other published dietary intake methods, such as total energy expenditure measured by the doubly labeled water method, reaching an accuracy of 79.6% (SD = 14.1%). In a retrospective analysis [48] with 2979 women and 642 men, Johnson et al. were already able to show in 2011 that participants in the top third of engagement with electronic food diaries were more likely to achieve clinically significant weight losses, i.e., over 5% of initial body weight. 5 Self-monitoring is a crucial and recognized factor for obesity treatment. Regular interaction with a counselor (human or automatic) has shown to improve the results of weight loss programs [59]. Research has demonstrated that electronic self-monitoring, i.e., recording food intake and physical activity, is more effective in terms of weight-loss than the more cumbersome paper diaries [45,51], as it is easier to use and less time consuming. Burke et al. were able to show in a 24-month RCT with 210 subjects aged 18–59 years that a combination of electronic self-monitoring and daily feedback tailored to the captured data and providing positive stimulations in form of motivational messages, resulted in the highest user adherence levels (90%) and achieved weight-loss (63%), compared to groups with no intervention (46% and 55%) or only electronic self-monitoring (80% and 49%). In another 2011 review by Burke et al. on self-monitoring activities for weight-loss, analyzing US-based studies [7], the authors found that through date and time stamping, an objective validation of the self-monitoring behavior could be achieved. Extensive databases compiling information about foods and restaurant dishes eliminated the necessity to look up and calculate the sum of nutrients and calories. In addition, the possibility to store frequently consumed food items eliminated the need for repeatedly searching identical entries. Already in 2007, Yon et al. [50] tried to confirm the advantage of personal digital assistants (PDA) in a 24-week behavioral weight-loss study with 61 obese and overweight subjects using Calorie King’s Diet Diary software on a PDA, compared to 115 similar subjects equipped with paper-based food diaries. Almost half of the participants (44%) complained about the PDA and the provided software due to shortcomings when trying to find commonly consumed foods. However, as no significant differences in weightloss or diet self-monitoring (measured in% of weekly FR submitted) between the two groups were found, the authors concluded that PDAs were at least comparable to traditional diaries. In a 2010 review of efficient technology-based weight-loss interventions [60], Khaylis et al. identified five key components that effectively drive technology-supported weight loss and determined its successful use: (1) self-monitoring, (2) frequent counselor feedback and communication, (3) social support, (4) use of a structured program, and (5) use of an individually tailored program allowing to adjust to the personal lifestyle. In this respect, Krukowski et al. [61] recognized the “feedback” factor (progress charts, physiological calculators, and past journals) as the best predictor for efficient weight loss during the intervention time, here of up to 12 months. The “social support” factor on the other hand was the best predictor for maintaining weight-loss after the intervention, which may explain the somewhat mixed results for long-term studies, in case social support may not be present. Table 3 summarizes the research body on successful use of computer-supported diet management. 3.2.2. Computer programs and mobile apps A large number of the food-related health and fitness apps that are commercially available in different app stores, such as iTunes or Google Play, are related to calorie counting and weight-loss. Food and calorie trackers, such as “MyFitnessPal”, “Lose It!”, or “Calorie Count” etc., allow users to log their daily food intake, define personal weight loss goals and review and analyze the gathered data. One of the critical issues in this context is the entry of new items into the food diary. Given the huge amount of possible food items, it is a particular challenge to implement an easy-to-use interface for food logging. For this purpose, many apps, such as “Food Scanner”, “FitDay” or “Foodzy”, have incorporated custom food databases containing nutritional information about a number of food products and offering different options to access this data, such as via manual search by typing in product names or hierarchical search through food categories. Some apps, such as “Calorie Count” or Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 Subject characteristics Results Acharya [21], 2011, USA PDA-based dietary record 6-month RCT; comparison between PDA- and paper-based approaches; measures: dietary intake through 24-HDR, calculated calorie intake, body weight 192 white obese subjects aged 18–59 Anton [22], 2012, USA Web-based computerized tracking system for FR, feedback and messaging 811 healthy, obese/overweight men and women aged 30–70 Arab [35], 2011, USA Web-based 24-HDR Within a 2 year RCT testing the efficacy of four macronutrient diets, an evaluation of the usage and effects of the web-based system has been performed. Validation study using the doubly labeled water method; comparison to FFQ results. Measures: body weight, dietary intake and total energy expenditure. Atienza [11], 2008, USA PDA-based dietary recall and education PDA group significantly increased fruit (P = 0.02) and vegetable (P = 0.04) consumption compared to paper-based group; PDA group significantly decreased consumption of refined grains (P = 0.02) compared to paper-based group; Both groups had significant reductions in weight, energy intake and calories (P < 0.001) Participants with higher usage of the system showed higher weight loss (−8.7% of initial body weight) as compared to those with lower usage (−5.5%) (P < 0.001) Web-based dietary recalls offer an inexpensive and accessible solution for dietary assessment; validity of web-administered recall was superior to paper-based FFQ with respect to delivering stable results across different ethnic groups Intervention participants reported significantly higher increased vegetable intake (1-5-2.5 servings/day; P = 0.02) and greater intake of dietary fiber from grains (3.7–4.5 servings/day; P = 0.10) as compared to control. Burke [7,45], 2011, USA PDA-based self-monitoring applying FR and feedback Cadmus-Bertram [62], 2013, USA Web-based self-monitoring for overweight/obese women at increased breast cancer risk Carter [37], 2012, UK 8 week pilot RCT; intervention group monitored their vegetable and whole-grain intake using a PDA; control group received written educational material related to nutrition in middle-aged and older adults; measures: dietary intake assessed via Block FFQ. 6-month RCT; three groups: (a) PDA self-monitoring, (b) Paper diary/record; (c) PDA self-monitoring plus feedback; measures: weight-change after 6 months and adherence over time 115 black and 118 white healthy adults aged 21–69 27 subjects aged 50 or older 210 healthy adults aged 18-59 with mean BMI of 34.0 kg/m2 50 overweight/obese women at increased breast cancer risk Smartphone-based dietary assessment applying FR 12-week RCT; intervention group (n = 33) used SparkPeople website for self-monitoring (goal setting, tracking diet and exercise); control group (n = 17) received dietary information only 1-week validation trial; used 7 days smartphone app; conducted twice a 24-HDR for reference; Carter [63], 2013, UK Smartphone-based dietary assessment applying FR 6-month RCT; Smartphone group; Web-based group; Paper-based group 128 healthy overweight (BMI >27 kg/m2 ) adults (aged 18–65) Thomas [49], 2013, USA Smartphone-based self-monitoring applying FR keeping and feedback Pilot study, 12–24 weeks; measures: weight, adherence, physical activity, and satisfaction; compared to results from other primary literature. 20 overweight/obese (25–50 kg/m2 ) adults (aged 18–70) 50 healthy adults; mean age 35; mean BMI 24 Combined approach (PDA + feedback) achieved >5% weight loss as compared to paper based records (P = 0.05) or electronic approach without feedback (P = 0.09); A greater proportion of PDA groups, compared to paper diary group, was adherent >60% of time (P = 0.03) Intervention group lost 3.3 ± 4.0 kg, comparison group gained 0.9 ± 3.4 kg (P < 0.0001). High correlation of recorded energy intake between both approaches: day 1: r 0.77 (95% CI 0.62, 0.86), day 2: r 0.85 (95% CI 0.74, 0.91) Adherence was significantly higher in the smartphone group compared with the website group and the diary group (P < 0.001); Smartphone group showed the highest decrease in weight, BMI, and body fat compared to the two other approaches. Weight-loss monitored was substantially larger than the loss of 3–5% of initial body weight obtained with text message only-based interventions. Adherence to the self-monitoring protocol was 91% (SE 3.3%) and 85% (SE 4.0%) at 12 and 24 weeks, respectively. This was substantially higher than rates seen in other trials of behavioral weight-loss treatment using paper diaries (e.g. 55%) Abbreviations: PDA, personal digital assistant; RCT, randomized controlled trial; FR, food record; 24-HDR 24-hour dietary recall; FFQ, Food frequency questionnaire; BMI, body mass index ARTICLE IN PRESS Study design/analysis approach G Model Type of computer based intervention A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx Reference and country of origin IJB-3231; No. of Pages 12 6 Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 Table 3 Studies demonstrating the successful use of computer-supported diet management with respect to weight management. G Model IJB-3231; No. of Pages 12 ARTICLE IN PRESS A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx “Bon’App” even enable voice input. More elaborated food tracker apps (e.g., “MyFitnessPal”, “Lose It!”, “Calorie Count”, “Fooducate”, “FoodScanner”) provide barcode scanning possibilities using the smartphone camera, which is supposed to facilitate the identification of branded food items. However, the usability of these food entry options depends on the completeness of the underlying food databases, i.e., data about food products can only be retrieved given their listing in the food database used by the app. Thus, the quality of a food and calorietracking app highly depends on the quality and quantity of data available in its food database. This is why some food tracking apps, including “Foodzy”, “FoodScanner” and “FatSecret”, provide the opportunity for users to extend their food databases with custom products, which are in some cases automatically included into the underlying food database and thus made available for other users as well. Nevertheless, even the largest current food databases are still far from being complete and often contain only country-specific products. To evade this problem of lacking food-related data, some apps that implement photo-based food diaries have emerged. For instance, with “PhotoCalorie” or “MealSnap”, users only need to take a photo of their meal and provide a brief corresponding textual description in order to create a food log entry, upon which corresponding nutritional values are automatically estimated. However, user reports show that these values are often inaccurate. Some food-related health apps aim at personalized meal planning, taking into account the user’s health and weight-loss goals as well as previously defined food preferences. “Pocket Dietitian” offers automated meal planning with regard to individual daily nutrient levels. The “intelli-Diet” app creates a personal wellbalanced diet based on a list of favorite foods specified by the user and an eating plan for each day of the week, and it even automatically generates a corresponding shopping list. In 2009, Breton et al. [64] reviewed 204 apps available in the iTunes app store for compliance with evidence-informed practices in weight-loss. Of the reviewed apps, 43% provided tools for keeping a food diary but less than 10% offered advice on meal planning. Food nutritional databases were applied in one third of the apps (n = 67), and only 15% of the apps (n = 30) were designed to be used in conjunction with a website. A small fraction of 3% (n = 7) had some type of social network integrated. Based on this study, it can be concluded that only a small portion of commercially available apps allowed individual meal planning based on food databases. In a recent 2013 pilot study with 20 overweight participants over 12–24 weeks [49], Thomas and Wing showed that a smartphone application offering self-monitoring functionalities achieved much better effects with respect to weight-loss than only sending supportive text messages (9% weight-loss on average instead of only 3–5%). Furthermore, they found higher adherence rates for an app-based self-monitoring protocol (91%) as compared to a paper-based diary (55%). For their study, the authors used the commercially available “DailyBurn” app for tracking food intake, weight, and physical activity combined with the self-developed “Health-E-Call” app for texting, providing supportive videos and other material, as well as for setting behavioral goals. This study also highlights the need for integrated solutions, in which a mere tracking of food intake is enhanced by additional support to further increase the users’ motivation to adhere to the intervention. This additional support appears to play a crucial role, similar to the support in conventional weight-loss programs accompanied by regular meetings with physicians and nurses. Many food and diet trackers offer forum groups and enable their users to share their food diaries with friends in order to receive support and encouragement (e.g., through Twitter or Facebook). For example, the “SparkPeople” app applies a game-like approach using leaderboards, prizes and awards to encourage a “friendly competition” concerning fitness and weight-loss. In some other cases, apps provide the opportunity 7 to connect to a health care professional. With “My Dietitian”, users can receive customized daily feedback on their food journal from a personal registered dietitian. Other apps, e.g. “Pocket Dietitian”, allow users to export and email dietary reports to their physicians. In a web-based computer-tailored intervention named FATaintPHAT to promote energy balance among 883 overweight adolescents [47], Ezendam et al. did not find the expected reduction of BMI and waist circumference. The two-group RCT showed only minor positive dietary behavioral effects in the short term (4-month follow-up) but not in the long term (2-year follow-up). The intervention concept was a non-commercial web-based educational platform that used FFQ and 24-HDR for capturing food intake and provided goal setting, action planning and behavioral feedback, but this approach may have lacked sufficient support and motivation tools as integrated by some of the other programs mentioned above. Similarly, Bauer et al. [44] could not demonstrate a statistically significant reduction in BMI Standard Deviation Scores for an SMS-based maintenance treatment with weekly self-monitoring of data on eating, exercise and emotions in a 12-week study comprising 40 overweight subjects. In contrast, in 2012 Anton and his colleagues were able to show in a study with 811 participants that overweight subjects with a high usage of a web-based tracking system for dietary assessment and feedback lost significantly greater amounts of weight than participants with low usage (8.7% versus 5.5% of initial body weight) [22]. The authors attributed the system’s success to its immediate feedback on reported behaviors and dietary intake, including assessment of key behavioral indicators of adherence that may not be available in many other current applications. In a 2012 validation study [37], Carter et al. compared 24-HDR conducted via phone interviews to smartphone-based food and drink records employing a database comprising 40,000 commercial food items including generic and branded items [65] in an obese population of 50 subjects. On an individual level, large disagreement between both approaches could be monitored, but on a group level, taking FR on mobile phones appeared to bear potential as a diary assessment method, yielding results comparable to the dietary recall approach. In a later pilot study in 2013 [63] with 128 overweight subjects, the authors reported significantly higher adherence to their smartphone-based approach (92 days) as compared to web-based (35 days) and paper-based (29 days) methods. In 2012, Lieffers et al. reviewed available studies on mobile devices for food intake recording in healthy adult populations in relation to general weight-loss approaches [25]. The authors differentiated between applications by means of record selection from food databases (e.g. USDA National Nutrient Database for Standard Reference) and picture taking in conjunction with reference objects and annotation through text or voice input. The authors found good correlations for both methods regarding energy and nutrient intake in comparison with conventional methods (24-HDR, paper-based FR). 3.3. Computer-supported dietary management for diabetes 3.3.1. Scientific approaches Similar to obesity management, computer-aided diabetes management mainly consists of self-monitoring and education. The UK National Institute for Health and Clinical Excellence (NICE) guidelines for management of type 2 diabetes [66] “encourage high-fiber, low-glycemic-index sources of carbohydrate in the diet, such as fruit, vegetables, whole grains and pulses; include low-fat dairy products and oily fish; and control the intake of foods containing saturated and trans fatty acids.” In a pilot study by Arsand et al. [26], five important points were highlighted for IT devices designed for diabetes type I and II: (1) a complete food pick-list, (2) a smartphone touchscreen concept, Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model IJB-3231; No. of Pages 12 8 ARTICLE IN PRESS A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx (3) the possibility to download data to a PC, (4) editing possibilities of entries, (5) reinforcement cues, such as emoticons. The mentioned design concepts were viewed as useful and potentially powerful tools in both self-care and provider-supported care settings. The food pick-list should be constantly re-ordered based on frequency of item selection, and it should allow for specifying portion and serving sizes. Participants found both positive and negative reinforcement cues appealing and rewarding in respect of their progress. In a 2011 literature review and comparison of available mobile type I and II diabetes application features against evidence-based guidelines [67], Chomutare et al. reviewed features including self-monitoring, social media integration, data export and communication as well as synchronization with PHR systems or patient portals. Their literature research comprising 26 studies showed that most approaches included some kind of PHR synchronization (69%), insulin and medication recording (65%), diet recording (65%), and data export and communication (62%). Most notably, Chomutare et al. revealed that PHR synchronization was present in only 17% of the applications available on the online markets (n = 101). Here, the most prominent features were insulin and medication recording (62%), data export and communication (60%), diet recording (47%), and weight management (43%). It turned out that capturing consumed food items was a highly manual task, as the users either had to estimate carbohydrates or navigate through an extensive food hierarchy or through a menu. The authors concluded that most approaches introduced in the literature comprised PHR integration, which was not true for most apps available on the market, highlighting the gap between scientifically reasonable approaches and practically available strategies. In a 2013 short review by Goyal and Cafazzo [68], the authors concluded that a significant potential lies in direct, real time communication between health professionals and individuals in order to be able to capture data electronically, and thus to provide decision support more easily. Menu planning and tools aiding in choosing dishes have shown to be important features for diabetes patients. In a pilot study [28] with 33 type II diabetes mellitus (T2DM) adults, Bader et al. were able to show that web-based menu planning during a 24 week period had the potential to lead to clinically important weight reductions (above 5%) in more than 25% of the adherent participants. 3.3.2. Mobile apps Mobile apps in the diabetes domain have become increasingly abundant. Important drivers for successful app development are consumer expectations. In a 2011 review on diabetes-related telemedicine approaches by Franc et al. [69], the authors summarized the patient expectations into three concepts: (1) An easy to use mobile and pocket-sized system to improve the compliance as compared to systems involving desktop computers; (2) Systems should respond immediately to patients’ questions and provide automatic assessment of carbohydrate contents through using a reliable food database, while in addition, the devices should also guide food choices through an onboard database; (3) Interactions with a known caregiver as a key component for the success of telemedical systems for diabetes care. Besides the possibility to log food intake (carbohydrates), most apps targeted at diabetes management allow the logging of other relevant parameters, such as blood glucose, dosage of insulin, blood pressure, pulse, weight, and sport activities. “MyNetDiary Diabetes Tracker” provides a tool for the daily and weekly analysis of the logged data to support users in improving their diet. Furthermore, it offers diet planning, allowing users to define their individual macronutrient targets. With “Diabetes In Check”, users have access to diabetes-friendly recipes, sample meal plans and customized daily menus, and they receive tips and constructive feedback on a regular basis as a motivation to improve their medical condition. Such motivational aspects also play an important role in the “mySugr Diabetes Companion” app. In this tool, users receive immediate feedback on their entries through a virtual character called “diabetes monster”. With respect to data management, which is important for sharing with other health professionals, most apps offer the possibility to export a report as a printable PDF or Excel file, or even a direct transmission of the report to a physician via e-mail. Reminders to measure blood glucose, to take medication, or to track food and exercise are also implemented in many diabetes management apps. Social interaction with a community seems to be less important than with weight-loss apps, perhaps as the personal motivation of subjects with a disease is stronger, and the link to health professionals is usually given. Nevertheless, some diabetes apps integrate social media interfaces. The “Glucose Buddy Diabetes Log” app offers Facebook and Twitter functionalities, while “Diabetes In Check” provides access to community message boards for posting personal questions, sharing success stories and providing support to others. In a recent review by Eng and Lee [70], available iPhone apps (n = 492) related to diabetes management were scrutinized based on their summary descriptions. Most of the apps (33%) focused on health tracking, such as blood sugar, insulin doses, and carbohydrates, involving manual entry, but only 8% of the analyzed apps provided food reference databases. Only two apps allowed capturing blood sugar levels through glucometers directly attached to the smartphone. Additional features were teaching/training (8%), social blogs/forums (5%) and physician-directed apps (8%). The authors highlighted that only the “WellDoc” system appeared suitable for direct integration into health care workflows or Electronic Medical Record systems. Further, only “WellDoc”, “Glooko”, and “IGBStar” have received clearance from the US Food and Drug Administration (FDA). The authors pointed out safety concerns about the majority of the apps, which were non-FDA certified, although they should be so according to safety regulations. In line with these observations, El-Gayar and colleagues concluded in a 2013 review of commercial applications for diabetes self-management [31] that mobile applications have the potential to positively impact diabetes selfmanagement, but also identified limitations, such as the lack of personalized feedback, usability issues, such as difficult data entry, and missing integration with PHR. Arsand et al. concluded in a review article on mobile health applications assisting patients with diabetes [27] that using mobile phone picture diaries is useful for the identification of treatment obstacles for type 1 diabetes mellitus (T1DM) patients. It was further suggested that the food information on phones for T2DM should not be too fine-grained, as too much detailed information may result in user discouragement and little user friendliness. Lee et al. concluded in their review on mobile terminal-based tools for diabetes diet management [33] that in order to make such mobile tools feasible for diet management, these should enable the recording of food intake in an easy but accurate manner, and suggested that photographs could be a meaningful strategy. 4. Integrative summary and discussion This review aimed at providing a descriptive overview of the current status of computer-supported diet management, integrating scientific evidence as well as highlighting important aspects of commercially available applications and developments in this field. Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model ARTICLE IN PRESS IJB-3231; No. of Pages 12 A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx 9 Table 4 Summary of tools in computerized diet management and associated advantages and disadvantages and scientific evidence across application areas. Type of dietary assessment & self-management Dietary management techniques applied Associated advantages Associated drawbacks Scientific evidence References Web-based 24-HDR; self-monitoring; FR; goal setting; feedback; Inexpensive; widely accessible; Tedious or cumbersome FR input due to user interface limitations; [22,26,28,35,36,39,40,43, 46–48,52,53,58,62,63,72] Mobile FR; 24-HDR; self-monitoring; feedback; food picture diary High validity compared to traditional methods; high user acceptance and user adherence; effective for weight-loss and self-management Expensive; only preliminary evidence of effectiveness of food picture diary. RCT (n = 3), pilot (n = 3), usability (n = 3) trials and one retrospective analysis in areas of overweight/obesity, weight-loss, and diabetes. Additionally, four validation studies have been performed. Study measures included dietary intake, physical activity (minutes/week), energy expenditure, body weight and height. Sample sizes ranged from 9 (pilot validation study) to 3621 subjects (retrospective analysis), age range 18–70. RCT (n = 4), pilot (n = 5) or usability studies (n = 2) available in areas of overweight/obesity, weight-loss. Only one RCT for diabetes and one validation study. Study measures included dietary intake, calculated calorie intake, body weight change, adherence and satisfaction. Sample sizes ranged from 27 to 365 subjects, including children, adolescents, adults and elderly. [11,18,19,21,23,24,37,38, 41,42,44,45,49–51] Abbreviations: 24-HDR: 24-hour dietary recall; FR: food record; RCT: randomized controlled trial. 4.1. Principal results From a scientific viewpoint, it can be assumed that web-based only solutions for tackling obesity in young adults are not effective [47]. Mobile solutions are at least equally effective as traditional paper-based methods [50], and they appear superior to traditional approaches when allowing for personalized feedback [45]. Furthermore, Burke et al. demonstrated that with suitable functionality (access to food database) and integration into the health care workflow (giving feedback with respect to patient actions), a high level of adherence and weight-loss can be achieved [7,45]. This is supported by the findings of Yon et al. [50], who argued that suitable food databases are required to achieve a satisfying user experience. Generally, in research, FFQs and 24-HDRs are the most commonly used tools for food intake monitoring; occasionally FRs are offered, and barcode-scanning is hardly ever used for food record input. This is clearly related to the fact that the commonly used food data in the reviewed settings were most often derived from food composition databases and only rarely from food product databases that contain information on branded food products. The end-users’ demand for suitable food databases and patient-caregiver interaction has also been identified by Franc et al. [69]. Existing scientific evidence for web-based and mobile dietary management is summarized in Table 4, also highlighting associated advantages and drawbacks. In this respect, it is noteworthy to emphasize the general limitations of employing food composition databases for determining nutritional and caloric composition of the finally consumed product, which may differ from the values captured in the database due to “factory to fork” losses, i.e., following storage and kitchen procedures applied, such as freezing/thawing, mixing, chopping, heating etc. [71]. However, this applies to all underlying databases and is not limited to computer aided dietary assessment. Additional limitations are the natural variations of the listed food items as well as the difficulty of the consumer to judge serving sizes. With respect to the used app features, commercially available apps show increased innovative functionalities, such as keeping FR via barcode scanning and diet documentation through photographs. Promising approaches for picture-based identification of food as well as for calorie and nutrient estimation exist in research [18,38,41,42], but apps that implement these features are often inaccurate. This is due to the discrepancy between the limited laboratory settings in research as compared to the varying real-life environments. The opportunity to share information and experiences and to receive feedback and support from a community of like-minded people seems to be an important aspect concerning apps targeting weight-loss. It was noticed that an integration with a PHR or in the health care workflow is present in the literature [30,70,73], while in contrast, applications accessible in the app stores generally do not provide such features. At most, the apps allow for data export (e.g., via email) to health care professionals, however, they fail to actively engage them. The “WellDoc” app [70] is a notable exception in this context. With the aim to promote health-related apps of high quality, the British National Health Service (NHS) offers an online Health Apps Library [74]. It contains health apps from different domains (e.g. diabetes, nutrition, heart, cancer) that have been reviewed and approved by the NHS. Doctors are encouraged to prescribe such apps to their patients in order to facilitate and improve their treatment. 4.2. Limitations As this review has integrated data from scientific publications, the described functionalities and findings were taken only from the published articles and were not further tested or verified. Due to the huge number of applications already available and the extremely rapid development of the market, combined with time constraints, we were unable to take into account all available applications in the present review, and we were far from being able to test all these applications. We thus had to rely on the descriptions made in the catalogues of the suppliers and in the corresponding test reports. A lot of scientific and practical work with respect to computer diet management has been carried out in the field of obesity and diabetes. Some of the publications reviewed in this article are high level clinical studies, but others report the results of observational or usability studies. Scientific studies concerning diet management in the areas of other medical conditions, such as food hypersensitivities, cancer or CVD, are rather sparse, and they are thus not considered in this review. 5. Conclusions and perspectives The need for well-established, reliable and affordable techniques for monitoring food intake (FFQ, 24-HDR, FR) is evident, Please cite this article in press as: A.G. Arens-Volland, et al., Promising approaches of computer-supported dietary assessment and management—Current research status and available applications, Int. J. Med. Inform. (2015), http://dx.doi.org/10.1016/j.ijmedinf.2015.08.006 G Model ARTICLE IN PRESS IJB-3231; No. of Pages 12 10 A.G. Arens-Volland et al. / International Journal of Medical Informatics xxx (2015) xxx–xxx Conflicts of interest Summary points What was already known on the topic • Computer-supported dietary assessment and management technologies support the user and health care professional in food intake monitoring. • Various techniques are employed in different application areas, such as weight-loss, diabetes etc., as well as in scientific and commercial settings. None declared. Funding This work was supported by the ERDF (European Research and Development Fund). What this study added to our knowledge Authors’ contributions • Many computer-based approaches implement wellestablished nutritional concepts for dietary assessment. • Both food records and barcode scanning are less prominent in research but are frequently offered within commercial applications. • Integration with a personal health record (PHR) or a health care workflow is suggested in the literature but is rarely found in commercial applications. • Major challenges in the context of computer-supported diet management: • Simple, intuitive and robust user interfaces for input of food records. • Comprehensive and reliable food databases for packed food. Arens-Volland was responsible for the organization and creation of the manuscript. He performed literature search and evaluation of articles. Spassova reviewed available mobile apps and web-based solutions and contributed to the development and content of the manuscript. Bohn reviewed analyses and scientific findings of scientific articles and aided in overall manuscript structuring. All authors reviewed and contributed to the preparation of the final manuscript. both for collecting large data with a scientific purpose, but also for individuals controlling their own dietary behavior. Innovative input methods (barcode scanning, FR) that are largely available in commercial apps have so far been used only rarely in science. However, several studies have indicated that computer-supported diet management has many advantages, including efficacy and efficiency as well as the possibility to collect detailed nutrition-related data and to offer in-time communication and feedback. In our opinion, there are two major factors that will drive the usability and acceptance of computer-supported FR: (1) the development of simple, intuitive and robust user interfaces for the input of food records, especially for mobile diet-related apps; and (2) the availability of comprehensive food databases for packed food that provide reliable data. The first challenge might be tackled through further developments in the area of picture-based food recognition, leading to a more accurate identification of food type and serving sizes, or through the incorporation of novel approaches, such as spectrometer-based nutrient recognition (e.g., TellSpec [75]) or unobtrusive sensors, such as the ear-worn device “BitBite”, which uses a microphone to recognize chewing patterns and to allow voice input of food records [76]. Concerning the second challenge, we believe that a combination of established food composition databases and food product databases might be a favorable solution for achieving a comprehensive food database suitable for use in computer-supported diet management applications. On the other hand, the lacking integration and financing of available mobile apps in the health care sector with a clear legal status is a major disadvantage that should be overcome in order to facilitate access of a broader population to such health-supporting tools. In summary, electronic means for dietary management have shown to offer some advantages over traditional ones, i.e. paperbased approaches. However, it should be kept in mind that computer-supported dietary assessment merely presents one strategy of dietary support, and it should be ideally combined with other means, including e.g. psychological and social support, to successfully motivate healthy behavioral changes toward e.g. weight loss. 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