ENZYMES
Carbonic Anhydrase
(H+ + HCO3- º
º H2 CO3) º
º H2O + CO2
Catalase
H2O2 º
º 2 H2O + O2
Rateenz
Rateuncat
Urease:
(NH2)2 C=O + H2O º
º 2 NH3 + CO2
ENZYMES: INORGANIC COFACTORS
ENZYMES: ORGANIC COFACTORS
1
CLASSIFICATION OF ENZYMES
enz
à P
S
1. Oxidoreductases
2. Transferases
3. Hydrolases
4. Lyases
5. Isomerases
6. Ligases
Reaction Rates versus Equilibria
Sà
à P
Rate = k[S]
k rate constant
∆Grxn
Rate % 1/∆ G‡
KNN eq = 10 -∆∆G
/RT
∆Grxn = ∆GP
- ∆GR
rxn
k (s-1) =
k
h
kT
h
e-∆∆ G /RT
‡
= Boltzmann constant 1.381 x 10 -23 J/K
= Planck’s constant 6.626 x 10-34 J s
2