1 DNA: The Genetic Material (continued) Student Edition, pp. 326–332 Reading Essentials, pp. 127–131 Complete the table below about geneticists and their discoveries. Scientist Discovery Year Frederick Griffith Oswald Avery Alfred Hershey and Martha Chase James Watson and Francis Crick Copyright © McGraw-Hill Education. Permission is granted to reproduce for classroom use. GET IT? Explain how Avery discovered the transforming factor. GET IT? Explain why it is important that new viruses were produced in the bacteria. Science Notebook • Molecular Genetics 161 1 DNA: The Genetic Material (continued) Organize the characteristics of nucleotides by filling in the graphic organizer below. Characteristics of Nucleotides All nucleotides have a five-carbon a negative one of four In DNA it is In DNA they are and in RNA it is and in RNA they are GET IT? Explain why Chargaff’s data was an important clue for putting together the structure of DNA. Synthesize and rephrase how a DNA strand that is 200 million bases long can fit inside a cell. Science Notebook • Molecular Genetics 162 Copyright © McGraw-Hill Education. Permission is granted to reproduce for classroom use. Create a memory device to help you remember how the nitrogenous bases are always paired. 1 DNA: The Genetic Material (continued) REVIEW IT ! 1. MAINIDEA Summarize the experiments of Griffith and Avery that indicated that DNA is the genetic material. 2. Describe the data used by Watson and Crick to determine the structure of DNA. Copyright © McGraw-Hill Education. Permission is granted to reproduce for classroom use. 3. Draw and label a segment of DNA showing its helix and complementary base pairing. 4. Compare and contrast the structure of prokaryotic and eukaryotic chromosomes. 5. Describe two characteristics that DNA needs to fulfill its role as a genetic material. Science Notebook • Molecular Genetics 163 1 DNA: The Genetic Material (continued) 6. Evaluate Hershey and Chase’s decision to use radioactive phosphorus and sulfur for their experiments. Could they have used carbon or oxygen instead? Why or why not? Copyright © McGraw-Hill Education. Permission is granted to reproduce for classroom use. Science Notebook • Molecular Genetics 164
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