BLM 9.9
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Haemophilia, which is described in Table 8.3 on page 192 of your textbook, is a sex-linked genetic disorder.
Doctors have known about this condition for literally thousands of years. Jewish sons were excused from
circumcision if there was a family history of bleeding after the operation.
A classic study of this disorder is in the modern royal family, which has many cases. Figure 2 shows a
pedigree of many of the descendants of Queen Victoria, including the present royal family. Examine this
pedigree chart and answer the following questions.
Figure 1 Queen Victoria and some of her relatives
Edward
Duke of Kent
(1767–1820)
Victoria
Princess of Saxe-Coburg
(1786–1861)
Victoria
Queen of England
(1819–1901)
Albert
(1813–1861)
Victoria Frederick Edward VII Alexandra
of England
Wilhelm Sophie of
II
Greece
Alice
Irene
George V
Louise of Hesse Alfred
Henry
Fred
Helena
Alix
Louise
Nikolas II
of Russia
Arthur
Leopold
Helen
Beatrice
Alice of
Athlone
Henry
Alfonso XIII Eugenie Leopold Maurice
of Spain
?
George VI
Princess Queen
Margaret Elizabeth
Waldemar Prince Henry
Sigmund
of Prussia
Prince
Phillip
Olga
Tatiana Marie Anastasia Alexis
Lady May Rupert
Albel Smith
Alfonso
normal male
Gonzalo
Juan Carlos
of Spain
normal female
haemophlic male
Princess Prince Prince Prince
Ann Charles Andrew Edward
carrier female
?
male died in infancy,
possible haemophilic
Figure 2 Pedigree chart of the royal family and haemophilia
224
Science Edge 4 Teacher Resource Pack Blackline Masters
© Nelson Australia Pty Ltd 2007. This page may be photocopied for educational use within the purchasing institution.
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BLM 9.9 (continued)
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Questions
1
How many males and females are in this pedigree chart?
2
How many individuals suffer haemophilia? What gender are they?
3
State the relationship between Prince Charles and Queen Victoria.
4
Identify the evidence there is in the pedigree chart that this disease is a recessive trait.
5
What evidence is there in the pedigree chart that this disease is sex-linked?
6
Assign on the chart, the appropriate allele symbols for this disease.
7
What chance did Alfonso and Eugenia have of conceiving another son? Show your working.
8
What would be the chance that this son would suffer haemophilia?
Science Edge 4 Teacher Resource Pack Blackline Masters
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© Nelson Australia Pty Ltd 2007. This page may be photocopied for educational use within the purchasing institution.
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