Nucleic Acid Solutions
Flexible Therapeutic Oligo Manufacturing & Development Services
Launch of Therapeutic
Oligo Development
Services &
Manufacturing
Flexible Therapeutic Oligo Development Services & Manufacturing
Agilent’s Nucleic Acid Solutions Division provides the highest value for therapeutic oligonucleotide
manufacturing and development via:
• State-of-the-art, multi-product 33,500 sq. ft. facility in Boulder, CO with design based upon
significant industry experience
• World-class team with extensive expertise in high complexity therapeutic oligo manufacturing and
development
• Complete set of turn-key oligo development services
Nucleic Acid
Solutions
Agilent Nucleic Acid Solutions provides much
more than just manufacturing of preclinical
and clinical oligonucleotide materials
• Turn-key solutions encompassing all oligo
development activities enables customers
to initiate or progress through clinical trials
more quickly
Analytical
Services/QC
Analytical
Development
• Enables companies to fully outsource oligo
manufacturing and development activities
in order to focus on core competencies
Manufacturing
Process
Development
Quality
Assurance
Project
Management
Customer
Agilent’s Nucleic Acid Solutions Capabilities include:
Full Spectrum of Analytical Method
Development and Validation Capabilities:
Broad Oligonucleotide Manufacturing Capabilities:
• GMP production at gram to kilogram scale:
• LCMS impurity profile analysis
• Research through toxicology/pre-clinical studies
• Process Intermediate and Final Drug
Substance Characterization
• Clinical trial through commercial production
Therapeutic Development Services:
• Multiple HPLC Chromatographic
Techniques
• HPLC Detection Capabilities
• Process development and scale-up
optimization
• Gas Chromatography Mass Spectrometry
Detection Capabilities
• ICH stability testing and data
evaluation
• Transition Melt Analysis (TM)
• Regulatory (CMC) submission
support
• Volumetric and Coulometric Water
Determination
• Process impurity trouble-shooting
• Osmolality
• Process validation
• Endotoxin Analysis
• Technology transfer
• Binding Assays
• Metals Analysis by ICP-MS
Call us today to discuss your
therapeutic development project
with one of our project managers
at 303 222 4900
• Ultra Violet Spectroscopy (UV)
• Nuclear Magnetic Resonance (NMR)
• Total Organic Carbon Analysis (TOC)
• Fourier Transform Infrared Spectroscopy
(FTIR)
QA/GMP Experienced Quality Staff:
• Ion Chromatography
• FDA audits
• Capillary Electrophoresis
• Validation
• Wet Chemistry Capabilities
• Part 11 compliant document system
• USP and EP Testing
Research Services:
• Lead optimization
• Custom amidite development
• Conjugation chemistry
• Forced degradation studies
Or email us at
[email protected]
Agilent Technologies, Inc.
5555 Airport Blvd.
Suite 100
Boulder, CO 80301
303 222 4900 ph
303 440 0273 fax
[email protected]
www.agilent.com/chem/nucleicacid
This information is subject to change
without notice
© Agilent Technologies, Inc. 2006
Printed in USA October 12, 2006
Call us today to discuss your therapeutic
development project with one of our project
managers at 303 222 4900
Or email [email protected]
Agilent Technologies, Inc.
5555 Airport Blvd.
Suite 100
Boulder, CO 80301
303 222 4900 ph
303 440 0273 fax
[email protected]
http://www.agilent.com/chem/nucleicacid
This information is subject to change without
notice
© Agilent Technologies, Inc. 2006
Printed in USA October 12, 2006