Product Specification Sheet
Zeta LabFreeze and PilotFreeze
For improving scale-up and design of new industrial freezing and thawing processes
The Zeta LabFreeze unit is a small volume controlled freeze unit that provides a profound base to develop
mechanistic understanding and modelling of the freezing process. It establishes the foundation for the controlled scaling of freezing processes for the PilotFreeze and the customized industrial freezer units.
Benefits

The PilotFreeze system with 700 ml is the
smallest freezing unit, built according to industrial standard. It uses the same construction
materials and incorporates the same freezing
and thawing technology. It is also the central
scaling tool for all customized industrial freezing scales.
Product stability studies
The LabFreeze and the PilotFreeze system
allow multiple experiments since the frozen
product can be removed without thawing.

Process improvement
The LabFreeze and PilotFreeze systems can
generate a wide temperature range and fully
automated temperature profiles.

Enhanced process know-how and mechanistic understanding of scaling support the requirements of QbD.
The LabFreeze system allows multiple experimental studies while using very little product
due to minimal working volumes of 200 ml
and reproducible conditions.


Controlled freezing processes and accurately
defined boundary conditions provide excellent
reproducibility for freezing, thawing and storage.
Process control
Various temperature probes at different positions, the measurement of pH in a frozen state
and the optional implementation of a PAT
probe for monitoring proteins and excipients
during the process are available for the specific process control system.
Scalability
The LabFreeze system with 200 ml is the
smallest system within the scaled Zeta Freeze
System series. It identifies the essential parameters of the freezing process.
200 ml – LabFreeze
Abbreviated validation

Automated freeze control unit
Automated control of temperature target values and actual temperature values achieves
reproducible and highly accurate tempering.
Trending for the temperature of the freeze
controller. Softkeys for several temperature
profile functions.
Optional integration of a process temperature
probe into the freeze control unit for an advanced temperature profile with a delta T.
700 ml – PilotFreeze
Key Values
LabFreeze
PilotFreeze
Working volume
200 ml
700 ml
Gross volume
300 ml
1140 ml
Material
316L, EPDM, sight cover
1.4435, EPDM
Dimension
300 x 570 x 177 mm
200 x 173 x 450 mm
Temperature range
-45°C – 90°C
-70°C – 130°C
Ports
7 temperature sensors
3 ports for movable temperature
sensors
12 ports for sampling
1 port for movable pH sensor
1 port for additional PAT probe
Freeze Controller
Pump connection
M24x1,5AG
M24x1,5AG
Max media flow
55 l/min
55 l/min
Max media pressure
0.9 bar
0.9 bar
Weight (net)
56 kg
90 kg
Dimension
425 x 270 x 636 mm
425 x 400 x 720 mm
Electrical connection
230 V, 50Hz,
230 V, 50Hz
Thermal fluid
Silicone oil
Silicone oil
Digital
RS232 and RS485 for connecting PC, SPS or PLS
Ethernet, USB (host and device), RS232
Analogue
Input: 1 times 0/4-20mA or 010V
Input: ECS ONE
Interface
Output: POKO ONE
Output: 3 times 0/4-20mA or 010V
Temperature accuracy
0.01K
0.01K
Temperature probe
internal/external
Pt100
Pt100
at 0°C
at -20°C
at -40°C
at -60°C
at -75°C
0.7 kW
0.4 kW
0.06 kW
0.65 kW
0.6 kW
0.6 kW
0.3 kW
0.06 kW
Noise level pressure
62 dB(A)
62 dB(A)
Cooling power
Zeta Biopharma GmbH, Zetaplatz 1, 8501 Lieboch/Graz
Phone +43 3136 / 90 10 - 0, Email: [email protected]
www.zeta.com