Estradiol
http://www.3dchem.com/moremolecules.asp?ID=241&othername=Estrogen
http://www.hmdb.ca/metabolites/HMDB00151
Question 1
• a) What is the electronic geometry of the oxygen atoms in this molecule?
• b) What is the molecular geometry of the oxygen atoms in this molecule?
Question 1
• a) What is the electronic
geometry of the oxygen atoms in this molecule?
• b) What is the molecular
geometry of the oxygen atoms in this molecule?
• Answers:
• a) tetrahedral
• b) bent
Question 2
• Considering the entire molecule, what kind of molecular bonds does it possess? Can you show them on paper?
a) Polar covalent b) Non polar covalent
c) Both a & b
d) ionic
Question 2
• Considering the entire molecule, what kind of molecular bonds does it possess? Show them!
a) Polar covalent b) Non polar covalent
c) Both a & b
d) ionic
Question 3
• Overall, is the molecule polar or non polar?
Why?
Question 3
• Overall, is the molecule polar or non polar?
Answer: Polar (but very slightly so!)
Why? Most bonds are C‐H (non polar), but the few polar ones make the molecule very slightly polar.
Question 4
• Is this molecule soluble in water?
Answer:
Why? Question 4
• Is this molecule soluble in water?
Answer: No
Why? Because it is only very slightly polar, and the largest part of the molecule is indeed non‐
polar. Water is very polar. Remember like disolves
like!
Question 5
• Estradiol binds to which of the following receptors?
a) Antiestrogen receptor
b) Estrogen receptor
c) Tamoxifen receptor
d) Testosterone receptor
Question 5
• Estradiol binds to which of the following receptors?
a) Antiestrogen receptor
b) Estrogen receptor
c) Tamoxifen receptor
d) Testosterone receptor
Question 6
• How do ligands (ions or molecules) bind to their receptor’s binding sites?
a) Intermolecular forces
b) Intramolecular forces
c) Both a & b
d) Neither
https://www‐pls.llnl.gov/?url=about_pls‐print&content=data/pages/science_and_technology/life_sciences/cancer_diet.xml
Question 6
• How do ligands (ions or molecules) bind to their receptor’s binding sites?
a) Intermolecular forces
b) Intramolecular forces
c) Both a & b
d) Neither
https://www‐pls.llnl.gov/?url=about_pls‐print&content=data/pages/science_and_technology/life_sciences/cancer_diet.xml
Time to build molecules!
Step 1
Take out your modeling sets.
Step 2
Build the following molecules.
Helpful Tips
z
z
Count valence electrons.
If you're having trouble, draw out the molecule first.
Carbon Dioxide
Carbon Dioxide
Perchlorate
Perchlorate
Ammonium
Ammonium
BONUS
Using your AMMONIUM molecule, make
Ammonia
Ammonia