10.5005/jp-journals-10015-1240
Fernanda
Godoy Rocha et al
REVIEWRegina
ARTICLE
Use of Salivary Biomarkers for Diagnosis of Periodontal
Disease Activity: A Literature Review
Fernanda Regina Godoy Rocha, Rafael Scaf de Molon, Mateus Rodrigues Tonetto, Shelon Cristina Souza Pinto
Eduardo Mariscal Munoz, Jose Eduardo Cesar Sampaio
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Periodontal disease is an infectious disease characterized by SURELQJLVQRWVSHFL¿FHQRXJKDQGPD\UHYHDOIDOVHSRVLWLYH
the connective tissue destruction and consequent alveolar bone UHVXOWV4 Thus, it has been proposed to seek predictive
loss in response to plaque accumulation on the tooth surface.
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The clinical diagnosis of periodontal disease is based both on
clinical examination involving the evaluation of probing depth GLVHDVHDFWLYLW\DQGWUHDWPHQWHI¿FDF\GLDJQRVWLFWHVWVIRU
3,5
and radiographic examination of alveolar bone loss but these SHULRGRQWDOGLVHDVH
examinations are not enough to determine the activity of the
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disease process. For that reason, it has been proposed to
periodontal disease and the diagnosis of its active phase is
seek predictive disease markers in an attempt to assess the
GLVHDVHDFWLYLW\DQGVRHYDOXDWHWKHHI¿FDF\RIWKHSHULRGRQWDO still a challenge for clinicians and researchers, often with
disease treatment. The aim of this review is to present recent UHVXOWVWKDWDUHGLI¿FXOWWREHFRPSDUHGIURPRQHVWXG\WR
advances in the development of proteomic, genomics and DQRWKHU7KXV WKH SRVVLELOLW\ KDV EHHQ GHPRQVWUDWHG WKDW
microbial biomarkers and potential clinical applications. It was
concluded that periodontal treatment based on assessing the DVLPSOHDQGDFFXUDWHGLDJQRVWLFWRROWKHXVHRIVDOLYDU\
levels of salivary biomarkers emerges as a promising method ELRPDUNHUV FRXOG SURYLGH PRUH DFFXUDWH DQG DOORZ PRUH
in near future and will become an integral part of the evaluation UHOLDEOHHYDOXDWLRQSHULRGRQWDOGLVHDVHVWDWH6
ABSTRACT
of periodontal health.
Keywords: Salivary glands, Periodontal disease, Oral
diagnosis, Periodontitis.
How to cite this article: Rocha FRG, de Molon RS, Tonetto
MR, Souza Pinto SC, Munoz EM, Sampaio JEC. Use of Salivary
Biomarkers for Diagnosis of Periodontal Disease Activity: A
Literature Review. World J Dent 2013;4(4):250-255.
Source of support: Nil
&RQÀLFWRILQWHUHVWNone declared
INTRODUCTION
Periodontal disease is a chronic bacterial infection
characterized by the destruction of connective tissue
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periodontitis, local tissue destruction by the defense cells
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The clinical diagnosis of periodontal disease is
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level, plaque index, bleeding on probing and radiographic
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to assess the severity of the disease, but not yet fully
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LITERATURE REVIEW
Saliva as a Diagnostic Tool
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World Journal of Dentistry, October-December 2013;4(4):250-255
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Use of Salivary Biomarkers for Diagnosis of Periodontal Disease Activity: A Literature Review
ABOUT THE AUTHORS
Shelon Cristina Souza Pinto
Fernanda Regina Godoy Rocha
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Rafael Scaf de Molon
Eduardo Mariscal Munoz
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Correspondence Address: 5XD+XPDLWi$UDUDTXDUD6mR
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Jose Eduardo Cesar Sampaio
Mateus Rodrigues Tonetto
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$GMXQFW3URIHVVRU'HSDUWPHQWRI'LDJQRVLV and Surgery, School of
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World Journal of Dentistry, October-December 2013;4(4):250-255
255