Description
Article code
Kitsize
Ordering information
IRMA
AFP
KIPB1441
96 tests
CA 125
KIP0301
96 tests
CA 15.3
KIP0321
96 tests
CA 19.9
KIP0311
96 tests
CEA
KIP0331
96 tests
KIPERB321
100 tests
KIP0429
96 tests
KIPEMD302
100 tests
Free Beta HCG
KIP1001
96 tests
NSE
KIP2471
96 tests
PSA
RVRK-10CT
100 tests
Free PSA
RVRK-85CT
100 tests
RVR-CM-100
100 tests
CgA (Chromogranin A)
CT-us (Calcitonin)
Gastrin
Tg-S
CANCER MARKERS
ELISA
AFP
KAPD1468
96 tests
CgA
KAPEPKT812
96 tests
CT-us
KAP0421
96 tests
LIT3003-1505
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Along with other tests, tumor (cancer)
markers can be used to help identify if cancer
is present, to determine the type of cancer,
and to help show if treatment is working.
Serum tumor (cancer) markers is a term commonly used to refer to molecules that can be detected in a blood sample by
immunochemical methods. Tumor markers are produced either by the tumor (cancer) itself or by the body in response to the presence
of cancer or certain non-cancerous (benign) conditions.
Units
Sample
type
Sample
Size (µl)
Incubation
Time´(min)
Standard
Range
Detection
Limit
Reference
Intervals
Shelf Life
(weeks)
IRMA
Measurements of tumor marker levels by serum markers can be useful in following clinical settings:
AFP
IU/ml
S
50
15 + 30
3 - 400
0.2
F:0.49 – 9.84
M:0.46 – 6.41
10
CA 125
U/ml
S
100
120 + 60
4.8 – 786
0.7
98% < 35
11
CA 15.3
U/ml
S
20
90 + 90
2.86 – 331
0.33
98% < 30
11
CA 19.9
U/ml
S
25
30 + 60
7.8 – 1061
0.7
98% < 37
11
CEA
ng/ml
S
100
120
2 – 200
0.17
89.7% < 3
9
CgA
nmol/L
S, P
50
20 h + 30 + 15
0.156 – 5
0.4
< 0.4
12
CT-us
pg/ml
S
200
18 h
8 – 674
0.9
< 10
5
Gastrin
pmol/L
S
100
60 + 30 + 15
15.6 – 500
5
< 60
11
4. DETECTION OF RESIDUAL DISEASE
After surgery of a specific cancer, serum tumor markers can be used to indicate whether the entire tumor burden has been successfully
removed.
Free Beta
HCG
mIU/ml
S
50
30 + 30
0.29 – 93
0.03
< 0.1
9
NSE
ng/ml
S
50
120
2.5 – 270
0.19
98% < 12.5
11
5. MONITORING TREATMENT
Serum tumor markers can be used as tool to assess the outcome of treatment by monitoring a patient’s response to a specific or
various treatment regimens. In general serum marker levels will drop if treatment is beneficial and will remain elevated or increase when
treatment is not effective.
PSA
ng/ml
S
100
120
0.1 – 80
0.004
<3
8
Free PSA
ng/ml
S
100
120
0.1 – 100
0.047
< 0.7
8
Tg-S
ng/ml
S, P
50 (N)
100 (S)
120 + 18 h
1.5 – 600 (N)
0.75 – 600
(SE)
0.25 (N)
0.1 (SE)
< 50
8
1. DIAGNOSIS
Serum tumor markers can, when used along with X-rays or other tests, aid in diagnosis of some types of cancer. They also can aid in
locating the source of cancers that have metastasized.
2. MONITORING FOR RECURRENCE OF TUMOR
After successful treatment of a cancer patient, tumor marker(s) are regularly tested to indicate whether there is a recurrence of the
cancer.
3. PROGNOSIS AND STAGING
Serum tumor markers can be used as aid in the tumor volume estimation, as a helpful tool to indicate tumor progression, or as indicator
of metastasis involvement.
Currently, the main use of tumor markers is to assess a cancer’s response to treatment and to check for recurrence.
ELISA
Tumor markers overview
AFP
IU/ml
S
25
30 + 10
10 – 160
1
1 – 10
60
Adrenal Gland
CgA
Lung
NSE, CEA, CgA
CgA
ng/ml
S
25
120 + 60 + 20
31 – 830
5
< 100
60
Bladder
NSE, CEA
Neuroendrocrine
CgA, NSE
CT-us
pg/ml
S
50
18 h + 30
10 – 400
0.7
< 11
60
Bone Metastases
Osteocalcin
Ovary
CA125, CEA, AFP, HCG + B
CT-us = Calcitonin
CgA = Chromogranin A
Brain
NSE, CEA
Pancreas
CA19.9, CEA, CgA
S = Serum
P = Plasma
Breast
CA15.3, CEA
Pituitary Gland
Prolactin
Cervix
CEA
Prostate
PSA, Free PSA
Colon
CEA, CA19.9, CgA
Stomach
CEA, CA19.9, CgA
Gallbladder
CA19.9, CEA
Testicle
AFP, Free BHCG, HCG + B
Kidney
CEA, NSE
Thyroid
Tg, Calcitonin, CEA
Liver
AFP, CEA, CA19.9, CgA
Uterus
Free BHCG, HCG + B
N = Normal procedure
DIASOURCE MAIN FEATURES
▪︎ Very good correlation with leading diagnostics companies
▪︎ Excellent analytical performances
▪︎ Small sample size
▪︎ Extended measuring range
SE = Sensitive procedure