5th International CEDH Conference - June 24-26, 2016 Chronic Diseases in Children Robert C Dumont, MD and Youngran Chung, MD CEDH International Conference Chicago, 2016 5th International CEDH Conference - June 24-26, 2016 Approaching the Young Child First meeting: sizing up the child 5th International CEDH Conference - June 24-26, 2016 Interactions The Child is the most important person in the Room Size up the child and interact with him/her first Begin forming a sense of his “energy”, constitutional/behavioral style 80-90% important elements of an exam can be from simple observation. Recognize their developmental level (and where they are at the time emotionally) and interact at that level Remember parents will often tell you only the things they believe are important you or they believe is related to that particular complaint To Treat the Child, First Treat the Mother (parents) 5th International CEDH Conference - June 24-26, 2016 Gastrointestinal Behavior Respiratory Dermatology Pediatrics Other 5th International CEDH Conference - June 24-26, 2016 Common Pediatric issues Respiratory URIs Eczema Otitis media Acne Allergic Rhinitis Other Rashes Sinusitis Dermatology Neurologic/Behavior Bronchitis/pneumonia • ADHD Bronchiolitis • Autism Asthma • Tantrums and ODD • Insomina/parasomnias Gastrointestinal/nutritional GERD/Upper GI dyspepsia Recurrent abdominal pain/IBS Constipation Diarrhea Failure to gain weight/feeding problems Other Endocrine Dysmenorrha Genitourinary Urinary tract infections Enuresis 5th International CEDH Conference - June 24-26, 2016 Clinical Homeopathic Approach Histopathological or pathophysiological approach Pathogenetic approach Approach by the Chronic Reactional Mode (CMR) Sensitive type (ST) approach Etiological approach 5th International CEDH Conference - June 24-26, 2016 The range of disease and symptom expression Etiology/Triggering event Chronic Reactional Mode (Sensitive Type) Strong Stressful event Moderate Weak Pathophysiologic reaction/symptoms Disease is predominant Common disease expression with individual variation of symptoms Toxicology (detoxification) Individual expression is predominant 5th International CEDH Conference - June 24-26, 2016 Pathogenic Approach Pharmacology & Toxicology “Herrings Cross” Lesional stage, tissues, location Sensation modalities concomitant symptoms Clinical Indications (Experience) Chosen Medicine(s) 5th International CEDH Conference - June 24-26, 2016 It is more important to know what sort of person has a disease than to know what sort of disease a person has. -Hippocrates Terrain Medicines: Chronic Reactional Mode and Sensitive Type 5th International CEDH Conference - June 24-26, 2016 Chronic reactional Modes Medicines PSORIC Arsenicum album Hepar sulphuris Lachesis Lycopodium Nux vomica Psorinum Sulphur Graphites Kali bichromicum SYCOTIC Causticum TUBERCULINIC Arsenicum iod. Dulcamara Calcarea phos. Natrum sulph. Iodum Natrum mur. Medorrhinum Nitricum acidum Phosphorous Pulsatilla Thuja occ. Sulphur iod. Rhus tox. Tuberculinum Phytolacca Argentum nit. Hydrastis can. Ignatia Drosera PSORO-SYCOTIC Silicea Calcarea carb. Sepia (Graphites) 5th International CEDH Conference - June 24-26, 2016 CRM in Children: Tuberculinic Recurrent ENT infections Especially in thin children with tendency to lymph adenopathy Arsenicum iodatum Calcarea phosphorica Iodum Natrum muriaticum Phosphorous Pulsatilla Sulphur iodatum Tuberculinum Argentum nitricum Ignatia Drosera 5th International CEDH Conference - June 24-26, 2016 CRM in Children: Psoric reactive mode or reactional pattern Skin, Mucous membrane (and serous membrane) Inflammatory or spasmodic (and metabolic) Family History May have begun as rash/eczema Arsenicum album Hepar sulphur Lachesis Lycopodium Nux vomica Psorinum Sulphur Graphites Kali bichromicum 5th International CEDH Conference - June 24-26, 2016 CRM in Children: Sycotic The problem never stops: Causticum Chronic secretions (of mucous membranes) rhinitis, chronic serous otitis media… Natrum sulphuricum Medorrhinum Nitricum acidum Thuja occidentalis Rhus tox. Phytolacca Hydrastis canadensis There may be a precipitating event Dulcamara 5th International CEDH Conference - June 24-26, 2016 And not to forget: The Psoro-Sycotic Medicines Silicea Calcarea carb. Sepia (Graphites) 5th International CEDH Conference - June 24-26, 2016 A few Sensitive types Phosphorus – may start out shy but then warms up quickly Pulsatilla – shy and often clingy (may see the mottled legs) Silicea – shy and lack of confidence Sulphur- robust Sulphur iodatum – mild Sulphur often with increased energy with ENT issues (infections) Calcarea carbonica – “steady”, may be fearful Calcarea phosphorica – long and lanky, fatigue Lycopodium – maybe quiet or open but often correcting parents, emotionally sensitive – self esteem. 5th International CEDH Conference - June 24-26, 2016 Etiologic Treatment vaccines beginning daycare or school repeated antibiotic treatments recurrent infections major and disturbing emotional events (divorce, new child in family Grief - Ignatia Abandonment - Pulsatilla Jealousy - Lachesis 5th International CEDH Conference - June 24-26, 2016 Gastroesophageal Reflux: A Way of Thinking The phenomenon of reflux We all have reflux The manifestations of reflux How does reflux present? The root of reflux? What is causing the reflux 5th International CEDH Conference - June 24-26, 2016 GERD: Presenting Symptoms in Infants Emesis/Spitting up Chronic sinus problems Regurgitation Respiratory symptoms Irritability Feeding refusal/aversion FTT/weight loss Recurrent ear infections Apnea Reactive airway disease Pneumonia Hoarseness Cough 5th International CEDH Conference - June 24-26, 2016 There May be One or More Contributing Factors Constipation (younger child) consider homeopathic treatment Metabolic problems Anatomic problems Dysmotility Protein intolerance/allergy (all ages) Dysbiosis Stress (older child, adolescent) – consider homeopathic treatment 5th International CEDH Conference - June 24-26, 2016 Dysmotility and ppi use are independent risk factors for small intestinal bacterial and/or fungal overgrowth C Jacobs*, E Coss Adame+, A Attaluri*, J Valestin*, and SSC Rao*,+ *Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA +Department of Internal Medicine, Georgia Regents University, Augusta, GA Aliment Pharmacol Ther. 2013 June ; 37(11): 1103–1111. doi:10.1111/apt.12304. 5th International CEDH Conference - June 24-26, 2016 Gastroesophageal Reflux and Dyspepsia Aethusa cynapium Sudden, profuse vomiting (projectile vomiting) right after a meal or later (in clots) with great efforts during vomiting May see loose stools watery greenish stools or stools with mucus Aethusa plus Calcarea carbonica (agg. From starches and milk,: atopic dermatitis, seborrheic dermatitis, diaper rash) 5th International CEDH Conference - June 24-26, 2016 Intolerance to dairy MAGNESIA CARBONICA Sour smelling baby, with low tone (weak muscles) aggravated by milk, may be cold sensitive. May have frothy green diarrhea Terrain: Calcarea carbonica) Nux vomica Dyspepsia – may refuse feeding Irritable, hyperactive and impatient May be colicky with abdominal distension, +/vomiting tendency to constipation 5th International CEDH Conference - June 24-26, 2016 Terrain medicines: Cow’s milk allergy Lycopodium Sulphur Calcarea carbonica 5th International CEDH Conference - June 24-26, 2016 Gastroesophageal Reflux and Dyspepsia Pyrosis Robinia: Complement medicine, epigastric burning, < eating esp. fatty foods, night time Sulphuricum acidum: Tendency to develop oral aphthae) and acidic gastroesophageal reflux (burning epigastric pain. Sour odor in babies. Iris versicolor: Burning of entire tract, belching and burping 5th International CEDH Conference - June 24-26, 2016 Gastroesophageal Reflux and Belching Asa foetida eructation with GERD, esophageal spasms Antimonium crudum nausea and vomiting, excessive eating tendency to overeat, coated tongue, taste-smell of food eaten Argentum nitricum Loud belching, (inflammation, ulceration – pain) 5th International CEDH Conference - June 24-26, 2016 Tourette’s Syndrome and Tic Disorders Lycopodium (facial) Often the CRM medicine given weekly Agaricus muscarinus (all tic disorders and choreiform movements) Mygale lasiodora (shoulder, neck) Magnesia phosphorica (painful facial tics) Manganum metallicum (throat clearing tic) Ignacia (tics from emotional issues, hypersensitive, spasmodic) Staphysagria (tics from held in emotions) Ambra gresea 5th International CEDH Conference - June 24-26, 2016 “The organs weep the tears the eyes refuse to shed” Sir William Osler EK was a 13 year old with significant motor tics Digging into family dynamics – conflict with mother Treatment Lycopodium 30C weekly Staphysagria 30C 2 x daily and then tapering Chronic need for Staphysagria while in mother’s house 10 years later – stable lifestyle engaged, steady job, without tics 5th International CEDH Conference - June 24-26, 2016 The Problem Child of Pediatrics: Diseases of Immune Dysregulation 5th International CEDH Conference - June 24-26, 2016 Homeopathy and immune dysregulation What we know about Immune dysregulation What we know about homeopathy and how it works Homeopathic Intervention in diseases of Immune Dysregulation 5th International CEDH Conference - June 24-26, 2016 Immune Dysregulation Let’s Set the Stage 5th International CEDH Conference - June 24-26, 2016 Clinical Homeopathic Approach Histopathological or pathophysiological approach Pathogenetic approach Approach by the Chronic Reactional Mode (CMR) Sensitive type (ST) approach Etiological approach Clearance of substances, drainage, etc 5th International CEDH Conference - June 24-26, 2016 Immune Dysregulation Environmental Allergy/Sensitivities Food Sensitivities Eczema Asthma Autoimmune Diseases Ulcerative colitis Crohn’s Disease Autism PANDAS Rheumatoid arthritis Alopecia 5th International CEDH Conference - June 24-26, 2016 From: Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. Sep 2002;347(12):911–920. 5th International CEDH Conference - June 24-26, 2016 5th International CEDH Conference - June 24-26, 2016 Allergic Diseases Presentation by Cezmi A. Akdis Swiss Institute of Allergy and Asthma Research 5th International CEDH Conference - June 24-26, 2016 It is not Nature vs Nurture Instead: Nature + Nurture 5th International CEDH Conference - June 24-26, 2016 Systems Biology “Medical practice is three dimensional chess and yet most practitioners are still playing checkers” 5th International CEDH Conference - June 24-26, 2016 Nurture Illnesses do not come upon us from out of the blue. They are developed from small daily sins against nature. When enough sins have accumulated, illness will suddenly appear. Hippocrates (400 B.C.) 5th International CEDH Conference - June 24-26, 2016 “When a patient is sick, the doctor should first regulate the patient’s diet and lifestyle” Sun Si-Miao 5th International CEDH Conference - June 24-26, 2016 Hahnemann on curable and non curable disease Those diseases are inappropriately named chronic, which persons incur who expose themselves continually to avoidable noxious influences, who are in the habit of indulging in injurious liquors or aliments, are addicted to dissipation of many kinds which undermine the health, who undergo prolonged abstinence from things that are necessary for the support of life, who reside in unhealthy localities, especially marshy districts, who are housed in cellars or other confined dwellings, who are deprived of exercise or of open air, who ruin their health by overexertion of body or mind, who live in a constant state of worry, etc. These states of ill-health, which persons bring upon themselves, disappear spontaneously, provided no chronic miasm lurks in the body, under an improved mode of living, and they cannot be called chronic diseases. 5th International CEDH Conference - June 24-26, 2016 Environmental factors Diet and lifestyle Opportunity for new “targets” 5th International CEDH Conference - June 24-26, 2016 Nature + Nurture Nurture: Triggers (sycotic induction) - clearance of effects vaccines, viral infections, etc Toxins, heavy metals, pesticides (detox, body of substances and hepatic/renal clearance Hygiene theory/Microbiome - parasites, dysbiosis and regulation of immune system Food sensitivities, leaky gut, mucosal integrity homeopathics? Generation of an inflammatory state Residual damage 5th International CEDH Conference - June 24-26, 2016 Functional Medicine Lifestyle and Diet Diet Stress Sleep Physical activity Environmental toxins Healthy Non Healthy Genetic predisposition 5th International CEDH Conference - June 24-26, 2016 Non Homeopathic Interventions Determine and eliminate “sensitive” foods (often Dairy and Gluten) Organic, nutrient rich anti-inflammatory and microbiome supportive diet Avoidance of Pollutants and toxicants Adequate restful Sleep Adequate Physical activity Adequate periods of rest and relaxation Supportive 5th International CEDH Conference - June 24-26, 2016 Toxins, pollutants and Heavy Metals “We’ve got 80,000 chemicals approved for use in commerce, but we know very little about their immune effects. Our lifestyles are also different than they were a few decades ago, and we’re eating more processed food.” Should prevalence rates for heart disease and cancer continue their decline, Miller says, autoimmune diseases could become some of the costliest and most burdensome illnesses in the United States. Fred Miller, director, Environmental Autoimmunity Group at the National Institute of Environmental Health Sciences in: volume 119 | number 6 | June 2011 • Environmental Health Perspectives Environmental Factors in Autoimmune Disease Charles W. Schmidt, MS 5th International CEDH Conference - June 24-26, 2016 Autoimmune Disease and the Environment Hereditability of the disease accounts for 50–60 % of its variance, the HLA-DRB1 shared epitope–containing allele being the strongest genetic risk factor active and heavy tobacco smoking which is the most important environmental risk factor for RA with its attributable risk sustained for up to 20 years after discontinuation Sources of air pollution including traffic and probably solid fuels are associated with Rheumatoid Arthritis Is air pollution a risk factor for rheumatoid arthritis? Mickael Essouma and Jean Jacques N. Noubiap. Journal of Inflammation (2015) 12:48 5th International CEDH Conference - June 24-26, 2016 There is an association between Autoimmune Disease and environmental Toxicants Hemdan NY, Emmrich F, Faber S, Lehmann J, Sack U. Alterations of TH1/TH2 reactivity by heavy metals: possible consequences include induction of autoimmune diseases. Ann N Y Acad Sci. 2007 Aug;1109:129-37. Mishra KP. Lead exposure and its impact on immune system: a review. Toxicol In Vitro. 2009 Sep;23(6):969-72. Bahadar H, Abdollahi M, Maqbool F, Baeeri M, Niaz K. Mechanistic overview of immune modulatory effects of environmental toxicants. Inflamm Allergy Drug Targets. 2015;13(6):382-6. Suzuki Y, Inoue T, Ra C. Autoimmunity-inducing metals (Hg, Au and Ag) modulate mast cell signaling, function and survival. Curr Pharm Des. 2011 Nov;17(34):3805-14. 5th International CEDH Conference - June 24-26, 2016 What works in the Biomedical approach to Autism 74% of parents see behavioral improvement in their children with chelation of heavy metals 5th International CEDH Conference - June 24-26, 2016 Homeopathic medicines used in Autistic Disorder Treatment of Heavy Metals Alumina Cadmium sulphuricum Mercurius solubilis Plumbum metalicum Arsenicum album Petroleum? 5th International CEDH Conference - June 24-26, 2016 Infectious Triggers Streptococcus Epstein Barr virus 5th International CEDH Conference - June 24-26, 2016 Homeopathic medicines used in Autistic Disorder “Clearance” effect Medorrhinum Thuja Vaccinotoxinum Streptococcinum Morbillinum 5th International CEDH Conference - June 24-26, 2016 Diet and Immune Dysregulation “When diet is wrong, medicine is of no use; When diet is correct, medicine is of no need.” – Ayurvedic Proverb Hippocrates has been quoted as saying “death sits in the bowels” and “bad digestion is the root of all evil” (400 B.C.) 5th International CEDH Conference - June 24-26, 2016 Autoimmune Disease and the Environment Food Sensitivities Individuals with autoimmune disease have food sensitivities - There are many anecdotes of individuals who show marked improvement or resolution of symptoms of rheumatoid arthritis in conjunction with elimination of a particular food. There are also many individuals with autoimmune disease feel better when consuming an anti-inflammatory diet, in conjunction with fish oil supplementation. 5th International CEDH Conference - June 24-26, 2016 Food Sensitivities: Difficult Eczema Case 17 year old girl with chronic resistant eczema (on body, limbs and face. No response to conventional medications and no response to experimental medications. Tried off of dairy, gluten no change Combination of acupuncture and homeopathy (symptomatic and CRM): 40-50% improvement Reassessment of treatment protocol (correct) IgG sensitivity testing: Turkey Off turkey and completely resolved in 3 weeks Hygiene Theory: The role of the GI Environment, Microbiome and Parasites in Immune Dysregulation Marie-Antoinette "Qu'ils mangent de la brioche" (Let them eat cake) Marie-Antoinette What she really said: Qu'ils mangent de la terre (Let them eat dirt) 5th International CEDH Conference - June 24-26, 2016 Microbiota “The microbe is nothing, the soil is everything.” - Louis Pasteur « La bactérie n’est rien, c’est le terrain qui fait tout. » (Bacteria are nothing, the terrain is everything) Claude Bernard 1813 – 1878 “If I could live my life again, I would devote it to proving that germs seek their natural habitat – unhealthy tissue – rather than being the cause of unhealthy tissue.” Rudolf Virchow (1821–1902) 5th International CEDH Conference - June 24-26, 2016 Histopathologic Approach: Inflammatory Bowel Disease Inflammation: Argentum nitricum Arsenicum album Mercurius solubilis Mercurius corrosivus Nitricum acidum 5th International CEDH Conference - June 24-26, 2016
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