Fluorinated compounds
Fluorine is the most electronegative of all the elements, and forms very strong bonds to carbon and most other elements.
Its small atomic radius enables replacement of one or more hydrogen atoms in an organic structure by fluorine with
relatively little steric impact, but often with a profound influence on the stability, biological availability and activity of the
resulting molecule. Elemental fluorine is one of the most chemically reactive substances known, which, along with the high
toxicity of both fluorine and hydrogen fluoride, and their incompatibility with common materials, including glass, necessitate
highly specialized equipment and techniques for reactions in which they are involved. Direct fluorination of a pre-existing
organic structure with either F2 or HF may thus appear daunting to the non-specialist.
Although a range of more readily handled and selective fluorinating agents is available, in many cases the target molecule
may be more conveniently attained in fewer steps by utilizing fluorinated building blocks available from commercial
sources, among which Alfa Aesar, now part of Thermo Fisher Scientific, offers one of the largest ranges. Benzenoid
aromatic rings containing one or more fluorinated substituents, including mono- and difluoro, trifluoromethyl and
trifluoromethoxy groups, are a common feature of many existing pharmaceutical and agrochemical products.
Displayed below are prominent examples of Alfa Aesar's line of fluorinated compounds.
COOH
F
N
F
OCF3
F
H33463
F
NH2
H33278
CH2NH2
CH3O
F
H26432
2,3-Difluoropyridine-4-carboxylic acid,
5-Fluoro-2-(trifluoromethoxy)
2,6-Difluoro-4-methoxy
97%
aniline, 97%
benzylamine, 97%
[851386-31-7]
[123572-63-4]
[771573-20-7]
Order our products online www.alfa.com
For Research Use Only. Not for use in diagnostic procedures. © 2016 Thermo Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
PF_FluorinatedCompounds_2016_V1
Fluorinated compounds
F
F
F
F
CF3
F
F
F
F
F
F
F
F
F
F
F
F
CF3
F
CF3
F
F
F
F
F
F
A14233
F
A11500
F
CF3
F
B21500
Perfluoro(methylcyclohexane), 94%
Hexafluorobenzene, 99%
Perfluoro-1,3,5-trimethylcyclo-
[355-02-2]
[392-56-3]
hexane, mixture of isomers, tech.
[374-76-5]
F
O2N
CF3
F
Cl
F
F
CH2ONH2 .HCl
F
F
CN
F
NC
F
F
NO2
A17617
A18368
H61326
2-Chloro-3,5-dinitrobenzo-
O-(2,3,4,5,6-Pentafluorobenzyl)
trifluoride, 98+%
hydroxylamine hydrochloride, 99+%
98%
[392-95-0]
[57981-02-9]
[1835-49-0]
O
COOH
CF3 CF3
Tetrafluoroterephthalonitrile,
O
O
CH3O
CF3
O
COCl
NHFmoc
F
O
H51972
O
L16150
L14325
4-Fluoro-N-Fmoc-L-phenyl-
4,4'-(Hexafluoroisopropylidene)-
(R)-(-)-α-Methoxy-α-(trifluoro-
alanine, 95%
diphthalic anhydride, 99%
methyl)phenylacetly chloride, 98+%
[169243-86-1]
[1107-00-2]
[39637-99-5]
F
O
CH3O
COCl
O
HOCH2
N
O
OH
L14332
L16497
(S)-(+)-α-Methoxy-α-(trifluoro-
5-Fluoro-2'-deoxyuridine, 98+%
methyl)phenylacetyl chloride, 98+%
[50-91-9]
[20445-33-4]
For Research Use Only. Not for use in diagnostic procedures. © 2016 Thermo Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
PF_FluorinatedCompounds_2016_V1
F
F
HN
CF3
F
F
F
F
B
F
F
F
F
F
F
F
F
F
L18054
Tris(pentafluorophenyl)borane,
97%
[1109-15-5]
Fluorinated compounds
CF3
CH3
CH3
Si
N
CH3
O
Si
CH3
CH3
OH
CF3
Si(CH3)3
CH3
043939
O
CH3
CF3CON
A13141
31771
N,O-Bis(trimethylsilyl)trifluoroacetamide,
N-Methyl-N-(trimethylsilyl)tri-
Trifluoroacetic acid, 99.5+%
with 1% TMCS
fluoroacetamide, 97%
[76-05-1]
[25561-30-2]
[24589-78-4]
O
F
O
O
O
H61502
F
OCH2CH3
O
4-Fluoro-1,3-dioxolan-2-one,
F
CF3
H53425
H25750
Ethyl 4,4,4-trifluoro-2-butynoate,
2,2-Difluoroacetophenone, 95%
98%
97%
[395-01-7]
[114435-02-8]
[79424-03-6]
F
F
CF3
CF3
F
F
A11360
CH2Br
F
F
F
H
F
F
F
A11623
A13948
1,3-Bis(trifluoromethyl)benzene,
2,3,4,5,6-Pentafluorobenzyl bromide,
Pentafluorobenzene, 98+%
98+%
98+%
[363-72-4]
[402-31-3]
[1765-40-8]
CH3
F
F
SO2Cl
F
F
F
A17676
CH3
O
B
CH3
O
CH3
F
(CH3)3COCONH
H59194
F
N
NH
F
L19393
2,3,4,5,6-Pentafluorobenzenesulfonyl
4-(Boc-amino)-2-fluorobenzeneboronic
1-(2,4-Difluorophenyl)piperazine, 99%
chloride, 98+%
acid pinacol ester, 96%
[115761-79-0]
[832-53-1]
[1256256-45-7]
For Research Use Only. Not for use in diagnostic procedures. © 2016 Thermo Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
PF_FluorinatedCompounds_2016_V1
Order our products online www.alfa.com
For Research Use Only. Not for use in diagnostic procedures. © 2016 Thermo Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
PF_FluorinatedCompounds_2016_V1