Di-Methox
®
Sulfadimethoxine Antibacterial
In cattle, Di-Methox is an effective treatment of bacterial pneumonia,
shipping fever complex, calf diphtheria, and foot rot. Sulfadimethoxine has
been demonstrated clinically or in the laboratory to be effective against a
variety of organisms, such as streptococci, klebsiella, proteus, shigella,
staphylococci, E. coli, salmonella and fusobacterium.
In poultry, Di-Methox Oral Solution and Di-Methox Powder are
effective treatments for coccidiosis, fowl cholera, and infectious coryza.
Di-Methox Injection 40%
Di-Methox 12.5% Oral Solution
Di-Methox Powder
• Broad coverage of treatments
• Broad coverage of treatments
•
•
•
•
Shipping Fever Complex
Bacterial Pneumonia
Calf Diphtheria
Foot Rot
• Low dosage, quick acting
• Approved for lactating dairy cows, beef cattle and ruminating calves.
•
•
•
•
Shipping Fever Complex
Bacterial Pneumonia
Calf Diphtheria
Foot Rot
• Provides broad coverage for broilers, turkeys and chicks.
• Low dosage, quick acting
• Approved for dairy cattle, beef cattle,
ruminating calves, turkeys and chickens.
DI-METHOX® Soluble Powder
(SULFADIMETHOXINE)
ANTIBACTERIAL soluble powder
ANADA 200-031, Approved by FDA
Each packet contains: 3.34 oz.(94.6g) Sulfadimethoxine in the form of the soluble salt and disodium edetate.
INDICATIONS: For broiler and replacement chickens only - Use for the treatment of disease outbreaks of
coccidiosis, fowl cholera, and infectious coryza.
For meat producing turkeys only - Use for the treatment of disease outbreaks of coccidiosis and fowl cholera.
For dairy calves, dairy heifers and beef cattle - Use for the treatment of shipping fever complex, bacterial pneumonia, calf diphtheria and foot rot.
Dosage and Administration:
Species
Concentrations
Use Directions
Chickens
0.05%
Contents of packet to 50 gallons of water
Turkeys
0.025%
Contents of packet to 100 gallons of water
Species
Automatic proportioners - To make stock solution, add contents of 5 packets to 2 gallons of water for chickens and
to 4 gallons of water for turkeys. Set proportioner to feed at rate of 1 fl. oz. of stock solution per gallon of water.
Dairy Calves, Dairy
Heifers and Beef
Cattle
*Note: Make
a cattle stock
solution by
adding 1 packet of
Di-Methox Soluble
Powder to 1 gallon
of water.
Dosage:
25 mg/lb first day
followed by 12.5 mg/
lb/day for 4 days.
First Day Add:
Next 4 days add:
Amount of stock
solution for
Cattle*
Summer 1
gallon**/100
lb b.w.
Winter 1
gallon**/150
lb b.w.
Concentrations
Use Directions
Chickens
0.05%
Add 1 fl. oz.* to 2 gal. of drinking water -or- 25 fl. oz. to 50 gal. of drinking
water
Turkeys
0.025%
Add 1 fl. oz.* to 4 gal. of drinking water -or- 25 fl. oz. to 100 gal. of drinking
water
Automatic Proportioners** Stock Solution - To make 2 gallons of Stock Solution use:
Chickens
1 gal. Di-Methox 12.5% Drinking Water Solution Concentrate - plus - 1 gal. of water
Turkeys
2 qts. Di-Methox 12.5% Drinking Water Solution Concentrate - plus - 6 qts of water
Treatment period: 6 consecutive days
1 quart
10 gallons
7 gallons
2 quarts
20 gallons
14 gallons
1 gallon
40 gallons
28 gallons
1 quart
20 gallons
14 gallons
Dosage: 25 mg/lb
first day followed by
12.5 mg/lb/day for
4 days.
2 quarts
40 gallons
28 gallons
First Day Add:
1 gallon
80 gallons
DI-METHOX® INJECTION-40%
(SULFADIMETHOXINE INJECTION)
ANTIBACTERIAL
ANADA 200-038, Approved by FDA
Each mL contains: 400 mg sulfadimethoxine compounded with 20% propylene glycol, 1% benzyl alcohol,
0.1 mg disodium edetate, 1 mg sodium formaldehyde sulfoxylate, and pH adjusted with sodium hyroxide.
INDICATIONS: DI-METHOX (Sulfadimethoxine Injection 40%) is indicated for the treatment of bovine respiratory
disease complex (shipping fever complex) and bacterial pneumonia associated with Pasteurella spp. sensitive to
sulfadimethoxine; necrotic pododermatitis (foot rot) and calf diphtheria caused by Fusobacterium necrophorum
(Sphaerophorus necrophorus), sensitive to sulfadimethoxine.
Dosage and Administration: To be administered only by the intravaneous route in amounts to provide
25 mg/lb (55 mg/kg) for initial dose, followed by 12.5 mg/lb (27.5 mg/kg) for maintenance doses every 24 hours.
During treatment period, make certain that animals maintain adequate water intake. Representative weights and
doses are indicated in the following table:
Initial Dose 25 mg/lb (55
mg/kg)
Dairy Calves, Dairy
Heifers and Beef Cattle
56 gallons
** This dosage recommendation is based on a water consumption of 1 gallon per 100 lb of body weight per day,
the expected water consumption rate for summer. Water consumption during cold months (winter) may drop
markedly (30-40%). Accordingly, adjustments must be made in the dilution rates to compensate for this and
insure proper drug intake. For treatment of individual cattle, Di-Methox Soluble Powder stock solution for cattle
may be given as a drench. Administer using same mg/lb dosage as outlined above. Twenty fluid ounces of catlle
stock solution will medicate one-600 lb animal initially or two-600 lb animals on maintenance dose. Contents of
packet will medicate six-600 lb animals initially or twelve-600 lb animals on maintenance dose.
Treatment period: 5 consecutive days.
WARNINGS: Chickens and Turkeys - Withdraw 5 days before slaughter. Do not administer to chickens over 16
weeks (112 days) of age or to turkeys over 24 weeks (168 days) of age.
Cattle - Withdraw 7 days before slaughter. For dairy calves, dairy heifers and beef cattle only. A withdrawal period
has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
CAUTION: Chickens and Turkeys - If animal shows no improvment within 5 days, discontinue treatment and
re-evaluate diagnosis. Perpare fresh stock solution daily. Handle the recommended dilutions as regular drinking
water. Administer as sole source of drinking water and sulfonamide medication. Chickens and turkeys that have
survived fowl cholera outbreaks should not be kept for replacements or breeders.
Cattle: During treatment period, make certain that animals maintain adequate water intake. If animals show no
improvement within 2 or 3 days, re-evaluate diagnosis. Treatment should not be continued beyond 5 days.
Supplied: 107g (3.77 oz.) pouches
Animal Weight
DI-METHOX® 12.5% Oral Solution
(SULFADIMETHOXINE Oral Solution)
ANTIBACTERIAL
ANADA 200-030, Approved by FDA
EACH FLUID OUNCE CONTAINS: 3.75g Sulfadimethoxine solubulized with sodium hydroxide.
INDICATIONS: Broiler and replacement chickens - Use for the treatment of disease outbreaks of coccidiosis, fowl
cholera, and infectious coryza.
Meat producing turkeys - Use for the treatment of disease outbreaks of coccidiosis and fowl cholera.
Dairy calves, dairy heifers and beef cattle - Use in the treatment of shipping fever complex, bacterial pneumonia,
calf diphtheria, and foot rot.
Dosage and Administration:
Next 4 days add:
Water Consumption
Summer 1
gallon†/100
lb b.w.
Winter 1
gallon†/150
lb b.w.
1 pint
25 gallons
16 gallons
1 quarts
50 gallons
33 gallons
1 gallon
200 gallons
127 gallons
1 pint
50 gallons
33 gallons
1 quarts
100 gallons
66 gallons
1 gallon
400 gallons
266 gallons
†This dosage recommendation is based on a water consumption of 1 gallon per 100 lb of body weight per day,
the expected water consumption rate for summer. Water consumption during cold months (winter) may drop
markedly (30-40%). Accordingly, adjustments must be made in the dilution rates to compensate for this and
insure proper drug intake. For individual treatment of cattle, Di-Methox 12.5% Oral Solution may be given as a
drench. Administer using same mg/lb dosage as outlined above. Four fl. oz. will medicate one-600 lb animal or
two-600 lb animals on maintenance dose.
Treatment Period: 5 consecutive days
*1 fl. oz. 12.5% drinking water solution= 30mL or two Tablespoon fulls.
**Set proportion to feed rate of 1 fl. oz. of Di-Methox stock solution per gallon of water.
CAUTION: Store at room temperature. If freezing occurs, thaw before using. Protect from light. Direct sunlight may
cause discoloration. Freezing or discoloration does not effect potency. Prepare a fresh stock solution daily.
Chickens and Turkeys - If animal shows no improvement within 5 days, discontinue treatment and re-evaluate
diagnosis. Perpare fresh stock solution daily. Handle the recommended dilutions as regular drinking water.
Administer as sole source of drinking water and sulfonamide medication. Chickens and turkeys that have survived
fowl cholera outbreaks should not be kept for replacements or breeders.
Cattle - During treatment period, make certain that animals maintain adequate water intake. If animals show no
improvement within 2 or 3 days, re-evaluate diagnosis. Treatment should not be continued beyond 5 days.
WARNING: Chickens and Turkeys - Withdraw 5 days before slaughter. Do not administer to chickens over 16
weeks (112 days) of age or to turkeys over 24 weeks (168 days) of age.
Cattle - Withdraw 7 days before slaughter. For dairy calves, dairy heifers and beef cattle only. A withdrawal period
has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
Supplied: 3.8 L (1 gal.) jugs
Subsequent daily doses 12.5 mg/lb
(27.5 mg/kg)
250 lb (113.6 kg)
15.6 mL
7.8 mL
500 lb (227.2 kg)
31.2 mL
15.6 mL
750 lb (340.9 kg)
46.9 mL
23.5 mL
1000 lb (454.5 kg)
62.5 mL
31.3 mL
WARNING: Milk taken from animals during treatment and for 60 hours (5 milkings) after the latest treatment must
not be used for food. Do not administer within 5 days of slaughter. A withdrawal period has not been established
for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
Supplied: 250 mL bottles
STORAGE: 59-86ºF
Refer to product insert for full and complete
directions before using these products.
®
P.O. Box 3103 St. Joseph, MO 64503
800-542-8916 www.AgriLabs.com
©2010 Agri Laboratories Ltd.
ANAD-0030 Rev 0213