Course syllabus
Molekylära drivkrafter 2: Växelverkan och
dynamik
Molecular Driving Forces 2: Interactions and
Dynamics
KFKF01, 7,5 credits, G2 (First Cycle)
Valid for: 2012/13
Decided by: Education Board 2
Date of Decision: 2012-04-04
General Information
Main field: Technology.
Compulsory for: B2
Language of instruction: The course will be given in Swedish
Aim
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The aim with this course is to give the students knowledge about the connection
between the intermolecular interactions in a macroscopic system and the static and
dynamic properties of the system.
Learning outcomes
Knowledge and understanding
For a passing grade the student must
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be able to give a molecular description of the diffusion as transport phenomenon.
be able to explain activation energy and detailed balance and their fundamental
relevance in various contexts, such as reaction kinetics, protein folding and catalysis
be able to describe and classify the different molecular properties responsible for the
intermolecular interaction.
have enough knowledge of the electrical potiential to be able to discuss various
phenomena, such as electrochemical equilibria and ion solvation.
be able to use and understand the basis for some thermodynamic models that describe
macroscopic phenomena, such as phase transitions, miscibility gaps, azeotropes,
partition coefficients between different media and the nonideal behaviour of ionic
solutions.
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show fundamental knowledge of the most important physics of biopolymers, such as
cooperative secondary structure formation, adsorption, bio-catalysis, cooperative ligand
binding to proteins and the hydrophobic interaction.
be able to describe the mot important properties of liquid water, such as hydrogen bond
structure, the temperature dependence of the density, the hydrophobic effect and the
role played by water for the thermodynamics of biochemical processes.
be able to describe the principles of some molecular simulation methods.
Competences and skills
For a passing grade the student must
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be able to calculate the different contributions to the interaction between two
molecules, such as the mono and dipol moments, and dispersion forces.
be able to estimate some phenomena using simple cell-models, such as phase transitions,
destillation, miscibility gaps, secondary structure formation in proteins and adsorption
on surfaces.
be able to estimate, both practically and theoretically, the different contributions to
solibility, such as Born solvation and ion-ion interaction according to the DebyeHückel equation.
be able to estimate the effect of diffusion in biochemically relevant problems, such as
diffusion through gels and diffusion controlled reaction kinetics.
be able to write simple, but complete, reports of laboratory experiments.
Judgement and approach
For a passing grade the student must
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be able to discuss biologically relevant problems on the basis of the fundamental models
that are presented in the course.
be able to judge the validity of the models that are presented in the course.
Contents
The course shows how intermolecular interaction gives rise to structure on a microscopic
and mesoscopic level and how it gives a qualitative explanation of and an ability to predict
macroscopic properties. This presents a molecular explanation to much of
phenomenological thermodynamics and macroscopic transport processes. It also gives the
tools needed to predict how manipulations on the molecular level affect the microscopic
properties of a (bio)material. The course consists of classical electrostatics and
intermolecular interactions, and statistical thermodynamics with applications to
adsorption, liquids and solutions of electrolytes.
The properties of bioplolymers, such as proteins and DNA-molecules, are treated
specifically.
Two full lectures are used to cover the properties of liquid water and its unique
importance for the solvation of and the interactions between both large and small (bio)
molecules.
The course also treats molecular motion in liquids (diffusion) and thereby presents the
molecular basis for macroscopic transport processes and reaction kinetics of enzymes.
Examination details
Grading scale: TH
Assessment: The final grade is based on a written exam in the end of the course.
Laboratory practicals must also be completed.
Admission
Required prior knowledge: FMAA01 Calculus in One Variable, FMA420 Linear
Algebra, KFKA05 Molecular Driving Forces 1: Thermodynamics
The number of participants is limited to: No
The course overlaps following course/s: KFK080, KFK090
Reading list
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Dill, K and Bromberg, S: Molecular driving forces. Statistical thermodynamics in
Chemistry, Physics, Biology and Nanoscience. 2nd edition. Garland Publishing Inc
2010. ISBN: 9780815344308..
Contact and other information
Course coordinator: Kristofer Modig, [email protected]
Course homepage: http://www.cmps.lu.se/bpc/teaching/