SymSitive®
1609
4-t-Butylcyclohexanol
INSTANT SKIN
RELIEF
ANTI-BURNING / ANTI-STINGING
NEUROSENSORY SOOTHING
ACTIVES
SymSitive_A5_EXE.indd 2
23/03/15 15:17
INSPIRING MORE
ISN’T SKIN TOLERANCE
FIRST AND FOREMOST
A QUESTION OF DEGREE?
More and more consumers tend to perceive their skin
as over-reactive or intolerant to external aggressions or
personal care products. Most of the time, the irritation
symptoms include redness, tingling, tightness, but
they may also include burning and stinging sensations.
Research has shown that the later are precisely
characteristic of sensitive to highly sensitive skin.
CONSUMER INSIGHTS
In order to bring strong and instant relief to hyper senstive
skins Symrise have designed a soothing active principle
with a specific focus on burning and stinging sensations.
52
%
18%
SymSitive_A5_EXE.indd 3
OF CONSUMERS
WOULD SAY THAT
THEIR FACE SKIN IS
A “SENSITIVE SKIN”.
OF CONSUMERS THINK
THAT COSMENTIC
INTOLERANCE IS THE
MAIN CAUSE OF THEIR
SKIN, SCALP AND HAIR
PROBLEMS.
68
%
34%
OF CONSUMER SAY:
“MY SKIN IS MORE
SENSITIVE THAN A
FEW YEARS AGO”.
OF CONSUMERS SAY:
“MY SKIN OFTEN
BURNS THE WHOLE
DAY LONG BECAUSE OF
SHAVING/DEPILATION”.
23/03/15 15:17
SYMRISE INNOVATION
MODULATE
THE NEUROSENSORY
CHAIN REACTION
AT THE SOURCE
OF STINGING AND
BURNING SENSATIONS
SymSitive_A5_EXE.indd 4
23/03/15 15:17
SymSitive® 1609
THE ACTIVE
BENEFITS
THE IDEAL SOOTHER DEDICATED TO
SENSITIVE AND HYPER-SENSITIVE SKINS
SymSitive_A5_EXE.indd 5
23/03/15 15:17
PRODUCT FEATURES
INSTANT RELIEF
AND
HIGH TOLERANCE
APPLICATIONS
DEDICATED TO
INTOLERANT
& EXTREME
SENSITIVE
SKIN & SCALP
APPLICATIONS
• SENSITIVE SKIN CREAMS
• LOTIONS AND SERUMS
• HAIR COLORS
• PERMS AND RELAXERS
• BB CREAMS
SymSitive_A5_EXE.indd 6
25/03/15 12:31
SymSitive® 1609
PROTECTS AND BRINGS
INSTANT RELIEF TO SKIN AND SCALP
CLINICAL STUDY
STINGING AND BURNING INSTANT RELIEF SENSATIONS
-80% of stinging
and burning sensations.
0= no perception
1= doubtful, barely perception
2= slight perception
3= moderate perception
p<0.001 Significant
p<0.05 Significant
3% SymSitive® 1609 + Capsaicin
Capsaicin
3
2
1
0
STINGING
BURNING
TINGLING
PROTOCOL
20 VOLUNTEERS, SENSITIVE TO CAPSAICIN OVER 2 DAYS. APPLICATION SITE: NASOLABIAL FOLD.
SAMPLES: O/W EMULSION WITH 31.6 PPM CAPSAICIN +/- 1% ACTIVE MATERIAL. DAY 1: ASSESSMENT
OF SAMPLE WITH ACTIVE MATERIAL SymSitive® 1609 VS CONTROL. DAY 2: ASSESSMENT OF SAMPLE
WITHOUT ACTIVE MATERIAL SymSitive® 1609 VS CONTROL. EVALUATION OF THE STINGING EFFECT
3 MIN AFTER APPLICATION.
COSMETIC INTOLERANCE SYNDROME
65% reduction of overall
irritation.
1= -65%
2= -25%
p<0.03 Significant
Active
Placebo
PROTOCOL
20 VOLUNTEERS.
APPLICATION 2 X DAILY YO HALF FACE
VERSUS PLACEBO FOR 5 DAYS.
TEST PRODUCT: O/W EMULSION WITH
AND WITHOUT 1.2% SymSitive® 1609.
DAY 1 AND DAY 5: ASSESSMENTS
OF OVERALL IRRITATION (INCLUDING
STING AND BURNING) AFTER
1 MINUTE AND AFTER 3 MINUTES
(AFTER NOXIOUS SENSORY
STIMULATION).
SymSitive_A5_EXE.indd 7
0.4
D1+1mn
D1+3mn
D5+1mn
D5+3mn
0.2
0
-0.2
-0.4
-0.6
1
-0.8
-1
-1.2
2
Moment of truth
-1.4
23/03/15 15:17
EFFICACY DATA
SCALP RELIEF
13%
13%
• Hemi-head treated with SymSitive 1609
13%
is less affected.
• 93% of the subjects would insist to the hair dresser
to renew the product use for the hair coloration.
• Presents a significant soothing / healing effect
after a single application in comparison with placebo (p<0.01).
®
61%
IN VITRO STUDY
74% of the subjects did not
report discomfort sensation
during the hair coloration.
No functional discomfort on treated hemi-head
No functional discomfort on both hemi-head
Reduced discomfort on treated hemi-head
Discomfort on both hemi-heads
PROTOCOL
15 VOLUNTEERS WITH 3% SymSitive® 1609
APPLICATION: SINGLE AND STANDARDIZED HEMI-HEAD APPLICATION VERSUS PLACEBO (COLORATION)
EVALUATION OF THE PREVENTIVE HEALING / SOOTHING EFFECT:
BY COLLECTION OF CUTANEOUS SIGNS FELT BY THE SUBJECTS DURING HAIR COLORATION
IN COMPARISON WITH THE PLACEBO
SUBJECTIVE EVALUATION OF THE EFFICACY USING A QUESTIONNAIRE
EVALUATION AND SCORING BY THE HAIRDRESSER:
A) PRODUCT’S TOLERANCE
B) INFLUENCE OF THE PRODUCT ON THE SHADE
STATISTICAL ANALYSIS: DATA ANALYZED WITH A PAIRED T-TEST
SYMRISE INNOVATION
The burning and stinging sensations are the results of an
over expression of TRPV1 receptors. SymSitive® 1609 targets
selectively TRPV1 receptors resulting in the modulation of the
skin neurosensory response to irritation and aims at resetting
the balances of the skin.
SymSitive_A5_EXE.indd 8
23/03/15 15:17
ACTIVES
SOOTHING
ANTI-BURNING / ANTI-STINGING
SymSitive® 1609
INCI: Pentylene Glycol, 4-t-Butylcyclohexanol
Product number
399944
Formulation details
1 - 3% oil soluble, soluble in ethyl alcohol (35% vol.) propylene glycol and other glycols,
pH stable between 3 and 12, temperature stable up to 85°C.
Applications
Sensitive Skin Creams
Lotions and Serums
Hair Colors
Perms and Relaxers
BB Creams
Visit SymSelect® to request samples and discover
new ingredients. Scan code or visit www.symselect.com
DISCLAIMER
“Symrise makes no warranties, either express or implied, as to the accuracy or completeness of the information
set forth herein. Symrise expressly disclaims any implied warranty of merchantability and fitness for a particular purpose.
Prospective users are requested to determine for themselves the suitability of Symrise materials and suggestions
for any use prior to their utilization. Any necessary approvals from regulatory authorities for finished products must
be obtained by the prospective user. Suggestions for applications involving our products or the reference to,
or incorporation of, descriptive materials from patents and the citation of specific patents in this document may
not be understood as recommendation for the use of Symrise products in violation of any patent or as a permission
or licence to use any patent of Symrise or a third party.”
© 2015 Symrise. All rights reserved.
www.symrise.com
1
SymSitive_A5_EXE.indd 1
23/03/15 15:17