The Copper Connection
www.wilsonsdisease.org
Wow! The WDA Is 30 Years Old!!!
By Carol Terry, WDA Secretary, Past President and Co-founder
When a small group of people in Binghamton, NY, decided to form
a non-profit patient advocacy organization to help Wilson disease
patients and their families and friends in 1978, what did they hope to
accomplish? Did they envision how successful the Wilson Disease
Association would be after its incorporation in March, 1983, that it
would become international in scope, help so many people, and
continue to grow and thrive for 30 years? As one of the founders of
the WDA, along with the Pei
family and their friend, John
Chung, I can say for certain
that the WDA has wildly
exceeded my expectations.
It has been able to do that
thanks in great part to the
efforts of many volunteers,
past and present officers
and Board Members, in
particular Past President,
Ascher Sellner and current
President, Mary Graper,
WDA Birthplace
and our many members and
Peking Restaruant - Conklin, NV
donors. continued on page 6
Scientific Workshop on Copper Metabolism
Disorders Held in April; Patient Advocate Panel
Highly Effective
Pam Meadows, MSN-Ed., Chair, WDA Professional Education and Medical
Affairs Committee
On April 8th and 9th, at Johns Hopkins University, an International
Workshop was held entitled: “Human Disorders of Copper
Metabolism: Recent Advances and Main Challenges.” This intense
two-day conference, funded by the Wilson Disease Association
and the National Institutes of Health, focused on the advances and
challenges of Copper Metabolism Disorders.
The conference hosted researchers, providers and scientists from
all over the world: United States, Germany, England, Austria, Italy,
Netherlands, France, Australia, Denmark, Canada, China, Korea,
continued on page 3
Summer 2013
New U.S. Patient Assistance
Program for Cuprimine and
Syprine
Mary Graper, WDA President
Valeant Pharmaceuticals launched its
new patient assistance program, Valeant
Coverage Plus Program (VCPP), on July
8, 2013. This program was newly created
to ensure that U.S. patients have better
access to their medication with fewer
out-of-pocket expenses. Recently, users
of Cuprimine and Syprine have been
experiencing unaffordable co-pays when
refilling their prescriptions. The WDA
has been providing financial assistance,
to some of these patients, thanks to a
generous donation given specifically for
this purpose. The new VCPP aims to
solve these issues.
Valeant recently mailed an informational
flyer, Financial Support for Improved
Access to Cuprimine® (penicillamine)
and Syprine® (trientine hydrochloride)
Capsules to all prescribing physicians in
the United States. To ensure that your
physician is aware of the new program
you will need to do your part as well.
Before you need a new refill (we suggest
at least 2 weeks prior) go to www.syprine.
com, www.cuprimine.com, or www.
wilsonsdisease.org/wilson-disease/
wilsondisease-treatment.php to read
more about the program and download
the Patient Enrollment Form. Complete
your portion of the form and contact your
physician’s office to let them know what
needs to be done by them. If you have
any questions, please contact a Coverage
Plus Representative at 888-607-7267
Information available on
the WDA website, www.
wilsonsdisease.org and
Facebook page, https://
www.facebook.com/
wilsondiseaseassociation
The Copper Connection
Summer 2013
Board of Directors
Mary L. Graper, President
Milwaukee, Wisconsin
Stefanie F. Kaplan, Vice President
Long Beach, California
Table of Contents
Carol Terry, Secretary
Luray, Virginia
Wow! The WDA Is 30 Years Old!!!
1
Scientific Workshop on Copper Metabolism Disorders
1
New U.S. Patent Assistance Program for Cuprimine and Syprine 1
Workshop Poster Award Winners
4
2013 Conference At A Glance
6
Scientific Workshop Sponsors
7
Thanks for your support7
Wilson Disease Association Annual Conference Registration Insert
Wilson Disease Association International 2013 Election BallotInsert
Jean P. Perog, Treasurer
Quichena, BC, Canada
Jeanne A. Friedman, LCSW
Kew Gardens, New York
Drew Katz
Cherry Hill, New Jersey
Pamela Meadows R.N., BSN
Denver, Colorado
Len Pytlak, CPA
Ann Arbor, Michigan
Honorary Board
Janene Bowen
Logan, Utah
NEWSLETTER DEADLINE:
If you would like to submit an article to be published in the next printed edition
of The Copper Connection the deadline for submission is October 1, 2013.
Please e-mail your article to the WDA office at [email protected]
Kenneth Peterson M.D.
Scottsdale, Arizona
Patricia Satherstrom R.N
Ottawa, Canada
Michael Terry
Luray, Virginia
Medical Advisory Committee
Michael Schilsky M.D., Chairman
Yale University
New Haven, Connecticut
Fred Askari M.D., PhD.
University of Michigan
Ann Arbor, Michigan
Sihoun Hahn M.D., PhD.
University of Washington
Seattle, Washington
Svetlana Lutsenko, PhD.
Johns Hopkins University
Baltimore, Maryland
Eve A. Roberts M.D.
University of Toronto
Toronto, Canada
Dennis Thiele PhD.
Duke University
Durham, North Carolina
2
The Copper Connection
The Wilson Disease Association is a nonprofit 501 (c)(3) organization.
The Copper Connection is a semi-annual newsletter published by
the Association that informs members of findings in the area of Wilson Disease.
There is no copyright. Newsletters and other publications can disseminate any
information in The Copper Connection. Please cite attribution to the Association and the author.
The Copper Connection
5572 N. Diversey Blvd.
Milwaukee, WI. 53217
414-961-0533 • Toll Free: 866-961-0533 • Fax: 414-962-3886
[email protected]
www.wilsonsdisease.org
Our Mission Statement
The Wilson Disease Association funds research and facilitates and
promotes the identification, education, treatment and support of
patients and other individuals affected by Wilson Disease.
Wilson Disease Association
Summer 2013
The Copper Connection
Scientific Workshop cont.
India, Russia, Spain and Sweden. The collective knowledge of this global group was both impressive and
informative. Each of these professionals had something to contribute to the knowledge and/or advancement of
treatment for copper overload and copper deficiency in humans.
Wilson disease, an inherited copper overload problem in humans, and Menkes disease, an inherited copper
deficiency in humans, are both fatal if left untreated. Obviously, this conference was of great importance to those
whose lives are affected by Wilson disease and Menkes disease. As such, collaboration took place between
The Wilson Disease Association and The Menkes Foundation, and an unusual model was presented in this
scientific conference: A Patient Advocate Panel. This panel
was chosen by the WDA and panel participants posed
questions to the scientists, researchers and clinicians
regarding patient/advocate/research concerns, enlightened
the scientific audience on how the advances in science
had personally affected their lives, and were available
for a questions and answer session from the scientific
audience. This session occurred towards the end of the
conference and the feedback from the scientific audience
was overwhelmingly positive. Many thanks were expressed
by those in attendance at the thoughtful questions and
comments posed by the patient advocate panel; several
of the conference attendees expressed how “seeing their
work in action” was very satisfying and validating to their
life’s work. Many said it was a delight to have the patient
advocate panel putting a “voice” to the outcome of their
research.
In the end, the patient advocate panel also expressed
how empowering it was to have a voice in the scientific
community and to share their own personal experiences
with these professionals. Those on the patient advocate
panel attended the entire scientific conference, soaking up
new information and feeling rejuvenated that so much work
is being done on copper metabolism disorders. Although a
bit unusual for a scientific conference, this patient advocate
panel was a perfect complement to the conference. Many
thanks go out to Mary Graper, President of the WDA, who
created this idea and collaborated with the Menkes Disease
Foundation to present this patient advocate panel.
Editors Note: For the full Workshop White Paper, please
visit www.wilsondisease.org.
Patient advocate perspective;
key themes presented included:
• The need for and value of patient registries
for Menkes and Wilson disease to support
effective research;
• The need for early detection of both Menkes
and Wilson disease through newborn
screening and the associated need to
increase awareness in the pediatric medical
community;
• The need for more effective treatments
for these conditions and for the chronic
disabilities that can result from them;
• The need to facilitate translation of research
outcomes to clinical practice guidelines;
• Identification of approaches to reduce
patient frustration, minimizemisinformation,
and improve communication.
Wilson Disease Association
The Copper Connection
3
The Copper Connection
Summer 2013
Workshop Poster Award Winners
A prominent feature of scientific meetings, such as medical conferences, is a Poster Session featuring paper posters
that represent the research of junior investigators [researchers] in the subject field of interest. The posters illustrate
the individuals’ research methods and outcomes. Prospective poster presenters are asked to submit a short abstract
of their presentation, which is then reviewed by senior
colleagues who are experts in the same field, before the
presentation is accepted for a meeting.
Organizers of the Copper Metabolism Workshop, held
last April, reviewed and accepted 26 poster abstracts
representing novel research in the field of copper
metabolism. The posters, accompanied by their authors,
were displayed throughout the two-day meeting. The
posters represented research being conducted in the
countries of China, Germany, India, Italy, Korea, Russia,
and the United States. Poster entries were judged by
senior scientists and cash awards were presented to the
four best entries.
Here are the four award winning poster abstracts. The
authors kindly agreed to provide a simplified interpretation
of their original abstracts for our readers.
Drs Shilsky and Assis with
Assis’s Poster Presentation
New Tools for Copper(I) Biochemistry: Water Soluble
Fluorescent Probes and Robust Affinity Standards
Christoph J. Fahrni*, M. Thomas Morgan, Pritha Bagchi
School of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA
The distribution and storage of copper in the body is tightly regulated by an intricate network of proteins, which
guarantee not only a sufficient supply of this trace nutrient but also prevent from its potential toxicity. In Wilson’s
disease, dysregulation of a trafficking pathway leads to copper accumulation in the liver and brain. At present, the
redistribution mechanisms of excess copper remains mostly elusive. To address this problem, we developed a series
of water-soluble fluorescent probes that are capable of detecting biological copper with high sensitivity by fluorescence
imaging techniques. Furthermore, we characterized a series of new copper-selective chelators as biochemical tools to
study the mechanism of copper exchange between proteins. Altogether, these biochemical tools will be instrumental to
further our understanding of copper trafficking in normal cells and tissues and its dysregulation in Wilson’s disease.
Hepatocyte-Specific inactivation of MURINE Atp7b revealed AN important role of non-hepatic cells in
liver pathology
Abigael Muchenditsi1, Lisa Aaronov2, S.Lutsenko1
1
-Department of Physiology, Johns Hopkins University, Baltimore, MD 2-InGenious Targeting Laboratory, Ronkonkoma, NY
Wilson disease (WD) is a genetic disorder of copper metabolism, caused by mutations in a copper transporter ATP7B.
Mice that lack a functional Atp7b (Atp7b-/-) in all tissues recapitulate many features of human WD, such as high levels
of copper in the liver and urine, low ceruloplasmin, and pathological changes in liver function and morphology. It is
thought that WD is caused primarily by copper accumulation in hepatocytes, the main cell type of the liver in which
Atp7b is normally present at high level. To test this hypothesis we generated a mouse strain (Atp7b∆Hep), in which
Atp7b was deleted only in hepatocytes. Consistent with the loss of Atp7b function in hepatocytes, the Atp7b∆Hep
4
The Copper Connection
Wilson Disease Association
2013 Annual Conference
WOW! The WDA is 30 Years Old!
The Hotel Palomar – Westwood
10740 Wilshire Blvd. , Los Angeles, CA.
October 12, 2013
The WDA is pleased to present this year’s conference at no cost to members! Yet, we are offering the same quality
program as in the past. We are determined to excel in providing expanded knowledge about WD, an opportunity to
learn from the experts, and a chance to connect with others in the Wilson disease community. Hope to see you there!
This year’s topics will include:
~ Clinical Manifestations of Wilson disease
~ Genetic Counseling
~ Medical Therapies, Current and Future
~ Botox and Other Symptomatic Treatments
~ Diagnostic Challenges
~ Diet and Wilson's
~ Rare Disease Challenges
Full program information will be posted on the WDA website and sent to those for whom we have e-mail addresses.
REGISTRATION FORM
Registration Deadline: Tuesday, September 10, 2013
Attendee Information:
Mr.
Mrs.
Miss
Ms.
Dr.
Full Name
Other
Institution (if applicable)
Address
City
E-Mail
Phone Number
State/Province
Zip/Postal Code
Alternate Phone Number/Cell
Names of Other Attendees:
Registration (includes all sessions and meals)
WDA Member
@ FREE = $0.00
TOTAL
th
I/We will attend the special 30 Anniversary Conference Banquet
NUMBER ATTENDING
Special Dietary Request
Kosher
Vegetarian
Other
IMPORTANT
Please make your hotel reservations prior
to September 10, 2013 to receive group
discounted rates.
Online: www.wilsonsdisease.org
Click on: WDAConferenceRegistration
Call: Hotel reservations 1-619-515-3088
Please complete the form fields and e-mail or mail your completed Registration Form to:
Wilson Disease Association
5572 North Diversey Blvd. Milwaukee, Wisconsin 53217
[email protected] Phone: 414-961-0533
Wilson Disease Association International
2013 Election Ballot
Displayed below is the ballot that will be used for elections at the Annual Conference in Los Angeles. If you will not be attending the
conference and are a current member of the WDA, you may vote by mailing this ballot to the WDA office before the Conference.
I. Nominees for Officer (3 -year term):
President – Mary L. Graper – Mrs. Graper has over 30 years experience as a volunteer leader, and is recognized for
her creativity, organizational and leadership skills. She lives in Milwaukee, WI, where she owns and manages investment
real estate with her husband. Two of her three children are WD patients. She joined the WDA Board of Directors in 2000,
and was first elected President in 2003.
Vice-President – Len Pytlak, CPA – Mr. Pytlak has his own CPA firm in Ann Arbor, MI. He has WD and has served on
the WDA Board as Vice President and Treasurer in the past. He lost a brother to WD and his sister is also a WD patient. He
is currently a Board Member and has been very active in the WDA for many years.
Secretary – Carol A. Terry – Mrs. Terry retired from a 31-year career as an accountant and manager in the Federal
Government in 2002. She lives in Virginia with her husband, Sparky, and does consulting work part-time. She was
diagnosed with WD in 1973 and helped found the WDA in 1982. She has served as President, Vice-President, and Treasurer
in the past, and was first elected Secretary in 2003.
Treasurer - Jean P. Perog – Mrs. Perog is a Chartered Accountant and is retired from employment in the public health
care system and lives in Quilchena, British Columbia, Canada, with her husband, Jim. She has WD and has a brother with
WD. She has served as Treasurer since 2005.
II. Nominee for re-election to Board of Directors (3-year term):
Jeanne A. Friedman – Ms.Friedman is a retired clinical social worker psychotherapist and art therapist. She and her
sister have WD, and they lost their father to WD in 1956. She has served as WDA Treasurer in the past and was recently
appointed as Board Member to replace a member who resigned/
III Nominee to Board of Directors for initial 1-year term:
Patricia Paulin – Ms. Paulin is a Registered Nurse and has worked as the patient contact at the Wilson Disease Clinic at
the WDA Center of Excellence at the University of Michigan for over 11 years. She also made presentations at a past WDA
Annual Conference and the recent Scientific Workshop held at Johns Hopkins University.
Summer 2013
The Copper Connection
mice accumulate copper in the liver. They also show elevated urinary copper excretion and low levels of Cu-loaded
ceruloplasmin in the blood. Unexpectedly, despite all these symptoms Atp7b∆Hep liver show no obvious pathologic
changes in contrast to inflammation and abnormal cell morphology seen in the age-matched Atp7b-/- livers. The
absence of pathology in Atp7b∆Hep mice despite copper accumulation suggest that inter-cell and inter-tissue
communication may play an important role in the liver copper balance and pathology development in WD. The
mechanism of cell-cell communication in Atp7b-/- liver is being investigated.
Copper uptake via the Copper transporter Ctr1
Helena Öhrvik, Yasuhiro Nose, L. Kent Wood, Byung-Eun Kim, Charlotte S. 1Gleber, Martina 2Ralle, and Dennis J. Thiele
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA, 1X-ray Science Division, Advanced Photon
Source, Argonne National Laboratory, Argonne, IL, 60439, USA, 2Department of Biochemistry and Molecular Biology, Oregon Health & Science University Portland,
Oregon 97239, USA
Copper is essential for human growth and development. While many of the components responsible for obtaining,
distributing, and exporting copper in tissues have been identified, the ways that these processes are controlled are
not well understood. We study the uptake of copper from the diet and how it is imported into cells in mouse models.
Our goal is to understand how the whole body, organs, and individual cells achieve proper copper levels. The copper
transporter Ctr1, located at the cell surface, plays a central role in copper uptake and is essential for embryonic
development and survival. The function and expression of Ctr1 can be modified in several ways to control the
copper uptake into the body and cells. In response to high copper levels the amount of Ctr1 importers on the plasma
membrane of cells rapidly decreases. Furthermore, it has been shown that the copper-binding region of Ctr1 can be
removed, generating a shorter form of the transporter that imports copper less efficiently.
While we have a good understanding of the function of Ctr1, the role of the related protein copper transporter 2 (Ctr2)
is not well understood. Previously, Ctr2 has been proposed to function as a copper importer at the plasma membrane
but with lower capacity than Ctr1 or, alternatively, in transporting copper from intracellular stores into the cytoplasm
of cells. We are interested in the physiological role of Ctr2, and how it impacts copper accumulation in cells and in
tissues. Results derived from these studies will provide insights into the biological links between copper regulation and
disease of human copper imbalance, and may yield insights into how copper import into human cells can be controlled.
MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy
Martinelli D, 2Travaglini L, 3Drouin CA, 2Rizza T, 4Ceballos-Picot I, 2Bertini ES, 4de Lonlay P, 5El Hachem M, 4Hubert L, 2Carrozzo R , 6Montpetit A, Torre G, 2Petrini S, 1Dionisi-Vici C.
Division of Metabolism, 2Divison of Molecular Medicine, 5Unit of Dermatology, 7Division of Hepatology, Bambino Gesù Children’s Hospital, IRCCS, Italy; 3Department of
Dermatology, Centre Hospitalier Regional Grand-Portage, Canada; 4Necker Hopital des Enfants-Malades, Paris, France; 6McGill University, Canada.
1
1
MEDNIK syndrome- acronym for mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratodermia
- caused by mutations in AP1S1 gene, has recently been described as a new disorder of copper metabolism.
It combines clinical and biochemical signs of both Menkes (neurocutaneous abnormalities; hypocupremia and
hypoceruloplasminemia in the blood) and Wilson diseases (basal ganglia abnormalities at brain MRI, hepatopathy and
copper accumulation in the liver, increased urinary excretion of copper in 24h). The disorder is due to the detrimental
effect of the absence of AP1S1 protein on physiological intracelluar trafficking of ATP7A and ATP7B, the Menkes
and Wilson proteins, respectively. A MEDNIK syndrome patient, with a new homozygous mutation in AP1S1 gene,
showed severe mental retardation (Development Quotient <45 at cognitive scales), hepatopathy, hypocupremia,
increased serum free copper level and urinary copper excretion, liver copper accumulation, raised total bile acids, and
intrahepatic cholestasis. We started in this patient oral therapy with zinc acetate (a drug approved for the treatment of
Wilson disease), at the dose of 50 mg/day, in order to reduce copper adsorption at intestinal level. After one year of
therapy, the patient showed striking improvement of her general clinical condition, skin problem, and hepathopathy.
She also showed marked improvement of cognitive functions (Development Quotient = 60) at a second psychometric
evaluation. Serum transaminases, ceruloplasmin, serum free copper and urinary copper excretion normalized,
along with striking reduction of plasma total bile acids (10.2 mmol/l) and liver copper overload (0.42 mg/mg). We
demonstrated for the first time that MEDNIK syndrome, a new defect of copper metabolism, is treatable with zinc
acetate.
Wilson Disease Association
The Copper Connection
5
The Copper Connection
Summer 2013
30 Years cont.
We have accomplished an incredible amount in the last 30 years – growth in membership from around 15
founding members to over 1500 current members; development of a very informative website; publication of a
newsletter, a patient guide, and other educational brochures; a Medical Advisory Committee composed of six
internationally recognized WD experts; establishment of six WDA Centers of Excellence for diagnosis and treatment
of WD patients; awarding of research grants and prizes for winners of a contest for medical students who wrote
a paper on a topic related to Wilson disease; participation in a program to help provide needed medicine to WD
patients in developing countries; holding patient support group meetings and Annual Conferences at different
locations in North America to educate and inform
attendees and provide an opportunity for peer support;
and, establishment of an internet peer support platform
through the Inspire website.
I believe our most impressive accomplishment to date
is the sponsorship and organization of two international
scientific workshops which brought together clinicians and
researchers from all over the world to exchange ideas and
information related to WD and other disorders of copper
metabolism. The first of these was held in 2006, but a
larger one sponsored primarily by the WDA, with help from
NIH and Johns Hopkins University was just held this past
April. This newsletter provides summaries of many of the
presentations made at that workshop. WDA President,
Mary Graper, and the other members of the organizing
committees worked tirelessly to make both these
workshops successful. Thank you, Mary!
Original WDA meeting room in the
Pei family restaurant
2013 Annual Conference
WOW! The WDA is 30 Years Old!
Los Angeles, CA. October 11 – 13, 2013
Conference At A Glance
Venue
Hotel Palomar - Westwood
10740 Wilshire Boulevard
Los Angeles, CA. 90024
www.hotelpalomar-lawestwood.com
Discounted Room Rates:
Deluxe King Rooms $150/night + tax
Double Occupancy $150/night + tax
Triple Occupancy $170/night + tax
Quadruple Occupancy $190/night + tax
Discounted Parking Rate:
$30/night
CUTOFF DATE FOR DISCOUNTED ROOMS
September 10, 2013
Group Code: Wilson disease #1300801613
Call: 1-619-515-3088
Online: http://bit.ly/17vUDKN
Friday, October 11, 2013
5:00 – 6:00 p.m. Complimentary wine hour provided by the hotel. A
perfect way to start off the conference weekend and your first evening in
Los Angeles!
Saturday, October 12, 2013
8:00 - 8:30 a.m.
Registration and Continental Breakfast
8:30 – 9:00 a.m.
Welcome and Opening Remarks
9:00 a.m. – Noon General Sessions
Noon – 1:30 p.m. Lunch & WDA Annual Membership Meeting
1:30 – 3:00 p.m.
General Sessions
3:00 – 5:00 p.m.
Breakout Sessions
6:30 – 9:30 p.m.
30th Anniversary Conference Banquet
Sunday, October 13, 2013
9:00 a.m. – 5:00pm WDA Board Meeting
Final program information will be posted on the WDA website
www.wilsonsdisease.org
6
The Copper Connection
Wilson Disease Association
The Copper Connection
Summer 2013
Special thank you to the sponsors of the Scientific Workshop:
National Institute Of General Medical Sciences (NIGMS)
National Center For Advancing Translational Sciences (NCATS)
National Institute Of Neurological Disorders And Stroke (NINDS)
Thanks for your support
CONTRIBUTIONS:
We apologize that these donations are not broken down into specific categories this time. We are currently
in the process of merging information from our old database program to a new one.
Abid Mohammad
Accu-Tool, LLC
Amanda Elrod
Amitabh Upadhyaya
Anil and Mamta Mehra
Arlene Gottlieb
Arthur and Ellen Johnson
AT&T
Becky Scribner
Bill and Mildred Shannon
Boeing Employees
Community Fund
Breeanna Cooley
Brendan Cunningham
Bruce Sutherland
Bruno Garlepp
Carol McCullough
Cathleen Bergmann
Chua Hooi
Constantin and Nichole
Langa
David and Delia Ruiz
Dennis P. and Thea A.
Henderson
Dennis Sobieraski
Diane and Diane Laurain
Dorothy A Gorbacz
Drew Katz
Edna Cross
Edward Cavallari
Emese Greksa
Gina Hernandez
Gustavo Gitlin
Harvey Checkman
Heidi Sullivan
Hugh Rienhoff, Jr.
IGive.com Holdings
James Fine
Jeff Nehal
Jeffrey Fink
Jeffrey Nehal
John Wu
Joseph and Berna Heyman
Joyce Hoggard
Judith Kesler
Judy and Connor Brown
Karen Anderson
Karen Mally
Katherine Basch
Kathleen Zaruba
Kerry Cooley
Leonard Levin
Lewis Katz
Linda Schwebke
Lori Shindel
Loyd and Mary Tysinger
Lynda Levine
Maggie Naden
Maria Lewin
Mary Klouse
Matthew Ferber
Meilan Chen
Melissa Miller
Millie Quinn
Miriam Rabin
Nancy Marsala
Patricia Pei
Paul Fausneaucht
Paul Zandhuis
Peter E Protzel
Peter E. and Gracia V.
Sheptak
Phil Portney
Robert Haughney
Robert Smith
Ron and Cindy Olch
Ronald Marchese
Rosa Chavez
Roxanne Driedger
Samantha Taylor-Flynn
Sheilvrina Berthold
Sonia Pone
Steve and Steve Earley
Susan Grosman
Sylvia Trujillo
Vinny Desrochers
Vivienne Taylor
Vivienne Tayor
Walter Wall
Wayne Register
Wilder Family
William and Teresa Siegart
Zoukhra Bash
For your convenience, you can make your donations online by visiting our website.
Just visit www.wilsonsdisease.org you will see the Donate button on the front page. This will direct you
to a secure PayPal link where you can safely enter your information. We encourage you to donate
online as it will save you time and postage! If you prefer to mail a check, or do not have online
access, please send your tax-deductible donation to the WDA office at:
Wilson Disease Association
5572 N. Diversey Blvd.
Milwaukee, WI. 53217
Wilson Disease Association
The Copper Connection
7
Summer 2013
WILSON DISEASE ASSOCIATION, INTERNATIONAL
The Copper Connection
5572 N. Diversey Blvd.
Milwaukee, WI. 53217
(FORWARDING SERVICE REQUESTED)
TO:
2012 SUPPORT MEETINGS
SPECIAL INSERT!!!
Wilson Disease Association International
2013 Election Ballot
&
Annual Conference Registration Form
Registration deadline: Tuesday, September 10, 2013