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PARENT OF ORIGIN, PHENOTYPIC
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DIFFERENCES IN BIPOLAR DISORDER
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Med Genet – Neuropsychiatric Genetics, 1998)
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confirmation
Parent of origin – use in molecular genetics
Human Molecular Genetics, 1998
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First segregation analysis evidence of different inheritance
patterns by proband age of onset (Am J Med Genet –
Neuropsychiatric Genetics, 2001)
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Archives of General Psychiatry, 2009
Age of onset, family history and gender
differences (Am J Med Med Genet – Neuropsychiatric
Genetics, 2005)
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differences
Strong influence of FH-type on AO There was a
significant variation in AO according to the type of FH in
females but not in males . BP female patients with a
negative FH for major psychoses had a later AO than
females with either a FH of bipolar and/or schizoaffective
disorder or a FH of recurrent Mdd-UP only .
Similar to schizophrenia, females with negative FH had
a later AO than males with negative FH.
In the group with FH of bipolar and/or schizoaffective
disorder, females had an earlier AO than males.
Impact of age of onset and family history on
treatment and course of BP
CANDIDATE GENES
Genotype – phenotype correlations
Genotype – phenotype correlations
Persecutory delusions and G72/G30 gene in BP
Genotype – phenotype correlations
Persecutory delusions, mood episodes and G72/G30 gene
in BP
Genotype – phenotype correlations
Persecutory delusions, mood episodes, G72/G30 gene in
Romanian BPI patients
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Affective
Disorders,
1991, Elsevier,
Holland