Drug Information Center/KAUH
DRUGS CONTRAINDICATED IN PREGNANCY
Disclaimer: This chart represents information on select drugs that are
contraindicated (Pregnancy category X) for women who are pregnant. This is not an
inclusive list of products that carry that pregnancy category. Those drugs that are
contraindicated at a certain phase of the pregnancy are listed next to the product
name. For more information on specific drug monographs, see product entries or
consult the manufacturer.
Prepared by: Pharm.D ,Neda' Rawashdeh
Date: 5/12/2013
ALLERGIC
DISORDERS
(hydroxyzine) Early
pregnancy
CARDIOVASCULAR
SYSTEM
(niacin /lovastatin)
(dipyridamole/aspirin)
3rd
trimester
(lovastatin)
(aspirin) 3rd trimester
(amlodipine/atorvastatin)
(warfarin sodium)
(rosuvastatin)
(sitagliptin/simvastatin)
(fluvastatin)
(ambrisentan)
(pitavastatin)
(dronedarone)
(pravastatin)
(niacin extrel/simvastatin)
(bosentan)
(ezetimibe/simvastatin)
(simvastatin)
CENTRAL NERVOUS
SYSTEM
(drospirenone/ethinyl
estradiol)
(quazepam)
(triazolam)
(hydroxyzine) Early
pregnancy
(drospirenone/ethinyl
estradiol)
ENDOCRINE SYSTEM
NEOPLASMS
(testosterone)
(tositumomab)
(methyltestosterone)
(bicalutamide)
(tesamorelin)
(sitagliptin/simvastatin)
(estradiol valerate)
(fluorouracil)
(leuprolide acetate)
(oxandrolone)
(histrelin acetate)
(nafarelin)
GASTROINTESTINAL
TRACT
(phenobarbital/ergotamine
tartrate)
(misoprostol)
INFECTIONS &
INFESTATIONS
(sulfamethoxazole/
trimethoprim) 3rd trimester
(ribavirin)
(Metronidazole) 1st trimester
for trichomoniasis.
(nitrofurantoin) Pregnancy at
term
(sulfisoxazole) 3rd trimester
(griseofulvin)
(leuprolide acetate)
(raloxifene HCl)
(degarelix)
(esterified estrogens)
(lenalidomide)
(nitrofurantoin as
macrocrystals and
monohydrate)
Pregnancy at term
(ribavirin/interferon alfa -2b)
(bexarotene)
(thalidomide)
(triptorelan pamoate)
(methotrexate)
(histrelin acetate)
(abiraterone acetate)
NUTRITION
(benzphetamine)
(genistein/citrated zinc/
cholecalciferol)
(megestrol acetate)
(orlistat)
Sulfadiazine Pregnancy at
term
(tinidazole) 1st trimester
(oxytetracycline HCl/
sulfamethizole/phenazopyridi
ne) Late pregnancy
PAIN MANAGEMENT
METABOLIC DISORDERS
(aspirin) 3rd trimester
(miglustat)
(aspirin/caffeine/
salicylamide) 3rd
(ibuprofen) 3rd trimester
(naproxen sodium) 3rd
trimester
DERMATOLOGICAL
DISORDERS
(isotretinoin)
MUSCULOSKELETAL
DISORDERS
(ibuprofen) 3rd trimester
(tazarotene)
(naproxen sodium) 3rd
trimester
(flurbiprofen) Late pregnancy
(drospirenone/ethinyl
estradiol)
(fluorouracil)
(leflunomide)
(norethindrone acetate/
ethinyl estradiol)
(norgestimate/
ethinyl estradiol)
(finasteride)
(diclofenac sodium/
misoprostol)
(aspirin) 3rd trimester
(silver sulfadiazine) Late
pregnancy
(diclofenac potassium) Late
pregnancy
(mequinol/tretinoin)
(celecoxib) 3rd trimester
(acitretin)
Choline magnesium
trisalicylate
Pregnancy at term
(dantrolene)
OB/GYN
(aspirin/caffeine/
salicylamide) 3rd trimester
ALL ORAL
CONTRACEPTIVES
ALL HORMONE
REPLACEMENT
THERAPY
(norethindrone acetate)
(oxaprozin) 3rd trimester
(povidone-iodine)
(urofollitropin)
(ibuprofen/famotidine) Late
pregnancy (≥30wks)
Etodolac Late pregnancy
(celecoxib) 3rd trimester
(raloxifene HCl)
(cetrorelix)
(piroxicam) Late pregnancy
Diclofenac sodium Late
pregnancy
Diflunisal 3rd trimester
trimester
(ergotamine tartrate/
caffeine)
(diclofenac potassium)
Late
pregnancy
(celecoxib) 3rd trimester
Choline magnesium
trisalicylate
Pregnancy at term
(dihydroergotamine
mesylate)
Diflunisal 3rd trimester
Etodolac Late pregnancy
(acetaminophen/
aspirin/ caffeine) 3rd
trimester
(butalbital/aspirin/caffei
ne)
3rd trimester
(butalbital/aspirin/
caffeine/codeine
phosphate) 3rd
trimester
(hydrocodone bitartrate/
ibuprofen) 3rd trimester
Ketorolac Late
pregnancy
(dihydroergotamine
mesylate)
(fenoprofen calcium) 3rd
trimester
(oxycodone HCl/aspirin)
3rd
trimester
(mefenamic acid) Late
pregnancy
(dihydrocodeine
bitartrate/aspirin/caffeine
) 3rd trimester
UROGENITAL
SYSTEM
(dutasteride HCl)
AVOID
(clomiphene citrate)
(medroxyprogesterone
acetate)
(micronized
progesterone)
Ectopic pregnancy
(follitropin beta)
Ibuprofen 3rd trimester
Ketoprofen Late pregnancy
Ganirelix acetate
(fenoprofen calcium) 3rd
trimester
(lansoprazole/
naproxen) 3rd trimester
Probenecid + Colchicine
(denosumab)
(methotrexate sodium)
Salsalate 3rd trimester
(carisoprodol/aspirin/codeine)
3rd trimester
(follitropin alfa)
(leuprolide acetate)
(lutropin alfa)
(menoptropins)
(methylergonovine)
(acetaminophen/
caffeine/pyrilamine) 3rd
trimester
(acetaminophen/pamabro
m) 3rd trimester)
(mifepristone)
(choriogonadotropin alfa)
(mefenamic acid) Late
pregnancy
(follicle-stimulating
hormone/luteinizing
hormone)
(clomiphene citrate)
(tinidazole) 1st trimester
(goserelin)
(meloxicam) 3rd trimester
Nabumetone 3rd trimester
HANDLING
CAPSULES
(alprostadil)
(dutasteride/tamsulosin
HCl)
(acetohydroxamic acid)
(finasteride) AVOID
HANDLING
CRUSHED/BROKEN
TABLETS
(naproxen/esomeprazole) Late
pregnancy (≥30wks)
References:
1-lexi.com
2-Drugs Contraindicated in Pregnancy, April 05, 2013. http://www.empr.com/drugscontraindicated-in-pregnancy/article/125914/