Drug Mixing Chart rt‐PA (Activase, Alteplase) 0.25 mg/hour 0.5 mg/hour 1.0 mg/hour 1.5 mg/hour 2.0 mg/hour rPA (Retavase, Reteplase) 0.25 units/hour 0.5 units/hour 0.75 units/hour 1.0 units/hour TNK (Tenectaplase) 0.25 mg/hour 0.5 mg/hour 0.75 mg/hour 1.0 mg/hour Rate of Infusion 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 Hour Supply Reconstituted
Volume of
Normal Saline* Drug needed *
100 mL bag 2.5 mg 100 mL bag 5.0 mg 100 mL bag 10.0 mg 100 mL bag 15.0 mg 100 mL bag 20.0 mg 100 mL bag 2.5 units 100 mL bag 5.0 units 100 mL bag 7.5 units 100 mL bag 10.0 units 100 mL bag 2.5 mg 100 mL bag 5.0 mg 100 mL bag 7.5 mg 100 mL bag 10.0 mg Total Hours
of therapy
10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours 10 hours Rate of
Infusion 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 10 mL/hour 25 Hour Supply Volume of
Reconstituted
Normal Saline* Drug needed *
250 mL bag 6.25 mg 250 mL bag 12.5 mg 250 mL bag 25.0 mg 250 mL bag 37.5 mg 250 mL bag 50.0 mg 250 mL bag 6.25 units 250 mL bag 12.5 units 250 mL bag 18.75 units 250 mL bag 25.0 units 250 mL bag 6.25 mg 250 mL bag 12.5 mg 250 mL bag 18.75 mg 250 mL bag 25.0 mg * Follow the manufacturer's directions to reconstitute the drug (in sterile water). Prior to adding drug to the normal saline bag, withdraw and discard a volume of saline equal to the volume of the reconstituted drug so that the final combined volume of drug and saline equals 100ml or 250ml, as appropriate. Total hours
of therapy 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours 25 hours This document is intended to demonstrate the calculation of a given dose of drug over a given infusion rate. EKOS makes no recommendations in connection with any dosing regimen and the ultimate responsibility for any such recommendation rests solely with the clinical practice. GXUS‐EKO‐2015‐0150