60 DEGREES: Is It the Gold Standard? R. Eugene Zierler, M.D. The D. E. Strandness, Jr. Vascular Laboratory University of Washington Medical Center Division of Vascular Surgery University of Washington, School of Medicine DISCLOSURE INFORMATION R. Eugene Zierler, M.D. No relevant financial or commercial relationships to declare WHY DOES DOPPLER ANGLE MATTER? Key Points Measurement of blood flow velocities using Doppler ultrasound is the primary method for classifying the severity of arterial stenosis This approach is based on the Doppler equation and some assumptions about the nature of blood flow Interpretation of velocities requires an appreciation of the possible errors in Doppler velocity measurements Accuracy and Minimizing Variability are both important DOPPLER VELOCITY MEASUREMENT What Does Doppler Really measure? Measures the Doppler frequency shift (not velocity) Calculates a velocity based on the Doppler equation Measured V= Calculated ∆f C 2 f cos θ What is this and why do we need it? DOPPLER VELOCITY MEASUREMENT What Do We Mean by “Doppler angle”? The Doppler angle “θ” is the angle between the ultrasound beam and the direction of blood flow The convention is to use the angle between the line of the ultrasound beam and the long axis of the vessel (vessel wall) This assumes that flow is axial or parallel to the vessel wall DOPPLER VELOCITY MEASUREMENT Why Is the Doppler Angle So important? Calculated Measured For axial flow, V1 is the true velocity vector Doppler measures V (projection of V1 on the beam) Calculates V1 using cos θ For non-axial flow (V1,V3,V4), use of the Doppler equation and cos θ results in velocity measurement errors – because: The true velocity vector is not known (and may not be axial)! DOPPLER VELOCITY MEASUREMENT What Happens When the Angle Changes? The cos varies from 0 to 1: cos 0° = 1 and cos 90° = 0 Same arterial site 3 different angles ∆f = θ = 35° θ = 55° θ = 85° 2 f V cos θ C Doppler shift decreases as the angle increases DOPPLER VELOCITY MEASUREMENT What Happens When the Angle Changes? V= 64 cm/s 107 cm/s θ = 40° θ = 50° ∆f C 2 f cos θ 116 cm/s θ = 60° 144 cm/s θ = 70° Same arterial site 4 different angles Calculated velocity increases as the angle increases DOPPLER VELOCITY MEASUREMENT So What is the “Best” Doppler Angle? Large and small angles are both “bad” Since the true direction of flow is not exactly known, the Doppler angle can only be estimated Large Angles (approaching 90°): Errors and variability in Doppler velocity measurements increase Small Angles (less than 30°): Refraction, reflection, and the “aperture effect” can produce errors in Doppler velocity measurements DOPPLER VELOCITY MEASUREMENT Why Large Angles Are Bad As the estimated Doppler angle approaches 90° Frequency shift becomes very small and system sensitivity is reduced Cosine changes more rapidly, resulting in larger errors in calculated velocity Doppler shift decreases with increasing angle in Calculated velocity error vs. angle error for various Doppler angles Courtesy of F. Kremkau DOPPLER VELOCITY MEASUREMENT Why Small Angles Are Bad Incident Ultrasound Beam Both of these effects increase at angles approaching 0° Refraction and Reflection Reflected Ultrasound Refracted Ultrasound Courtesy of F. Kremkau DOPPLER VELOCITY MEASUREMENT Why Small Angles Are Bad The Aperture Effect θ edge is smaller than θ mid Wide aperture beam forming results in angle errors at smaller angles Focused beam crosses the vessel at a range of angles Smallest angle (θ edge) should be used to calculate velocity Scanners use θ mid to calculate velocity Leads to overestimation of peak velocity Courtesy of F. Kremkau DOPPLER VELOCITY MEASUREMENT The “60 Degree Angle” The original duplex scanner had no velocity scale Spectral waveforms showed Doppler shift in KHz A protractor was used to measure the Doppler angle Velocities obtained using a programmable HP calculator and the Doppler equation ∆f C V= 2 f cos θ 60 degrees was a “convenient” angle for carotid duplex Cosine of 60 degrees = 0.5 DOPPLER VELOCITY MEASUREMENT How Can we Improve Accuracy and Minimize Variability? Both large angles (≈90°) and small angles (<30°) can result in errors Optimal angle is in the range of 30° to 60° The true velocity vector (direction of flow) is not known, but the arterial wall is always visualized The color-flow “jet” does not help (2D vs. 3D) Using a consistent and easily obtained angle is best DOPPLER VELOCITY MEASUREMENT Is 60 Degrees the “Gold Standard” Original selection of 60° was mostly for convenience First (and subsequent) carotid velocity criteria were based on a 60° angle Other velocity criteria (peripheral arterial, renal) have also been validated using a 60° angle The 60° angle has become the standard through long-term and widespread use The “60° or less” rule still applies 60° and parallel to the vessel wall is a good “compromise” between theory and practicality
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