Principal Investigator/Program Director (Last, First, Middle): Friedman, Jed
BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Jacob E. (Jed) Friedman
JACOB_FRIEDMAN
PROFESSOR, Pediatrics, Biochemistry &
Genetics
Molecular
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
YEAR(s)
FIELD OF STUDY
Springfield College, Springfield, MA
Kent State University, Kent, OH
East Carolina University SOM, Greenville, NC
Case Western Reserve University SOM, Cleveland, OH
B.S.
Ph.D
Post-Doc
Post-Doc
1980
1989
1991
1993
Biology
Applied Physiology
Endocrinology/Metabolism
Molecular Biology
A. Personal Statement
My expertise lies in molecular nutrition and disorders of metabolism in animals, humans, and their cells. The focus of
my research program is on understanding the role of early nutrition and the environment on molecular, endocrine, and
epigenetic origins of childhood obesity and diabetes. I have 20 years of experience investigating the pathophysiology of
obesity and its co-morbidities focused primarily (but not exclusively) on metabolic disorders of pregnancy and the
fetus. This involved developing novel animal models (mouse, Non-Human Primate, sheep) together with invasive
clinical investigation utilizing skeletal muscle, adipose tissue, and more recently placenta obtained from obese women
with Gestational Diabetes. I am PI, Co-PI, or Co-I on several basic, clinical, as well as large-scale epidemiological studies
of childhood obesity and maternal-fetal outcomes. In 2012 I became the founding Director of the Colorado Program in
Nutrition and Healthy Development. I have nurtured a strong cadre of highly collaborative investigators focused on the
role of nutrition and pregnancy outcomes, fetal-neonatal nutrition and growth, and the role of maternal nutrients and
inflammation aimed at reducing the incidence of early onset childhood obesity and diabetes. My lab was the first to
report the role of maternal obesity on fetal pre-natal fatty liver in Non-Human Primates (JCI, 2009), followed by an
MRI/MRS study in humans demonstrating steatosis in 2 wk old neonates from obese GDM mothers (Pediatrics, 2013).
More recently, with funding from the Bill and Melinda Gates Foundation, we have begun investigating the microbiome
and DNA methylation in obese pregnant women and their infants with a variety of metabolic complications of
pregnancy. I also direct the our NIH Nutrition Obesity Research Center (NORC) Metabolic Core Lab, as well as our NIHsupported Training program in Perinatal Biology and Medicine, and our NIH-Pediatric Nutrition Training grant. Over the
past 15 years I have mentored >25 MD fellows and Post-docs (8 K-awards, 5-F32s, 4 RO1s), the majority of whom are
Assistant Professor or above in academic institutions, including 9 currently on the faculty here in Colorado.
B. Positions and Honors
Positions and Employment
1993-1999 Assistant to Associate Professor of Nutrition with Tenure, Case Western Reserve University School of
Medicine, Cleveland, Ohio.
2000-2005 Associate to Professor, Department of Pediatrics (Primary), Biochemistry & Molecular Genetics,
and Reproductive Sciences (Secondary), University of Colorado SOM, Aurora, Colorado.
2000-present Director, Metabolism Core Laboratory for UC-Denver NIH Nutrition & Obesity Research Center;
2010-present Program Director, Colorado Obesity Research Initiative (CORI).
2012-present Director, Colorado Program in Nutrition and Healthy Development- Colorado Children’s Hospital
Research Institute.
Other Experience and Professional Memberships (21 Ad-Hoc Study sections, 2 as chair since 2006)
2006-2008 NIH-NIDDK Panelist, Integrated Physiology of Obesity and Diabetes (IPOD) study section.
2006-2008 NIH-NIDDK Panelist, Cellular Aspects of Diabetes & Obesity (CADO) study section.
2005-2009 NIH-NIDDK Panelist and Ad-hoc chair, SBIR/STIR study section, Diabetes, Obesity & Nutrition
2008
NIH-NIAMS Panelist, Building Interdisciplinary Research Team (BIRT) awards study section.
2009
NIH Panelist, Special Emphasis Review Panel, Supplemental Research Challenge Grants.
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle): Friedman, Jed
2008-2010
2009-2010
2009-2010
2008-2010
2010
2010
2011
2011
2011
2011-2012
2012
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2012
2012
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2013
2006-2012
1995-2007
2005-pres
2009-2010
2011-2012
2010-2012
NIH-Panelist, ZRG1 EMNR-A (02), Studies in Reproductive Endocrinology.
NIH-NIA Panelist, Program Project Review Panel: Adiposity, Aging, and Stem Cells.
NIH Special Emphasis Review Panel, ZRG1-EMNR-A, Diabetes and Obesity Reviews.
NIH-NIDDK Panelist, ZDK1 IR, Diabetes, Endocrinology, and Metabolic Disease Fellowships
NIH-Panelist, Pregnancy, Neonatology, and Nutrition Grants Special Emphasis Review.
NIH-NCRR- Member External Site Visit Panel, Yerkes National Primate Research Center, Atlanta,
NIH-Panelist (Chair), Metabolic Regulation and Obesity, EMNR-N (02) special emphasis review.
NIH-NCRR- Panelist, COBRE (Centers of Biomedical Research Excellence) review.
NIH-NIDDK Panelist, Kidney, Nutrition, Obesity and Diabetes (KNOD) study section.
ADA-Mentor-Based Postdoctoral Fellowship (MN) Review Committee.
NIH-Special Panelist, Genetic Variation and Evolution Study Section (GVE).
NIH-Chairman-Special Emphasis Panel on Diabetes and Obesity ZRG1-EMNR-P (02)M).
NIH-Special Panelist, R24 Team Science applications in Diabetes and Obesity review.
NIH-Special Panelist, Cellular, Molecular and Integrative Reproduction Study Section (CMIR).
NIH-Special Panelist, Cardiovascular and Sleep Epidemiology Study Section (CASE).
NIH- NIEHS - Centers for Children's Environmental Health and Disease Prevention Research (RFA-ES-12-001).
NIH-NIEHS review panel, Transgenerational Effects of Environmental Exposures, ES12-006.
Editorial Board, The Journal of Biological Chemistry
Editorial Board, American Journal of Physiology: Endocrinology & Metabolism
Editorial Board, Archives of Physiology and Biochemistry
Organizer and Co-Chair, 5th Aspen International Conference on Perinatal Biology.
Organizer and Co-Chair, Diabetes and Pregnancy Study Group West, Denver CO.
Past President, American Diabetes Association Council on Pregnancy and Reproductive Health.
Honors: 1990-1993 NIH Individual National Research Service Award, DK-F32-08477; 1993-1995 Juvenile Diabetes
Foundation Career Development Award; 1996-1998 NATO International Scientific Exchange Collaborative Research
Grant; 1996 NIH FIRST Award R29-DK50272; 1996 NIH-NICHD-Young Investigator Travel Grant -Society for
Perinatology; 1997 NIH-NIDDK, New Investigator Travel grant-Advancing the Genetics of Obesity Workshop; 1997
Okamoto New Investigator Award-International Society for SHR and Cardiovascular Genetics; 1999 Arthur C. Guyton
Award for Excellence in Integrative Physiology, American Physiological Society; 2004 Recipient, Outstanding Scientific
Award, 3rd International Congress on Developmental Origins of Health & Disease, Toronto, ON; 2008 Recipient,
Joseph Hoet Prize, European Society for the Study of Diabetes & Pregnancy; 2010 Chair and Keynote speaker,
International Perinatal Conference, Kyoto Japan; 2011 Bill and Melinda Gates Grand Challenge Initiative in Global
Health Award; 2012 Elected Board of Directors, Kern Lipid Conference.
C. Publications Relevant to the Current Application: (from >120 peer-reviewed papers):
1. Fox K, Colton LA, Erickson PF, Friedman JE, Cha HC, Keller P, MacDougald OA, and Klemm DJ (2008). Regulation of
cyclin D1 and Wnt10b gene expression by CREB during early adipogenesis involves differential promoter
methylation. Journal of Biological Chemistry, 283(50):35096-105, PMID: 18957421.
2. Thorn S, Regnault T, Roper M, Keng J, Rozance P, Brown L., Hay WW, and Friedman JE (2009).
Intrauterine growth restriction increases hepatic gluconeogenic capacity, reduces mRNA translation
initiation and impairs nutrient sensing in fetal liver and skeletal muscle. Endocrinology, 150(7):3021-30,
PMID:19342452.
3. McCurdy CE, Bishop J, Williams SM, Smith MS, Friedman JE+, and Grove KL+ (2009). Maternal high fat diet triggers
lipotoxicity in the fetal liver of the nonhuman primate. Journal of Clinical Investigation. 119(2):323-35. +Co-Senior
Authors. PMID:19147984.
4. Majka S, Fox K, Psilas J, Helm K, Childs C, Acosta A, Janssen R, Friedman JE, Woessner B, Shade T, Varella-Garcia M,
and Klemm D. (2010). De Novo generation of white adipocytes from the myeloid
lineage via mesenchymal intermediates is age, adipose depot and gender specific. Proceedings of the
National Academy of Sciences. PMID: 20679227.
5. Choudhury M, Qadri I, Rahman SM, Schoder-Glockner J, Janssen R, and Friedman JE (2010). C/EBP
is AMP kinase sensitive and regulates PEPCK gene expression in response to ER stress in hepatoma
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Principal Investigator/Program Director (Last, First, Middle): Friedman, Jed
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cells. Molecular and Cellular Endocrinology 331(1):102-8, PMID: 20797423.
Heerwagen MJ, Miller MR, Barbour LA, Friedman JE (2010). Maternal obesity and fetal metabolic
programming: a fertile epigenetic soil. American Journal of Physiology 299(3):R711-22.PMID: 20631295.
Kendrick A, Choudhury M, Rahman M, McCurdy C, Watson P, Sack M, Kahn CR, Friedman JE*,
and Jonsher K (2010). Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein
hyper-acetylation, Biochemical Journal PMID: 21044047 *Corresponding Author.
Barbour LA, McCurdy CE, Hernandez TC, and Friedman JE (2011). Chronically Increased S6K1
is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose
tolerance postpartum. Journal of Clinical Endocrinology & Metabolism PMID: 2128924.
Grant WF, Gillingham MB, Batra A, Fewkes NM, Comstock SM, Takahashi D, Laserev M, Grove KL,
Friedman JE, and Marks DL (2011). Maternal high fat diet is associated with decreased plasma n–3 fatty
acids and fetal hepatic apoptosis in Nonhuman Primates. Plos One. 6(2):e17261.PMID:21364873.
Choudhury M, and Friedman JE (2011). Childhood Obesity: Methylate now, pay later? Nature Reviews
Endocrinology, 21;7(8):439-40, PMID: 21691305.
Jonsher K, Jin L, Cambier J, Rahman M, and Friedman JE (2011). Targeted proteomics using immunoaffinity
purification, in Mass Spectrometry in Life Science Research:Applied Mass Spectroscopy Handbook,
McCurdy CE, Schenk S, Holliday MJ, Philip A, Houck J, Patsouris D, MacClean P, Olefsky J, Majka SM,
Klemm DJ, and Friedman JE (2012). Attenuated PIK3r1 expression prevents insulin resistance and adipose
tissue macrophage accumulation in diet-Induced obese mice. Diabetes 61(10):2495-505, PMID: 22698915.
Rahman M, Janssen RC, Choudhury M, Aiken, R. Baquero K, , De LaHoussaye B, Klemm D, and Friedman
JE (2012). CCAAT/Enhancer Binding Protein-β (C/EBP) regulates dietary-induced inflammation in
macrophages and adipose tissue in mice Journal of Biological Chemistry,287(41):34349-60.PMID:
22902781.
Suter MA, Chen A, Burdine MS, Harris RA, Lane R, Grove KL, Tackett A, Choudhury M, Friedman JE,
Aagaard KM (2012). A maternal high fat diet modulates fetal SIRT1 histone and protein deacetylase
activity in a non-human model. FASEB J, (12):5106-14. PMID: 22982377
Qadri I, Choudhury M, Knotts T, Iwahashi M, Puljak L, Simon FR, Kilic G, Fitz JG, and Friedman JE (2012).
Increased PEPCK gene expression and steatosis during Hepatitis C virus (HCV) subgenomic replication:
role of NS5A and C/EBP Journal of Biological Chemistry 287(44):37340-51, 2012 PMID: 22955269.
DuBois BN, O’Tierney P, Friedman JE, Thornburg K, and Cherala C (2012). Maternal pre-gravid body mass
index alters feto-placental Cytochrome P4501A1 activity. Placenta, 33(12):1045-51. PMID: 23046808.
Grant W, Nico L, Grove K, Thorn SR, Friedman JE, and Marks D (2012). Perinatal exposure to a high fat
diet is associated with reduced hepatic sympathetic innervation in 1 year old male Japanese Macaques.
Plos One 7(10):48119-27. PMID: 23118937.
Thorn SR, Brown LP, Rozance PJ, Hay WW, and Friedman JE (2013). Increased hepatic glucose production
in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes, 62(1):65-73, PMID:
22933111.
Rahman SM, Choudhury M, Janssen RC, Bacquero KC, Miyazaki M, and Friedman JE (2013). CCAAT/
Enhancer Binding Protein-β deletion increases mitochondrial function and protects mice from LXR induced
hepatic steatosis. Biochemical Biophysics Research Communication, 430(1):336-9. PMID: 23159614.
Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M,
Hoffman C, Pan Z, Friedman JE+, Barbour LA+ (2013). Intrahepatic fat is increased in the neonatal
offspring of obese women with gestational diabetes. Journal of Pediatics, PMID: 23260099 +Co-senior
authors.
Heerwagen M, Stewart M, De La Houssaye B, Aikens R, Janssen R, and Friedman JE (2013). Endogenous
increase in n-3/n-6 PUFA ratio reduces maternal inflammation and limits fetal metabolic programming in
mice.Plos One, (In Press).
D. Ongoing Research Support
American Diabetes Association/Glaxo Smith Kline Targeted Research Award 1-13-GSK-13 (Friedman, PI) “Role of
Maternal Obesity and Type 2 Diabetes on the Development of the Infant Microbiome and Adiposity” 2/2013-1/2016.
This grant focuses on comprehensively characterize development of the infant microbiome from birth to 1 yr of life in
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Principal Investigator/Program Director (Last, First, Middle): Friedman, Jed
T2D, OB, and normal weight (NW) glucose tolerant mother/infant dyads, in correlation with infant body composition
and weight gain. In parallel, we will deeply phenotype mother/infant dyads, by longitudinally measuring several factors
of potential importance to this process, including maternal microbiome, maternal metabolism, dietary influences, mode
of delivery, and the composition of breast milk.
Bill and Melinda Gates Foundation (Hambidge, Krebs Co-PI, Friedman, Co-I) “Preconception Maternal Nutrition”
1/2013-8/2018. These studies focus on the effects of delivery of a pre-conception vs. post-conception nutritional
supplement given to women in 3rd world countries with severe under-nutrition. The focus is on understanding the
impact on birthweight and infant development, with additional emphasis on maternal-fetal epigenetic signatures,
microbiome changes, and biomarkers of stress/inflammation/nutritional status.
NIH R24-DK102766
(Friedman, Grove, Thornburg M.P.I.)
09/01/10-08/30/15
Role of Dietary Nutrients in Fetal Metabolic Programming in NHP
This grant examines the effects of high fat diet exposure during pregnancy in obese and non-obese Non Human primates
on key fetal organs beginning in the early 3rd trimester, and continuing in juvenile animals. emphasizing mechanisms
underlying placental dysfunction, fetal pancreatic β cell neogenesis hepatic steatosis and gluconeogenesis, and skeletal
muscle insulin resistance and mitochondrial dysfunction in the offspring.
NIH RO1 DK076648
(Dabelea PI, Friedman, Co-I)
07/01/09-06/31/14
Exploring the Fuel-Mediated Programming of Neonatal Growth
The major goals of this project are to determine whether there are associations between maternal body size and
behaviors during pregnancy [pre-pregnant BMI, weight gain, diet], intra-partum fuels (glucose, lipids, FFA), markers of
inflammation and insulin resistance (HOMA-IR)], and infant body size (birth weight for gestational age), and fatness in
1,920 pregnant women enrolled prospectively before 15 weeks of gestation.
NIH RO1-DK078645
(Barbour, PI, Friedman Co-I)
12/01/09-11/30/14
Regulation of Maternal Fuel Supply and Neonatal Adiposity
The major goal of these studies is to determine the independent effect(s) of obesity and GDM on unexplained
hyperglycemia and lipid availability during early and late pregnancy and the relationship to fetal adiposity and
markers of insulin resistance in the fetus
Past Research Support
NIH R21 DK088324 (Barbour, Friedman, Hernandez, M.P.I.)
04/20/11-03/31/13
Role of Macronutrient Diet Composition in GDM on Maternal and Infant Metabolic Outcomes
This study compares the lipid profiles as well as the 72 hour glucose profiles using continuous glucose monitoring
(CGMS) in GDM women undergoing a higher fat/lower carbohydrate diet versus a higher carbohydrate/low fat
diet in women using a randomized, controlled cross-over design
NIH R01 DK078590
Friedman (PI)
Mechanisms for Fetal Hepatic Programming in the Non-Human Primate
NIH R01-DK059767
Regulation of Glucose Homeostasis by C/EBP
Friedman (PI)
07/01/07- 06/30/12
09/01/06-06/30/12
Bill and Melinda Gates Foundation Grand Challenge Pilot Exploration Award (PI w/Mahua Choudhury). 5/2011-2012
The major goal of this project is development a low-cost, rapid, sensitive epigenetic diagnostic and prognostic tool for
early detection of pre-eclampsia during pregnancy.
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