HISPANIC MEDICATION ADHERENCE STUDY TABLE OF CONTENTS EXECUTIVE SUMMARY........................................................................................................................................................................................... 2 INTRODUCTION....................................................................................................................................................................................................... 4 STUDY OBJECTIVES............................................................................................................................................................................................... 4 STUDY DESIGN AND METHODOLOGIES.............................................................................................................................................................. 5 PROVIDER KEY INFORMANT INTERVIEW RESULTS........................................................................................................................................... 6 Insights from the Key Informants.......................................................................................................................................................................... 7 SURVEY RESULTS................................................................................................................................................................................................. 10 When you don’t take your medication, what is the main reason you don’t take it?........................................................................................ 17 Affordability..................................................................................................................................................................................................... 17 Ways to Improve Medication Adherence........................................................................................................................................................ 17 What helps you remember your medication?................................................................................................................................................. 18 What would help Hispanics take their medication?........................................................................................................................................ 19 SUMMARY AND RECOMMENDATIONS................................................................................................................................................................ 20 Some of the key findings we can draw from our research are the following....................................................................................................... 20 Recommendations.......................................................................................................................................................................................... 21 Action items.................................................................................................................................................................................................... 21 ABOUT THE AUTHORS.......................................................................................................................................................................................... 22 About HolaDoctor................................................................................................................................................................................................ 22 About EnvisionRx................................................................................................................................................................................................ 22 About the Authors................................................................................................................................................................................................ 22 CONTACTS............................................................................................................................................................................................................. 23 EXHIBIT 1: HISPANIC MEDICATION ADHERENCE STUDY – COMPLETE RESPONSES TO ALL QUESTIONS............................................... 24 Section A: Total Responses................................................................................................................................................................................ 24 Section B: Demographics.................................................................................................................................................................................... 24 Section C: Medical History.................................................................................................................................................................................. 28 Section D: MMAS................................................................................................................................................................................................ 30 Section E: Initial Prescription.............................................................................................................................................................................. 32 Section F: Fulfillment........................................................................................................................................................................................... 35 Section G: Adherence......................................................................................................................................................................................... 36 REFERENCES........................................................................................................................................................................................................ 39 HISPANIC MEDICATION ADHERENCE | 1 EXECUTIVE SUMMARY Introduction: Hispanics are the largest and one of the fastest-growing minority groups in the United States. Hispanics have higher rates of certain medical conditions, e.g., diabetes, than non-Hispanic whites. For nearly all conditions, Hispanics have lower medication adherence than non-Hispanic whites. A limited number of interventions have been tested to increase medication compliance among Hispanics, but there is still very poor understanding of why Hispanics do not fill and/or adhere to their medication condition management protocols. Objectives: The overall objective of the study was to increase our understanding of how this increasingly dominant demographic group use and adhere to medication protocols. Specific objectives were to: (1) Gain a better understanding of medication adherence among Hispanics, (2) Obtain a deeper understanding of the ways in which language determines how Hispanics are educated about and use prescribed medications, (3) Elicit recommendations from subject matter experts as well as Hispanics themselves on how to increase medication adherence and (4) Propose practical approaches to translating these insights into actionable interventions. Design and Methodologies: The Hispanic Medication Study relied on three key sources of information: (1) A literature review using health and medical publications, (2) Key informant interviews with subject matter experts in the area of Hispanic health and (3) An online survey fielded to HolaDoctor’s database of over one million Hispanic health seekers residing in the U.S. and Puerto Rico. Findings and Results from Literature Review and Key Informant Interviews: The findings from the literature review and key informant interviews offered a number of common insights and the barriers to good medication adherence. Among these were that: Hispanics tend to “wait” to bring themselves or their family members to see a doctor, often trying alternative/natural approaches first; low health literacy has a negative impact on health seeking and adherence; visits to doctors are avoided because employment is more likely to be hourly wage-based and if they aren’t working, they aren’t earning money; there is a low understanding of how prescribed medications work or what they are for and how they are to be taken, all leading to distrust they will work and lower adherence; there is a greater concern about side effects with prescribed medications among Hispanics compared to non-Hispanic whites; cost of copays can be a serious deterrent for lower income Hispanics. Regarding “what works” to increase adherence, tactics included: home visits by lay health workers; conducting “show and tell” sessions with Hispanic patients, where the patient or caretaker is made to handle each medication and tell the provider what each is, how it is used and what it is for; reminders, including text messaging, are showing promise. Online Survey — Participants: We conducted an online survey with a total of 1,712 participants, 870 of whom were living in Puerto Rico and 842 of whom were in the United States. Fifty-one percent were between 35 and 54 years of age; 99 percent of survey respondents spoke Spanish at home. Three-quarters of the participants had some form of health insurance. Approximately 45 percent of the sample were taking three or more medications on a regular basis. High blood pressure, pain, high cholesterol, diabetes and acid reflux were the top conditions. Online Survey — Findings and Results: Survey participants in the U.S. reported feeling more disconnected from their doctor than those in Puerto Rico due to cultural and language barriers. Doctors were by far the preferred source of information about HISPANIC MEDICATION ADHERENCE | 2 medications with over 70 percent of respondents preferring a doctor for information on medications in both the U.S. and Puerto Rico. Conversely, pharmacists were preferred by 24 percent of Puerto Rican respondents compared to just 13 percent of Hispanics in the U.S. Less than a third of Hispanics ranked high on a standardized medication adherence scale: two-thirds were either moderate or poor adherers. The top reasons for not taken ones medications were: I forget (40 percent), I felt better (20 percent), high cost (17 percent). Online information, email and text messaging were the top three things Hispanics felt would help them remember to take medications. The top five ways that people remembered to take their medications were: pain/feeling worse, having a routine, alarm or calendar reminders, putting the medications out so they can be seen and knowing they are important for health and feeling better. When asked what participants thought would help other Hispanics have higher medication adherence, the strongest recommendation, by far, was more education and information about the condition and the medication itself. RECOMMENDATIONS AND ACTION ITEMS Health care providers, health plans and others professionals designing interventions to increase medication adherence among Hispanics should consider the following: • Hispanics have told us loud and clear, they need more and better understanding of their medical conditions and the medications they are being prescribed. • While non-Hispanics tend to accept information from a wide range of sources, among Hispanics, the doctor is still king. • Routines, alarms, calendars and simply putting medicines in a place that is easy to see are considered the most effective tactics for remembering to take one’s treatments. • Hispanics are connected, mobile and technologically savvy. Online information, emails and text messages were all considered good ways to receive information and reminders. Some things that health care educators and providers should do based on this study include: • Creating information about standard medications and conditions that doctors can give to their patients in the exam rooms — this is a fast way for doctors to deliver information. • Providing reminder tools through online and mobile technology to remind individuals to take their medications or take their medications with them. • Pairing medication financial assistance programs with information regarding conditions so that patients can access information and understand how to use their medication. HISPANIC MEDICATION ADHERENCE | 3 INTRODUCTION Hispanics are the largest and one of the fastest-growing minority groups in the United States1. By 2025, over 25 percent of the U.S. population is projected to be of Hispanic ethnicity. Hispanics have traditionally had the lowest rates of health insurance coverage of any demographic group2. An estimated eight in 10 uninsured Hispanics qualified for Medicaid, the Children’s Health Insurance Plan (CHIP) or lower costs on monthly premiums through the Health Insurance Marketplace. Since the passage of the Affordable Care Act, 4.2 million Hispanics (ages 18-64) have gained health insurance coverage, lowering the uninsured rate among Hispanics by 7.7 percent. If all states took advantage of new opportunities to expand Medicaid coverage under the Affordable Care Act, 95 percent of eligible uninsured Hispanics might qualify for Medicaid, CHIP or programs to help lower the cost of health insurance coverage in the Marketplace.3 Hispanics have higher rates of certain medical conditions, e.g., diabetes, than non-Hispanic whites4. For nearly all conditions, Hispanics have lower medication adherence than non-Hispanic whites5. Medication adherence among Hispanics is lower among Hispanics with heart disease6,7,8 and diabetes9, among other conditions. Hispanic Medicare recipients10,11 and those on psychotropic12 treatments also show significantly lower compliance with medication regimens than non-Hispanic whites. Empirical data on the attitudes, beliefs and practices of uninsured Hispanics and the use of discount medication programs are severely lacking. A limited number of interventions have been tested to increase medication compliance among Hispanics13, but there is still very poor understanding of why Hispanics do not fill their prescriptions and/or adhere to their medication condition management protocols. This study seeks to increase our understanding of how this increasingly dominant demographic group uses and adheres to medication protocols. STUDY OBJECTIVES The objectives of this study were to: • Gain a better understanding of medication adherence among Hispanics • Obtain a deeper understanding of the ways in which language determines how Hispanics are educated about and use prescribed medications • Elicit recommendations from subject matter experts as well as Hispanics themselves on how to increase medication adherence • Propose practical approaches to translating these insights into actionable interventions HISPANIC MEDICATION ADHERENCE | 4 STUDY DESIGN AND METHODOLOGIES The Hispanic Medication Study relied on three key sources of information: •A literature review using health and medical publications • Key informant interviews with subject matter experts in the area of Hispanic health •An online survey fielded to HolaDoctor’s database of over one million Hispanic health seekers residing in the U.S. and Puerto Rico In this report, we include the comprehensive findings from these three approaches. A version of the study results will be published as a shorter white paper as well as in an academic, peer-referenced journal article (forthcoming). Online Study Population: HolaDoctor operates the largest network of Spanish-language health care websites on the Internet, with over 3.5 million unique Hispanic visitors monthly. Approximately one million of these unique Hispanic visitors reside in the U.S. or Puerto Rico. HISPANICS ARE ONLINE AND MOBILE Until recently, online surveys among Hispanics may have missed the lowest-income consumers, who did not have Internet access. Today, however, nearly 78 percent of Hispanics in the U.S. and Puerto Rico report using the Internet. As with the general market, a large and very fast-growing percentage of these consumers access the Internet through their smartphones or other web-enabled mobile devices. Of the more than millions of pages of Spanish-language health information HolaDoctor serves up each month, over 70 percent are accessed through consumers’ mobile devices, and 76 percent of Hispanic Internet users report accessing the Internet through a mobile device.14 HISPANIC MEDICATION ADHERENCE | 5 Instrument Development: The survey instrument was based on best practices in the medication adherence field. The online questionnaire included demographic questions, the core set of questions from the MM4 questionnaire15 , culturally relevant questions particular to Hispanics and open-ended questions to elicit innovative strategies and tactics. A number of subject matter experts provided input on the survey question set. The final survey contained questions on demographics, health conditions, medication usage, attitudes, barriers and enablers to better medication compliance. Recruitment: Hispanic consumers who had opted into to HolaDoctor’s online community were invited to participate in the survey through an email invitation. Participants who completed the survey were provided with a $10 Amazon gift card. The survey was fielded over two rounds, one during November 2014 and a second during January 2015. Analysis: Frequencies tables were generated and stratified by residence (Puerto Rico vs. U.S. mainland). Differences were determined using chi-square at the p<0.05 significance level. PROVIDER KEY INFORMANT INTERVIEW RESULTS Three physicians who regularly care for Hispanic patients participated in the in-depth interviews: • Dr. Eduardo Montana. Pediatric cardiologist and current chair of the Hispanic Health Coalition of Georgia • Dr. Flavia Mercado. A pediatrician and former chair of the Hispanic Health Coalition of Georgia • Dr. Ken Dominguez. A director of HIV/AIDS at the Centers for Disease Control and Prevention and chair of the CDC Hispanic employees working group These subject matter experts/providers were interviewed about the barriers to medication adherence among Hispanics and, more importantly, what they have found works to increase adherence among this population. These key informants also provide input on the content of the survey instrument. HISPANIC MEDICATION ADHERENCE | 6 INSIGHTS FROM THE KEY INFORMANTS The qualitative insights and examples provided by the key informant physicians have been grouped by topic below. ATTITUDES TOWARD MEDICATIONS AND HESITANCY TO GO TO THE DOCTOR • Hispanics wait to bring children to the doctor. • Hispanics need to work and are often paid by the hour, so they are very reluctant to take time to go to the doctor. • They know going to the doctor “opens up a whole process.” They are hesitant to “get into it all.” LANGUAGE BARRIERS • Even if the doctor speaks Spanish, they still often don’t understand what the doctor is saying. It is more than language; it is also “health literacy.” PERSISTENCE • Refills – they usually fill the first script, but then don’t refill it. • Hispanics are more apt to share medicines. CHRONIC CONDITIONS • Chronic conditions are really tough because they need to keep track of so many medications for such a long period. • They don’t understand that patients have to be on some medications for a long time. • Asthma. They take curative medication, but they do not consistently take the maintenance meds. • Case study: Diabetic teen on metformin. His whole family was diabetic. He didn’t take his meds because he didn’t feel bad. He didn’t understand why he should take it. CONFLICT WITH SCHOOL • Schools can make the process even more complicated. The doctor and family need to submit letters and have to be identified, so sometimes they just want to avoid the whole situation by not reporting asthma to the school. • Asthma is the biggest chronic problem with children. We (doctors) start by teaching the parents, but “eventually we need to teach the children.” • “We providers think that compliance is the most important, but they (the parents and kids) are dealing with lots of other things, like just getting to school.” HISPANIC MEDICATION ADHERENCE | 7 UNDERSTANDING MEDICATIONS • Hispanics are very visual. They often just refer to the color of the pills — white pill, blue pill — but of course lots of pills are the same color, so that can create problems. • Some doctors use a visual graph or the PDR. • I had a patient whose child should be on ADHD meds, but the mom just didn’t want to have her child take it. She resisted and kept bringing in folk remedies. • It’s very important that they understand WHY they are taking the medicines. This can be a real issue with Hispanic patients. POOR UNDERSTANDING OF HOW TO USE MEDICATIONS • Hispanics often have a very poor understanding of what medicines they have been prescribed and how to take them. • It’s not uncommon that they put ear drops in the mouth. • Case study of asthma patient: The child was admitted to the hospital, which gave the parents medications. The mother already had some medications from the doctor and then got additional medications from the emergency room. The mother was very confused, so she came to her provider. “I’m not sure which of all these medicines to give my son. I got one from doctor and one from the hospital,” she said. She brought three bags in to the doctor. She had medications from the doctor, hospital and emergency room. Some were the same medications, but some were generic and some brand name. Hispanics often get medications from Walmart that often don’t get recorded in the health plan records. • What works best is to have them bring all of their medications in to the appointments and have the doctor explain what each one is for and how they are to be taken. • In AIDS, the large number of pills is an issue. It works much better if pills can be combined so they take fewer pills fewer times per day. • Elderly Hispanics: Need to use a large font and make the instructions clear. HISPANIC MEDICATION ADHERENCE | 8 SIDE EFFECTS • Hispanics tend to be very afraid of side effects from Western medicines, but don’t like to complain. But also it is likely that they just don’t complain to me because I am the doctor. • The key is to give them a heads up that there may be side effects. COST • Medicaid pays for some medications, health insurance others. The doctor has to be very careful to make sure the medications s/he is prescribing are affordable; otherwise, the patient won’t fill or refill them. • Cost is the key. If a family is on Medicaid, they will be very compliant. If not, or if they don’t have another form of health insurance, they won’t. WILLINGNESS TO TAKE MEDICATIONS • Antibiotics: Hispanics are very willing to take antibiotics. • “With kids and medicines, parents are really trying to do the right thing.” • “I think Hispanics really don’t want to give medicines.” They feel like other things can help first, like traditional cures. WHAT ELSE WORKS? • Home visits by lay health workers: they can check to make sure that the meds are stored properly, refrigerated; and they can do educational follow-up. • Show and tell: had parents show her how medications were administered. • Provider recommendations: CDC has found that the strength of the provider recommendation is very important, especially among pregnant women. • Reminders: text messaging and phone calls help. HISPANIC MEDICATION ADHERENCE | 9 SURVEY RESULTS Study Population: A total of 1,712 Hispanic consumers Residence completed the survey. Approximately half of the participants Puerto Rico 54% (n=870) were from Puerto Rico, while the rest were living in Florida 12% the United States (n=842). The states where they lived were Other 11% the top five Hispanic states: California, Florida, Illinois, New California 8% Texas 8% The majority of respondents were women (72 percent). Illinois 4% The age distribution of the respondents is presented in the New York 3% York and Texas. second graph at right. Nearly half of respondents were over 45 years old. Language: The survey was presented in Spanish to a community that was initially sourced through Spanish- 65+ 5% 15-24 5% 5-64 17% 25-34 22% language health websites and a free prescription medication program. It is not surprising, then, that most spoke only Age Distribution Spanish at home, or a mix of Spanish and English. Less than one percent spoke only English at home. As expected, (n=1,639) a significantly higher percentage of respondents living in Puerto Rico spoke only Spanish at home. In a separate question, 90 percent of participants indicated they prefer to 45-54 26% 35-44 25% receive health information in Spanish. WHICH LANGUAGES DO YOU SPEAK AT HOME?* English and Spanish equally More Spanish than English More English than Spanish Another language Only Spanish Only English TOTAL United States 169 22% 309 40% 18 2% 5 1% 260 34% 4 1% 414 Puerto Rico 107 12% 344 40% 6 1% 0 0% 405 47% 2 <1% 408 Total 276 17% 653 40% 24 2% 5 0% 665 41% 6 <1% 822 HISPANIC MEDICATION ADHERENCE | 10 Health Insurance: Over three-quarters of the sample reported having health insurance. Insurance coverage was significantly higher for those living in Puerto Rico (93 percent) than those living in the mainland U.S. (56 percent). The percentage of respondents on Medicaid, 21 percent, matches national statistics, which show that 68 million of the 316 million people in the U.S. are covered by Medicaid at some point during the year16. For those with insurance, people living in the U.S. were more likely to have coverage through Affordable Care Act exchanges (known to Hispanics as “Obamacare”), while those living in Puerto Rico were more likely to be covered by private insurance through a private company. INSURANCE TYPES FOR THOSE WITH COVERAGE For those with health insurance, 83 percent indicated that they had prescription drug coverage. Medicaid Medicare Insurance through an employer or spouse’s employer Private insurance through Obamacare Private insurance bought directly through a private company None TOTAL United States 79 20% 64 16% 145 37% 69 18% 37 9% 335 44% 762 Puerto Rico 161 22% 118 16% 258 35% 43 6% 167 23% 58 7% 862 Total 240 21% 182 16% 403 35% 112 10% 204 18% 393 24% 1,624 HISPANIC MEDICATION ADHERENCE | 11 MEDICAL CONDITIONS AND HISTORY Nearly all of the respondents had one or more medical conditions and were taking one or more prescription medications. (See below.) Number of Medical Conditions and Number of Medications Being Taken have at least one medical condition and take at least one medication 86% (n=1,712) Number of Medical Conditions 0 12% 1 18% 2 17% 3 17% 4 11% 5 7% 6 to 10 13% 11+ 3% Number of Medications Prescribed 0 13% 1 19% 2 16% 3 16% 4 10% 5 8% 6 to 10 13% 11+ 3% Number of Medications Being Taken 0 14% 1 22% 2 19% 3 14% 4 9% 5 8% 6 to 10 12% 11+ 3% The most prevalent medical conditions for which participants were taking medications were high blood pressure, pain, acid reflux and diabetes. Subjects living in Puerto Rico reported higher usage of medications for conditions. Which Health Conditions Do You Take Medications For? 50% n United States n Puerto Rico n Total 43% 40% 37% 37% 34% 31% 30% 20% 18% 23% 22% 20% 30% 29% 23% 22% 20% 19% 15% 10% 17% 14% 14% 14% 9% 8% 20% 20% 18% 19% 24% 23% 22% 8% 5% 5% 5% 0% 0% Asthma High Cholesterol 1% 1% 1% 1%1% COPD Diabetes Pain Acid Reflux Anemia Arthritis Birth Control High Blood Mental Health/ Hypo-/ Other Pressure Depression Hyperthyroidism HISPANIC MEDICATION ADHERENCE | 12 MEDICATION COMPLIANCE The MMAS Score is a validated, standardized set of questions that measure medication adherence15. Notably, a low score indicates high adherence, while a high score indicates low adherence. About 22 percent of the sample had an MMAS score of 0, so were highly compliant. Approximately 32 percent of the sample had an MMAS score of 3 or 4, so were deemed to have low medication adherence. 35% MMAS Scores 31% n United States n Puerto Rico n Total 30% 22% 25% 20% 15% 25% 21% 23% 22% 24% 23% 23% 17% 20% 15% 14% 9% 10% 12% 5% 0% 0 1 2 3 4 The key questions that make up the MMAS are listed in the following table, along with the percentage of participants answering Yes or No to each one. Have you ever forgotten to take medication for your condition? No Yes TOTAL Have you ever had problems remembering to take your medication? No Yes TOTAL When you feel better, do you sometimes stop taking your medications? No Yes TOTAL If you feel worse when taking your medication, do you stop taking it? No Yes TOTAL United States 330 43% 441 57% 771 503 65% 265 35% 768 463 60% 305 40% 768 486 63% 286 37% 772 Puerto Rico 248 29% 618 71% 866 482 56% 381 44% 863 516 60% 349 40% 865 475 55% 390 45% 865 Total 578 35% 1,059 65% 1,637 985 60% 646 40% 1,631 979 60% 654 40% 1,633 961 59% 676 41% 1,637 HISPANIC MEDICATION ADHERENCE | 13 MEDICATION DISCOUNT CARD About 40 percent of respondents use a medication discount card to help pay for medications, with a slightly higher usage among those living in Puerto Rico. DO YOU USE A DISCOUNT MEDICATION PROGRAM TO HELP PAY FOR YOUR MEDICATION?* No Yes, I’m in a program sponsored by a pharmaceutical company Yes, I’m in a program sponsored by a pharmacy Yes, I receive a medication discount through the clinic I go to Yes, I use a medication discount card Yes, I’m in a different program that decreases my medication costs TOTAL United States Puerto Rico Total 414 58% 9 1% 44 6% 40 6% 169 24% 38 5% 714 510 64% 7 1% 22 3% 5 1% 221 28% 33 4% 798 924 61% 16 1% 66 4% 45 3% 390 26% 71 5% 1,512 OF THOSE WHO USE MEDICATION DISCOUNT CARDS, ARE THEY UNIVISION CARDS OR OTHER CARDS? Other Univision TOTAL United States Puerto Rico Total 40 26 66 19% 10% 14% 169 235 404 81% 90% 86% 209 261 470 The high percentage of people with medication discount cards who responded that they have a Univision card is due to the fact that one of the sources of the sample population was people who had signed up for a medication discount card administered by Univision, EnvisionRx and HolaDoctor. HISPANIC MEDICATION ADHERENCE | 14 INTERACTING WITH DOCTORS AND HEALTH PROFESSIONALS ABOUT PRESCRIPTION MEDICATIONS: THE ROLE OF LANGUAGE When asked “Do you trust your doctor for information about prescription medications?,” 83 percent indicated that they always or usually trust their doctor. When asked “Have you ever felt disconnected from your doctor because of your culture?,” 23 percent of those living in the U.S. said that they had, compared to only eight percent of those living in Puerto Rico. The fact that nearly all doctors in Puerto Rico are from the island and speak Spanish, whereas in the U.S. there are few Spanish-speaking, culturally competent physicians, likely explains this significant difference. HAVE YOU EVER FELT DISCONNECTED FROM YOUR DOCTOR BECAUSE OF YOUR CULTURE? No Yes TOTAL United States Puerto Rico Total 569 755 1324 77% 92% 85% 170 63 233 23% 8% 15% 739 818 1,557 Interestingly, when participants were asked “How often do you have difficulty communicating with your doctor?,” the rates were similar among respondents in the U.S. and Puerto Rico. HOW OFTEN DO YOU HAVE DIFFICULTY COMMUNICATING WITH YOUR DOCTOR? Usually Sometimes Once in a while Never/Rarely TOTAL United States Puerto Rico Total 48 35 83 6% 4% 5% 149 143 292 20% 17% 18% 143 137 280 19% 16% 17% 425 536 961 56% 63% 60% 765 851 1,616 HISPANIC MEDICATION ADHERENCE | 15 The preferred source of information about medications was overwhelmingly a doctor, but pharmacists were much more highly regarded in Puerto Rico than in the U.S. Preferred Source of Information about Medications (n=1,712) 80% 78% n United States n Puerto Rico 72% 70% 60% 50% 40% 24% 30% 13% 20% 10% 0% 2% 1% Doctor Pharmacist Nurse 2% 1% 5% 3% Family Member Health Promoter 1% 1% Friend ADHERENCE Overwhelmingly, the most common reason participants did not take their medication was because they forgot. HISPANIC MEDICATION ADHERENCE | 16 When You Don’t Take Your Medication, What Is the Main Reason You Don’t Take It? n United States n Puerto Rico n Total 50% 40% 30% 20% 10% 0% Financial reasons/ too expensive It’s too difficult to go to the pharmacy I feel better I feel worse Need to get a refill I don’t understand why I have to take it I forget I don’t need it anymore Other N/A (I always take them) AFFORDABILITY Nearly 40 percent of the survey participants felt that their medications were either “unaffordable” (28 percent) or “very unaffordable” (11 percent). WAYS TO IMPROVE MEDICATION ADHERENCE The survey included a series of questions about things Hispanics felt would help them to remember to take medications. Those answering “yes” to closed-ended questions about specific tactics are presented in the graphic below. WAYS TO REMEMBER TO TAKE MEDICATION: PERCENT ANSWERING “YES” (n=1,712) ONLINE INFORMATION EMAIL REMINDERS TEXT REMINDERS @ United States Puerto Rico 87% 90% United States Puerto Rico 56% 57% United States Puerto Rico 59% 60% HISPANIC MEDICATION ADHERENCE | 17 We also asked the open-ended question “What helps you remember your medication?” The results were grouped and are presented in the following table. Besides feeling pain or discomfort, the three most common responses referenced the importance of routine, alarms/calendars and having the pills in a place where they can easily be seen. WHAT HELPS YOU REMEMBER YOUR MEDICATION? Number of Mentions Pain and/or feeling worse 110 Have a certain routine 108 Alarm/calendar reminder 90 Seeing the medications/putting them where they can be seen 74 Knowing it’s important for my health/wanting to feel better 71 Family/individual reminds me 38 Pillbox 27 Other reminders (calls, emails, written, texts, phone apps) 26 Other 12 Better financial access 2 REPRESENTATIVE QUOTATIONS FROM INDIVIDUALS WHEN ASKED WHAT HELPS THEM REMEMBER THEIR MEDICATION • I have a routine, and I also write it on a note on my fridge to be able to remember. • Knowing that some medications are necessary to get better from whatever illness one is suffering from and avoid something more serious or causing the illness to get worse or become fatal. • When I’m feeling well, I always remember. • A family member reminds me, and I note it on my cell phone calendar. • My son is my reason for staying healthy. He is only five years old, and I am a widow, so it’s just us. • I am very forgetful when it comes to taking medications, but if someone reminds me, it helps me to remember. HISPANIC MEDICATION ADHERENCE | 18 The final question asked the participants was “What would help Hispanics take their medication?” In other research, we have found that this question is revealing in that it takes the focus away from individual respondents and forces them to think about ways that might work for others like them. The overwhelming majority of responses indicated that Hispanics feel that better education and information about both the medical condition and the medications would be helpful in improving medication adherence. Alarms, reminders and routines were also mentioned, as they were in the previous question. Some suggested that better financial assistance and access (e.g., lower prices) would be helpful. Notably, only a small number of people felt that more information in Spanish or Spanish-speaking doctors was key to better adherence. This may be because most medication instructions are now available in Spanish. WHAT WOULD HELP HISPANICS TAKE THEIR MEDICATION? Number of Mentions More education/information regarding the condition and medication 168 Alarms/reminders through alarms or email 71 Better access/financial help to buy medications 63 Establishing a routine 57 Text messaging/applications 37 Reminders from family members 28 Other 20 Spanish-language materials/information 7 Other written/television reminders 6 Better doctors/doctors who speak Spanish 5 Pillbox 4 REPRESENTATIVE QUOTATIONS WHEN ASKED “WHAT WOULD HELP HISPANICS TAKE THEIR MEDICATION?” • Being better informed and knowing the benefits associated with taking them, without ignoring the risks associated with taking them. • Knowing that in order to make progress as a family, they need to be healthy. • Educating about the illness and learning more about it. • First being able to get it, then individually coming up with their own system that helps them remember to take it. • Having better access to information in a clear, complete and simple manner, either through a doctor or pharmacist who is trusted. • Having access to good medical treatment and advice in their own language. HISPANIC MEDICATION ADHERENCE | 19 SUMMARY AND RECOMMENDATIONS This study sought to better understand medication usage and adherence among the fast-growing and increasingly important Hispanic population. The large survey population was representative of Hispanics living in the U.S. or Puerto Rico and enabled us to compare and contrast whether there were differences between these two groups. SOME OF THE KEY FINDINGS WE CAN DRAW FROM OUR RESEARCH ARE THE FOLLOWING • Among this study population of mostly 25- to 55-year-old Hispanic females, many suffer from a number of medical conditions and are taking multiple medications for these maladies. • Like non-Hispanics, understanding these conditions and the prescribed treatments can be difficult. Most do not take their medications at times. • Hispanics trust their doctor most for information about their medications. In Puerto Rico, pharmacists are highly trusted. Notably, nurses were not well trusted for medication information. • Less than a third of Hispanics ranked high on a standardized medication adherence scale: two-thirds were either moderate or poor adherers. • Establishing a routine, setting up alarms and reminders and placing the medications in a place that is easy to see are key tactics to remember treatments. • Online information, email reminders and text messaging were all perceived as valuable ways to increase adherence. • Through an open-ended question set, Hispanics suggested that “better information about the medical conditions as well as the medications themselves” was sorely needed and that helping people understand these better could significantly increase medication adherence. HISPANIC MEDICATION ADHERENCE | 20 RECOMMENDATIONS Health care providers, health plans and other professionals designing interventions to increase medication adherence among Hispanics should consider the following: • Hispanics have told us loud and clear that they need more and better understanding of their medical conditions and the medications they are being prescribed. • While non-Hispanics tend to accept information from a wide range of sources, among Hispanics, the doctor is still king. • Routines, alarms, calendars and simply putting medicines in a place that is easy to see are considered the most effective tactics for remembering to take one’s medications. • Hispanics are connected, mobile and technologically savvy. Online information, emails and text messages were all considered good ways to receive information and reminders. ACTION ITEMS • Create information about standard medications and conditions that doctors can give to their patients in the exam rooms — this is a fast way for doctors to deliver information. • Provide reminder tools through online and mobile technology to remind individuals to take their medications or take their medications with them. • Pair medication financial assistance programs with information regarding conditions so that patients can access information and understand how to use their medication. HISPANIC MEDICATION ADHERENCE | 21 ABOUT THE AUTHORS ABOUT HOLADOCTOR HolaDoctor Inc. (www.holadoctor.net) is the leading Hispanic health marketing company in the U.S. HolaDoctor owns and operates the most popular Spanish-language health care website online (www.holadoctor.com) and is the exclusive health partner to Univision Interactive. The company provides strategic consulting, marketing solutions and culturally relevant programs to health plans, providers, governmental agencies and other health care entities. HolaDoctor has offices in Atlanta, Miami and Mexico City. ABOUT ENVISIONRX EnvisionRxOptions is a health care and pharmacy benefit management (PBM) company headquartered in Twinsburg, Ohio. We have over 1,500 employees supporting a rapidly growing membership base of over 23 million members, creating savings for them as well as thousands of plan sponsors. Rite Aid’s acquisition of Envision in 2015 brings together two national health care companies that give consumers more pharmacy options and give plan sponsors improved manufacturer relationships and analytic capabilities. ABOUT THE AUTHORS Dirk G. Schroeder, ScD, MPH: Dr. Schroeder is the executive VP and Chief Health Officer at HolaDoctor Inc. He is also an adjunct associate professor of global health at Emory University. He is a recognized expert in Hispanic health issues, including ways to increase access and address health disparities. Dr. Schroeder has lived and worked throughout Latin America as well as Southeast Asia. He has doctoral and master’s degrees in international health from Johns Hopkins University and a post-doc from Cornell. He completed his undergraduate work, with honors and distinction, at Stanford University. Meryam Alaoui: As general manager for EnvisionSavings, the direct-to-consumer line of business for EnvisionRxOptions, a national, fully integrated health care company, Ms. Alaoui oversees all prescription discount programs and copay buy-down offerings administered nationally by EnvisionRx. In this capacity, she works with public- and private-sector clients, including states, municipalities, nonprofit organizations and employers, to deliver valuable services to more than 10 million lives. Prior to joining Envision in 2009, Ms. Alaoui held executive roles with American Express in Finance, Operations, Tax, Treasury and Merchant Services. Before American Express, she worked for the National Council on Compensation Insurance (NCCI) overseeing the Assigned Risk investment portfolio. Brianna Keefe-Oates, MPH: Ms. Keefe-Oates serves as part of the strategic consulting branch of HolaDoctor. She has most recently worked on educational outreach programs focused on educating individuals about the Affordable Care Act. Ms. Keefe-Oates also has experience implementing health prevention projects with Hispanics in the Southeast U.S. and nationally. Ms. Keefe-Oates has worked on research and outreach projects in Paraguay and the Dominican Republic, where she spent three years as a Peace Corps volunteer. Ms. Keefe-Oates received a bachelor’s degree in Latin American studies from Macalester College and a master of public health degree from Emory University. HISPANIC MEDICATION ADHERENCE | 22 CONTACTS Dr. Dirk G. Schroeder Principal Investigator EVP & Chief Health Officer HolaDoctor, Inc. 900 Old Roswell Lakes Parkway, Suite 230 Roswell, Georgia 30075 [email protected] (678) 749-6772 HISPANIC MEDICATION ADHERENCE | 23 EXHIBIT 1: HISPANIC MEDICATION ADHERENCE STUDY – COMPLETE RESPONSES TO ALL QUESTIONS SECTION A: TOTAL RESPONSES United States 842 49% Puerto Rico 870 51% Grand Total 1,712 100% SECTION B: DEMOGRAPHICS SEX* Female Male TOTAL United States Puerto Rico Total 516 649 1165 68% 75% 72% 244 212 456 32% 25% 28% 760 861 1,621 HISPANIC MEDICATION ADHERENCE | 24 AGE 15-24 25-34 35-44 45-54 55-64 65+ TOTAL United States Puerto Rico Total 42 39 81 5% 4% 5% 197 171 368 26% 20% 22% 222 191 413 29% 22% 25% 157 270 427 20% 31% 26% 118 156 274 15% 18% 17% 34 42 76 4% 5% 5% 770 869 1,639 STATE/TERRITORY RESIDENCE Puerto Rico 54% Florida 12% Other 11% California 8% Texas 8% Illinois 4% New York 3% HISPANIC MEDICATION ADHERENCE | 25 WHICH LANGUAGES DO YOU SPEAK AT HOME?* English and Spanish equally More Spanish than English More English than Spanish Another language Only Spanish Only English TOTAL United States Puerto Rico Total 169 107 276 22% 12% 17% 309 344 653 40% 40% 40% 18 6 24 2% 1% 2% 5 0 5 1% 0% 0% 260 405 665 34% 47% 41% 4 2 6 1% <1% <1% 414 408 822 IN WHICH LANGUAGE DO YOU PREFER TO RECEIVE INFORMATION ABOUT YOUR MEDICATIONS? Spanish English TOTAL United States Puerto Rico Total 675 788 1463 89% 91% 90% 84 74 158 11% 9% 10% 759 862 1,621 United States Puerto Rico Total 335 58 393 44% 7% 24% 427 862 1231 56% 93% 76% 762 862 1,624 DO YOU CURRENTLY HAVE INSURANCE?** No Yes TOTAL HISPANIC MEDICATION ADHERENCE | 26 FOR THOSE WHO HAVE INSURANCE, WHAT KIND OF INSURANCE?* United States Puerto Rico Total 79 161 240 20% 22% 21% Medicaid Medicare Insurance through an employer or spouse’s employer Private insurance through Obamacare Private insurance bought directly through a private company TOTAL 64 118 182 16% 16% 16% 145 258 403 37% 35% 35% 69 43 112 18% 6% 10% 37 167 204 9% 23% 18% 394 747 1141 DOES YOUR INSURANCE COVER YOUR PRESCRIPTION MEDICATIONS? No Yes TOTAL United States Puerto Rico Total 67 139 206 16% 18% 17% 346 629 975 84% 82% 83% 413 768 1181 HISPANIC MEDICATION ADHERENCE | 27 SECTION C: MEDICAL HISTORY HOW MANY MEDICAL CONDITIONS DO YOU HAVE? 0: 12% 1: 18% 2: 17% 3: 17% 4: 11% 5: 7% 6-10: 13% 11+: 3% HOW MANY MEDICATIONS ARE YOU CURRENTLY PRESCRIBED? 11+ Six to 10 Five Four Three Two One Zero TOTAL United States Puerto Rico Total 15 38 53 2% 4% 3% 76 146 222 9% 17% 13% 40 95 135 5% 11% 8% 66 99 165 8% 11% 10% 128 143 271 15% 16% 16% 169 143 271 15% 16% 16% 193 130 323 23% 15% 19% 155 76 231 18% 9% 13% 842 879 1,712 HISPANIC MEDICATION ADHERENCE | 28 HOW MANY MEDICATIONS ARE YOU CURRENTLY TAKING? United States Puerto Rico Total 9 33 42 1% 4% 2.5% 71 134 205 8% 15% 12% 36 94 130 4% 11% 8% 63 89 152 7% 10% 9% 11+ Six to 10 Five Four Three Two One Zero TOTAL 108 132 240 13% 15% 14% 181 149 330 22% 17% 19% 207 173 380 25% 20% 22% 167 66 233 20% 8% 14% 842 870 1,712 For Which Conditions Are You Currently Prescribed Medication? (Respondents were able to select more than one) n United States n Puerto Rico n Total 50% 43% 40% 37% 37% 34% 31% 30% 20% 18% 23% 22% 20% 30% 29% 23% 22% 20% 19% 18% 19% 15% 10% 24% 23% 22% 17% 14% 14% 14% 9% 8% 20% 20% 8% 5% 5% 5% 0% 0% Asthma High Cholesterol 1% 1% 1% 1%1% COPD Diabetes Pain Acid Reflux Anemia Arthritis Birth Control High Blood Mental Health/ Hypo-/ Other Pressure Depression Hyperthyroidism HISPANIC MEDICATION ADHERENCE | 29 SECTION D: MMAS MMAS Overall Average: 1.8 (1-2=Moderately adherent) MMAS PR: 2.0 MMAS Other: 1.5 MMAS Scores 35% n United States n Puerto Rico n Total 31% 30% 22% 25% 20% 15% 25% 21% 23% 22% 24% 23% 23% 17% 20% 15% 14% 9% 10% 12% 5% 0% 0 1 2 3 4 HAVE YOU EVER FORGOTTEN TO TAKE MEDICATION FOR YOUR CONDITION?** United States No Yes TOTAL Puerto Rico Total 330 248 578 43% 29% 35% 441 618 1059 57% 71% 65% 771 866 1,637 HAVE YOU EVER HAD PROBLEMS REMEMBERING TO TAKE YOUR MEDICATION?** No Yes TOTAL United States Puerto Rico Total 503 482 985 65% 56% 60% 265 381 646 35% 44% 40% 768 863 1,631 HISPANIC MEDICATION ADHERENCE | 30 WHEN YOU FEEL BETTER DO YOU SOMETIMES STOP TAKING YOUR MEDICATIONS? No Yes TOTAL United States Puerto Rico Total 463 516 979 60% 60% 60% 305 349 654 40% 40% 40% 768 865 1,633 IF YOU FEEL WORSE WHEN TAKING YOUR MEDICATION, DO YOU STOP TAKING IT?** No Yes TOTAL United States Puerto Rico Total 486 475 961 63% 55% 59% 286 390 676 37% 45% 41% 772 865 1,637 HISPANIC MEDICATION ADHERENCE | 31 SECTION E: INITIAL PRESCRIPTION DO YOU USE A DISCOUNT MEDICATION PROGRAM TO HELP PAY FOR YOUR MEDICATION?* United States No Yes, I’m in a program sponsored by a pharmaceutical company Yes, I’m in a program sponsored by a pharmacy Yes, I receive a medication discount through the clinic I go to Yes, I use a medication discount card Yes, I’m in a different program that decreases my medication costs TOTAL Puerto Rico Total 414 510 924 58% 64% 61% 9 7 16 1% 1% 1% 44 22 66 6% 3% 4% 40 5 45 6% 1% 3% 169 221 390 24% 28% 26% 38 33 71 5% 4% 5% 714 798 1,512 OF THOSE WHO USE MEDICATION DISCOUNT CARDS, ARE THEY UNIVISION CARDS OR OTHER CARDS? Other Univision TOTAL United States Puerto Rico Total 40 26 66 19% 10% 14% 169 235 404 81% 90% 86% 209 261 470 HISPANIC MEDICATION ADHERENCE | 32 HOW FREQUENTLY DO YOU TRUST THE INFORMATION THAT YOUR DOCTOR GIVES YOU REGARDING YOUR HEALTH AND MEDICATION?* Always Usually Sometimes Once in a while Never/rarely TOTAL United States Puerto Rico Total 295 337 632 40% 42% 41% 289 357 646 40% 44% 42% 65 69 134 9% 9% 9% 54 34 88 7% 4% 6% 27 12 39 4% 2% 3% 730 809 1,539 HAVE YOU EVER FELT DISCONNECTED FROM YOUR DOCTOR BECAUSE OF YOUR CULTURE?** No Yes TOTAL United States Puerto Rico Total 569 755 1324 77% 92% 85% 170 63 233 23% 8% 15% 739 818 1,557 HISPANIC MEDICATION ADHERENCE | 33 HOW OFTEN DO YOU HAVE DIFFICULTY COMMUNICATING WITH YOUR DOCTOR? Usually Sometimes Once in a while Never/rarely TOTAL United States Puerto Rico Total 48 35 83 6% 4% 5% 149 143 292 20% 17% 18% 143 137 280 19% 16% 17% 425 536 961 56% 63% 60% 765 851 1616 WHO WOULD YOU PREFER TO GIVE YOU INFORMATION ABOUT HOW TO TAKE YOUR MEDICATION?* Friend Doctor Nurse Family member Pharmacist Health promoter TOTAL United States Puerto Rico Total 4 1 5 <1% <1% <1% 611 620 1231 78% 72% 75% 12 4 16 2% <1% 1% 16 12 28 2% 1% 2% 102 206 308 13% 24% 19% 37 22 59 5% 3% 4% 782 865 1647 HISPANIC MEDICATION ADHERENCE | 34 SECTION F: FULFILLMENT HOW OFTEN DO YOU HAVE DIFFICULTY COMMUNICATING WITH YOUR PHARMACIST?* Always Usually Sometimes Once in a while Never/rarely TOTAL United States Puerto Rico Total 30 15 45 4% 2% 3% 29 25 54 4% 3% 3% 112 100 212 14% 12% 13% 120 106 226 15% 12% 14% 502 614 1116 63% 71% 68% 793 860 1653 United States Puerto Rico Total 23 6 29 3% 1% 2% 30 21 51 4% 2% 3% 188 147 265 15% 17% 16% 146 161 307 18% 19% 19% 475 524 999 60% 61% 61% 792 859 1651 HOW OFTEN DO YOU HAVE DIFFICULTY REFILLING YOUR PRESCRIPTION? Always Usually Sometimes Once in a while Never/rarely TOTAL HISPANIC MEDICATION ADHERENCE | 35 SECTION G: ADHERENCE When You Don’t Take Your Medication, What Is the Main Reason You Don’t Take It? 50% 40% 30% 20% 10% 0% Financial reasons/ too expensive It’s too difficult to go to the pharmacy I feel better I feel worse Need to get a refill I don’t understand why I have to take it I forget I don’t need it anymore Other N/A (I always take them) HOW AFFORDABLE ARE YOUR PERSONAL MEDICATIONS?* Very affordable Affordable Unaffordable Very unaffordable TOTAL United States Puerto Rico Total 171 119 290 22% 14% 18% 323 411 734 41% 48% 44% 206 252 458 26% 29% 28% 95 82 177 12% 10% 11% 795 864 1659 HISPANIC MEDICATION ADHERENCE | 36 IF YOU READ ADDITIONAL INFORMATION ONLINE ABOUT YOUR CONDITION AND MEDICATION, WOULD IT HELP YOU TAKE YOUR MEDICATION? No Yes TOTAL United States Puerto Rico Total 103 86 189 13% 10% 11% 691 777 1468 87% 90% 89% 794 863 1657 United States Puerto Rico Total 351 369 720 44% 43% 44% 442 492 934 56% 57% 56% 793 861 1654 United States Puerto Rico Total 157 183 340 42% 40% 41% 221 271 492 59% 60% 59% 378 454 832 WOULD EMAIL REMINDERS HELP YOU TAKE YOUR MEDICATION? No Yes TOTAL WOULD TEXT REMINDERS HELP YOU TAKE YOUR MEDICATION? No Yes TOTAL WHAT USUALLY HELPS YOU REMEMBER TO TAKE YOUR MEDICATION? Number of Mentions Pain and/or feeling worse 110 Have a certain routine 108 Alarm/calendar reminder 90 Seeing the medications/putting them where they can be seen 74 Knowing it’s important for my health/wanting to feel better 71 Family/individual reminds me 38 Pillbox 27 Other reminders (calls, emails, written, texts, phone apps) 26 Other 12 Better financial access 2 HISPANIC MEDICATION ADHERENCE | 37 WHAT WOULD HELP HISPANICS TAKE THEIR MEDICATION? Number of Mentions More education/information regarding the condition and medication 168 Alarms/reminders through alarms or email 71 Better access/financial help to buy medications 63 Establishing a routine 57 Text messaging/applications 37 Family or other person helping them to remember 28 Other 20 Spanish-language materials/information 7 Other written/television reminders 6 Better doctors/doctors who speak Spanish 5 Pillbox 4 HISPANIC MEDICATION ADHERENCE | 38 REFERENCES U.S. Census Community Survey, 2013. 1 U.S. Census Community Survey, 2013. 2 http://www.hhs.gov/healthcare/facts-and-features/fact-sheets/aca-working-latino-community/index.html. 3 HHS Office of Minority Health, 2013. 4 Colby JA, Wang F, Chhabra J, Perez-Escamilla R. Predictors of medication adherence in an urban Latino community with healthcare disparities. J Immigr Minor Health. 2012 Aug;14(4):589-95. 5 Zhang Y, Baik SH. Race/ethnicity, disability and medication adherence among Medicare beneficiaries with heart failure. J Gen Intern Med. 2014 Apr;29(4):602-7. 6 Zhang Y, Baik SH, Chang CC, Kaplan CM, Lave JR. Disability, race/ethnicity and medication adherence among Medicare myocardial infarction survivors. Am Heart J. 2012 Sep;164(3):425-433.e4. 7 Lauffenburger JC, Robinson JG, Oramasionwu C, Fang G. Racial/ethnic and gender gaps in the use of and adherence to evidence-based preventive therapies among elderly Medicare Part D beneficiaries after acute myocardial infarction. Circulation. 2014 Feb 18;129(7):754-63. 8 Parada H Jr, Horton LA, Cherrington A, Ibarra L, Ayala GX. Correlates of medication nonadherence among Latinos with type 2 diabetes. Diabetes Educ. 2012 Jul-Aug;38(4):552-61. 9 Gaskin DJ, Briesacher BA, Limcangco R, Brigantti BL. Exploring racial and ethnic disparities in prescription drug spending and use among Medicare beneficiaries. Am J Geriatr Pharmacother. 2006 Jun;4(2):96-111. 10 Frankenfield DL, Wei II, Anderson KK, Howell BL, Waldo D, Sekscenski E. Prescription medication cost-related non-adherence among Medicare CAHPS respondents: disparity by Hispanic ethnicity. J Health Care Poor Underserved. 2010 May;21(2):518-43. 11 Lanouette NM, Folsom DP, Sciolla A, Jeste DV. Psychotropic medication nonadherence among United States Latinos: a comprehensive literature review. Psychiatr Serv. 2009 Feb;60(2):157-74. doi: 10.1176/appi.ps.60.2.157. Review. 12 Hu D, Juarez DT, Yeboah M, Castillo TP. Interventions to increase medication adherence in African-American and Latino populations: a literature review. Hawaii J Med Public Health. 2014 Jan;73(1):11-8. 13 Lopez, H, Gonzalez-Barrera, A, Patten, E. “Internet Use,” Closing the Digital Divide: Latinos and Technology Adoption. Pew Research Center, Hispanic Trends. 7 March, 2013. 14 Pedersini, R, Isherwood, G, Vietri, J. “Harmonizing measurement of adherence across the 4 item and 8 item Moriskey Medication Adherence Scale using cross-sectional data from patients treated for irritable bowel syndrome.” Kantar Health, Poster presented at the ISPOR 18th Annual European Congress, Dublin, Ireland. 2-6 November, 2013. 15 HHS and U.S. Census, 2015. 16 *=Could be a significant difference between Puerto Rican respondents and all other respondents, but difficult to determine **=Significant difference HISPANIC MEDICATION ADHERENCE | 39
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