SUPPLEMENT AAHA Anesthesia Guidelines for Dogs and Cats Crisis Management: How to Handle Emergencies and Complications What Really Works in Anesthetic and Perioperative Care RALPH HARVEY, DVM, MS, DACVA Distribution of these papers is sponsored by a generous educational grant from Abbott Animal Health. Crisis Management: How to Handle Emergencies and Complications RALPH HARVEY, DVM, MS, DACVA Things Can Go Wrong! problems from minor excess physiologic depression Anesthesia is intended to be a controlled, benign, and to death. reversible process. Unfortunately, anesthetic drugs produce their effects primarily by limited depression An overdose with barbiturates should be managed of vital processes. The inherent dangers of anesthesia with physiologic support of ventilation, continuous and the debilitation of injuries and illness that require monitoring of cardiopulmonary function, and IV anesthesia and surgery predispose the patient to risks fluid therapy to speed recovery and improve cardio- of serious complications and emergencies. Most anes- pulmonary function. In the context of cumulative thetic complications and emergencies can be related overdoses from repeated injections of barbiturates to human errors, equipment problems, ventilatory to prolong anesthesia, the intravenous administra- problems, or circulatory problems. Most anesthetic tion of bicarbonate at 0.5 to 1.0 mEq/kg can speed emergencies and complications can be prevented or recovery from barbiturate overdose by favoring elim- adequately managed. ination. The nonspecific stimulant-antagonist drug, doxapram, can be dangerous in treating depression Human Error due to barbiturate overdose. This stimulant can result Human error is ultimately responsible for the major- in very deleterious stress and should not substi- ity of problems encountered with anesthetic manage- tute for good care and proper dosing of anesthetics. ment. The importance of vigilance in anesthetic care Overdoses with other anesthetics are also managed cannot be overemphasized. It has been noted that with supportive care, which is often adequate in mild hundreds of errors are made due to not looking for to moderate overdose situations. every one error made due to not knowing. Fortunately there are specific antagonist drugs availIt should be recognized that there is a significant degree able to counteract the effects of some anesthetic of safety with familiarity. Errors are more common drugs. For narcotics, the pure antagonist agent, when the anesthetist is not familiar with either the naloxone, will reverse effects of an overdose. With a drugs or equipment being used. Miscalculation of large overdose or a longlasting narcotic, renarcoti- anesthetic drug doses is a common error. The narrow zation can occur with a return to the effects of the therapeutic index of most anesthetic drugs makes narcotic agent. For the tranquilizer/sedatives xylazine correct dose determination or titration crucial. An and dexmedetomidine, and other alpha-2 agonists, absolute or relative overdose of anesthetic can cause there are specific antagonists available. One of these, Adapted from AAHA/OVMA Toronto 2011 Proceedings © 2011 American Animal Hospital Association. All rights reserved. 2 Crisis Management: How to Handle Emergencies and Complications yohimbine, was approved for use in dogs years ago vaporizers, vaporizers filled with the wrong agent, to reverse the effects of xylazine. Atepamezole is a or overfilled vaporizers are common problems. better antagonist for dexmedetomidine and is often Delivery of nitrous oxide in combination with too effective by titration of reduced doses (approved for little oxygen should be carefully avoided and is not SC administration) to secure prompt recovery with always prevented by “fail-safe” systems incorporated less excitement and stress than would result from the in modern machines. administration of a higher dose. Kinked or plugged endotracheal tubes cause respiraNonspecific partial reversal of anesthetic depression tory obstruction. Improper cuff inflation can result is possible by administration of the respiratory stim- in obstruction, tracheal injury, or allow for aspira- ulant doxapram, but this is usually not an appropri- tion pneumonitis. Improper placement of endotra- ate replacement for positive pressure ventilation and cheal tubes is very common, even in species that are other supportive care. Although the net effect can easily intubated. Correct placement should always be be life saving, nonspecific reversal has been associ- verified. ated with residual undesirable effects related to CNS stimulation and even deaths! Other stimulants have An inability to adequately fill the rebreathing bag or been advocated to correct excessive effects of vari- to provide positive pressure ventilation by squeez- ous anesthetics, but the benefits are usually very ing the bag often indicates major leaks or discon- limited. nections. These can result in a failure to deliver anesthetics and oxygen and substantially contribute Anesthetics administered by an incorrect route can to anesthetic gas pollution of the veterinary hospi- have very adverse effects. The extravascular injection tal. Stuck valves in the anesthesia machine or circuit of barbiturates can cause severe irritation and slough- can cause difficulty in ventilation. Inappropriate ing of surrounding tissue. Extravasation should be rebreathing of exhaled gases or the accumulation of treated immediately with generous infiltration of excessive pressure results. Patients that consistently the site with lidocaine and saline, followed by warm seem to be too deep or too light may indicate that compresses. Errors in the administration of anesthet- the vaporizer is out of calibration due to wear and ics also include the misidentification of drugs and tear, there is accumulation of deposits within the accidental use of the wrong medication. vaporizer, or other factors. These common problems emphasize the importance of regular inspection and Equipment Problems maintenance of equipment. Among the most serious anesthetic complications is the failure to deliver oxygen to the patient. This Electrical problems with monitoring or support- can be caused by respiratory obstruction or misused ive equipment risk injury to personnel as well as to or defective anesthetic equipment. Empty tanks or patients. Inadequately grounded or protected equip- misconnected gas lines and breathing circuits prevent ment can cause electrical burns, electrocution, or the delivery of oxygen. Such problems must be recog- fires. Unsafe or substandard equipment should be nized and corrected immediately. Empty anesthetic repaired or replaced. 3 Crisis Management: How to Handle Emergencies and Complications Ventilatory Complications appropriately treat the problem. Incorrect manage- Hypoventilation due to anesthetic overdose is one ment may compound the problem and cause decom- of the most frequently encountered and serious pensation and immediate deterioration. complications in anesthesia. Inadequate breathing occurs with either relative or absolute over- Cyanosis rarely occurs in anesthetized patients breath- doses of many anesthetics. Weakened, debilitated ing oxygen. In order for cyanosis to develop, hemo- animals are more susceptible to the ventilatory globin must be present in sufficient quantities and in depression that may occur secondary to circula- the reduced (non-oxygenated) state. Hypoxemia that tory depression and inadequate perfusion of CNS accompanies anemia therefore will not become evident respiratory centers, electrolyte imbalances, muscle through cyanosis. When cyanosis of either mucous relaxant drugs, or thoracic injury. Support of venti- membranes or blood in the operative field does occur, lation requires endotracheal intubation and posi- oxygen should be administered and adequate ventila- tive pressure breathing, preferably with oxygen. tion and pulse quality should be ensured. Identification and correction of the primary problem is then undertaken. Bradycardia Bradycardia is often associated with procedures or Hyperventilation is often due to inadequate anes- drugs that cause increases in vagal parasympathetic thetic depth and represents an excessive response to nervous system tone. Difficult endotracheal intuba- surgical stimulation. It is important to rule out the tions, deep abdominal surgical procedures, intraocu- possibility of carbon dioxide accumulation, due to lar surgeries, and some surgeries on the neck or in exhausted absorber granules or improper connec- the thorax can all cause vagal-mediated bradycardia. tion of the breathing circuit, as the cause of hyper- Atropine or glycopyrrolate administration is effec- ventilation. Panting can occur with narcotics and tive in prevention of most vagal effects. Treatment thereby decrease the effective ventilation. Most often after the vagal effects become evident is often less this represents an inconvenience to the surgeon. A rewarding. less common cause of panting is actual hyperthermia. Erratic or jerky breathing patterns also usually Non-vagal bradycardias may result from exces- indicate improper anesthetic depth. As before, airway sive anesthetic depth, hypoxia, or hypothermia. obstruction and various causes of carbon dioxide Bradycardia can be a very serious sign of a significant accumulation should be ruled out. anesthetic emergency. Administration of atropine and attention to possible causes is imperative. Pallor and Cyanosis that it may occur as a compensatory response to Cardiopulmonary Arrest and Cardiopulmonary-Cerebral Resuscitation either excessively light or deep planes of anesthesia. Every member of a veterinary hospital staff should Reduced cardiac output due to anesthetic depression be prepared to constructively contribute in an emer- or increased sympathetic tone due to pain can cause gency resuscitation. Although not addressed here, pallor. It is important to identify the cause in order to CPCR must be addressed in every hospital. Pallor of mucous membranes is a complex sign in 4 Crisis Management: How to Handle Emergencies and Complications Hypotension ment of anesthetic plane, and support measures to Hypotension is caused by either decreased cardiac avoid cardiovascular deterioration are necessary. output, increased capacitance of the vasculature, or inadequate blood volume. Intraoperative fluid therapy Ventricular tachycardias are a much more serious at 10 ml/kg/hr is often appropriate for replacement in emergency. An occasional ventricular ectopic beat many surgical patients, but increased volumes can be is cause for concern but not necessarily indicative necessary. Clinical evaluation to distinguish between of patient distress. When ventricular arrhythmias hypovolemia and reduced cardiac-output states as become frequent or progress to ventricular tachy- causes of hypotension can be based on patient history cardia, immediate treatment is required. Ventricular and evaluation, including central venous and arterial arrhythmias indicate an irritated, hypoxic, or pressures. diseased myocardium. Vasodilatation is a very common side effect of many Ventricular tachycardia should be treated with intra- anesthetic drugs. The tranquilizer acepromazine is a venous bolus injection of 2% lidocaine at a dose of hypotensive drug, particularly at higher doses. The 1, 2, or 3 cc in small-, medium-, or large-size dogs volatile anesthetics also cause significant vasodilata- respectively. This rule of thumb will allow for imme- tion. Most anesthetics also are potent cardiac depres- diate therapy without an accurate dose calculation, sants, again particularly at higher doses. Hypotension which could contribute to a life-threatening delay. It under anesthesia is therefore most appropriately has been recommended that propranolol is the drug managed by reduction of anesthetics and fluid of choice for treating ventricular arrhythmias in cats. administration as primary management. Lidocaine is also effective in cats. Total dose limitation is more important in cats due to their smaller Tachycardia body size and blood volume. Heart rates above 180/min in dogs and 200/min in cats are associated with decreased efficiency and Success in emergency management of ventricular increased workload. Tachycardia can be due to fear, arrhythmias is evaluated by continuous ECG moni- pain, inadequate anesthetic depth, pre-anesthetic toring. Bolus injections of lidocaine can be repeated excitement, or a rough induction of anesthesia. to a total accumulated dose of about 10 mg/kg without Hypotension causes a compensatory tachycardia. significant risk of overdose. When two or three injec- These causes of supra-ventricular tachycardia should tions are required over a period of 15–20 minutes, it be recognized and treated. is necessary to convert to a continuous IV infusion of lidocaine at 30–80 micrograms/kg/min. Refractory Compensatory tachycardia in response to hypovole- arrhythmias may require conversion to therapy based mia and hypotension results in decreased coronary on alternative antiarrhythmic medication. artery blood flow and increased myocardial workload. If other conditions contribute to hypoxia there Delayed Recovery is significant risk of development of more serious Delayed recovery from anesthesia is managed by arrhythmias. Fluid therapy for hypovolemia, adjust- recognition of differential causes and a rule-out of 5 Crisis Management: How to Handle Emergencies and Complications individual possibilities. A systematic approach to field resistance electric heating systems are very potential causes will provide for balanced care, with effective and can be much less costly to use. correction of often multiple factors such as hypothermia, inadequate fluid support, reduced metabolism Warm water bottles or surgical gloves filled with or clearance of drugs, and debilitation associated warm water have been shown to be rather inef- with the stress of anesthesia and surgical trauma. fective in raising the body temperature of hypo- Deterioration due to a hypoxic episode must be thermic patients and at the same time constitute a considered. significant risk of causing thermal burns at the site of contact. Circulating warm water blankets are a Hypothermia much better alternative to warm water bottles or Hypothermia is among the most common of gloves, but these are of limited efficacy in rewarm- anesthetic complications. Body heat is lost with ing hypothermic patients. Forced warm air heating preparation of the surgical site, contact with systems are more effective than circulating warm- cool surfaces such as surgical tables, breathing of water blankets and can also be used to cool hyper- dry anesthetic gases, and evaporation from the thermic patients when set to deliver unheated airways and the surgical field. Moderate hypo- ambient air. Proper use of forced air systems must thermia is a frequent problem, even with atten- include some type of dispersive blankets to envelop tion to each of these factors. Body temperatures the patient in warmed air and avoid hot spots by down to approximately 92°F increase oxygen distributing the warmed air. The dispersive blan- and energy requirements during recovery, but kets and the high consumption of electricity both most patients can tolerate this level of hypother- increase the cost of use of the forced warm air mia. More extreme hypothermia causes delayed systems. recovery, reduces tissue perfusion, and increases morbidity and mortality. Other Complications Many other complications and emergencies can The risks of thermal injury are so great with older occur during or be associated with anesthesia. These consumer-style electric heating pads that their use include anaphylactic-like reactions, hyperthermia, in anesthetized, sedated, or depressed (many criti- biochemical imbalances, gastroesophageal reflux, cally ill) patients is considered extremely hazard- regurgitation, vomiting, aspiration, and many surgi- ous. A very different dispersed field or amorphous cal complications such as hemorrhage and pneu- resistance electrical heating blanket to avoid ther- mothorax. Avoidance of complications and effective mal injury and safely warm the patient is now avail- management of emergencies requires continued vigi- able from at least two sources. These new dispersed lance and immediate appropriate action. 6 What Really Works in Anesthetic and Perioperative Care RALPH HARVEY, DVM, MS, DACVA In recent years, anesthesia has become better and North American colleges of veterinary medicine. safer, in that we are now able to provide successful Through the North American Veterinary Technician anesthetic management for patients who would not Association, licensed veterinary technicians may have had a reasonable chance a few years ago. In many now pursue Veterinary Technician Specialist certi- cases, these are even managed as outpatients, quickly fication in anesthesia with advanced training and returned to their owners in full recovery. Our choice skills in veterinary anesthesia and membership in the of anesthetic drugs has greatly expanded, and safer Association of Veterinary Technician Anesthetists. anesthetic agents are indeed responsible for much of the improvement noted. The use of more sophisti- Monitoring and Attention to Detail cated monitoring and better physiologic support has In addition to veterinarians, well-trained technicians become widespread, with continued rapid growth continuously evaluate the patient throughout anes- apparent in this area. In spite of increased owner thesia. Awareness of the ever-changing condition of expectations and the fact that veterinarians now have the anesthetized patient is a shared responsibility that sicker patients presenting with concurrent diseases, can only be shared effectively and safely when the injuries, or debilitation, we can increasingly manage medical team works together. We intend to remain our patients successfully with the improvements in aware of even subtle changes in patient status under anesthesia and related perioperative care. anesthesia. We must always recognize that challenges to the welfare of our patients come not only from Better Training and Ongoing Training their underlying illness or injury, but also as unde- This paper on veterinary anesthesia helps to provide sired effects that even the best anesthetic care may an update on current and developing methods. present. Continuing education seminars and numerous other contemporary publications attempt to further Modern monitoring equipment is increasingly avail- these same goals. The education of veterinar- able at reasonable cost for veterinary use. We no longer ians and veterinary technicians now includes rather need to rely upon out-of-date, poorly serviced, unsafe, extensive attention to anesthesia and related topics. and inappropriate equipment that has been discarded Veterinarians with advanced training in anesthesia from human patient use. Fortunately, however, there and board certification by the American College of is good-quality equipment still available from the Veterinary Anesthesiologists are now involved in human patient market. Increasingly, that equipment the training of new veterinary students at almost all now can be found with good warranty protection, Adapted from AAHA/OVMA Toronto 2011 Proceedings © 2011 American Animal Hospital Association. All rights reserved. 7 What Really Works in Anesthetic and Perioperative Care recent service records, and, importantly, with design able inhalant, sevoflurane, can be used to provide for a and function capabilities well suited to veterinary remarkably rapid yet smooth induction and recovery patient needs. There is also good-quality equipment from anesthesia, and can provide for a rapid change in available specifically for the veterinary patient. Medical the level of anesthesia as needed. Appropriate use of equipment sold exclusively for veterinary use does not these new agents requires skill and knowledge and will receive the degree of oversight and approval required be addressed more fully. All anesthetics have a limited for human-use equipment. In spite of this, there is therapeutic index, or margin of safety. All can depress very good veterinary-specific medical equipment. The vital functions, and inappropriate use can result in demands of veterinarians, and of animal owners, for loss of life. It is useful to remember the old guideline: improved anesthetic delivery, monitoring, and support “There are no safe anesthetics, just safe anesthetists.” has fueled the growth of this industry. While we enjoy a wealth of new options and opportuNo longer is the application of relatively advanced nities in veterinary anesthesia, we must make changes monitoring equipment and anesthesia machines in our anesthetic strategies carefully, recognizing limited to academic institutions or referral practices that experience is necessary to identify any abnor- with heavy surgical caseloads. Monitoring of electro- mal responses from those that should be expected. cardiogram, temperature, blood pressure, and pulse Careful and conservative use of any new anesthetic oximetry are rapidly becoming more routine, even in or technique is crucial. “Nobody likes an adventurous general veterinary practices. Airway monitoring of anesthetist!” carbon dioxide and anesthetic gases in the breathing circuit is also becoming more popular. Proper use of Individualized Anesthetic Care these technologies requires a good working knowl- Much more important than the choice of which edge of the normal values, the significance of devia- specific anesthetic drugs or equipment we use, tions, and an understanding of appropriate manage- however, is the manner in which we select them and ment options. the skill and care with which they are used in our patients. Best use of various options requires an indi- New Options in Anesthetics vidualized approach to anesthetic management. In Through the use of a good variety of injectable and treating infectious diseases, veterinarians wouldn’t inhalant anesthetics, great anesthetic safety and choose the same antibiotic for every patient or condi- convenience is possible for our patients. Remarkable tion encountered. Similarly, the best choice among improvements have developed in outpatient anesthe- options in anesthetic care requires recognition of sia. The recent popularity of several injectable anes- individual needs and individual risk factors, which thetics, most popularly propofol, has greatly improved vary widely among veterinary patients. We recognize our options. Product shortages have resulted from the breed sensitivities and relative contraindications in removal of defective generic products, but we can the choice of anesthetics. For many years, breed asso- manage this temporary supply-and-demand issue. ciations have provided warnings based on anecdotal Isoflurane has been the strongly predominant inhal- reports. With continued research, some of these have ant anesthetic for several years. The more newly avail- been or will be substantiated. Others perhaps will 8 What Really Works in Anesthetic and Perioperative Care be refuted. In the absence of clarifying data, caution the family for more years. With an aging pet popula- dictates selection and use of the best anesthetics from tion, and with keen interest in keeping pets as very among the many choices available. functional members of the family group, we have the opportunity to care for many more geriatric patients. Patient differences that are important in anesthetic These much-loved pets often receive more extensive care are obviously not only those that relate to species, pre-anesthetic evaluations, which help to identify breed, and age differences. As a simple example, marginal reserve function and any subclinical organ patients undergoing elective surgery or those who are disease or dysfunction. Geriatric patients have dramat- traumatically injured both need analgesic therapy. ically reduced requirements for many anesthetics and Opioid analgesics, for instance, have varying efficacy could be overdosed at standard recommended drug and duration of action. The range of choices allows doses. Armed with this information, the veterinarian for brief, mild analgesia such as for an outpatient can individualize anesthetic care to minimize the risks neuter, all the way to profound analgesia for the care of complications. Typical of this patient type would of a substantially traumatized animal. be the older dog presented for routine dental care. Through our improved care, we can extend not only Pre-anesthetic Evaluation and Screening the lifespan, but also the “healthspan” of these animals. Better anesthetic care also includes a more thorough Outpatient Anesthesia pre-anesthetic evaluation, which can fit nicely into a As human patients, we expect to have most mini- comprehensive approach of well-patient care and the mally invasive medical procedures, and even many work-up of the non-elective patient. Pre-anesthetic substantial surgeries, conducted on an outpatient or evaluations should be tailored to the needs of the same-day basis. Reduced hospital costs are not the patient. For example, the pre-anesthetic evaluation only concern driving this change in human patient of a diabetic patient would include blood glucose care. Everyone is happier and can return to daily determination(s) to help guide physiologic support routines more quickly with shorter hospital stays. as a part of the anesthetic care. Basic physical findings This applies to veterinary medicine as well. Better may lead to more extensive evaluations. For example, if anesthetic care is a major component of this change. a heart murmur is detected in a young cat, an echocar- Clients personally experience it in their own medical diogram may be performed to rule out cardiomyopa- care from the perspective of patients, and now they thy before subjecting the animal to the stresses of anes- expect it in the veterinary care we deliver for their thesia. Not all patients need the same level or intensity pets as well. Reliable, fast, and smooth recovery from of pre-anesthetic evaluation or screening. Matching anesthesia is a wonderful feature of many of the more the process to the patient becomes cost effective for the modern anesthetic methods. While every patient pet owner as well as for the practice owner. differs, we’ve come to expect more and more of our patients to bounce back quickly. Geriatric Patient Care It is fortunate that the improved role of pets in our Prior Preparation Prevents Problems society has in various ways kept animals as a part of Readiness includes anticipation of contingencies and 9 What Really Works in Anesthetic and Perioperative Care willingness to consider, and perhaps move along Supportive Care to, what we have in mind as the “Plan B” for that As an example of basic physiological support, the patient. This is recognition of whatever else might provision of fluid therapy and appropriate patient be likely to happen for this animal other than the warming devices is increasingly commonplace in expected course of events. Those who are ready veterinary anesthetic care. Fluid therapy is an appro- for these contingencies can intercept developing priate measure to compensate for the vasodilatation problems before they reach the “crisis” stage. This and hypotension that can commonly occur with the requires attentiveness to warning signs. Good anes- best of anesthetic techniques. We also recognize, thetic monitoring and appropriate responses to through the increased use of blood pressure monitor- changing patient status are much more successful ing, that many of our patients can become hypoten- strategies for patient care than would be any level of sive. Our older patients may be particularly suscep- expertise in crisis management. tible to deleterious consequences of inadequate tissue perfusion. Pain Management Our clients expect optimal control of animal pain. Patient warming devices that gently circulate warm Clients expect the best in anesthetic survival and in air or warm water have replaced dangerous electric relief of pain. Their most basic expectations are that heating pads and bags or bottles of warm (or hot) their pet will survive and that it will not hurt. We do water. All too often, electric heating pads and hot have the tools available to effectively manage proce- water bags and bottles have either burned animals dural, traumatic, and perioperative pain. We also or failed to properly prevent hypothermia. With have increasingly fine methods for very effectively individualized patient management, which includes managing the more chronic pains of degenera- physiologic support, those animals with particular tive joint disease and cancer. The three principles of needs or susceptibilities are better prepared for the effective pain management are: (1) preemptive anal- rigors of anesthesia and surgery. gesia, (2) balanced analgesia, and (3) willingness to dose to effect. Application of these principles can A very different dispersed field or amorphous resis- help us devise very effective pain management for tance electrical heating blanket to avoid thermal every patient. Smart use of analgesic strategies offers injury and safely warm the patient is now available tremendous benefit through relief of unnecessary pain from at least two sources. These new dispersed field and suffering. Improvements in the areas of the recog- resistance electric heating systems are very effective nition and management of animal pain have been and can be much less costly to use. Forced warm air arguably greater than in any other aspect of veterinary heating systems are more effective than circulating anesthesia. Benefits include not only improved patient warm-water blankets and can also be used to cool comfort, but also reduced anesthetic requirements, hyperthermic patients when set to deliver unheated shortened hospital stays, improved immune function, ambient air. Proper use of forced air systems must and reduced morbidity and mortality. include some type of dispersive blankets to envelop the patient in warmed air and avoid hot spots by Good quality pain relief is also very cost effective. distributing the warmed air. The dispersive blankets 10 What Really Works in Anesthetic and Perioperative Care and the high consumption of electricity both increase care is indeed moving forward. Many animal owners the cost of use of the forced warm air systems. assume that the veterinary anesthetic care and pain management their animals receive are already at a very Summary high level of sophistication, perhaps even comparable There seems to be little upper limit to the sophisti- to that afforded to human patients. Our obligation to cation of medical care demanded by the pet-owning do the best we can for our patients and for our clients public. Improvements in all areas of veterinary medi- requires that we move forward and maintain very cine are being rapidly embraced. The standard of high standards in providing anesthesia and analgesia. 11
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