A New example of Steroid-Amino Acid Hybrid:
Construction of constrained nine membered D-ring
steroids
Shagufta and Gautam Panda*
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow226001, UP, India
[email protected]
* Author to whom correspondence should be addressed
Supporting Information
Contents:
1.
1
H and 13C NMR Spectra of Compounds 3-17: Page no. 2-31
2.
1
H-1H COSY, HSQC, HMBC Spectra of 3b: Page no. 32-34
1
Fig. 1: 1H NMR Spectrum of Benzylated Estriol 9
2
Fig. 2: 13C NMR Spectrum of Benzylated Estriol 9
3
Fig. 3: 1H NMR Spectrum of Diol 7
4
Fig. 4: 13C NMR Spectrum of Diol 7
5
Fig. 5: 1H NMR Spectrum of TBDMS Derivative 11
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Fig. 6: 13C NMR Spectrum of TBDMS Derivative 11
7
Fig. 7: 1H NMR Spectrum of Aldehyde 4
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Fig. 8: 13C NMR Spectrum of Aldehyde 4
9
Fig. 9: 1H NMR Spectrum of Amine 14a
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Fig. 10: 13C NMR Spectra of Amine 14a
11
Fig. 11: 1H NMR Spectrum of Amine 14b
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Fig. 12: 13C NMR Spectrum of Amine 14b
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Fig. 13: 1H NMR Spectrum of Amine 14c
14
Fig. 14: 13C NMR Spectrum of Amine 14c
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Fig. 15: 1H NMR Spectrum of N-Methyl Amine Derivative 15a
16
Fig. 16: 13C NMR Spectrum of N-Methyl Amine Derivative 15a
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Fig. 17: 1H NMR Spectrum of N-Methyl Amine Derivative 15b
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Fig. 18: 13C NMR Spectrum of N-Methyl Amine Derivative 15b
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Fig. 19: 1H NMR Spectrum of N-Methyl Amine Derivative 15c
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Fig. 20: 13C NMR Spectrum of N-Methyl Amine Derivative 15c
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Fig. 21: 1H NMR Spectrum of Alcohol 16a
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Fig. 22: 13C NMR Spectrum of Alcohol 16a
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Fig. 23: 13C NMR Spectrum of Alcohol 16b
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Fig. 24: 1H NMR Spectrum of Hydroxy Acid 17a
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Fig. 25: 13C NMR Spectrum of Hydroxy Acid 17a
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Fig. 26: 13C NMR Spectrum of Hydroxy Acid 17b
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Fig. 27: 1H NMR Spectrum of Lactone 3a
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Fig. 28: 1H NMR Spectrum of Lactone 3b
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Fig. 29: 13C NMR Spectrum of Lactone 3b
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Fig. 33: 1H NMR Spectrum of Lactone 3c
31
Fig. 30: 1H-1H COSY Spectrum of Lactone 3b
32
Fig. 31: 2-D HSQC Spectrum of Lactone 3b
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Fig. 32: 2-D HMBC Spectrum of Lactone 3b
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