FastTest
You’ve read the book...
... now test yourself
To ensure you have learned the key points that will improve your
patient care, read the authors’ questions below. Please refer back to
relevant sections of the book to address any areas of uncertainty.
1
Epidemiology
1. Which of the following statements are true?
a)In general, the incidence of lymphomas increases with age
b)The incidence of Hodgkin lymphoma is considerably higher in
Western Europe than any other geographic region
c) HIV/AIDS is a major risk factor for the development of lymphoma
d)In the USA and Western Europe, 50% of patients with Hodgkin
lymphoma are positive for Epstein–Barr virus
Reveal Answer
2
Cellular and molecular aspects
2. Which of the following statements are true?
a)There are two types of lymphocyte
b)Each lymphoma arises from a single abnormal lymphocyte
c) Lymphomas arise as a result of acquired genetic changes in
lymphocytes
d)It is thought that most lymphomas arise from changes to
lymphoctyes during the antigen-independent phase of the
lymphocyte life cycle
Reveal Answer
3
Presentation, biopsy and diagnostic
laboratory techniques
3. Which of the following statements are true?
a)Unexplained anemia is the most frequent systemic presentation of
lymphoma
b)Lymphoma commonly presents as a single lump
c) Lymphoma can affect any organ
d)As most lymphoma arises in the bone marrow, bone pain is a
common presenting feature
Reveal Answer
4. Histological evaluation of biopsy tissue is essential for
diagnosis of lymphoma. Which type of lymphoma is shown
here?
(a)
(b)
(c)
(d)
Reveal Answer
5. Which of the following statements are true?
a)Immunophenotyping can help to determine disease subtype
b)Karyotyping is conducted on cells in the metaphase (the stage in the
cell cycle when the cell is about to divide)
c) Deletions of chromosomal material can help to distinguish specific
types of non-Hodgkin lymphoma
d)Gene expression microarray has identified two major subtypes of
diffuse large B-cell lymphoma
Reveal Answer
4
Staging and general management
principles
6. Which of the following statements are true?
a)Non-Hodgkin lymphoma (NHL) is almost always nodal
b)According to the Ann Arbor classification system, stage III NHL
involves lymph-node groups on the same side of the diaphragm
c) Not all residual masses that are present after chemotherapy contain
active disease
d)Neutropenic sepsis is a life-threatening complication of
chemotherapy requiring urgent assessment
Reveal Answer
7. Which of the following is not a ‘B’ symptom in staging:
a)More than 10% weight loss in 6 months
b)Pruritus
c) Night sweats
d)Headache
e)Fever
Reveal Answer
8. Which of the following should be performed in patients
who relapse?
a)Rebiopsy
b) Full-body skeletal scintigraphy
c) Complete restaging
d) A different chemotherapy regimen
Reveal Answer
5
Aggressive B-cell lymphomas
9. What is appropriate treatment for a patient with early-stage
diffuse large B-cell lymphoma (DLBCL)?
a)Rituximab alone
b)R-CHOP chemotherapy
c) CHOP chemotherapy
d)Tositumomab or ibritumomab
Reveal Answer
6
Indolent B-cell lymphomas
10.What is appropriate treatment for a patient with advancedstage follicular lymphoma?
a)No initial treatment (‘watch and wait’)
b)R-CVP chemotherapy
c) R-CHOP chemotherapy
d)R-bendamustine chemotherapy
Reveal Answer
7
T-cell and natural-killer cell lymphomas
11.Which of the following statements are true?
a)T-cell lymphomas commonly present in the brain and spinal cord
b)Peripheral T-cell lymphomas often present with marked systemic
symptoms
c) Most T-cell lymphomas are aggressive and often progress during
treatment
d)T-cell lymphoblastic lymphoma most commonly presents in older
people
Reveal Answer
8
Immunocompromised and HIV-positive
patients
12.What is appropriate management for lymphomas that arise
after transplantation?
a) No initial treatment (‘watch and wait’)
b) Reducing the level of immunosuppression
c) Rituximab alone
d) R-CHOP
Reveal Answer
9
Hodgkin lymphoma
13.What is appropriate first-line treatment for a patient with
stage IIA Hodgkin lymphoma?
a)Surgical resection
b)Extended-field radiotherapy
c) ABVD chemotherapy
d)All of the above
Reveal Answer
10
Treatment modalities
14.Which of the following treatment modalities are used to
treat lymphoma?
a)Chemotherapy
b)Radiotherapy
c) Surgical resection
d)Immunotherapy
Reveal Answer
15.What is the molecular target of the monoclonal antibody
rituximab?
a)CD52
b)LAP (lymphoma-associated protein)
c)CD30
d)CD20
Reveal Answer
11
Supportive care
16.Which of the following supportive care measures may be
implemented for a patient who presents with tumor lysis
syndrome after the start of multiagent chemotherapy?
a)Oral allopurinol
b)Intravenous fluid support
c) White blood cell growth factor for all cycles of treatment
d)Intravenous rasburicase
Reveal Answer
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