ILLINOIS DEPARTMENT OF PUBLIC HEALTH AIDS Drug Assistance Program (ADAP) FORMULARY as of 11/10/2014 158 DRUGS CATEGORY I Reverse Transcriptase Inhibitors (RTIs) abacavir sulfate (Ziagen) didanosine (DDI, Dideoxyinosine, Videx, Videx EC) emtricitabine (Emtriva, FTC) lamivudine (3TC, Epivir) stavudine (D4T, Zerit) tenofovir DF (Viread) zidovudine (AZT, Azidothymidine, Retrovir) Combination Drugs ***atripla (Efavirenz/Emtricitabine/Tenofovir) **combivir (Epivir and Retrovir Combination) CATEGORY III Non-Nucleoside (RTIs) delavirdine (Rescriptor) efavirenz (Sustiva) etravirine (Intelence) nevirapine (Viramune) rilpivirine (Edurant) Entry Inhibitor maraviroc (Selzentry) - Requires Trofile assay Intergrase Inhibitor dolutegravir (Tivicay) raltegravir (Isentress) vitekta (Elvitegravir) Boosting Agents ***complera(Emtricitabine/Nilpivirine/Tenofovir) Antibiotics amoxicillin (Amoxil, Trimox, Wymox) *azithromycin dihydrate (Zithromax) cefixime (Suprax) suspension Ceftriaxone 250 mg (Rocephin) cephalexin monohydrate (Keflex) chlorhexidine gluconate (Peridex, PerioGard) *clarithromycin (Biaxin) dicloxacillin sodium (Dycill, Dynapen, Pathocil) doxycycline hyclate (Doryx, Vibramycin, Vibra-Tabs) *levofloxacin (Levaquin) metronidazole penicillin G benzathine **epzicom (Epivir and Ziagen Combination) cobicistat (Tybust) penicillin LA ****stribild(Elvitegravir/Cobicistat/Emtricitabine Tenofovir Disoproxil Fumarate) ***triumeq (Dolutegravir/Lamivudine/Abacavir) ritonavir (Norvir) – reference prescribing gudelines penicillin VK ***trizivir (Epivir, Retrovir and Ziagen Combination **truvada (Emtriva and Viread combination) CATEGORY II Treatment and Prophylaxis of PCP amphotericin B (Fungizone) I.V. only clotrimazole (Mycelex, Lotrimin) fluconazole (Diflucan) itraconazole (Sporanox) miconazole (Monistat) nystatin (Mycostatin) Protease Inhibitors (PIs) amprenavir (Agenerase), solution only atazanavir (Reyataz) darunavir (Prezista) fosamprenavir calcium (Lexiva) indinavir (Crixivan) lopinavir/ritonavir (Kaletra) nelfinavir mesylate (Viracept) ritonavir (Norvir) – reference prescribing gudelines saquinavir mesylate (Invirase) tipranovir (Aptivus) Anti-Fungals atovaquone (Mepron) – Pre-Approval (required) clindamycin HCl (Cleocin Hcl) dapsone pentamidine isethionate (NebuPent, Pentam 300) primaquine phosphate sulfamethoxazole/trimethoprim (SMZ/TMP, Bactrim) trimethoprim (TMP, Proloprim, Trimpex) Hepatitis B Treatments adefovir Dipivoxil (Hepsera) entecavir (Baraclude) Anti-Virals acyclovir (acycloguanosine, Zovirax) cidofovir plus probenecid (Vistide) intravenous famciclovir (Famvir) valacyclovir hydrochloride (Valtrex) Cryptosporidiosis paromomycin sulfate (Humatin) Mycobacterial Infections *azithromycin dihydrate (Zithromax) ciprofloxacin (Cipro) *clarithromycin (Biaxin) ethambutol (Myambutol) isoniazid (Isonicotinic Acid Hydrazide, INH) isoniazid/pyrazinamide/rifampin (Rifater) *levofloxacin (Levaquin) pyrazinamide pyridoxine hydrochloride (B6) rifabutin (Mycobutin) rifampin (Rifadin, Rimactane) Anti-Diarrhea or Wasting Syndrome diphenoxylate/atropine (Lomotil) loperamide (Imodium) Toxoplasmosis *azithromycin dihydrate (Zithromax) clindamycin palmitate (Cleocin Pediatric Granules) Leucovorin Calcium (Folinic Acid) clindamycin phosphate (Cleocin Phosphate) pyrimethamine (Daraprim) sulfadiazine sulfamethoxazole (Gantanol, Urobak) CATEGORY IV Anti-Convulsants keppra (Levetiracetam) valproic acid (Divalproex) Anti-Depressants Other Angiotensin-Converting Enzyme Inhibitors Antidiabetic: Thiazolidinediones pioglitazone (Actos) Anti-Psychotics olanzapine (Zyprexa) risperidone (Risperdal) quetiapine (Seroquel, XR) valproic acid Beta-Adrenergic Blocking Agents amitriptyline *bupropion (Wellbutrin SR, Wellbutrin XL) citalopram (Celexa) atenolol/chlorthalidone (Tenoretic) atenolol (Tenormin) doxepin duloxetine (Cymbalta) escitalopram (Lexapro) carvedilol (Coreg) metoprolol (Lopressor, Toprol XL) propranolol (Inderal LA) fluoxetine (Prozac) mirtazapine (Remeron) timolol (Blocadren) paroxetine (Paxil, Paxil CR) sertraline (Zoloft) amlodipine (Norvasc) diltiazem (Cardizem, Taztia XT) venlafaxine (Effexor, Effexor XR) felodipine (Plendil) nifedipine XL, ER (Procardia, Adalat) Antidiabetic: Bigunanides metformin (Glucophage Glucophage XL) Antidiabetic: Combinations glyburide/metformin (Glucovance) rosiglitazone/metformin (Avandamet) Antidiabetic: Insulins gabapentin (Neurontin) imiquimod cream (Aldara) testosterone cypionate (no Kits) testosterone enanthate, I.M only (no Kits) benazepril (Lotensin) enalapril (Vasotec) enalapril/hctz (Vaseretic) lisinopril (Prinivil, Zestril) quinapril (Accupril) ramipril (Altace) Humalog (all formulations) Humalog Mix Humulin (all formulations) insulin glargine (Lantus) Novolin (all formulations) Novolog (all formulations) Novolog Mix Flexpen Antidiabetic: Sulfonylureas glipizide (Glucotrol, XL) Calcium-Channel Blocking Agents verapamil (Covera HS) verapamil (Verelan, Isoptin SR, Calan, Calan SR) Cardiac losartan (Cozaar) losartan/hctz (Hzaar) valsartan (Diovan) valsartan/hctz (Diovan HCT) Central Agonists clonidine (Catapres) minoxidil Diuretics furosemide (LASIX) hctz/triamterene (DYAZIDE, MAXIDE) hydrochlorothiazide lisinopril/hctz (Prinzide, Zestoretic) glyburide (Diabeta) CATEGORY IV cont. Nitrates and Nitrites Lipid Lowering Agents atorvastatin (Liptor) fenofibrate (Tricor) pravastatin (Pravachol) nitroglycerin sublingual tab, spray, cap Smoking Cessation *bupropion (Wellbutrin SR, Wellbutrin XL) CATEGORY V REQUIRING PRIOR APPROVAL "Category V" drugs are pre-approval drugs only, all pre-approval forms are located on the IDPH website (www.idph.state.il.us/health/aids/adap.htm enfurvirtide (Fuzeon); requires pre-approval and limited to a cap of 15 clients concurrently. valaganciclovir hydrochloride (Valcyte) ; Oral only and is limited to a cap of 35 clients concurrently. atovaquone (Mepron) - requires prior approval in all of the following situations: 1) use for more than 21 days 2) use as prophylaxis (rather than treatment); or 3) more than one prescription per year is written for a patient not approved for use of atovoquone as prophylaxis. Pre Approval for Gender Transition and Maintenance only (See "Prescribing Guidelines" for link on guidelines and protocols) Estradiol, Oral Estradiol, Transdermal Estradiol, Injectable Finasteride Progestin Spironolactone * Duplicate drug appears in more than one sub category **Indicates a fixed combination of two-drugs that are considered two drugs in the 5+ drug limit. *** Indicates a fixed three-drug combination and are considered three drugs in the 5+ drug limit. ****Stribild is a three-drug combination and is considered three drugs in the 5+ drug limit. See ADAP Prescribing Guidelines for quantity limits on some drugs. Prescriptions for multi-source drugs should be written indicating "product subsitution permitted" to ensure all efforts for fiscal stewardship on behalf of ADAP. In addition, this procedure will reduce the number of call-backs to prescribers by dispensing pharmacy. All prescriptions for multi-source drugs (drugs available in a brand-name and equal or greater than 1 generic formulation) will be filled with the lowest cost option available. Use of brand name drugs on the ADAP formulary is for informational purposes only. ILLINOIS DEPARTMENT OF PUBLIC HEALTH AIDS Drug Assistance Program (ADAP) FORMULARY as of 11/10/2014 158 DRUGS Drug Name abacavir sulfate (Ziagen) acyclovir (acycloguanosine, Zovirax) adefovir Dipivoxil (Hepsera) amitriptyline amlodipine (Norvasc) amoxicillin (Amoxil, Trimox, Wymox) amphotericin B (Fungizone) I.V. only amprenavir (Agenerase), solution only atazanavir (Reyataz) atenolol/chlorthalidone (Tenoretic) atenolol (Tenormin) atorvastatin (Lipitor) atovaquone (Mepron) – Pre-Approval (required) ***atripla (efavirenz/emtricitabine/tenofovir) *azithromycin dihydrate (Zithromax) bupropion (Wellbutrin SR Wellbutrin XL) benazepril (Lotensin) carvedilol (Coreg) cefixime (Suprax) suspension Ceftriaxone 250 mg (Rocephin) cephalexin monohydrate (Keflex) chlorhexidine gluconate (Peridex, PerioGard) cidofovir plus probenecid (Vistide) intravenous ciprofloxacin (Cipro) citalopram (Celexa) *clarithromycin (Biaxin) clindamycin HCl (Cleocin Hcl) clindamycin palmitate (Cleocin pediatric granules) leucovorin calcium (folinic acid) clindamycin phosphate (Cleocin Phosphate) clonidine (Catapres) clotrimazole (Mycelex, Lotrimin) cobicistat (Tybust) **combivir (Epivir and Retrovir Combination) Drug Name Drug Name enfurvirtide (Fuzeon) entecavir (Baraclude) **epzicom (Epivir and Ziagen Combination) escitalopram (Lexapro) Estradiol, Oral Estradiol, Transdermal Estradiol, Injectable ethambutol (Myambutol) etravirine (Intelence) famciclovir (Famvir) felodipine (Plendil) gabapentin (Neurontin) glipizide (Glucotrol, XL) glyburide (Diabeta) glyburide/metformin (Glucovance) hctz/triamterene (DyazideYazide, Maxide) Humalog (all formulations) Humalog Mix Humulin (all formulations) hydrochlorothiazide imiquimod cream (Aldara) indinavir (Crixivan) insulin glargine (Lantus) itraconazole (Sporanox) isoniazid (isonicotinic acid hydrazide, INH) isoniazid/pyrazinamide/rifampin (Rifater) keppra (Levetiracetam) lamivudine (3TC, Epivir) levofloxacin (Levaquin) lisinopril/hctz (Prinzide, Zestoretic) lisinopril (Prinivil, Zestril) loperamide (Imodium) lopinavir/ritonavir (Kaletra) losartan (Cozaar) losartan/hctz (Hzaar) maraviroc (Selzentry) - Requires Trofile assay metformin (Glucophage Glucophage XL) metoprolol (Lopressor, Toprol XL) fenofibrate (Tricor) Finasteride fluconazole (Diflucan) fluoxetine (Prozac) fosamprenavir calcium (Lexiva) furosemide (Lasix) metronidazole miconazole (Monistat) minoxidil mirtazapine (Remeron) nelfinavir mesylate (Viracept) nevirapine (Viramune) ***complera(emtricitabine/rilpivirine/tenofovir) dapsone darunavir (Prezista) delavirdine (Rescriptor) dicloxacillin sodium (Dycill, Dynapen, Pathocil) didanosine (ddI, dideoxyinosine, Videx, Videx EC) diltiazem (Cardizem, Taztia XT) diphenoxylate/atropine (Lomotil) dolutegravir (Tivicay) doxycycline hyclate (Doryx, Vibramycin, Vibra-Tabs) doxepin duloxetine (Cymbalta) efavirenz (Sustiva) emtricitabine (Emtriva, FTC) enalapril (Vasotec) enalapril/hctz (Vaseretic) Drug Name nifedipine XL, ER (Procardia, Adalat) nitroglycerin sublingual tab, spray, cap Novolin (all formulations) Novolog (all formulations) Novolog Mix Flexpen nystatin (Mycostatin) olanzapine (Zyprexa) paromomycin sulfate (Humatin) paroxetine (Paxil, Paxil CR) penicillin G benzathine penicillin LA penicillin VK pentamidine isethionate (NebuPent, Pentam 300) pioglitazone (Actos) pravastatin (Pravachol) Drug Name pyrimethamine (Daraprim) quetiapine (Seroquel, XR) quinapril (Accupril) raltegravir (Isentress) ramipril (Altace) rifabutin (Mycobutin) rifampin (Rifadin, Rimactane) rilpivirine (Edurant) risperidone (Risperdal) ritonavir (Norvir) – reference prescribing gudelines rosiglitazone/metformin (Avandamet) saquinavir mesylate (Invirase) sertraline (Zoloft) Spironolactone stavudine (d4T, Zerit) ****stribild(elvitegravir/cobicistat/emtricitabine tenofovir disoproxil fumarate) Drug Name tenofovir DF (Viread) testosterone cypionate (no Kits) testosterone enanthate, I.M only (no Kits) timolol (Blocadren) tipranovir (Aptivus) trimethoprim (TMP, Proloprim, Trimpex) ***trizivir (Epivir, Retrovir and Ziagen Combination **truvada (Emtriva and Viread combination) valacyclovir hydrochloride (Valtrex) valganciclovir hydrochloride (Valcyte) valproic acid valproic acid (Divalproex) valsartan (Diovan) valsartan/hctz (Diovan HCT) venlafaxine (Effexor, Effexor XR) Progestin primaquine phosphate sulfadiazine verapamil (Covera HS) verapamil (Verelan, Isoptin SR, Calan, Calan SR) propranolol (Inderal LA) sulfamethoxazole (Gantanol, Urobak) vitekta (Elvitegravir) pyrazinamide pyridoxine hydrochloride (B6) sulfamethoxazole/trimethoprim (SMZ/TMP, Bactrim) zidovudine (AZT, azidothymidine, Retrovir) Prior Approval Drugs "Category V" drugs are pre-approval drugs only, all pre-approval forms are located on the IDPH website (www.idph.state.il.us/health/aids/adap.htm enfurvirtide (Fuzeon); requires pre-approval and limited to a cap of 15 clients concurrently. valaganciclovir hydrochloride (Valcyte); Oral only and is limited to a cap of 35 clients concurrently. atovaquone (Mepron) - requires prior approval in all of the following situations: 1) use for more than 21 days 2) use as prophylaxis (rather than treatment); or 3) more than one prescription per year is written for a patient not approved for use of atovoquone as prophylaxis. Pre Approval for Gender Transition and Maintenance only (See "Prescribing Guidelines" for link on guidelines and protocols) Estradiol, Oral Estradiol, Transdermal Estradiol, Injectable Finasteride Progestin Spironolactone * Duplicate drug appears in more than one sub category ** Indicates a fixed combination of two-drugs that are considered two drugs in the 5+ drug limit. *** Indicates a fixed three-drug combination and are considered three drugs in the 5+ drug limit. **** Stribild is a three-drug combination and is considered four drugs in the 5+ drug limit. See ADAP Prescribing Guidelines for quantity limits on some drugs. Prescriptions for multi-source drugs should be written indicating "product subsitution permitted" to ensure all efforts for fiscal stewardship on behalf of ADAP. In addition, this procedure will reduce the number of call-backs to prescribers by dispensing pharmacy. All perscriptions for multi-source drugs (drugs available in a brand-name and equal or greater than 1 generic formulation) will be filled with the lowest cost option available. Use of brand name drugs on the ADAP formulary is for informational purposes only. ILLINOIS DEPARTMENT OF PUBLIC HEALTH AIDS DRUG ASSISTANCE PROGRAM (ADAP) PRESCRIBING GUIDELINES Drugs provided by the AIDS Drug Assistance Program (ADAP) MUST not exceed a $2,000 per month benefits cap and MUST be prescribed in accordance with these guidelines. Revisions to prescribing guidelines may be made upon recommendations of the Department’s ADAP Medical Issues Advisory Board. CATEGORY I Category I anti-retroviral therapies should be prescribed in accordance with the latest Public Health Service (PHS) guidelines. The Website is: http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf All newly FDA approved anti-retroviral therapies will be considered for addition to the formulary, however: a. b. No more than five (5) drugs* from Category I (and Fuzeon) prescribed concurrently (Up to two protease inhibitors or a protease inhibitor and an NNRTI may be provided concurrently), except with prior approval from ADAP. There are no exceptions to this prescribing guideline, except ritonavir (Norvir), at a reduced dosage may be prescribed for pharmacokinetic (PK) boosting, cobicistat (Tybust), and Any change in Category I therapies will require a discontinue order of the old prescription to be sent or faxed to CVS Caremark Pharmacy before the new order can be filled. * Combivir, Truvada, and Epzicom are fixed dose combinations and are considered two (2) drugs when ordered. * Trizivir, Atripla, Stribild, Complera and Triumeq are fixed-dosage combinations of 3 drugs and are considered three (3) drugs when ordered. * Kaletra contains Norvir at a reduced dosage and is considered one plus PK boosted drug when ordered. HIV co-receptor (CCR5 and/or CXCR4) tropism assay must be run and submitted to ADAP prior to prescribing Selzentry. CATEGORY II atovaquone (Mepron) prescriptions will require prior approval in all the following situations: 1) use for more than 21 days, 2) use as prophylaxis (rather than treatment); or 3) more than one prescription per year is written for a patient not approved for use of atovoquone as prophylaxis. Pre-approval form will be available on the IDPH website (www.idph.state.il.us). ritonavir (Norvir) - tablets will be dispensed unless other formations are required by prescriber due to tolerance issues. ADAP may require prior approval for other formulations. CATEGORY V enfurvirtide (Fuzeon); requires a separate application. Eligibility is based on medical criteria, with a cap limit of 15 clients. Prior approval by the Department will be faxed, via electronic file to the pharmacy as authorization. Fuzeon is considered one of the five (5) drugs along with those in Category 1. valganciclovir (Valcyte) oral only: limited to a cap of 35 clients concurrently. atovaquone (Mepron) – see notes under Category II. Neither enfurvirtide (Fuzeon) nor valganciclovir (Valcyte) are considered within the $2,000 benefits cap. OTHER GENERAL GUIDELINES All prescriptions for multi-source drugs (drugs available in a brand-name and equal or greater than 1 generic formulation) will be filled with the lowest cost option available. Use of brand name drugs on the ADAP formulary is for informational purposes only. For coverage under ADAP, prescriptions for multi-source drugs should be written indicating “product substitution permitted” to ensure all efforts for fiscal stewardship are able to be implemented by ADAP through its dispensing pharmacy. In addition, this procedure will reduce the number of call-backs to prescribers by dispensing pharmacy. All prescriptions must be written for no more than 3 refills. Then the client will be required to re-visit their HIV Care Provider before a new prescription can be written. All pre-approval form can be located on the IDPH website (www.idph.state.il.us) for all prescriptions requiring preapproval. Revised: 11/10/2014 ILLINOIS DEPARTMENT OF PUBLIC HEALTH AIDS DRUG ASSISTANCE PROGRAM (ADAP) PRESCRIBING GUIDELINES Guidance References for Primary Care Protocol for Hormone Treatment for Gender Transition and Maintenance: 1) The Center for Excellence for Transgender Health ‐ Primary Care Protocol ‐ Hormone Administration: http://transhealth.ucsf.edu/trans?page=protocol‐hormones 2) The World Professional Association for Transgender Health ‐ Standards of Care: http://www.wpath.org/uploaded_files/140/files/Standards%20of%20Care,%20V7%20Full%20Book.pdf Revised: 11/10/2014
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