VOLUME 15 NUMBER 12 DECEMBER 2014
O B I T U A RY
1091 Ray D. Owen
Michael P Cancro
C O M M E N TA R Y
DCs
tSNE dim. 2
10
6
9
12
Eosinophils
5
16
13
1
24
27
Innate lymphoid cells
28
14
4
15
Red pulp
macrophages
Spleen and kidney
macrophages
3
Microglia
23
26
25
7
2
Neutrophils
tSNE dim. 1
Myeloid cell subsets are difficult to
classify objectively because of the
range of subjective definitions based
on various cell surface markers.
Through the use of a 38-antibody
mass cytometry analysis panel and
a dimensionality-reduction method,
Becher et al. (p 1181; and News and
Views by Irish, p 1095) systematically
categorize mouse myeloid cells from
eight different tissues. The original
figure by Jinmiao Chen shows
individual myeloid cells from all mice
and all tissues plotted on the basis
of their phenotypic relationships in a
single plot. Artwork by Lewis Long.
npg
© 2014 Nature America, Inc. All rights reserved.
22
8
11
Alveolar
macrophages
21
17
18
Monocytes
1092 The physician scientist: balancing clinical and research duties
Penelope A Morel & Gillian Ross
pDCs
20
19
NEWS AND VIEWS
1095 Beyond the age of cellular discovery
Jonathan Michael Irish
see also p 1181
1097 Systematic analysis of immunodeficiency
David F Tough
see also p 1134
1099 ParadYm shift: Ym1 and Ym2 as innate immunological regulators of IL-17
Gaia Muallem & Christopher A Hunter
see also p 1116
1100 The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3
Manira Rayamajhi & Edward A Miao
see also p 1126
1103 RESEARCH HIGHLIGHTS
REVIEW
1104 Molecular regulation of effector and memory T cell differentiation
John T Chang, E John Wherry & Ananda W Goldrath
Figure 5
A RT I C L E S
1116 Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between
nematode killing and host damage
Tara E Sutherland, Nicola Logan, Dominik Rückerl, Alison A Humbles,
Stuart M Allan, Venizelos Papayannopoulos, Brigitta Stockinger, Rick M Maizels &
see also p 1099
Judith E Allen
The physician scientist (p 1092)
Nature Immunology (ISSN 1529-2908) published monthly by Nature America Inc. trading as Nature Publishing Group, 75 Varick Street, Fl 9,
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© 2014 Nature America, Inc. All rights reserved. Printed in USA.
i
VOLUME 15 NUMBER 12 DECEMBER 2014
1126 RNA viruses promote activation of the NLRP3 inflammasome through a RIP1RIP3-DRP1 signaling pathway
Xiaqiong Wang, Wei Jiang, Yiqing Yan, Tao Gong, Jiahuai Han, Zhigang Tian &
see also p 1100
Rongbin Zhou
1134 A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is
impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4
Laia Alsina, Elisabeth Israelsson, Matthew C Altman, Kristen K Dang, Pegah Ghandil,
Laura Israel, Horst von Bernuth, Nicole Baldwin, Huanying Qin, Zongbo Jin,
Romain Banchereau, Esperanza Anguiano, Alexei Ionan, Laurent Abel, Anne Puel,
Capucine Picard, Virginia Pascual, Jean Laurent Casanova & Damien Chaussabel
see also p 1097
1143 A central role for Notch in effector CD8+ T cell differentiation
Ronald A Backer, Christina Helbig, Rebecca Gentek, Andrew Kent, Brian J Laidlaw,
Claudia X Dominguez, Yevan S de Souza, Stella E van Trierum, Ruud van Beek,
Guus F Rimmelzwaan, Anja ten Brinke, A Marcel Willemsen, Antoine H C van Kampen,
Susan M Kaech, J Magarian Blander, Klaas van Gisbergen & Derk Amsen
1152 Autophagy is essential for effector CD8+ T cell survival and memory formation
Xiaojin Xu, Koichi Araki, Shuzhao Li, Jin-Hwan Han, Lilin Ye, Wendy G Tan,
Bogumila T Konieczny, Monique W Bruinsma, Jennifer Martinez, Erika L Pearce,
Douglas R Green, Dean P Jones, Herbert W Virgin & Rafi Ahmed
Immunological functions of chitinase
(pp 1099 and 1116)
1162 A microRNA upregulated in asthma airway T cells promotes TH2 cytokine
production
Laura J Simpson, Sana Patel, Nirav R Bhakta, David F Choy, Hans D Brightbill,
Xin Ren, Yanli Wang, Heather H Pua, Dirk Baumjohann, Misty M Montoya,
Marisella Panduro, Kelly A Remedios, Xiaozhu Huang, John V Fahy,
Joseph R Arron, Prescott G Woodruff & K Mark Ansel
1171 The transcription repressors Bach2 and Bach1 promote B cell development by
repressing the myeloid program
Ari Itoh-Nakadai, Reina Hikota, Akihiko Muto, Kohei Kometani, Miki Watanabe-Matsui,
Yuki Sato, Masahiro Kobayashi, Atsushi Nakamura, Yuichi Miura, Yoko Yano,
Satoshi Tashiro, Jiying Sun, Tomokatsu Ikawa, Kyoko Ochiai, Tomohiro Kurosaki &
Kazuhiko Igarashi
npg
© 2014 Nature America, Inc. All rights reserved.
Autophagy and memory (p 1152)
RESOURCE
Virus-induced inflammasome
activation (pp 1100 and 1126)
1181 High-dimensional analysis of the murine myeloid cell system
Burkhard Becher, Andreas Schlitzer, Jinmiao Chen, Florian Mair, Hermi R Sumatoh,
Karen Wei Weng Teng, Donovan Low, Christiane Ruedl, Paola Riccardi-Castagnoli,
Michael Poidinger, Melanie Greter, Florent Ginhoux & Evan W Newell
see also p 1095
NATURE IMMUNOLOGY CLASSIFIED
NATURE IMMUNOLOGY
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