Isotopes for Nuclear Medicine
CONTENT
ABOUT CMR . .
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OXYGEN-18 (I.E. ≥ 98%) FOR PET-TOMOGRAPHY .
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REAGENT KITS FOR FDG PRODUCTION .
STABLE ISOTOPES .
ISOTOPES FOR LABELLED COMPOUNDS . .
RADIOPHARMACEUTICALS . .
CONTACT US .
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www.isotope-cmr.com
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ABOUT CMR
Center of Molecular Research known
as CMR is a Russian isotope production company which is included into the
group of companies, founded in 1993. By
now our company is one of the world’s
largest manufacturers and suppliers of
Oxygen-18 water and other stable isotopes worldwide. For more than twenty
years Center of Molecular Research has
been a reliable supplier of isotopes for
our customers in different industries
basically nuclear medicine, science and
industry. Our Product List includes various stable and industrial isotopes.
Briefly about our products
CMR is the manufacturer of GMP certified stable isotope Oxygen-18 water.
Moreover we try to satisfy customs needs
in full that’s why we offer a wide range of
reagent kits, chemicals for PET-tomography and PET precursors. All CMR reagents are produced in clean rooms and
dispensed under controlled conditions.
Material and kits are sterile and nonpyrogenic. Vials are doubly packaged in
a special vacuum bag within a compact
carton box.
We offer enriched stable isotopes for cyclotron and reactor targets. This list includes
the following elements: Xe-124, Te-124,
Ni-64, Tl-203 and many others. CMR is
ready to accept orders for almost full range
of isotope elements of Periodic Table. Our
full Product List is always available on our
web-site or can be sent by e-mail after request for it.
Industrial isotopes are also on our Product
List. There are Heavy Water, Depleted Zinc
Oxide, Lithium-7 Hydroxide Monohydrate
and others.
We constantly expand assortment of products
and now are ready to organize supplies of
radioactive isotopes. We have experience
of delivery Radiopharmaceuticals and
Generators Tc-99m all over territory Russian Federation.
We offer high quality products due to the
fact that manufacture process totally complies with applicable international standards as well as national and is certified by
GMP authorities.
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OXYGEN-18 (I.E. > 98%) for PET-TOMOGRAPHY
CAS
number
Isotopic
Enrichment
Molecular
Weight
14314-42-2
≥ 98 %
20.02
H2 O
18
GMP certified
Product description: Enriched Oxygen-18 water is used as a target which is
bombarded with the help of cyclotron
or linear accelerator in order to produce
Flourine-18. Flourine-18 is synthesized
into
2-deoxy-2-18F-β-D-glucopyranose
18
( F-FDG) which is a radiolabelled sugar
molecule used in PET (Positron emission tomography) for determining sites
of abnormal glucose metabolism and for
localization of many types of tumors. Today 18F-FDG is the most widespread and
successful PET radiopharmaceutical. 18FFDG is an analogue of glucose, it is injected in vivo and then 18F-FDG is transported from blood to tissues in a way similar
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to glucose. Cells absorb FDG like glucose
but it cannot be metabolized. A very important advantage of FDG-PET is that it
helps accurately define stage and sites of
recurrent disease in many cancer types.
Packaging: we supply Oxygen-18 water
in the borosilicate US standard glass vials
with rubber-stoppers and aluminum crimp
seals. The vials special sterilized prior to
filling.
F-FDG structure
18
HO
HO
OH
OH
18F
REAGENT KITS for FDG production
CMR supplies a wide range of reagent kits,
chemicals for PET-tomography and PET
precursors.
All CMR reagents are produced in clean
rooms and dispensed under controlled
conditions. Material and kits are sterile and
non-pyrogenic. Vials are doubly packaged
in a special vacuum bag within a compact
carton box.
We also supply other materials. Please contact us for more information.
Cryptand 222
Acetonitrile Anhydrous
CAS
number
Purity
Molecular
Weight
CAS
number
Assay
Molecular
Weight
23978-09-8
> 99 %
376.49
75-05-8
> 99,8 %
41.05
CH3CN
C18H36N2O6
Triflate Mannose
CAS
number
Purity
Molecular
Weight
92051-23-5
> 99 %
480.37
C15H19F3O12S
Hydrochloric Acid
CAS
number
Appearance
Bacterial
endotoxins
7647-01-0
clear, colorless
liquid
< 10.0 I.U./ml
HCL
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STABLE ISOTOPES
CMR provides a wide range of stable isotopes. We do our best in order to meet the
needs of our customers most effectively.
Stable isotopes offered by our company to
its clients are produced by several methods
including:
• the gas centrifuge method
• electromagnetic separation
• rectification separation
• photo-chemical method
• chemical exchange separation method
We provide stable isotopes which serve as a
basis for the state-of-the-art technology in
different spheres of human activities:
• the production of radiopharmaceuticals
• fundamental and goal-oriented researches
• creation of high-precision measurement instruments and devices for
technical and medical diagnostics.
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Ag 107, 109
Ar 36, 38, 40
Ba 130, 132, 134, 135, 136, 137, 138
Ca 40, 42, 43, 44, 46, 48
Cd 106, 108, 110, 111, 112, 113, 114, 116
Ce 136, 138, 140, 142
Cr 50, 52, 53, 54
Cu 63, 65
Dy 156, 158, 160, 161, 162, 163, 164
Er 162, 164, 166, 167, 168, 170
Eu 151, 153
Fe 54, 56, 57, 58
Ga 69, 71
Gd 152, 154, 155, 156, 157, 158, 160
Ge 70, 72, 73, 74, 76
Hf 174, 176, 177, 178, 179, 180
In 113
Ir 191, 193
K 39, 40, 41
Kr 78, 80, 82, 83, 84, 86, 124, 126, 128, 129
La 138, 139
Lu 175, 176
Mg 24, 25, 26
Mo 92, 94, 95, 97, 98, 100
Nd 142, 143, 144, 145, 146, 148, 150
Ni 58, 60, 61, 62, 64
Os 184, 186 187, 188, 189, 190, 192
Pb 204, 206, 207, 208
Pd 102, 104, 105, 106, 108, 110
Rb 85, 87
Re 185, 187
S 32, 33, 34, 36
Sb 121, 123
Se 76, 77, 78, 80, 82
Si 28, 29, 30
Sm 144, 147, 148, 149, 150, 152, 154
Sn 112, 115, 116, 117, 118, 119, 120, 122, 124
Sr 84, 86, 87, 88
Te 120, 122, 123, 124, 125, 126, 128, 130
Ti 46, 47, 48, 49, 50
Tl 203, 205
W 180, 182, 183, 184, 186
Xe 124, 126, 128, 129, 130, 131, 132, 134, 136
Yb 168, 170, 171, 172, 173, 174, 176
Zn 64, 66, 67, 68, 70
Zr 90, 91, 92, 94, 96
Stable Isotopes in Gas Form
C13
Deuterium 2D
He3
Kr78, 80, 82, 83, 84, 86
Ne20
Ne22
N15
O18
Xe124, 126, 128, 129, 130, 131, 132, 134, 136
Different types of valves are available:
¼ NPT, DIN-477, G ¾, G ⅝ and many others.
Different volumes are available: 0,5 L, 1 L,
2 L or more, depending on customer’s preferences.
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ISOTOPES for LABELLED COMPOUNDS
We provide a wide range of isotopic materials for synthesis and manufacturing of
labelled compounds. Main of them are
deuterium gas, D2O, Tritium, O-18, C-13,
C-14, Lu-177, Ga-68. These materials can
be ordered from our warehouse for fast
delivery. Many others isotopes can be prepared on a special request.
• D2O WATER
• O-18
• DEUTERIUM GAS
• TRITIUM
• C-13
• Lu-177
• C-14
• Ga-68
• and many others
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RADIOPHARMACEUTICALS
Technetium-99m generator GT-4K
Areas of application: Tc-99m generator is
intended for multiple production of sterile
pyrogen-free sodium pertechnetate in physiological saline solution (0,9% NaCl).
Sodium pertehnetate is applied in medicine
for diagnostic use. This important radiopharmaceutical is being introduced in human’s
body in the process of isotope scanning of
thyroid, sialaden, gaster and encephalon; radionuclide angiocardiography and ventriculography. Additionally, sodium pertechnetate
is used for getting various radiopharmaceuticals on the basis of kits of appropriate reagents applied in the process of diagnostic of
lungs, bones, nephros and liver.
Parent Isotope activity
4 GBq, 6 GBq, 8 GBq,
11 GBq, 19 GBq
Appearance
Colorless, transparent solution
Radioactive
concentration
74 - 3700 MBq/ml
pH
4.0-7.0
Radiochemical purity
not less than 99.0%
Expiry
15 days from the production date
Generator weight
14 kg (weight of generator including the package)
Sodium Iodide I-131
Indication: Diagnostics and thyroid gland
treatment: for an evaluation of thyroid
gland function, scanning and scintigraphy
of thyroid gland at various diseases, including for diagnostics of infringement of thyroid gland functions, and also small-celled
cancer of a thyroid gland and metastasises.
With a view of therapy, Sodium iodide
I-131 is used for thyrotoxicosis treatment
and metastatic cancer of a thyroid gland.
Sodium o-Iodohippurate I-131
Indication: Diagnostics of kidneys diseases.
Sodium Iodide I-131 in isotonic solution
Indication: Diagnostics and thyroid gland
treatment.
Kits for Technetium-99m generator
lyophilizate for preparation of solution for
intravenous introduction.
Description
Bromezida,
Tc-99m
Macrotech,
Tc-99m
Pentatech,
Tc-99m
Indications
Bromezida, Tc-99m is suitable agent for dynamic
scintigraphy of the hepatobiliary system.
Macrotech, Tc-99m is suitable for scintigraphy of the lungs.
Pentatech, Tc-99m is suitable agent for
dynamic scintigraphy of the kidneys, for
glomerular filtration rate measurements,
for radionuclide angiocardiography, for
visualization of the brain tumours.
Description
Technemag,
Tc-99m
Indications
Technemag, Tc-99m is suitable agent for
evaluation of renal function radionuclide
measurements.
Technemek, Tc-99m is suitable agent for
scintigraphy of the kidneys, has proven
valuable in the detection of the size, shape,
position and presence of the damage of the
kidneys and its function.
Technephyte, Tc-99m is suitable agent for
liver scintigraphy, has proven valuable in the
Technephyte,
detection of the shape, size and presence of
Tc-99m
the damage of the liver and spleen at tumours,
cirrhosis, hepatitis and others diseases.
Technephore, Tc-99m is suitable agent for
Technephor, bone scintigraphy, has proven valuable in the
Tc-99m
detection of primary and metastatic tumours,
osteomyelitics, bone-joint tuberculosis etc.
Phosphotech, Tc-99m is suitable agent for
Phosphotech, bone scintigraphy, has proven valuable in the
Tc-99m
detection of primary and metastatic tumours,
osteomyelitics, bone-joint tuberculosis etc.
Teoxim, Tc-99m is suitable agent for regional
Teoxim,
cerebral blood flow scintigraphy and for
Tc-99m
white blood cell Labelling in vitro.
Pirphotech,99m Tc is suitable agent for bone
Pirfotech
scintigraphy, detection of acute myocardial inTc-99m
farctions and malignant tumours of the ovaries,
for the red blооd cells (АВС) labeling in vivo.
Technemek,
Tc-99m
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REPRESENTATIVES WORLDWIDE
• Argentina
• Australia
• Austria
• Belarus
• Belgium
• Brazil
• Canada
• Chile
• China
• Colombia
• Finland
• France
• Germany
• Holland
• India
• Indonesia
• Italy
• Japan
• Jordan
• Kazakhstan
• Kuwait
• Malaysia
• Mexico
• New Zealand
• Oman
• Pakistan
• Saudi Arabia
• South Korea
• Sweden
• Taiwan
• Turkey
• The UK
• The United
Arab Emirates
• The US
• Ukraine
• Uruguay
• Venezuela
• Vietnam
Russia, Moscow
Tel.: +7 495 662 9492
[email protected]
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11 • •
Russia, Moscow
Tel.: +7 495 662 9492
[email protected]
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