Supplementary material online
Wybraniec MT, Mizia-Stec K, Więcek A. Contrast-induced acute kidney injury: the dark side of cardiac
catheterization. Pol Arch Med Wewn. 2015; 125: xx-xx.
Table S1 Different definitions of acute kidney injury
KDIGO 2012 Guidelines; definition of CI-AKI by Harjai et al.[1,4]
Stage
1
KDIGO Guidelines 2012
Harjai et al.[1,4]
change in SCr
diuresis
change in SCr
≥1.5–1.9 × ↑SCr
↓UO <0.5 ml/kg/h
>1.25 × ↑SCr within 48 ha
within 7 daysa
for ≥6 h
and
or
↑SCr by ≤44 µmol/l
↑SCr by >26.2 µmol/l (0.3
(0.5 mg/dl)
mg/dl) within 48 ha
2
≥2.0–2.9 × ↑SCra
↓UO <0.5 ml/kg/h
>1.25 × ↑SCr within 48 h
for ≥12h
and
↑SCr by > 44 µmol/l
(0.5 mg/dl)
3
≥3.0 × ↑SCr
↓UO <0.3 ml/kg/h
or
for ≥24 h
SCr ≥ 353.6 µmol/l (4 mg/dl)
or
or
anuria for ≥12 h
RRT initiation
or
↓eGFR <35 ml/min/1.73 m2
in patients aged <18 y
diuresis
RIFLE classification; AKI Network criteria[2,3]
Stage
RIFLE classification
AKI Network criteria
change in SCr
diuresis
change in SCr
diuresis
riskc or stage
≥1.5–1.9 × ↑SCr
↓UO <0.5
≥1.5–1.9 × ↑SCr
↓UO <0.5 ml/kg/h
1d
within 7 days a
mL/kg/h
within 48 h
for ≥6h
or
for ≥6h
or
↓eGFR by ≥25% b
↑ SCr by ≥26.2
µmol/l (0.3 mg/dl)
injuryc or
≥2.0–2.9 × ↑SCr
↓UO <0.5
≥2.0–2.9 × ↑SCr
↓UO <0.5 ml/kg/h
stage 2d
within 7 days a
mL/kg/h
within 48 h a
for ≥12h
or
for ≥12h
↓eGFR by ≥50% b
failurec
≥3.0 × ↑SCr
↓UO <0.3
≥3.0 × ↑SCr
↓UO <0.3 ml/kg/h
or
within 7 days a
ml/kg/h for ≥24
within 48 h a
for ≥24 h
stage 3d
or
h
or
or
SCr >353.6 µmol/l (4
or
SCr >353.6 µmol/l (4
anuria for ≥12 h
mg/dl) and acute ↑ by > 44
anuria for ≥12 h
mg/dl) and acute ↑ by
µmol/l (0.5mg/dl)
> 44 µmol/l (0.5
or
mg/dl)
↓ eGFR by ≥75% b
or
RRT initiation
a relative to initial SCr; b relative to initial eGFR; c refers to the RIFLE classification filtration rate
d refers to the AKI Network criteria
Abbreviations: eGFR, estimated glomerular filtration rate; RRT, renal replacement therapy; SCr, serum
creatinine concentration; UO, urine output
Table S2 Mehran CI-AKI risk score [adapted from ref. 7]
Risk factor
Points
1. hypotension
5
2. IABP use
5
3. heart failure - NYHA III-IV class
5
4. >75 years old
4
5. anemia
3
6. diabetes mellitus
3
7. volume of contrast media (per 100 ml)
1
8. SCr >1.5 mg/dl
4
9. eGFR (MDRD
formula)
40-60 ml/min/1.73 m2
2
20-40 ml/min/1.73 m2
4
<40 ml/min/1.73 m2
6
points
CI-AKI risk [%]
RRT risk [%]
1-year mortality [%]
≤5
7.5
0.04
2.0
6-10
14.0
0.12
5.7
11-15
26.1
1.09
13.5
≥16
57.3
12.6
33.0
Abbreviations: IABP, intra-aortic balloon pump; NYHA, New York Heart Association, SCr,
serum creatinine soncentration; MDRD, Modification of Diet in Renal Disease; RRT, renal
replacement therapy