Thank you for downloading this presentation. This presentation is provided by Orexo US, Inc. for educational purposes only and may not be modified in any way. Your use of this presentation is governed by and subject to the following terms of use. If you do not agree to these terms, please do not use this presentation. BY USING THIS PRESENTATION, YOU ACKNOWLEDGE THAT YOU HAVE READ, UNDERSTAND AND AGREE TO THESE TERMS This presentation provides information about a range of topics. Like any print material, it may become out of date over time. It is important that you rely on the advice of a healthcare professional to employ good clinical judgment for the specific conditions of individual patients. This information is not intended to be a substitute for the advice of a healthcare professional, or a recommendation for any particular treatment plan. All content, names, logos, trademarks, service marks, characters, graphics, designs, copyrights, trade dress, or other intellectual property appearing in the presentation, and the organization, compilation, look and feel, illustrations, artwork, and other works in this presentation are owned by Orexo US, Inc. and its affiliates or used with permission or under license from a third party and are protected under copyright, trademark, and other intellectual property and proprietary rights laws. This presentation is intended for use by residents of the United States aged 18 years and older. 2015 Orexo US, Inc. © All Rights Reserved Think about small town America. Think about one town in particular. Let’s say its population is close to 17,000 people. Now imagine that over the course of 12 months, every single one of those people was killed. And now imagine that the exact same thing is going to happen next year in another small town. And another town the year after that. Every day in America, something is killing 46 people.1 They are our neighbors, our friends, our family. 46 people a day, spread out over 365 days a year. The size of a small town. A small town in America. Simply wiped off the face of the Earth. We think it’s about time someone did something about it. THE MONSTER IS ACCIDENTAL OPIOID ADDICTION. There is a Monster. The Monster is real. A Monster that can take from you what you most prize. A Monster that can kill. The Monster doesn’t care if you’re rich or you’re poor. The Monster doesn’t distinguish between college-educated and high school drop-out. The size of your home, the color of your skin, the strength of your moral fiber — none of it makes a bit of difference to the Monster. LOVING PARENT. TEACHER. BROTHER. ADDICTED. In 2011, over 200 million opioid prescriptions were written for pain management.2 Prescription opioids are a type of narcotic pain medication, prescribed to treat moderate or severe pain. Opioid drugs work by binding to opioid receptors in the brain, spinal cord, and other areas of the body thereby reducing the intensity of pain signals that reach the brain.3 However, frequent opioid use can physically change the brain to the point where it needs opioids just to function normally.4 It is estimated that about 5% of people who have been prescribed opioids by their doctor will develop an addiction.5 Right now in America, more than four and a half million people are at risk of succumbing to the Monster because THEY ARE MISUSING PRESCRIPTION OPIOIDS. 6 Misusing opioids doesn’t mean these men and women are bad people. They're not lacking in moral fiber. They were prescribed opioids by their doctors for genuine reasons. Post-childbirth pain. An injury suffered at work. Lingering pain from surgery. Managing the chronic pain associated with rheumatoid arthritis. But long term use of opioids can lead to addiction.5 And like other chronic diseases, such as diabetes or high blood pressure, the likelihood of developing addiction is influenced by a combination of genetic and environmental factors.4,7 So through possibly no desire or fault of their own, these men and women find themselves in the grasp of the Monster. We call this Monster “Accidental Opioid Addiction.” Although it is accidental, opioid addiction can have deadly consequences. Over 16,000 people a year die in the U.S. from an overdose of prescription pain relievers.1 This Monster doesn’t just wound. It kills. Drug overdoses are the number one accidental killer in this country.8,9 It’s not car crashes, it’s not workplace accidents. And it’s not complications from surgery. It’s drug overdoses, driven by opioid use.8 The Monster that is accidental opioid addiction contributes to over 16,000 deaths a year.8,9 And yet, the Monster remains in the shadows, where it does its best work. Where it can isolate its victims and convince them they're alone in this struggle. The Monster seeks out people who are in legitimate pain and then promises to help. But in addition to pain relief, the Monster can also deliver suffering, regret and degradation. Our society has been conditioned to view addiction as a weakness, an inability to control ones self. That is what the Monster wants. To shame you, to isolate you. And to then manipulate you into actions you never once would have thought possible. Marginalize me. Generalize me. Mislabel me. Ignore me. SO LONG AS YOU… FEED ME. Our communities and even our economy have been ravaged by the Monster. A rise in crime and disease — that’s the Monster’s doing. Fraying and fracturing relationships with friends, family, co-workers, classmates — that’s what the Monster does. Leading men and women towards heroin — a cheaper substitute for prescription pain relievers10 — that’s the work of the Monster. Our hospitals are overrun with 1.4 million emergency room visits a year from people misusing prescription medicines including opioids.8 In 2007, the last comprehensive survey totaled the cost of battling the Monster at $56 billion per year.8 That is on par with the cost of treating more recognized diseases including stroke and asthma.11,12 The Monster is a thief. Stealing the dignity of those in pain and driving many to indescribable lengths as it seeks to maintain the relationship. The Monster occupies the body and hijacks the mind. The effect of opioid addiction on our lives, our families, and our loved ones IS MONSTROUS. Those under the spell of the Monster will often go to great lengths to CONCEAL ITS EXISTENCE. This can be due to shame, embarrassment or the seductive grip of the Monster. Regardless, these following behaviors and emotions may be signs of opioid addiction:13 _Mood _ swings, depression, anger and irritability _Marital _ or relationship problems _Social _ isolation, loss of friendships _Poor _ performance at school or work resulting in financial problems _Borrowing _ or owing money, selling of personal or family possessions _Arrests _ for driving under the influence, stealing, drug dealing People with opioid addiction will experience withdrawal symptoms when they stop taking opioids, even for a short time. These symptoms may include:4,14,15 _Tearing _ _Runny _ or stuffy nose _Yawning _ _Sweating _ _Chills _ _Muscle _ pain _Nausea _ _Vomiting _ _Cramps _ _Diarrhea _ _Anxiety _ _Cravings _ _Trouble _ sleeping If you fear that you or someone you know is battling the Monster, know that OPIOID ADDICTION However, for any treatment to be effective, the person living with the Monster must first assume personal responsibility for their actions. Opioid addiction is a chronic condition in need of long-term management, but there is no single treatment that is right for everyone.4 Research has shown that when treating substance use disorders, such as opioid addiction, responsible Medication Assisted Treatment, or MAT, in combination with counseling is the best choice.4 There are specially trained doctors who can treat addiction and are certified to prescribe MAT. If you or someone you know is struggling with the Monster, speak with a certified doctor about a personalized treatment plan. CAN BE SUCCESSFULLY TREATED. IN ORDER TO BEAT THE MONSTER, WE MUST FIRST BE ABLE TO SEE THE MONSTER. For what it is and what it isn’t. Exposing the Monster to the world and providing a clear path forward to defeating it, is at the heart of everything we do. Every day the Monster grows, capturing more of our mothers, fathers, brothers, sisters and friends. At OREXO, we won’t stop until everyone understands what the Monster is and how best to fight it. The Monster cannot be defeated alone. It is going to take all our efforts. And it begins by acknowledging that the Monster is real. Please spread the word about this plague that’s laying waste to our families, our communities and our lives. Monsters prefer to live in the shadows. The more light we can shine, the less places the Monster can hide. THE MONSTER HAS BEEN LOOSE FOR FAR TOO LONG. Terrorizing our homes, our offices, our communities, our lives. For far too long, the healthcare industry has tried unsuccessfully to tame the Monster. The Monster cannot be tamed. It must be fought. Responsible Medication Assisted Treatment (MAT) can take the fight to the Monster. OREXO is committed to destroying the Monster once and for all. And in the process, helping millions of people reclaim their lives. For more information and additional resources devoted to battling the Monster, visit: OutTheMonster.com 1 "Opioid Painkiller Prescribing." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 01 July 2014. http://www.cdc.gov/vitalsigns/opioidprescribing/ Accessed February 18, 2015. 2 Volkow, Nora. “Prescription Drug Abuse: It’s Not what the doctor ordered.” National Prescription Drug Abuse Summit. Orlando, FL. April 2012. 3 "Prescription Drug Abuse." National Institute on Drug Abuse. N.p., Nov. 2014. http://www.drugabuse. gov/publications/research-reports/ prescription-drugs/opioids/how-doopioids-affect-brain-body. Accessed February 18, 2015. 4 Medication-Assisted Treatment for Opioid Addiction: Facts for Families and Friends. N.p.: n.p., n.d. U.S. Department of Health and Human Services Substance Abuse and Mental Health Services Administration. 2011. http://store.samhsa.gov/shin/content/ SMA09-4443/SMA09-4443.pdf. Accessed February 18, 2015. 6 Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-48, HHS Publication No. (SMA) 14-4863. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2014. 5 "Opioids and Chronic Pain | NIH MedlinePlus the Magazine." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. http://www.nlm.nih.gov/medlineplus/ magazine/issues/spring11/articles/ spring11pg9.html Accessed February 18, 2015. 7 Sehgal N, Manchikanti L, Smith HS. Prescription opioid abuse in chronic pain: a review of opioid abuse predictors and strategies to curb opioid abuse. Pain Physician. 2012;15:ES67-ES92. 8 "Prescription Drug Overdose in the United States: Fact Sheet." Centers for Disease Control and Prevention. http://www.cdc.gov/ homeandrecreationalsafety/overdose/ facts.html. Accessed February 18, 2015. 11 Heart Disease and Stroke Prevention Addressing the Nation’s Leading Killers. http://www.cdc.gov/ chronicdisease/resources/publications/ aag/pdf/2011/heart-disease-andstroke-aag-2011.pdf. Accessed February 18, 2015. 9 Policy Impact: Prescription Painkiller Overdoses. N.p.: National Center for Injury Prevention and Control, 2011. 12 Asthma's Impact on the Nation: Data from the CDC National Asthma Control Program. Centers for Disease Control and Prevention. http://www. cdc.gov/asthma/impacts_nation/ asthmafactsheet.pdf. Accessed February 18, 2015. 10 “Every ‘Never’ I Ever Said Came True”: Transitions from opioid pills to heroin injecting. Mars, Sarah G. et al. International Journal of Drug Policy, Volume 25, Issue 2, 257 - 266 14 Kahan, Meldon et al. “Misuse of and Dependence on Opioids: Study of Chronic Pain Patients.” Canadian Family Physician 52.9 (2006): 1081. Print. 15 "Opiate Withdrawal: MedlinePlus Medical Encyclopedia." MedlinePlus. U.S. National Library of Medicine. http://www.nlm.nih.gov/medlineplus/ ency/article/000949.htm. Accessed February 18, 2015. 13 "Buprenorphine: An Office-Based Treatment for Opioid Dependence." City Health Information 27.4 (2008): 25-36. http://www.nyc.gov/html/ doh/downloads/pdf/chi/chi27-4.pdf. Accessed March 12, 2015. 2015 Orexo US, Inc. © All Rights Reserved ORX041 OutTheMonster.com Sponsored by
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