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Procedure/Use
Scale
1. Used as a
reagent.
This
chemical is
used in
experimental
processes at
scales no
64),#%&'(,)(1'5W!X+;,22+4A!><+!
more than
,-!-);+!<3/+:A<!-,1!01)4<-+1!,-!3/*3!
100 mL, at
G,:>2+!,-!;3+2/;):<!,4:@D!!!
temperatures
less than 100
o
Body Protection: Y+)1!
C, and at 1
N-/1+#-:)2+!1+</<0)40O!:)B!;,)0!
atm.
N$&&Z!;,00,4!B)<+AO[!;,00,4!
Further, for
work inside
B)<+A!;:,03/4*[!->::!:+4*03!7)40<!
a glove box:
,1!+Q>/G):+40[!)4A!;:,<+R0,+A!)4A!
use in experi;:,<+R3++:+A!<3,+<D
mental
processes at
scales less
than 20 mL,
at temperatures less
o
than 100 C,
and at 1 atm.
Any deviation from this SOP requires approval from PI.
Notes
Initials of individuals
using this
procedure
Engineering
Controls/Equipment
Nitromethane is highly
flammable and must be
kept away from potential
sources of ignition, and
stored separately from
other combustable
materials. Nitromethane is
classified as a potential
explosive; when heating
nitromethane on large scale
(>1g), a blast shield should
be used. Due to the
potential for explosion,
oxidants should not be
mixed with nitromethane.
PPE (eye, face, gloves,
clothing)
Eye protection: safety glasses
with side shields or tightly fitting
safety goggles
Hand Protection: Use nitrile or
neoprene gloves.
Procedure Steps and Special
Precautions for this Procedure
For working outside of the glove box,
nitromethane should be transferred from
the reagent bottle using a pipette or a
cannula. Reagent bottles should be
stored in the flammable cabinet.
!
!
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Procedure/Use
Scale
2. Used as a
solvent in an
organic reaction.
100 mL is the
maximum
quantity that
may be used
without P.I.
permission.
Notes
Initials of individuals
using this
procedure
Engineering
Controls/Equipment
Nitromethane is highly
flammable and must be
kept away from potential
sources of ignition, and
stored separately from
other combustables.
Nitromethane is classified
as a potential explosive,
and consequently when
heating nitromethane on
large scale (>1g) a blast
shield should be used. Due
to the potential for
explosion, oxidants should
not be mixed with
nitromethane.
PPE (eye, face, gloves,
clothing)
Eye protection: safety glasses
with side shields or tightly fitting
safety goggles
Procedure Steps and Special
Precautions for this Procedure
For working outside of the glove box,
nitromethane should be transferred from
the reagent bottle using a pipette or a
cannula. Reagent bottles should be
Hand Protection: Use nitrile or
stored in the flammable cabinet.
neoprene gloves.
Distillation requires heating above the
flash point (35 °C) and should be done
64),#%&'(,)(1'5W!X+;,22+4A!><+! with care under a nitrogen atmosphere.
,-!-);+!<3/+:A<!-,1!01)4<-+1!,-!3/*3! When distilling nitromethane, use
MgSO4 as the drying agent. In addition,
G,:>2+!,-!;3+2/;):<!,4:@D!!!
distillation must not be done with an
open flame, and a heating mantel
Body Protection: Y+)1!
should be used.
Further, for
work inside
a glove box:
use in
experimental
processes at
N-/1+#-:)2+!1+</<0)40O!:)B!;,)0!
scales less
N$&&Z!;,00,4!B)<+AO[!;,00,4!
than 20 mL,
at
B)<+A!;:,03/4*[!->::!:+4*03!7)40<!
temperatures
,1!+Q>/G):+40[!)4A!;:,<+R0,+A!)4A!
less than 100
;:,<+R3++:+A!<3,+<D
o
C, and at 1
atm.
Any deviation from this SOP requires approval from PI.
!
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