DSM and White Biotechnology
Feike Sijbesma
Chairman Managing Board Royal DSM
BioVision, Lyon, 8 March 2009
DSM White Biotechnology
Company Profile 2009 Royal DSM
8
Focus on:
LIFE SCIENCES & MATERIALS SCIENCES
Sales:
~ € 9 billion
Employees: ~ 23.500
Sites:
> 200 locations worldwide
Triple P Company (people - planet - profit)
DSM White Biotechnology
DSM: Ability to change
100 years of successful transformations
Evolution
Bioterials / Biologics
Life Science Products
Performance Materials
Petrochemicals
Fertilizers
Coal
• 1902 • 1930 • 1950 • 1970 • 1990 • 2000• 2010 Technological competences
Classical Biotechnology
DSM White Biotechnology
Mechanical engineering
Chemical engineering
Polymer technology
Material science
Fine chemicals
Modern Biotechnology
White Biotechnology: the next biotech S-curve
Industrial Applications today
Market
penetration
Bio-feedstock
• Replacement
oil/gas with
biomass
Bio-processes
Red
biotech
White
Biotech
• Replacement
chemical synthesis:
fermentation/biocat
Green
biotech
Bio-products
• Products with new
characteristics
(biopolymers, enz,
health ingredients)
DSM White Biotechnology
Today
Time
Key drivers for White Biotechnology
“We will harness the sun and the
winds and the soil to fuel our cars
and run our factories.”
Barack Obama inauguration speech
January 2009
Combination of Technology development - Climate Change/Energy/Sustainability
DSM White Biotechnology
Advantages have been demonstrated along
all dimensions of sustainability
People
•New jobs
•Broad technological capabilities
Planet
•Less emissions (water, air)
•Less energy
•Less resource depletion
DSM White Biotechnology
Profit
Lower costs
Lower risk
New products
DSM track record in White Biotechnology
Aldolases for cholesterol–
lowering drug
Vitamin B2
Cephalosporin
Arachidonic acid for infant nutrition
Maxiren for cheese industry
1990
1992
1994
1996
1998
DSM White Biotechnology
2000
2002
2004
2006
2008
DSM has unique technology capabilities
Technology
Crop
Processing
Biomass
Conversion
(Pretreatment/Enzyme)
DSM
Agro
manufacturers
Chem
manufacturers
Technology
providers
BioEthanol
Producers
DSM White Biotechnology
Sustainable Chemicals
Production
Ethanol
Other
More sophisticated
Derivatives
Production
&Applications
Focus on Life Sciences and Material Sciences
Climate and
Energy
Health and
Wellness
Functionality and
Performance
Life Sciences
Materials Sciences
EBAs
Nutrition
Pharma
Emerging
Economies
Performance
Materials
Polymer
Intermediates
Exploiting strong market positions and technology platforms
DSM White Biotechnology
Bio-Performance Materials:
A DSM EMERGING BUSINESS journey
BioMaterial
products
DSM Biotech
Toolkit
BioPolymers
BioBased
Chemicals
Carbon Source
Other renewables
Compounding
Formulation
Polymerization
Fermentation
Fermentation/
Chemical conversion
DSM Market
Strength
Phased approach to full integration
DSM White Biotechnology
While the innovation potential around traditional chemical
building blocks appears to be largely exploited…
Polymer innovation based on fossil building blocks
Ethylene
Propylene
Butadiene
Benzene
Toluene
Xylene
Methanol
UF
PF
1900
DSM White Biotechnology
Source: McKinsey
PED
PUR
PIB
PET
PA
SBB
LDPE
PMMA
BR
PS
PVC
1920
PPS
POM
PAR
PTFE
EPM
EDPM
iso.PP
HOPE
ABS
PAN
Epoxy
PBT
Silicone
1940
Latest New
Polymer:
DSM’s
ForTii
LLDPE
PEEK
PES
PI
PEI
1960
LCP
1980
2000
… new bio-based building blocks could create the next wave
of innovation in polymers and beyond
Polymer innovation based on fossil building blocks
Lactic acid
Succinic
acid
3HP
PDO
…
UF
PF
1900
DSM White Biotechnology
Source: McKinsey
PED
PUR
PIB
PET
PA
SBB
LDPE
PMMA
BR
PS
PVC
1920
PPS
POM
PAR
PTFE
EPM
EDPM
iso.PP
HOPE
ABS
PAN
Epoxy
PBT
Silicone
1940
LLDPE
PEEK
PES
PI
PEI
1960
New Polymers
• Sorona
• PLA
• PHs
• Blends…
LCP
1980
2000
Succinic acid production at DSM
• DSM produces succinic acid chemically in Linz – Austria
• Global production succinic acid (derivatives): ~ 25.000 T/Y
• Succinic acid used in:
–
–
–
–
Food (acidulant, flavor)
Coatings (car finish)
Pharmaceuticals (building block)
Coolant (engines)
DSM White Biotechnology
Why bio-succinic acid?
Producing succinic acid via biological routes has several
advantages:
1. Lower environmental impact
1.
2.
3.
4.
No use of fossil fuels (crude oil)
Bio-renewable feedstocks
Absorbs instead of emits CO2
Cost proposition allows for high volume green chemicals and materials
2. New biobased & biodegradable applications feasible
1. Production of ‘green’ plastics like PBS (for a.o. agricultural films)
2. Biobased fibers for clothing
3. Bio-based resins (e.g. polymer of bio-succinic acid and isosorbide
[biobased product made by Roquette])
DSM White Biotechnology
Why Roquette the partner in bio-succinic acid?
• Roquette is leading global producer of starch (products)
• Roquette/DSM share same beliefs for these technologies:
– Innovation by partnership approach
– Strong focus on sustainability
– Need for developing bio-based economy
• Roquette and DSM are a perfect match
–
–
–
–
Complementary skills and know-how
Unique strengths to develop and implement leading technology
Creating knowledge and strengths over the new value-chain
Innovation at the interface of Life-Sciences and Material Sciences
DSM White Biotechnology
The ROQUETTE Group today
ƒ Leading global producer of starch products ( Number 2 in
Europe; In the Top 4 in the world)
ƒ World leading producer of cereals-based specialties like
polyols e.g. Sorbitol, Mannitol, Maltitol, and pyrogen-free
dextrose and gluconate
ƒ 18 factories worldwide including the largest cereals based
biorefinery in Europe (Lestrem, F; using 7000 t/day of cereals)
Main Agricultural Raw Materials:
Corn, Wheat, Potatoe, Pea
Volume: 6 mln tons of renewable raw
materials (+ 550,000 hectares cultivated)
Employees: 6 000
Turnover: in excess of 2.5 billion €
Headquarters Lestrem (F)
ROQUETTE strongly committed
to sustainable innovation
A STARCH BASED CHEMISTRY
PIONEER
ƒ
250 FTE R&D in Lestrem
ƒ
R&D :40 Mln € per annum
ƒ
More than 20 patents filings
per annum
ƒ
ƒ
More than 100 researchpartnership agreements per
annum
Coordinator of 2 Innovation
programs (supported by Oséo
Innovation) : BIOHUB® &
ALGOHUB™
ƒ
BIOHUB®: program towards new
chemicals & new white biotech
processes [including the BioSuccinic project with DSM]
ƒ
GAIAHUB®: new functional
polymers program
PLAYING A LEADING EDGE ROLE IN
NUTRITION-HEALTH MARKET
ƒ
NUTRAHUB®: Health and
Nutrition program
ƒ
ALGOHUB™ , micro-algae
program
Bio-Succinic acid: striking example of CO2 abatement
CO2
CO2
GLUCOSE
Succinic acid
Succinic acid
Market approach via partnerships
Biobased thermoplastics
Biobased thermosets
Renewable
Feedstock
Bio-SA
Fermentation
ROQUETTE-DSM
Alliance
1,4-Butanediol, tetrahydrofuran
and derivatives
Esters: solvents
Salts: food and freezing point
depression applications
Value chain integration partners
Bio-succinic acid: a new green platform chemical
Esters:
solvents
Butanediol:
PBT plastics
THF:
Spandex /
Elastane
Biobased
resins:
coatings
Bio-based
Succinic Acid
Salts: deicing
Biobased
polymers:
agricultural film
Food: acidulant
Bio-Succinic acid :
Monomer for performance materials
starch
Enzymatic
hydrolysis
glucose
Fermentation
succinic
acid
hydrogenation
butanediol
PolyButylene
Succinate (PBS)
starch
starch
Enzymatic
hydrolysis
Enzymatic
hydrolysis
glucose
glucose
Fermentation
hydrogenation
succinic
acid
sorbitol
New biodegradable
polyesters for films
dehydration
isosorbide
PolyIsosorbide
Succinate (PIS)
New polyesters for
coatings
Mulch film based
on PBS
Powder coating
based on PIS
Bio-succinic acid well on schedule
Excellent collaboration between DSM and Roquette
Strongly committed partners
Strong technology position via in-house development & open innovation
As of mid 2008 we are operating a pilot equipment in Lestrem, France
Currently building demo-plant in Lestrem (several 100 MT) =>
operational end of 2009
Large scale manufacturing as of 2011/2012
Main conclusions
White Biotechnology will have a fundamental impact on the future of the
chemical industry, and in enabling society to respond to the challenges of
climate change, resource and energy scarcity
As the leader in White Biotechnology DSM is ideally positioned to take
advantage of the opportunities that exist around this technology;
conversely, a lack of White Biotechnology capability will represent a
major threat to the long-term viability of those businesses that don't
participate
DSM will work with several partners for the most unique product-market
combinations and for succinic acid we have found a perfect partner in
Roquette.
DSM White Biotechnology
Contact:
DSM MEDIA RELATIONS
P.O. Box 6500, 6401 JH Heerlen, The Netherlands
℡ (+31) 45 578 2421
(+31) 45 574 0680
e-mail: [email protected]
internet: www.dsm.com
Visiting address: Het Overloon 1, Heerlen, The Netherlands
DSM White Biotechnology