METO,qI4 TOCJIIAXEHH'
O B.C. Cyxan, 20'15
y.0K 616. 248-Q07
-
053. 1.615.98: 578. 835'13.
B.C. CYXAH
yxaopodctxuil uatgouanauud yuieepcumem, Qaxynamem nicnndunnouuoi'oceimu ma
doyuieepcumemcaxoi nidromo"ru, xaQedpa nynbMoHonoeil, Qmusiampilma Qisiomepanii, Yxeopod
HEEinAt43EpHA TEpAntr sK METo,q tHrAnnLltt4HoT AEPo3onbrEPAnli v nlKvBAHHl
XBOPl/IX HA EPOHXIANbHY ACTMY
3a ocraHue gecntunittR iHransqiriHa repania ehuurna Ha RricHo Hoeutfi pieeHu, Ll.lo 3yl\4oBneHo 3 BnpoBaAxeHHf,M
sat,lvae o4He
iHrannropie ocraHHboro noroniHHR - He6ynarasepie. Ha gaHnra vac noAaqa nixi vepes He6ynarisep
qac 3arocrpeHHb ra
s npoai4Hrax vicqu e cyqacHoMy iHrannr-liriHorr,ry niryeaHHi 6ponxianuHoi acrMtl, co6nueo niA
BaxKLrx nepe6irie 3axBoPtoBaHHR.
Knroqoei cnoBa: 6poHxianuHa acTMa, iHranqqitiHa aepo3onbrepanin' He6ynat'tsepu'
XXI cropiuufl xapaKrepl43yerbctl ulHpot(xM BnpoBaA)KeHHtM y xliHi,lHy [paKTHKy HoBHX ctlcreM Aocraexn :rirapcbKr4x flpenaparis y AHxaJlb]ll txJlflxH
xBopnx ir 6poHxolereHeBHMtl 3axBopIoBaHHflMH.
qK
Oco6rt4eo ue crocyerbcfl TaKoFo 3axBoploBaHHt'
6poHxianuua acrr'la (EA). Caue orruva:ruuuI en6ip
raco6y AocraBKH lixapcsxHx npelaparie, 3aJIexHo
eiA xriHiqlroro cral{y ra eixy xBoporo, BnJIItBae Ha
eQerrneuicru nixyeaHHr Aasoi xareropii xeopHx.
3vina niaxo.lis y rixyaauni EA eKasaua y pospo6rax
Ta BnpoBaAxeHHtx B [IpaKrlrKy oxopoHH 3AopoB'tl
ocHoBHux noroxeHb noroAxyBanbutlx Aoxyueuria
po6ouoi rpynr,i CINA (Clobal Initiative for Asthrna)
1995 p., neperrrAie 2002, 2006, 2001, 2008, 2009 pp'
Ae MeroAaM inI-arruiitloi repanii eiAeoAilrucr ettpirxalbHa pors [6, 15,32,33,34].
Poset4rox cyra*roi inranquifiHoi repanii po3fror{aBcq y cepeAraHi XIX cropiuun ir creopeuHt cKJlt-
iuralnropie neplxl4x npncrpoi'n. cnpoMoxHrlx
rlopnynarra uryvtri aepo:o:ri. OAut'rv i: neprunx anaparie A:rr po3rl4neHHt piaraH r Meroto iuranruii 6ye
3a[ponoHoBantrii LLIue.uepon'r i Baruuerv y I 826 p.
Ioprarneunft npncrpiii g qierc Merorc crnopue Qpa-
uux
nqy:rrnt7 eqenHfi Calec-fupou y 1859
y
p.
1872 p. e OrcQopAcbl(oMy cnoBHI'lt(y Bnepue
3'flenBct repltiH <He6ylaftrep>. He6ynafirepH Malorl
,uoery icropilo 3acrocyBaHH.q - 6rt{suxo 150 poxie.
YaocroHareHHq itrranruiiiuoi rexuolorii y rtacrynHi
porn 6yro noe'n3aHo: excnascieio iHNerropuux
iurannropia. Y 60 70-x pp.XX cropiuun isranrrtiiitta
repanin orpt4Mana uoeriil noryNHnfi
lMnynbc,
roe'qgaHHfi ir crsopeuHnv iH:uteiayalbHHX Ao3oBaHux iHrarqropia ra noleolo ynbrpa3ByKoBnx lHFaJIs"ropie 122,23,25,261.
Cepel cylacnr.lx saco6ie AocraBKh lixapcuxux
npenaparie BaxrHBofo 3HaqeHHfl Ha6yearcrs ue6yraiiseprz (eia nar. nebula - ryMaH, ro6ro <ryuattoyreoprceav>) - npncrpoi Ant po3nl4neHHfl JllKapcbKllx
npenaparie ta ix Aocrasru y arzxa,ruHi wtnxn 11 ,22,
23,261"
He6y:rafi:epnir't repanii siAeoAurF,cq BaxJluBe Mlcue y lixysaHHi ra pea6i:rirauii xsopltx is 6poHxorereHeBr.r\414 3axBoploBaHHtMu Ha ecix eranax HaAaHHt
veAwquoi AortoMorI'1. BoHu rr,toNyrb 3acrocoByBarHcr
xoauii cicuux
Vtrzopodca
qK [pr.4 cra6ilrHorvty nepe6iry xeopo6 opraHie 1uxaHHR, rarc i npra Ix :arocrpeu ui 126,21 '29,30)
Flacanrnepe.u, Ay)Ke Ba)I(nnBoro 3l{atleHHr ua6yaae
ue6ylalsepua repanil rrct dozocnimarbLto^ty emant, B
rouy vucli npa rraAartHi HeeiArraAHoi naeaaquoi AonoMorr.r. llpra urovy, uJI4poKo Bnl(opncroByroru 6po-
uxolitnxH, oporH3aIIaJlbHi npenaparrz uunxou ue6y14, 5,9, 12,281
IIa crnatliouapuouy entani He6y:raii:epHa repanin
raroN nociAac orHc r npoei.Duhx urcus y ,rixyeaHHi
:rirarrii
xBopllx
:
pecniparopHolo raroJloriero. I{e crocy€rbcn
raKux npenaparin, lx uyxolirlzxH,
6portxo,rirHxh, nporn3aIa,rnHi ra aurrr6arrepia-nsHi
BrlKop14crattHfl
:aco6l.l. 3apas nenoNnneo co6i ynBt'lrvl Qiriorepaneerrrqne eiAAireuur 6es iHra,'rnropiro 12,3' 13, l4'211.
Il a
e
m an
ox
s
id
H
oen rc e a,r
a
u oz
rt
n i xyo a n
n
n
(av6y -
JraropHo-ltonixniniqnHfi, caHaropHo-Kypoprurafi) ue-
6ylaiiaepHa repanir e ueeia'eN4Holo rlacrllHolo pea6irirauifiHoi nponpanlr'r y xBoprx Ha EA [10, l6' 11 ,
I 81.
3acrocyeauun ne6ynaft:epie 6ylo 3anponoHoBaHo
6araro poxie romy, o.[HaK JltauJe c60ro.IlHl BoHII
orpnMann [ilpoKe 3acrocyBaHHn y nixyeauHi xeopnx
r 6ponxoo6crpyKTtzBHI,IM ra cnacrlllHl4M cl4H,qpoMaMH. y TI4x BHnaAKax, rolu tteo6xiAHo BBecrn Bent,rKi
AorH rixie (npn ea>xxoruly Hanaai lryxx' npn 3arocrpeuHi narororiqsoro npouecy) crae oco6rileo AouiFIocrt
Jr bFr r.r r\4 3aBAfl rn i i e ucox i fi e(lexrvteuocri, 6es treq
201.
l9'
l,
18,
I
14,
ra eKoHoMHocri12,7,8,
Buacliaox rora,liraLtii naroroti'Jtlolo npouecy B
luxal b Hl.Ix ulJttxax naii6 il u ru e(le rrnu n H u c noco6ou
3acrocyBaHHr rixapcurux npenaparie nprl 6poHxolefeHeBux 3axBoprcBaHHrx e iunarqIlifiHrzr"l'
BnKJrlorra€Tbcr eQexr <first
-
flpu urouty
pass> (neptuofo npoxo-
Ay) ra 3HuxeHHR axrueHocti npenapary e neqiHui'
Cytreeoro nepeBarolo iura:rsuii;iuoi repanii e BHcoKa
roHueHrpauit MeArlKaMeHrie y ruxaJlblll'lx Jl'IXax
npH HerHaqsifi sararuFtiii xirsxocri llpen ary I
uusuxtafi piBeHb xoHuenrpattii e opraxirvi e uirovty
I
t, 20, 24,251.
Jlixapcsri peltoBllHH B aepo3oJtflx np14 lHralruiiiHon,ty cnoco6i 3acrocyBaFlHt BrlJIilBalorb Ha
6inuuy noBepxHlo c,'ttz:oeoi o6oloHrcn AilxaJlbHt4x
urrrxie, uo BeAe Ao niABnureHrrr (lapnaxo,'toriqsoi
lt1utaD, rltnycK
I
(51)' 2015 p'
METOII4 IIOCJIIIXEH}T'I
i
BnAaJte eerHri rlacrK14 aepo3onro. I-lr earrltlea
qacrnHa ue6ynaii:epa Bu3Flaqa€ i-tolo octtoeFti xapar-
ueu.[Kofo l'epaIeBTil'JHoro eQeKnpenapar noaacrbct Ao
,rixapcurcuil
roro,
ry. Kpirv
cJ'lH3oBl.rx o6oloHox eepxnix AuxaJlbHHX ru,rqxie i
J'IereHr, xivi.{Ho 6i,rrur axrrzeHnv suacli,a.oK po3nl4neHoro craHy y elrrnx4i aepo:onro [22].
Beruqnua qacroK (,uucnepcHicru), rirpocxoniquicru, TeMrteparypa, ereKTpl4rlHuh sapnr, ro:roe'Hi (laxropu ocaAy aepo3olro. tlacrxu Aiauterpou 8-10 vxv ociaarcrb y rlopoxHl4Hi pora i Hoca.
ei.[ 5 ao 8 vnn,t - y eepxHix AIxanbHnx unflxax I Tpaxer', aia 3 lo 5 N4KM - y Hnxtuix anxarbHux I'IlJItxax,
eia I ao 3 nxv - y 6pouxiorax, eia 0,5 4o 2 vxv - y
xovipxax. figpo$i,'Isli tracrKu npurtryrcrb BoAy 3
noeirpr, :6iruurytorrcn y po:rvipax ra ocinaroru y
eepxnix AuxirrlbHHX IUJItxax. fiapor!o6Hi qacrK14
TI.IBl-ro
aepo3onrc, HaBnaK14, OClAalOTb y At4cranbHHX AI4XarbHLrx rxJrrxax 122, 23, 251.
Aepo:oli, niair-piri Ao reMneparypu ri:ra (37 'C)'
6iruu: cra6i,ruHi. Aepoaolb 3 KpynHHNl14 qacrKaMil
nrae 6yrH nililpirr.ru. Aepo:ons : api6Huvtl qacrKa-
xaJlbHl4x
aKTHBHocri :rixie
MH He norpe6ye nilit'piey. roMV tuo reMneparypa
aepo3onrc nilerzulyerucn trp14 AoctlrHeHHi r:rta6oxtlx
eiaai,ria 6poHxoeoro AepeBa i xo:roAoeoro 6poHxocrra3My He BaHuKae. IIptl racrocyeaHHi cyracunx
ue6yrafrepis ni4irpie aepo3onrc ir porviporv qacroK
Ao 5 rrarn He norpi6eH [19,22,251.
He6ynafi:ep - npracrpifi, uo neperBopto€ po3qHH
rirapcunoro [penapary na,u.pi6uoancnepcrufi
aepo-
3oJt b.
lcHyroru Aea ocHoetri rnna He6ylafi:epis:
L Y,rurpa:eyxoei, e tKhx po3n]4JleHHt Aoctfaerb3aBAtKH eucoxoqacrorFrifi ei6pauii n'egoerexrprfrlHrzx rpucra:rie.,{lrcnepcHicru aepo:onie, lxi
yrBoplolorbct ynbrpa3ByKoBl4MH iHralrropauu,,uocr4rb Br4coKa i craHoeHru eia 2 ao 50 utrv. CycneH:ii,
nacrrHi po3rrnHI4 [paKTtTttHo He neperBoptotorbct Ha
aeporori 3a nonoMororc ynbrpa3ByKoBl4x lHraJlsropie. Ix He peKoN4eHAyerbcn BnKopncroByBaru nJlfl
cfl
po3nh,leHHfl pelloBhH,
lllo
Malo'Ib Be,lnKl MoneKynH
(Hanpnr,raA, attrtt6iornxtt). Heaoui:tsu14N4 e BilKopl"lcraHHt B ynbrpa3Byt(oBltx iHrarnropax Aoportlx
rirapcuxlrx npenaparie 'tepe: ix Bent'iKy Bnrpary y
Qa:i nlranxy. Icxyroru AaHi uroAo pyfiHyeaHun rarux
,rixapcuxnx npenaparie. nr inytrovo.uynflroplz, rnrcroxoprHxoiAu, cyp(raxraHr, renapl'iH, iucy,riu, nia
BnJruBoM ynbrpa3ByKy. 3a aonorulorolo uilx npllcrpote
MoxHa po3nilrloBarH ser]4xi o6'evn pialzHu (20-30
vt za 20-25 xnHnHu), ueo6xiAHi Ant [poBeAeHHfl
aialuocrr.r,rHHx AocliAxeHu (:oxpeva,,[n[ orpnN4aHHr iH,[yr<osatloro MoKporraHHx). He,uolit<ov ylsrpa3ByKoBhx
ix
iuralrropie
€ BHcoKa aapricrs,
ruupore 3acrocyBaHHn
22,23,25,261.
2" Kounpecopni,
y
uo
crpr4Mye
t<triHi'luift nparrraui [19,
T9p14CTllt(H.
Ilpnuuan po6orr.r crpyiittoro He6yrail:epa
3acHo-
eaHl.{ri Ha rar<oHi Eepwyni. floeirpr 3 KoMrpecopa
npoxoAr,ITt vepe: cneuia-nr'Hltt7 oreip HeBeJrnKol'o
po:nripy (eeHrypr,r), Ha suxoAi 3 tKoFo naAae rucr' I-le
niAeauye [BHAKlcrb ra3y ra npHBoAI4Tb Ao tlpoHr'iKHeHun pi.rrrHI qepe3 n'rir<porpy6ouKu 3 pe3epByapy.
Ilpra :n,riuryeanni pi.lnHn'ra noeirprHoro [oroKy
yrBoploerbcn aepo3onb. froro eertrxi '{acrrr4 ociAarcrb Ha sacrilrui ra ctiHrcax xauep i noBroplro po3nl4rrororucr. flpn uboMy, AtlcIepcHlcrb yrBopeHoro
aepo3onlo Korr4Ba€Tbct aia 0,5 Ao 5 vt<ir'1, [lo e onruAnfl npor{14KHeHHfl y Aucra,rsHi eiaaira luurrxie - 6porrxionr ra roviprcn. Kiluxicru
ur4x qacroK (pecnipa6enuuoi rfpaxuii) e nafi6irt'tl.t
MaJrbrrHM
Bax(JlHBolo xapaKrepncrllxoto ue6ylafisepa. flx npaBl4Jro, BoHa cKraaae He N4ellule Hirx 50% BiA 3aranbHol'
aepororsHoi' noryrxHocri npl'lcrpoto flletlAxicrs noroKy fa3y v rre6ylaii:epax craHoBI''lru 6 l0 ,r/xs, 'lac
po3rn4JreHHt - 5 10 xBlllll4H. Icnye gexinrKa rnrllB
KoMnpecopH Hx He6yraii:ePin:
l. 3eli.rafiHufi ue6ynaiirep, sxuit npaurc€ y
nocriiiHorvy pe>xutr,li. ftoro ocHoeuuii He.lorit< oorqfa€ y rol\{y, uo feHepa(lfl aepo3oJl}o [poxoAl4Tb y
rpa:y sgttxy ra Bl.ral4xy xBoporo, rolvly 3HaqHa qacrl4Ha aepo3onlo norpafinqc e arlaocrpepy i ltlule eiAHocno ueee:rnra (7%o) e rereHi [19,22,251
2. FTe6yrai-lrep, rrnii npauloe y nocririuorr,ty pexnpri ra 3acrocoByerbcfl BpyLlHy' BiH ei.npisunerscr
Tr.rM, ulo nauietrr N4ae 3Nlory y rpari ntl4ttxy nplznhHI4'ru suxig aepo3o.:tlo, TllM caMtlM 3N4eHUyloqu iloFo
Brpary e arrvocdtepY [3 l, 36, 38, 39],
3. He6ynafisep, nwuit ynpaBnflerr,ct BAIlxoN4 xBoporo i npawoe y rrvriuHolvy pe>rtHn,li. Tcttye cneutaluurzi;i KJranaH, axui.t 3aKpnBaerbcfl npt4 Bl"iAllxy
nauieura. IIpra usolly y aHxa,rrHi [IlrtxH florpannte
,rixapcsroro 3aco6y [3 I, 39].
4..{oruverprruHrlii ne6y,rail:ep, nxnit reHepye
aepo3onb rilsxtl y Qa3y BAtrxy 3aBArKH crleulanbHoMy KnanaHy, po6ororo n Koro Kepye e-nexrpoHutlii
.[arL14K. HeAonir<ov Uboro lpnJlaAy e 3HaqHa Tpuearicru oarriei iHrarsuii ra fioro BHcoKa eapricru [36,
| 5%o
3 81.
flepeearavu He6yraii:epuoi repanii y nopieHrHni
: iuruul,tn BHAaMH irrransuiIlro1'repanii e
a) vorxrrHeicrb 3acrocyBaHnr e 6yau-rrorvy niui y
3B't3Ky r eincyrHicno tteo6xiauocri cuHxpoHisauii
BArixy ra iHra,rsuii;
:
6) tuoNnraeicru iuranruii BllcoKHx Ao3 fipenapary;
s) Heeeruxa rlparcuix npenaparie, ulo ociAae e nopo)I{Htl}ll poTa;
y
tKwx reHepauir aeporomo
:AiIcuroerrct crtlcHeHilv noeirprv a6o K14cHeN4.
KorvtnpecopHi ne6ynafirepu cKraAalorbct 3 Kol\lnpe-
r) ei.acyruicrt rtponerettrie, u-to Iloapa3HrcIorb
luxaruHi tlJrflxti;
copa, nxriii e A)KeperoNt norot()' ra3y, Ta tte6y,raiirepHor' KaN4epn, ne 6etnocepetrtso po3nnrloerbcfl
pianna. Karvepa erlpirHrerscn eiA seu'lafiHoro lHrarflTooa HaseHicrto cneuianbHoi racliuxu, tKa cereK-
Kltcllto i ury'lrroi' eeHru,rruil JtereHb:
280
Hoyxoauit eicuurc
V)t
A)
voxnrrsicrb
e) npocrora
na[leHTa:
BKJltoLlellHfl
y
KoHTyp noAaql
rexHixt't ra rcov{roprHicrb
)ryisepcutneru1t, cepist <MedutlamaD' GunycK
I 61)'
Anfl
2015 p'
METOII4 IOCJIITXEHH.g
n<)
BKXOpI4CTaHHt nlKapcbl(l4x
exolotvtivHicru
IrpenaparlB]
r) uenAxa MicueBa 4in po6nru uel; MeroA 6inbul
Kopr4cHuM ra 6e:neqsuv y :lixynauHi sarocrpeHs o6-
y noplBHtHlrl 13
3afanbHonpufiHsroro c14crsMHolo iH{lylifiuoto rec'rpyKTHBHIIX 3aXBOprcBaHb JIefeHb
pariero
ll9, 22, 25,
3
1, 39),
lixyeautre 3arocrpeur EA e crauioHapHrx
yvroBax 6esnepevrti nepeBafl4 vae ue6ylaI3epHa repanir [14, 32,33,34, 40]. V uiil cnryauii e rni]riqHii
fiir
nparruui,
tK
rrpaBHno, B14Kop14croBy]orb Kol\lnpe-
copHi He6yrafirepra, ocrirul(14 yJlbrpa3Byxoni
rixi a.
AeqKux AocltiAxesH-sx 13, 211
voxyrr
exe ieaneHrHa edreK'rrzeHi
crs i Hrarqui fi
npr4 BI4KopHcraHHi ne6ylat7sepa
ra
rprox poria 12, 351. TIil '13s
nplr3l{aqa}orl eer Hxi Ao3t'l
EA
AirqNr
sxi
He6yr
6e:-
33, 34].
.I{,rr ocHauteHsr crauiouapia, a raxon( ans nlKy-
fle,]Hiure BBoAr{rr,r vepet
lHAl4-
BcraHoBJleHa
eiaya,ruHi He6ylafirepui iHrarnropn IIapi Boii ra
txon irnxi
Typ6o Boii (<Pari>), Bopearr (<Flaem Nuova>) <Om-
6po
e
Ao3oBaHoro aepo-
(AAI) si cneiicepov BertlKofo
o6'euy, Parolt s rIzM, rlpl{ cepeaHifi eaNrocri nepe6iry 3axBopIoBaHHR ra npH 3afocrpeHxrx BA,
oco6rlreo y nrcAelz noxuJloro nixy ra airef, cria
HaAaBarH flepeBary He6y:raiirepnifi repanii, ocrirsru
3oJrbHoro iurarxropa
:a6e:neqnrn roaraBKy BI4coKl4x lor 6poHxo:lirrzxie y
Alrcraruui eiAairu 6potxonoro AepeBa MoxHa rlJIbKl'{
3a AonoMoforc He6ynafilepa. l-{e rloJloxeHHt crocyerbcfl raKox xBopl'{x Ha BA, rxi norpanHll4 B craqionap 3 nepeAo3yBaHHtM B-aronicrin, BBeAeHltx 3a
AorroMorolo AAI [8, 14,16,361,
B aocliANesurx [37] AoBeAeHo, uro 98% xBopl4x
i: rarocrpeHuqNa BA 3AarHi po3Bxearn iucniparopHuI
norir, Aocraruiii alr e(terruettoro 3acrocyBaHl{t
6pomonirraxie,lepe: nopoulroeHft iura,rrrop (fTT)
ir
aarcouovipHo po3BuBalorll4M TaxlrlHoe rlepeBary criA HaAaearu BBeAeHHlo 6ponxoriraxie veper He6ynafi: ep Ua,26l.
Tarnv r{I4HoM, npu niryeauni cepeaguoeaxKnx ra
xBopux
KoHryp ailapary lllBll 122, 23, 261.
Fle6y:rafieep e eAIaHt4M Mo)KJlt4BltM saco6ov AoaraBKil npeflapary npl4 3arocrpeuni BA y Airefi Ao
BaHHt B aovautHix yMoBax BltKopHcroBylorb
rN,tiHrosaril crpyt(rypy. arrueHicru
B
ue 4 c, a raKo)It pyxoBl nopyllleHHt ra ropylueHHfl
3l]. Ipra Heo6xiaHocri iHrarquift eelrzxrx o6'ettie ra npoeeAeH+lR iHra,'l-suiI niA qac
ruryruoi eelrrtlrsuii rlereHb (lllBn) rpaute en6r'rpartl
ynbrpa3ByKoei inrurropn. qxi NloNtta [i.[K:toqa'rn e
csiAolaocri t2,
BaxK[x craHis :axeop]oBaHb 6poHxolereHeeoi cHcreM14 frepeBary clia Ha/]:aBArv He6ylafisepau.
06'errtreHHvr,t xpurepirrr,lla earKxocri craHy raKux
nauieHrie e 3HHxteHHt iHcniparopuoi Nhlreeoi el\4socri rereHu ()Ken) MeHUe uix 10,5 nar/rr (735 v-tt
y xBopHX earolo 70 r<r), iHcnipatopunfi norix MeHIue
HiN 30 r xB- t, HegaarHicrs 3arpl'rMarl4 A[xaHHq 6irs-
ron>>
122,23,26].
ltn
PeKolveuAoeaHo 3acrocoByearu He6ylafizepu
nocrifiHoi repauii BAoMa xBopxlt Ha EA, y trKI4x Ao-
BeaeHa BplcoKa edrexrrtnHicru liryeaHun BIlcoKI4M14
Ao3aMu 6poHxolirrarie [1a], 3acrocyeaHHt Bt4coKl,rx
gos crepor.u.ie reper He6yraiire Moil(rlHBe y lirynaHui xnopnx lta ropruoHo3anexHy A eaxxoro nepe6ir<y
3 Meroro 3Hl4xeHHt ni4rprznayrovoi ao:t't cl4creMHIzx
Koprl4Kocreporaie [6, 21,24, 32, 33, 35' 40].
Bn6ip rr,liN pisnuvrz [AI ra fll enstraqaerucR
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yana, T. Yazaki, M' Arai // ResPir' Drug Delivery .
-2003 -
V,S SUKHAN
lJzhhorod National university, Faculty of
continuing
Pre-lJniversity Training' Depaftment
of Pulmonology, Tuberculosis and Physiotherapy, U
NEBULAYZERNATHERAPYASAMETHODINHALAT|oSoLINPATIENTSW|THBRONCH|AL
ASTHMA
bound with the introduction of the latest generation
ln the last decade inhalation therapy came to a new level that
occupies a leading position in modern inhalation
of inhalers - nebulizers. currently, the supply of drugs nebulized
disease'
severe
and
acute
during
treatment of asthma, especially
Key words: asthma, inhalation aerosol, the nebulizer
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a)),BttnycK
t (5t),2015P.' 283