π΄π΄π΄π΄ πππππ οΏ½β―β―οΏ½ πππππ , πππππ , β¦ , πππππ across all tissues Select a number π Randomly select πππ sample sets with π tissues in the sample set. For each tissue set, we calculate the correlations between the miRNA and its targets. Then average these correlations For each tissue set, we calculate the proportion of negative correlations Totally, we have the means Totally, we have the of correlations, proportions of negative ππ , ππ , β¦ , ππππ correlations, Loss function algorithm π Calculate πππ , β¦, πππ π πππ = πππ + (π β π)ππ . . πππ ππ = πππππ + (π β π)ππππ πβπ denotes the smallest πππ πΆβπ is the corresponding tissue set of πβπ Find MTI-supported tissues πΆβπ for the tissue number π πΆβπ , πΆβπ , β¦, πΆβππ πβπ , πβπ , β¦, πβππ Select for different tissue numbers π and repeat the procedure again The tissue set πΆπβ with the smallest πβπ MTI-supported tissues
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